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ONTOLOGY REPORT - ANNOTATIONS


Term:attachment of spindle microtubules to kinetochore
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Accession:GO:0008608 term browser browse the term
Definition:The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
Comment:This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation).
Synonyms:exact_synonym: attachment of spindle microtubules to chromosome;   kinetochore-microtubule attachment;   microtubule anchoring at kinetochore;   spindle chromosome attachment;   spindle kinetochore attachment
 narrow_synonym: microtubule capture
 broad_synonym: kinetochore microtubule interaction;   microtubule and chromosome interaction;   spindle-chromosome interaction
 related_synonym: amphotelic attachment;   bipolar attachment;   microtubule and kinetochore interaction
 alt_id: GO:0051313


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attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABRAXAS1 abraxas 1, BRCA1 A complex subunit involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:83,459,517...83,485,137
Ensembl chr 4:83,459,517...83,523,348
JBrowse link
G ABRAXAS2 abraxas 2, BRISC complex subunit involved_in IMP
IBA
(PMID:26195665)
(PMID:21873635)
UniProt
GO_Central
PMID:21873635 PMID:26195665 NCBI chr10:124,801,803...124,836,670
Ensembl chr10:124,801,819...124,836,667
JBrowse link
G AURKB aurora kinase B involved_in TAS (PMID:19774610) UniProt PMID:19774610 NCBI chr17:8,204,731...8,210,767
Ensembl chr17:8,204,733...8,210,600
JBrowse link
G AURKC aurora kinase C involved_in TAS (PMID:19774610) UniProt PMID:19774610 NCBI chr19:57,230,317...57,235,550
Ensembl chr19:57,230,802...57,235,548
JBrowse link
G BUB3 BUB3 mitotic checkpoint protein involved_in IDA (PMID:18199686) UniProt PMID:18199686 NCBI chr10:123,154,402...123,170,467
Ensembl chr10:123,154,402...123,170,467
JBrowse link
G CENPE centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chr 4:103,105,811...103,198,408
Ensembl chr 4:103,105,349...103,198,445
JBrowse link
G CEP152 centrosomal protein 152 involved_in IEA InterPro GO_REF:0000002 NCBI chr15:48,662,534...48,811,904
Ensembl chr15:48,712,928...48,811,146
JBrowse link
G EML4 EMAP like 4 involved_in IMP (PMID:25789526) UniProt PMID:25789526 NCBI chr 2:42,169,353...42,332,548
Ensembl chr 2:42,169,353...42,332,548
JBrowse link
G KNL1 kinetochore scaffold 1 involved_in IDA
IBA
IEA
(PMID:17981135)
(PMID:21873635)
UniProt
GO_Central
InterPro
PMID:17981135 PMID:21873635 GO_REF:0000002 NCBI chr15:40,594,012...40,664,342
Ensembl chr15:40,594,020...40,664,342
JBrowse link
G NDC80 NDC80 kinetochore complex component involved_in IMP (PMID:19468067) UniProt PMID:19468067 NCBI chr18:2,571,557...2,616,635
Ensembl chr18:2,571,557...2,616,635
JBrowse link
G SGO1 shugoshin 1 involved_in IDA (PMID:17621308) UniProt PMID:17621308 NCBI chr 3:20,160,593...20,188,143
Ensembl chr 3:20,160,593...20,186,206
JBrowse link
G TEX14 testis expressed 14, intercellular bridge forming factor involved_in IBA
IEA
ISS
(PMID:21873635) GO_Central
InterPro
UniProt
PMID:21873635 GO_REF:0000002 GO_REF:0000024 NCBI chr17:58,556,678...58,692,045
Ensembl chr17:58,556,678...58,692,055
JBrowse link
G ZNF207 zinc finger protein 207 involved_in IBA
IMP
(PMID:21873635)
(PMID:24462186), (PMID:24462187)
GO_Central
UniProt
PMID:21873635 PMID:24462186 PMID:24462187 NCBI chr17:32,350,157...32,381,885
Ensembl chr17:32,350,132...32,381,885
JBrowse link
attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 involved_in IMP (PMID:22581055) UniProt PMID:22581055 NCBI chr16:88,803,789...88,809,258
Ensembl chr16:88,803,789...88,809,258
JBrowse link
G CENPC centromere protein C involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:67,468,762...67,545,503
Ensembl chr 4:67,468,762...67,545,503
