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ONTOLOGY REPORT - ANNOTATIONS


Term:attachment of spindle microtubules to kinetochore
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Accession:GO:0008608 term browser browse the term
Definition:The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
Comment:This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation).
Synonyms:exact_synonym: attachment of spindle microtubules to chromosome;   kinetochore-microtubule attachment;   microtubule anchoring at kinetochore;   spindle chromosome attachment;   spindle kinetochore attachment
 narrow_synonym: microtubule capture
 broad_synonym: kinetochore microtubule interaction;   microtubule and chromosome interaction;   spindle-chromosome interaction
 related_synonym: amphotelic attachment;   bipolar attachment;   microtubule and kinetochore interaction
 alt_id: GO:0051313



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attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABRAXAS2 abraxas 2, BRISC complex subunit involved_in ISO (PMID:26195665) UniProt PMID:26195665 NCBI chr10:121,360,324...121,397,994
Ensembl chr10:125,628,423...125,664,833
JBrowse link
G BUB3 BUB3 mitotic checkpoint protein involved_in ISO (PMID:18199686) UniProt PMID:18199686 NCBI chr10:119,712,244...119,723,410
Ensembl chr10:123,987,541...123,998,011
JBrowse link
G CENPE centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chr 4:95,562,005...95,654,397
Ensembl chr 4:106,185,283...106,277,229
JBrowse link
G EML4 EMAP like 4 involved_in ISO (PMID:25789526) UniProt PMID:25789526 NCBI chr2A:42,267,435...42,430,231
Ensembl chr2A:43,119,984...43,281,825
JBrowse link
G KNL1 kinetochore scaffold 1 involved_in ISO (PMID:17981135) UniProt PMID:17981135 NCBI chr15:19,539,264...19,609,593
Ensembl chr15:37,801,705...37,860,858
JBrowse link
G NDC80 NDC80 kinetochore complex component involved_in ISO (PMID:19468067) UniProt PMID:19468067 NCBI chr18:11,666,099...11,711,456
Ensembl chr18:13,972,637...14,018,261
JBrowse link
G SGO1 shugoshin 1 involved_in ISO (PMID:17621308) UniProt PMID:17621308 NCBI chr 3:20,079,671...20,096,390 JBrowse link
G TEX14 testis expressed 14, intercellular bridge forming factor involved_in ISO (MGI:5318128|PMID:22405274) UniProt PMID:22405274 MGI:5318128 NCBI chr17:52,627,335...52,768,926
Ensembl chr17:57,480,369...57,621,055
JBrowse link
G ZNF207 zinc finger protein 207 involved_in ISO (PMID:24462186), (PMID:24462187) UniProt PMID:24462186 PMID:24462187 NCBI chr17:24,405,632...24,425,868
Ensembl chr17:24,690,903...24,714,628
JBrowse link
attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:22581055) UniProt PMID:22581055 NCBI chr16:69,516,728...69,522,419
Ensembl chr16:89,174,071...89,177,823
JBrowse link
G CENPE centromere protein E involved_in ISO (PMID:15843429) UniProt PMID:15843429 NCBI chr 4:95,562,005...95,654,397
Ensembl chr 4:106,185,283...106,277,229
JBrowse link
G CHAMP1 chromosome alignment maintaining phosphoprotein 1 involved_in ISO (PMID:21063390) UniProt PMID:21063390 NCBI chr13:95,382,649...95,411,763
Ensembl chr13:114,457,481...114,459,919
JBrowse link
G KIF2C kinesin family member 2C involved_in ISO (PMID:23891108) UniProt PMID:23891108 NCBI chr 1:44,042,565...44,070,922
Ensembl chr 1:45,408,734...45,436,844
JBrowse link
G MIS12 MIS12 kinetochore complex component involved_in ISO (PMID:23891108) UniProt PMID:23891108 NCBI chr17:5,534,305...5,538,736
Ensembl chr17:5,529,017...5,529,634
JBrowse link
G NDC80 NDC80 kinetochore complex component involved_in ISO (PMID:23891108), (PMID:25743205) UniProt PMID:23891108 PMID:25743205 NCBI chr18:11,666,099...11,711,456
Ensembl chr18:13,972,637...14,018,261
JBrowse link
G SEH1L SEH1 like nucleoporin involved_in ISO (PMID:17363900) UniProt PMID:17363900 NCBI chr18:1,342,928...1,379,719
Ensembl chr18:16,464,446...16,500,693
JBrowse link
homologous chromosome orientation involved in meiotic metaphase I plate congression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRCA2 BRCA2 DNA repair associated ISO RGD PMID:16964288 RGD:1599505 NCBI chr13:13,574,422...13,658,967
Ensembl chr13:32,010,066...32,091,332
JBrowse link
lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CENPE centromere protein E involved_in ISO (PMID:23891108) UniProt PMID:23891108 NCBI chr 4:95,562,005...95,654,397
Ensembl chr 4:106,185,283...106,277,229
JBrowse link
mitotic sister chromatid biorientation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BOD1 biorientation of chromosomes in cell division 1 involved_in ISO (PMID:17938248), (PMID:24157919) UniProt PMID:17938248 PMID:24157919 NCBI chr 5:168,951,787...168,960,934
