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ONTOLOGY REPORT - ANNOTATIONS


Term:attachment of spindle microtubules to kinetochore
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Accession:GO:0008608 term browser browse the term
Definition:The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
Comment:This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation).
Synonyms:exact_synonym: attachment of spindle microtubules to chromosome;   kinetochore-microtubule attachment;   microtubule anchoring at kinetochore;   spindle chromosome attachment;   spindle kinetochore attachment
 narrow_synonym: microtubule capture
 broad_synonym: kinetochore microtubule interaction;   microtubule and chromosome interaction;   spindle-chromosome interaction
 related_synonym: amphotelic attachment;   bipolar attachment;   microtubule and kinetochore interaction
 alt_id: GO:0051313



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attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abraxas1 abraxas 1, BRCA1 A complex subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:8,796,281...8,810,625
Ensembl chr14:8,796,266...8,810,622
JBrowse link
G Abraxas2 abraxas 2, BRISC complex subunit involved_in ISO
IBA
(PMID:26195665)
PMID:21873635
RGD PMID:26195665 PMID:21873635 RGD:13792537 NCBI chr 1:187,647,078...187,672,660
Ensembl chr 1:187,647,067...187,672,655
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein involved_in ISO (PMID:18199686) RGD PMID:18199686 NCBI chr 1:186,330,358...186,340,969
Ensembl chr 1:186,327,931...186,395,036
JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2673075|PMID:12925705) RGD PMID:12925705 MGI:2673075 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Eml4 EMAP like 4 involved_in ISO (PMID:25789526) RGD PMID:25789526 NCBI chr 6:11,219,545...11,334,824
Ensembl chr 6:11,219,566...11,334,879
JBrowse link
G Knl1 kinetochore scaffold 1 involved_in IBA
ISO
PMID:21873635
(PMID:17981135)
RGD PMID:17981135 PMID:21873635 RGD:13792537 NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO (PMID:18455984), (PMID:19468067) RGD PMID:18455984 PMID:19468067 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex involved_in ISO (PMID:18455984) RGD PMID:18455984 NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766
JBrowse link
G Sgo1 shugoshin 1 involved_in ISO (PMID:17621308) RGD PMID:17621308 NCBI chr 9:6,672,109...6,687,908
Ensembl chr 9:6,672,123...6,687,805
JBrowse link
G Spc24 SPC24 component of NDC80 kinetochore complex involved_in ISO (PMID:18455984) RGD PMID:18455984 NCBI chr 8:20,300,315...20,305,354
Ensembl chr 8:20,300,319...20,305,310
JBrowse link
G Spc25 SPC25 component of NDC80 kinetochore complex involved_in ISO (PMID:18455984) RGD PMID:18455984 NCBI chr 3:53,930,013...53,988,940
Ensembl chr 3:53,975,704...53,988,959
JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor involved_in IEA
ISO
ISS
IBA
GO_REF:0000107
GO_REF:0000002
(MGI:5318128|PMID:22405274)
GO_REF:0000024
PMID:21873635
Ensembl
InterPro
RGD
UniProt
PMID:22405274 PMID:21873635 GO_REF:0000002 GO_REF:0000024 GO_REF:0000107 MGI:5318128, RGD:13792537 NCBI chr10:72,231,766...72,356,938
Ensembl chr10:72,231,801...72,355,805
JBrowse link
G Zfp207 zinc finger protein 207 involved_in ISO (PMID:24462186), (PMID:24462187) RGD PMID:24462186 PMID:24462187 NCBI chr10:65,385,823...65,397,591
Ensembl chr10:65,385,740...65,397,386
JBrowse link
attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:22581055) RGD PMID:22581055 NCBI chr19:50,620,713...50,625,659
Ensembl chr19:50,620,713...50,625,659
JBrowse link
G Cenpc centromere protein C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:21,988,067...22,046,732
Ensembl chr14:21,988,144...22,055,476
JBrowse link
G Cenpe centromere protein E involved_in ISO (PMID:15843429) RGD PMID:15843429 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Champ1 chromosome alignment maintaining phosphoprotein 1 involved_in ISO
IBA
(PMID:21063390)
PMID:21873635
RGD PMID:21063390 PMID:21873635 RGD:13792537 NCBI chr16:75,733,958...75,744,977
Ensembl chr16:75,733,805...75,744,984
JBrowse link
G Kif2c kinesin family member 2C involved_in ISO
ISS
IEA
(PMID:23891108)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:23891108 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:130,637,347...130,662,680
Ensembl chr 5:130,637,347...130,662,637
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:14,320,892...14,630,750
Ensembl chr12:14,320,892...14,630,703
JBrowse link
G Mapre1 microtubule-associated protein, RP/EB family, member 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:23001180)
UniProt
RGD
PMID:23001180 GO_REF:0000024 NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983
JBrowse link
G Mis12 MIS12 kinetochore complex component involved_in ISO
ISS
(PMID:23891108)
GO_REF:0000024
RGD
UniProt
PMID:23891108 GO_REF:0000024 NCBI chr10:55,739,590...55,747,915
Ensembl chr10:55,739,564...55,751,068
JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO
IEA
(PMID:23891108), (PMID:25743205)
GO_REF:0000104
(PMID:23891108), (PMID:25743205), (PMID:30409912)
RGD
UniProt
PMID:23891108 PMID:25743205 PMID:30409912 GO_REF:0000104 NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:81,693,675...81,722,765
Ensembl chr13:81,693,598...81,722,766
JBrowse link
G Seh1l SEH1-like nucleoporin involved_in ISO (PMID:17363900) RGD PMID:17363900
homologous chromosome orientation involved in meiotic metaphase I plate congression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated IMP RGD PMID:16964288 RGD:1599505 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpe centromere protein E involved_in ISO (PMID:23891108) RGD PMID:23891108 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