JBrowse link
G CENPE centromere protein E involved_in IMP (PMID:15843429) UniProt PMID:15843429 NCBI chr 4:103,105,811...103,198,408
Ensembl chr 4:103,105,349...103,198,445
JBrowse link
G CHAMP1 chromosome alignment maintaining phosphoprotein 1 involved_in IBA
IEA
IMP
(PMID:21873635)
(PMID:21063390)
GO_Central
InterPro
UniProt
PMID:21063390 PMID:21873635 GO_REF:0000002 NCBI chr13:114,314,503...114,327,322
Ensembl chr13:114,314,482...114,337,626
JBrowse link
G KIF2C kinesin family member 2C involved_in IMP (PMID:23891108) UniProt PMID:23891108 NCBI chr 1:44,739,704...44,767,767
Ensembl chr 1:44,739,818...44,767,767
JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:1,815,795...2,232,945
Ensembl chr 7:1,815,793...2,233,243
JBrowse link
G MIS12 MIS12 kinetochore complex component involved_in IMP (PMID:23891108) UniProt PMID:23891108 NCBI chr17:5,486,374...5,490,814
Ensembl chr17:5,486,285...5,490,814
JBrowse link
G NDC80 NDC80 kinetochore complex component involved_in IMP
IEA
IBA
(PMID:23891108), (PMID:25743205)
(PMID:21873635)
UniProt
InterPro
GO_Central
PMID:21873635 PMID:23891108 PMID:25743205 GO_REF:0000002 NCBI chr18:2,571,557...2,616,635
Ensembl chr18:2,571,557...2,616,635
JBrowse link
G NUF2 NUF2 component of NDC80 kinetochore complex involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:163,321,948...163,355,764
Ensembl chr 1:163,266,576...163,355,764
JBrowse link
G RMDN1 regulator of microtubule dynamics 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:86,467,055...86,514,357
Ensembl chr 8:86,468,257...86,514,357
JBrowse link
G SEH1L SEH1 like nucleoporin involved_in IMP (PMID:17363900) UniProt PMID:17363900 NCBI chr18:12,947,988...12,987,665
Ensembl chr18:12,947,133...12,987,536
JBrowse link
homologous chromosome orientation involved in meiotic metaphase I plate congression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRCA2 BRCA2 DNA repair associated ISO RGD PMID:16964288 RGD:1599505 NCBI chr13:32,315,508...32,400,268
Ensembl chr13:32,315,086...32,400,268
JBrowse link
lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CENPE centromere protein E involved_in IMP (PMID:23891108) UniProt PMID:23891108 NCBI chr 4:103,105,811...103,198,408
Ensembl chr 4:103,105,349...103,198,445
JBrowse link
mitotic sister chromatid biorientation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BOD1 biorientation of chromosomes in cell division 1 involved_in IMP (PMID:17938248), (PMID:24157919) UniProt PMID:17938248 PMID:24157919 NCBI chr 5:173,607,145...173,617,072
Ensembl chr 5:173,607,145...173,616,659
JBrowse link
monopolar spindle attachment to meiosis I kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CENPC centromere protein C involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:67,468,762...67,545,503
Ensembl chr 4:67,468,762...67,545,503
JBrowse link
positive regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN1 beclin 1 involved_in IMP (PMID:23478334) CACAO PMID:23478334 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G HNRNPU heterogeneous nuclear ribonucleoprotein U involved_in IBA
IMP
(PMID:21873635)
(PMID:21242313)
GO_Central
UniProt
PMID:21242313 PMID:21873635 NCBI chr 1:244,850,297...244,864,543
Ensembl chr 1:244,840,638...244,864,560
JBrowse link
positive regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNB1 cyclin B1 involved_in IMP (PMID:18195732) BHF-UCL PMID:18195732 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245
JBrowse link
G CENPE centromere protein E involved_in ISO (MGI:2447982|PMID:12361599) UniProt PMID:12361599 MGI:2447982 NCBI chr 4:103,105,811...103,198,408
Ensembl chr 4:103,105,349...103,198,445
JBrowse link
G RCC2 regulator of chromosome condensation 2 involved_in IMP (PMID:12919680) UniProt PMID:12919680 NCBI chr 1:17,406,760...17,439,677
Ensembl chr 1:17,406,760...17,439,677
