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ONTOLOGY REPORT - ANNOTATIONS

Term:folic acid transmembrane transporter activity
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Accession:GO:0008517 term browser browse the term
Definition:Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
Synonyms:exact_synonym: folate transmembrane transporter activity;   folate transporter activity;   vitamin B9 transporter activity;   vitamin M transporter activity
 related_synonym: folic acid transporter activity
 xref: Reactome:R-HSA-200652 "SLC19A1 transports 5-methyl-THF from extracellular region to cytosol";   Reactome:R-HSA-200680 "SLC25A32 transports THF from cytosol to mitochondrial matrix";   Reactome:R-HSA-200720 "SLC25A32 transports THF from mitochondrial matrix to cytosol";   Reactome:R-HSA-200729 "SLC46A1 transports FOLA from extracellular region to cytosol";   reactome:R-HSA-200646 "Cytosolic folate export across the plasma membrane"


show annotations for term's descendants           Sort by:
folic acid transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdpn podoplanin NOT|enables ISS
ISO		 GO_REF:0000024
(PMID:12032185)		 UniProt
RGD		 PMID:12032185 GO_REF:0000024 NCBI chr 5:155,601,691...155,635,656
Ensembl chr 5:155,601,691...155,635,656 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 enables ISO (PMID:9111015), (PMID:9748272)
(PMID:36071163), (PMID:36265513), (PMID:36575193)		 RGD PMID:9111015 PMID:9748272 PMID:36071163 PMID:36265513 PMID:36575193 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Slc25a32 solute carrier family 25 member 32 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:70,142,958...70,160,726
Ensembl chr 7:70,142,964...70,160,770 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 enables ISS
ISO		 GO_REF:0000024
(PMID:17129779), (PMID:17475902), (PMID:19762432), (PMID:29344585), (PMID:32893190), (PMID:34619546)		 UniProt
RGD		 PMID:17129779 PMID:17475902 PMID:19762432 PMID:29344585 PMID:32893190 More... GO_REF:0000024 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
folate:monoatomic anion antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc19a1 solute carrier family 19 member 1 enables IDA
ISO
IBA		 (PMID:14609557), (PMID:22554803), (PMID:28885847)
GO_REF:0000033		 RGD
GO_Central		 PMID:14609557 PMID:22554803 PMID:28885847 PMID:11600421 GO_REF:0000033, RGD:735239 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
folic acid:proton symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc46a1 solute carrier family 46 member 1 enables ISO (PMID:19389703), (PMID:34040256)
(PMID:17962486)		 RGD PMID:17962486 PMID:19389703 PMID:34040256 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21087
    transporter activity 1269
      transmembrane transporter activity 1162
        modified amino acid transmembrane transporter activity 33
          folic acid transmembrane transporter activity 4
            folate:monoatomic anion antiporter activity 1
            folic acid:proton symporter activity 1
Path 2
Term Annotations click to browse term
  molecular_function 21087
    transporter activity 1269
      transmembrane transporter activity 1162
        organic anion transmembrane transporter activity 281
          carboxylic acid transmembrane transporter activity 192
            folic acid transmembrane transporter activity 4
              folate:monoatomic anion antiporter activity 1
              folic acid:proton symporter activity 1
paths to the root