mitotic sister chromatid biorientation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bod1 biorientation of chromosomes in cell division 1 involved_in ISO (PMID:17938248), (PMID:24157919) RGD PMID:17938248 PMID:24157919 NCBI chr10:15,993,454...15,999,795
Ensembl chr10:15,993,454...15,999,787
JBrowse link
monopolar spindle attachment to meiosis I kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpc centromere protein C involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:21,988,067...22,046,732
Ensembl chr14:21,988,144...22,055,476
JBrowse link
positive regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 involved_in ISO (PMID:23478334) RGD PMID:23478334 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U involved_in IBA
IEA
ISO
ISS
PMID:21873635
GO_REF:0000107
(PMID:21242313)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:21242313 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588
JBrowse link
G Kat2b lysine acetyltransferase 2B involved_in ISO (PMID:23001180) RGD PMID:23001180 NCBI chr 9:6,562,525...6,667,064
Ensembl chr 9:6,562,288...6,667,064
JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISO
ISS
(PMID:30409912)
GO_REF:0000024
RGD
UniProt
PMID:30409912 GO_REF:0000024 NCBI chr 1:202,895,751...202,903,178
Ensembl chr 1:202,895,751...202,903,458
JBrowse link
positive regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 involved_in ISO (PMID:18195732) RGD PMID:18195732 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cenpe centromere protein E involved_in ISO (MGI:2447982|PMID:12361599) RGD PMID:12361599 MGI:2447982 NCBI chr 2:223,637,035...223,695,692
Ensembl chr 2:223,636,998...223,695,669
JBrowse link
G Rcc2 regulator of chromosome condensation 2 involved_in ISO (PMID:12919680) RGD PMID:12919680 NCBI chr 5:152,994,406...153,017,223
Ensembl chr 5:152,993,665...153,017,205
JBrowse link
G Sirt2 sirtuin 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5567889|PMID:24334550)
UniProt
RGD
PMID:24334550 GO_REF:0000024 MGI:5567889 NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
JBrowse link
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B involved_in ISO (PMID:28751710) RGD PMID:28751710 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3701148|PMID:17227893)
(PMID:17227893)
GO_REF:0000107
RGD
Ensembl
PMID:17227893 GO_REF:0000107 MGI:3701148 NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696
JBrowse link
G Cdc42 cell division cycle 42 involved_in ISO
ISS
(PMID:15642749)
GO_REF:0000024
RGD
UniProt
PMID:15642749 GO_REF:0000024 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Ect2 epithelial cell transforming 2 involved_in ISO (PMID:15642749) RGD PMID:15642749 NCBI chr 2:109,975,813...110,037,911
Ensembl chr 2:109,975,813...110,037,911
JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding protein involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:21402792)
UniProt
RGD
PMID:21402792 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 3:105,800,762...105,820,555
Ensembl chr 3:105,800,954...105,820,715
JBrowse link
G Nek2 NIMA-related kinase 2 involved_in ISO (PMID:18297113) RGD PMID:18297113 NCBI chr13:103,405,818...103,419,063
Ensembl chr13:103,405,819...103,419,051
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 involved_in ISO (PMID:15642749) RGD PMID:15642749 NCBI chr 7:130,750,936...130,780,891
Ensembl chr 7:130,750,936...130,780,831
JBrowse link
G Spag5 sperm associated antigen 5 involved_in ISO (PMID:21402792) RGD PMID:21402792 NCBI chr10:63,198,717...63,216,746
Ensembl chr10:63,198,768...63,216,745
JBrowse link
sister chromatid biorientation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Champ1 chromosome alignment maintaining phosphoprotein 1 involved_in IBA
ISO
PMID:21873635
(PMID:21063390)
RGD PMID:21063390 PMID:21873635 RGD:13792537 NCBI chr16:75,733,958...75,744,977
Ensembl chr16:75,733,805...75,744,984
JBrowse link
G Rb1 RB transcriptional corepressor 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:20551165)
Ensembl
RGD
PMID:20551165 GO_REF:0000107 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20099
    cellular process 18695
      cell cycle process 1246
        attachment of spindle microtubules to kinetochore 39
          attachment of mitotic spindle microtubules to kinetochore + 17
          attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation + 2
          negative regulation of attachment of spindle microtubules to kinetochore + 0
          positive regulation of attachment of spindle microtubules to kinetochore + 9
          regulation of attachment of spindle microtubules to kinetochore + 16
          sister chromatid biorientation + 3
Path 2
Term Annotations click to browse term
  biological_process 20099
    cellular process 18695
      cell cycle 1634
        cell cycle process 1246
          nuclear chromosome segregation 297
            attachment of spindle microtubules to kinetochore 39
              attachment of mitotic spindle microtubules to kinetochore + 17
              attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation + 2
              negative regulation of attachment of spindle microtubules to kinetochore + 0
              positive regulation of attachment of spindle microtubules to kinetochore + 9
              regulation of attachment of spindle microtubules to kinetochore + 16
              sister chromatid biorientation + 3
paths to the root