JBrowse link
G SIRT2 sirtuin 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr19:38,878,555...38,899,733
Ensembl chr19:38,878,555...38,899,862
JBrowse link
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AURKB aurora kinase B involved_in IDA (PMID:28751710) CACAO PMID:28751710 NCBI chr17:8,204,731...8,210,767
Ensembl chr17:8,204,733...8,210,600
JBrowse link
regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AC005726.1 novel protein involved_in IEA InterPro GO_REF:0000002 Ensembl chr17:28,455,752...28,614,185
Ensembl chr17:28,455,752...28,614,185
JBrowse link
G APC APC regulator of WNT signaling pathway involved_in
acts_upstream_of_or_within
NAS
IMP
(PMID:11283619)
(PMID:17227893)
UniProt
MGI
PMID:11283619 PMID:17227893 NCBI chr 5:112,707,498...112,846,239
Ensembl chr 5:112,707,498...112,846,239
JBrowse link
G CDC42 cell division cycle 42 involved_in IMP (PMID:15642749) UniProt PMID:15642749 NCBI chr 1:22,052,709...22,101,360
Ensembl chr 1:22,025,511...22,101,360
JBrowse link
G ECT2 epithelial cell transforming 2 involved_in IMP (PMID:15642749) UniProt PMID:15642749 NCBI chr 3:172,750,694...172,829,273
Ensembl chr 3:172,750,682...172,821,474
JBrowse link
G KNSTRN kinetochore localized astrin (SPAG5) binding protein involved_in IEA
IMP
IBA
(PMID:21402792)
(PMID:21873635)
InterPro
UniProt
GO_Central
PMID:21402792 PMID:21873635 GO_REF:0000002 NCBI chr15:40,382,721...40,394,288
Ensembl chr15:40,382,721...40,394,246
JBrowse link
G NEK2 NIMA related kinase 2 involved_in IMP (PMID:18297113) UniProt PMID:18297113 NCBI chr 1:211,658,256...211,675,621
Ensembl chr 1:211,658,657...211,675,630
JBrowse link
G RACGAP1 Rac GTPase activating protein 1 involved_in IMP (PMID:15642749) UniProt PMID:15642749 NCBI chr12:49,989,162...50,033,206
Ensembl chr12:49,976,923...50,033,136
JBrowse link
G SPAG5 sperm associated antigen 5 involved_in IMP
IEA
(PMID:21402792) UniProt
InterPro
PMID:21402792 GO_REF:0000002 NCBI chr17:28,577,574...28,599,025
Ensembl chr17:28,577,565...28,599,025
JBrowse link
sister chromatid biorientation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHAMP1 chromosome alignment maintaining phosphoprotein 1 involved_in IMP
IBA
(PMID:21063390)
(PMID:21873635)
UniProt
GO_Central
PMID:21063390 PMID:21873635 NCBI chr13:114,314,503...114,327,322
Ensembl chr13:114,314,482...114,337,626
JBrowse link
G RB1 RB transcriptional corepressor 1 involved_in IMP (PMID:20551165) BHF-UCL PMID:20551165 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18537
    cellular process 17456
      cell cycle process 1272
        attachment of spindle microtubules to kinetochore 38
          attachment of mitotic spindle microtubules to kinetochore + 15
          attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation + 2
          negative regulation of attachment of spindle microtubules to kinetochore + 0
          positive regulation of attachment of spindle microtubules to kinetochore + 7
          regulation of attachment of spindle microtubules to kinetochore + 15
          sister chromatid biorientation + 3
Path 2
Term Annotations click to browse term
  biological_process 18537
    cellular process 17456
      cell cycle 1686
        cell cycle process 1272
          nuclear chromosome segregation 301
            attachment of spindle microtubules to kinetochore 38
              attachment of mitotic spindle microtubules to kinetochore + 15
              attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation + 2
              negative regulation of attachment of spindle microtubules to kinetochore + 0
              positive regulation of attachment of spindle microtubules to kinetochore + 7
              regulation of attachment of spindle microtubules to kinetochore + 15
              sister chromatid biorientation + 3
paths to the root