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ONTOLOGY REPORT - ANNOTATIONS

Term:sterol 14-demethylase activity
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Accession:GO:0008398 term browser browse the term
Definition:Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase].
Synonyms:narrow_synonym: cytochrome P450 51 activity;   cytochrome P450 CYP51;   lanosterol 14-alpha-demethylase activity;   lanosterol 14-demethylase activity;   obtusufoliol 14-demethylase activity
 related_synonym: lanosterol 14alpha-demethylase activity;   sterol 14-alpha-demethylase activity;   sterol 14alpha-demethylase activity
 xref: EC:1.14.14.154;   MetaCyc:1.14.13.70-RXN;   RHEA:54028


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sterol 14-demethylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp51 cytochrome P450, family 51 enables IDA
ISO		 (PMID:20149798) RGD PMID:20149798 PMID:7665087 PMID:7581240 RGD:1298863, RGD:2316902 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      demethylase activity 42
        sterol 14-demethylase activity 1
Path 2
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      oxidoreductase activity 854
        monooxygenase activity 159
          oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 39
            sterol 14-demethylase activity 1
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