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ONTOLOGY REPORT - ANNOTATIONS

Term:monoamine transmembrane transporter activity
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Accession:GO:0008504 term browser browse the term
Definition:Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other.
Synonyms:alt_id: GO:0015201
 xref: Reactome:R-HSA-5660706 "Defective SLC6A3 does not cotransport DA, Na+ from extracellular region to cytosol";   reactome:R-HSA-372542 "Loading of dopamine into synaptic veiscles";   reactome:R-HSA-379393 "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol";   reactome:R-HSA-380586 "loading of Serotonin in synaptic vesicles";   reactome:R-HSA-380620 "Reuptake of serotonin from the synapse";   reactome:R-HSA-444160 "VMAT1/2 can mediate the transport of biogenic amines"


show annotations for term's descendants           Sort by:
monoamine transmembrane transporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a1 solute carrier family 22 member 1 enables IDA
ISO		 tyramine
PMID:11502595
PMID:8955087
PMID:10570053
PMID:15662044
(PMID:12439218), (PMID:24688079), (PMID:24961373), (PMID:35469921), (PMID:9260930)
PMID:16581093
(PMID:24961373), (PMID:35469921)		 RGD PMID:9260930 PMID:12439218 PMID:24688079 PMID:24961373 PMID:35469921 More... RGD:1643122, RGD:155663523, RGD:155663519, RGD:155663521, RGD:155663532, RGD:155663558 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 enables IEA
ISO
IDA
ISS		 GO_REF:0000107
(PMID:12089365), (PMID:15212162), (PMID:16581093), (PMID:17072098), (PMID:17460754), (PMID:9687576)
PMID:9812985
GO_REF:0000024
PMID:11758759		 Ensembl
RGD
UniProt		 PMID:9687576 PMID:12089365 PMID:15212162 PMID:16581093 PMID:17072098 More... GO_REF:0000024 GO_REF:0000107, RGD:155888554, RGD:155663558, RGD:155888557 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 enables IDA
ISO		 PMID:16581093
(PMID:18513366)
(PMID:10196521), (PMID:16581093), (PMID:20858707), (PMID:23505051)		 RGD PMID:10196521 PMID:16581093 PMID:18513366 PMID:20858707 PMID:23505051 More... RGD:155663558 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc29a3 solute carrier family 29 member 3 enables ISO
IEA
ISS		 (PMID:19164483)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:19164483 GO_REF:0000024 GO_REF:0000107 NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388 		JBrowse link
G Slc29a4 solute carrier family 29 member 4 enables IDA
ISO
IBA		 1-methyl-4-phenylpyridinium
(PMID:20858707), (PMID:23255610)
GO_REF:0000033
(PMID:15448143), (PMID:16099839), (PMID:17018840), (PMID:17121826), (PMID:20592246), (PMID:20858707), (PMID:22396231), (PMID:23505051)		 RGD
GO_Central		 PMID:15448143 PMID:16099839 PMID:17018840 PMID:17121826 PMID:20592246 More... GO_REF:0000033, RGD:7794726 NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 enables ISO (PMID:16024787)
(PMID:20858707)		 RGD PMID:16024787 PMID:20858707 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 enables ISO (PMID:16024787)
(PMID:20858707)		 RGD PMID:16024787 PMID:20858707 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 enables ISO (PMID:16024787)
(PMID:20858707)		 RGD PMID:16024787 PMID:20858707 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
dopamine:sodium symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a1 solute carrier family 22 member 1 IDA RGD PMID:9776363 RGD:1643122 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 IDA RGD PMID:9830022 RGD:1643215 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 enables ISO
IBA		 (PMID:11093780), (PMID:8125921)
GO_REF:0000033		 RGD
GO_Central		 PMID:8125921 PMID:11093780 GO_REF:0000033 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 enables IDA
ISO
IBA
IMP		 MGI:2386303 (PMID:10375632), (PMID:9520487)
GO_REF:0000033
PMID:1948034
PMID:1502198
(PMID:10375632), (PMID:11093780), (PMID:1406597), (PMID:15505207), (PMID:19478460), (PMID:8302271)
PMID:8125921
PMID:1948035		 RGD
GO_Central		 PMID:1406597 PMID:8302271 PMID:9520487 PMID:10375632 PMID:11093780 More... GO_REF:0000033, RGD:730166, RGD:730247, RGD:152995550, RGD:152995566, RGD:730214, RGD:4139887 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
monoamine:proton antiporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc18a1 solute carrier family 18 member A1 enables IEA
IDA
ISO		 GO_REF:0000107
PMID:8125935
(PMID:8643547)
(PMID:16326835), (PMID:23337945)
(PMID:21712771)		 Ensembl
RGD		 PMID:8643547 PMID:16326835 PMID:21712771 PMID:23337945 PMID:8125935 GO_REF:0000107, RGD:155663520 NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 enables IDA
IEA
ISO		 PMID:25355561
PMID:8860238
PMID:8125935
GO_REF:0000107
(PMID:23363473), (PMID:8643547), (PMID:8860238)		 Ensembl
RGD		 PMID:8643547 PMID:8860238 PMID:23363473 PMID:25355561 PMID:8860238 More... GO_REF:0000107, RGD:155230738, RGD:155663540, RGD:155663520 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc18a3 solute carrier family 18 member A3 enables ISO (PMID:25355561) RGD PMID:25355561 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Slc18b1 solute carrier family 18 member B1 enables ISS
ISO		 GO_REF:0000024
(PMID:25355561)		 UniProt
RGD		 PMID:25355561 GO_REF:0000024 NCBI chr 1:21,628,235...21,670,807
Ensembl chr 1:21,628,237...21,670,684 		JBrowse link
norepinephrine:sodium symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a1 solute carrier family 22 member 1 IDA RGD PMID:9776363 RGD:1643122 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
G Slc6a2 solute carrier family 6 member 2 enables IDA
ISO
IBA		 (PMID:16269905)
GO_REF:0000033
(PMID:2008212), (PMID:8125921)		 RGD
GO_Central		 PMID:2008212 PMID:8125921 PMID:16269905 PMID:10196144 GO_REF:0000033, RGD:634151 NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 enables IDA
IBA		 PMID:8125921
GO_REF:0000033		 GO_Central PMID:8125921 GO_REF:0000033, RGD:152995566 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413 		JBrowse link
serotonin:sodium:chloride symporter activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc18a1 solute carrier family 18 member A1 enables IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:16926160 GO_REF:0000033, RGD:5130998 NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 enables TAS
ISO
IBA
IDA
IMP		 (PMID:9037532)
GO_REF:0000033
(PMID:10407194), (PMID:12869649), (PMID:17506858), (PMID:8987735)
PMID:1944572
PMID:15627510
PMID:8601815
PMID:10716733
PMID:11709063		 RGD
GO_Central		 PMID:8987735 PMID:9037532 PMID:10407194 PMID:12869649 PMID:17506858 More... GO_REF:0000033, RGD:730261, RGD:155663539, RGD:155663546, RGD:8553308, RGD:155663514, RGD:8554226, RGD:8553990, RGD:1580635 NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20633
    transporter activity 1253
      transmembrane transporter activity 1153
        active transmembrane transporter activity 447
          monoamine transmembrane transporter activity 12
            dopamine:sodium symporter activity 4
            monoamine:proton antiporter activity 4
            norepinephrine:sodium symporter activity 3
            serotonin:sodium:chloride symporter activity 3
            tyrosine:tyramine antiporter activity 0
paths to the root