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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid 4-hydroxylase activity
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Accession:GO:0008401 term browser browse the term
Definition:Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid.
Synonyms:narrow_synonym: cytochrome P450 CYP261
 xref: Reactome:R-HSA-5602050 "Defective CYP26C1 does not 4-hydroxylate 9cRA";   Reactome:R-HSA-5602063 "Defective CYP26B1 does not 4-hydroxylate atRA";   reactome:R-HSA-211874 "CYP2S1 4-hydroxylates atRA";   reactome:R-HSA-211923 "CYP26C1 4-hydroxylates 9cRA";   reactome:R-HSA-212007 "CYP26A1,B1 4-hydroxylate atRA";   reactome:R-HSA-5362525 "CYP26A1,B1,C1 4-hydroxylate atRA"

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retinoic acid 4-hydroxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101698313 cytochrome P450 2W1 enables ISO (PMID:26936974) UniProt PMID:26936974 NCBI chrNW_004624740:26,545,725...26,551,906
Ensembl chrNW_004624740:26,544,715...26,549,433 		JBrowse link
G LOC101699044 cytochrome P450 26A1 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624737:4,324,964...4,329,488
Ensembl chrNW_004624737:4,325,755...4,329,758 		JBrowse link
G LOC101708363 cytochrome P450 26C1 enables ISO (PMID:14532297) BHF-UCL PMID:14532297 NCBI chrNW_004624737:4,312,711...4,323,833
Ensembl chrNW_004624737:4,312,772...4,320,978 		JBrowse link
G LOC101708592 cytochrome P450 2C55 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004624737:6,040,817...6,100,509
Ensembl chrNW_004624737:6,040,202...6,102,086 		JBrowse link
G LOC101714280 cytochrome P450 26B1 enables ISO (PMID:10823918) RGD
BHF-UCL		 PMID:10823918 PMID:14592467 RGD:6771357 NCBI chrNW_004624762:1,455,828...1,474,201
Ensembl chrNW_004624762:1,456,440...1,472,381 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 18441
    catalytic activity 5677
      oxidoreductase activity 693
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 180
          retinoic acid 4-hydroxylase activity 5
            all-trans retinoic acid 4-hydrolase activity 0
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