Ensembl chr 5:175,857,814...175,866,951
JBrowse link
positive regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN1 beclin 1 involved_in ISO (PMID:23478334) CACAO PMID:23478334 NCBI chr17:14,493,619...14,507,809
Ensembl chr17:14,719,781...14,733,286
JBrowse link
G HNRNPU heterogeneous nuclear ribonucleoprotein U involved_in ISO (PMID:21242313) UniProt PMID:21242313 NCBI chr 1:220,450,218...220,461,412
Ensembl chr 1:225,817,899...225,842,031
JBrowse link
positive regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCNB1 cyclin B1 involved_in ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chr 5:44,826,103...44,836,832
Ensembl chr 5:46,394,362...46,405,332
JBrowse link
G CENPE centromere protein E involved_in ISO (MGI:2447982|PMID:12361599) UniProt PMID:12361599 MGI:2447982 NCBI chr 4:95,562,005...95,654,397
Ensembl chr 4:106,185,283...106,277,229
JBrowse link
G RCC2 regulator of chromosome condensation 2 involved_in ISO (PMID:12919680) UniProt PMID:12919680 NCBI chr 1:16,353,770...16,386,810
Ensembl chr 1:17,409,432...17,432,031
JBrowse link
G SIRT2 sirtuin 2 involved_in ISO (MGI:5567889|PMID:24334550) UniProt PMID:24334550 MGI:5567889 NCBI chr19:35,984,453...36,005,582
Ensembl chr19:44,533,965...44,554,799
JBrowse link
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AURKB aurora kinase B involved_in ISO (PMID:28751710) CACAO PMID:28751710 NCBI chr17:43,447,661...43,453,864
Ensembl chr17:48,180,066...48,186,129
JBrowse link
regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway acts_upstream_of_or_within ISO (MGI:3701148|PMID:17227893)
(PMID:17227893)
MGI PMID:17227893 MGI:3701148 NCBI chr 5:108,070,697...108,208,273
Ensembl chr 5:113,904,352...114,009,709
JBrowse link
G CDC42 cell division cycle 42 involved_in ISO (PMID:15642749) UniProt PMID:15642749 NCBI chr 1:21,245,970...21,286,210 JBrowse link
G ECT2 epithelial cell transforming 2 involved_in ISO (PMID:15642749) UniProt PMID:15642749 NCBI chr 3:169,756,885...169,828,087
Ensembl chr 3:177,938,164...178,008,381
JBrowse link
G KNSTRN kinetochore localized astrin (SPAG5) binding protein involved_in ISO (PMID:21402792) UniProt PMID:21402792 NCBI chr15:19,316,854...19,328,425 JBrowse link
G NEK2 NIMA related kinase 2 involved_in ISO (PMID:18297113) UniProt PMID:18297113 NCBI chr 1:187,225,947...187,243,605
Ensembl chr 1:192,092,885...192,105,737
JBrowse link
G RACGAP1 Rac GTPase activating protein 1 involved_in ISO (PMID:15642749) UniProt PMID:15642749 NCBI chr12:38,729,885...38,766,063
Ensembl chr12:39,625,796...39,672,256
JBrowse link
G SPAG5 sperm associated antigen 5 involved_in ISO (PMID:21402792) UniProt PMID:21402792 NCBI chr17:28,176,288...28,198,493
Ensembl chr17:28,680,492...28,702,050
JBrowse link
sister chromatid biorientation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHAMP1 chromosome alignment maintaining phosphoprotein 1 involved_in ISO (PMID:21063390) UniProt PMID:21063390 NCBI chr13:95,382,649...95,411,763
Ensembl chr13:114,457,481...114,459,919
JBrowse link
G RB1 RB transcriptional corepressor 1 involved_in ISO (PMID:20551165) BHF-UCL PMID:20551165 NCBI chr13:29,453,872...29,624,665
Ensembl chr13:48,155,795...48,324,575
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12658
    cellular process 11791
      cell cycle process 985
        attachment of spindle microtubules to kinetochore 30
          attachment of mitotic spindle microtubules to kinetochore + 11
          attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation + 1
          negative regulation of attachment of spindle microtubules to kinetochore + 0
          positive regulation of attachment of spindle microtubules to kinetochore + 7
          regulation of attachment of spindle microtubules to kinetochore + 14
          sister chromatid biorientation + 3
Path 2
Term Annotations click to browse term
  biological_process 12658
    cellular process 11791
      cell cycle 1273
        cell cycle process 985
          nuclear chromosome segregation 233
            attachment of spindle microtubules to kinetochore 30
              attachment of mitotic spindle microtubules to kinetochore + 11
              attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation + 1
              negative regulation of attachment of spindle microtubules to kinetochore + 0
              positive regulation of attachment of spindle microtubules to kinetochore + 7
              regulation of attachment of spindle microtubules to kinetochore + 14
              sister chromatid biorientation + 3
paths to the root