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ONTOLOGY REPORT - ANNOTATIONS

Term:sterol 14-demethylase activity
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Accession:GO:0008398 term browser browse the term
Definition:Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase].
Synonyms:narrow_synonym: cytochrome P450 51 activity;   cytochrome P450 CYP51;   lanosterol 14-alpha-demethylase activity;   lanosterol 14-demethylase activity;   obtusufoliol 14-demethylase activity
 related_synonym: lanosterol 14alpha-demethylase activity;   sterol 14-alpha-demethylase activity;   sterol 14alpha-demethylase activity
 xref: EC:1.14.14.154;   MetaCyc:1.14.13.70-RXN;   RHEA:54028

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sterol 14-demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101724157 lanosterol 14-alpha demethylase enables ISO (PMID:20149798) RGD
UniProt		 PMID:7581240 PMID:7665087 PMID:20149798 RGD:1298863 RGD:2316902 NCBI chrNW_004624809:1,080,427...1,110,802
Ensembl chrNW_004624809:1,080,656...1,100,254 		JBrowse link
Term paths to the root
Path 1
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  molecular_function 18442
    catalytic activity 5600
      demethylase activity 37
        sterol 14-demethylase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 18442
    catalytic activity 5600
      oxidoreductase activity 698
        monooxygenase activity 110
          oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 24
            sterol 14-demethylase activity 1
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