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ONTOLOGY REPORT - ANNOTATIONS

Term:IkappaB kinase complex
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Accession:GO:0008385 term browser browse the term
Definition:A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Synonyms:exact_synonym: IKK complex;   heterotrimeric IKK complex;   trimeric IKK complex


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IkappaB kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHUK component of inhibitor of nuclear factor kappa B kinase complex part_of ISO
IBA
IEA
TAS		 (PMID:18626576) RGD
GO_Central
TreeGrafter
Ensembl
UniProt		 PMID:17419723 PMID:18626576 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 RGD:2298661 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G ERC1 ELKS/RAB6-interacting/CAST family member 1 part_of IDA (PMID:15218148) UniProt PMID:15218148 NCBI chr12:989,959...1,495,933
Ensembl chr12:990,509...1,495,933 		JBrowse link
G IFIT5 interferon induced protein with tetratricopeptide repeats 5 located_in IMP (PMID:26334375) UniProt PMID:26334375 NCBI chr10:89,414,568...89,420,997
Ensembl chr10:89,414,568...89,421,605 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta part_of ISO
IBA
IEA
TAS		 (PMID:18626576) RGD
GO_Central
TreeGrafter
UniProt		 PMID:17419723 PMID:18626576 GO_REF:0000033 GO_REF:0000118 RGD:2298661 NCBI chr 8:42,271,302...42,332,460
Ensembl chr 8:42,271,302...42,332,460 		JBrowse link
G IKBKG inhibitor of nuclear factor kappa B kinase regulatory subunit gamma part_of ISO
IBA
IEA
IDA
TAS		 (PMID:23776175)
(PMID:18626576)		 RGD
GO_Central
TreeGrafter
MGI
UniProt		 PMID:17419723 PMID:18626576 PMID:23776175 GO_REF:0000033 GO_REF:0000118 RGD:2298661 NCBI chr  X:154,541,238...154,565,046
Ensembl chr  X:154,541,199...154,565,046 		JBrowse link
G PYCARD PYD and CARD domain containing part_of
located_in		 TAS
IDA		 (PMID:12656673)
(PMID:12486103)		 HGNC-UCL
UniProt		 PMID:12486103 PMID:12656673 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450 		JBrowse link
G PYDC1 pyrin domain containing 1 part_of IDA (PMID:12656673) HGNC-UCL PMID:12656673 NCBI chr16:31,215,962...31,217,135
Ensembl chr16:31,215,962...31,217,135 		JBrowse link
G TRIM40 tripartite motif containing 40 part_of IDA (PMID:21474709) UniProt PMID:21474709 NCBI chr 6:30,136,140...30,148,735
Ensembl chr 6:30,136,124...30,148,735 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20938
    cellular anatomical entity 20557
      cytosol 5775
        IkappaB kinase complex 8
Path 2
Term Annotations click to browse term
  cellular_component 20938
    protein-containing complex 7613
      catalytic complex 1915
        transferase complex 962
          transferase complex, transferring phosphorus-containing groups 362
            protein kinase complex 160
              serine/threonine protein kinase complex 146
                IkappaB kinase complex 8
paths to the root