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ONTOLOGY REPORT - ANNOTATIONS

Term:retinoic acid 4-hydroxylase activity
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Accession:GO:0008401 term browser browse the term
Definition:Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid.
Synonyms:narrow_synonym: cytochrome P450 CYP261
 xref: Reactome:R-HSA-5602050 "Defective CYP26C1 does not 4-hydroxylate 9cRA";   Reactome:R-HSA-5602063 "Defective CYP26B1 does not 4-hydroxylate atRA";   reactome:R-HSA-211874 "CYP2S1 4-hydroxylates atRA";   reactome:R-HSA-211923 "CYP26C1 4-hydroxylates 9cRA";   reactome:R-HSA-212007 "CYP26A1,B1 4-hydroxylate atRA";   reactome:R-HSA-5362525 "CYP26A1,B1,C1 4-hydroxylate atRA"

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retinoic acid 4-hydroxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 enables IEA Ensembl GO_REF:0000107 NCBI chr 9:86,310,142...86,328,622
Ensembl chr 9:86,325,401...86,328,775 		JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 enables ISO
IEA 		RGD
Ensembl		 PMID:14592467 GO_REF:0000107 RGD:6771357 NCBI chr14:35,030,011...35,057,164
Ensembl chr14:35,038,654...35,057,176 		JBrowse link
G CYP26C1 cytochrome P450 family 26 subfamily C member 1 enables IEA Ensembl GO_REF:0000107 Ensembl chr 9:86,311,950...86,319,834 JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 enables ISO (PMID:11093772) UniProt PMID:11093772 NCBI chr 9:87,881,444...87,941,586 JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 enables IEA Ensembl GO_REF:0000107 NCBI chr 9:88,154,131...88,183,915
Ensembl chr 9:88,154,134...88,183,458 		JBrowse link
G CYP2W1 cytochrome P450 family 2 subfamily W member 1 enables IEA Ensembl GO_REF:0000107 NCBI chr28:20,580,272...20,592,771
Ensembl chr28:20,582,287...20,591,497 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 enables ISO (PMID:11093772) UniProt PMID:11093772 NCBI chr28:13,297,566...13,330,023 JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 enables IEA Ensembl GO_REF:0000107 Ensembl chr28:13,313,930...13,331,832 JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 enables IEA Ensembl GO_REF:0000107 NCBI chr28:13,473,649...13,517,905
Ensembl chr28:13,491,483...13,519,507 		JBrowse link
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Term Annotations click to browse term
  molecular_function 19734
    catalytic activity 5499
      oxidoreductase activity 700
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 183
          retinoic acid 4-hydroxylase activity 9
            all-trans retinoic acid 4-hydrolase activity 0
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