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ONTOLOGY REPORT - ANNOTATIONS

Term:folate:monoatomic anion antiporter activity
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Accession:GO:0008518 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF.
Synonyms:broad_synonym: folate:anion antiporter activity
 related_synonym: reduced folate carrier activity;   reduced folate transmembrane transporter activity;   reduced folate transporter
 xref: TC:2.A.48


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folate:monoatomic anion antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc19a1 solute carrier family 19 member 1 enables IDA
ISO
IBA		 (PMID:14609557), (PMID:22554803), (PMID:28885847)
GO_REF:0000033		 RGD
GO_Central		 PMID:14609557 PMID:22554803 PMID:28885847 PMID:11600421 GO_REF:0000033, RGD:735239 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20633
    transporter activity 1253
      transmembrane transporter activity 1153
        monoatomic ion transmembrane transporter activity 762
          monoatomic anion transmembrane transporter activity 151
            folate:monoatomic anion antiporter activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20633
    transporter activity 1253
      transmembrane transporter activity 1153
        organic acid transmembrane transporter activity 189
          carboxylic acid transmembrane transporter activity 188
            folic acid transmembrane transporter activity 4
              folate:monoatomic anion antiporter activity 1
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