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ONTOLOGY REPORT - ANNOTATIONS


Term:IkappaB kinase complex
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Accession:GO:0008385 term browser browse the term
Definition:A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Synonyms:exact_synonym: IKK complex;   heterotrimeric IKK complex;   trimeric IKK complex


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IkappaB kinase complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chuk component of inhibitor of nuclear factor kappa B kinase complex part_of IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:17419723 PMID:21873635 RGD:2298661, RGD:13792537 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 part_of ISO
IEA
(PMID:15218148)
GO_REF:0000107
RGD
Ensembl
PMID:15218148 GO_REF:0000107 NCBI chr 4:152,763,664...153,055,706
Ensembl chr 4:152,767,419...153,055,639
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta part_of IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:17419723 PMID:21873635 RGD:2298661, RGD:13792537 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma part_of IDA
ISO
IBA
(PMID:23776175)
PMID:21873635
RGD PMID:23776175 PMID:17419723 PMID:21873635 RGD:2298661, RGD:13792537 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 colocalizes_with ISO UniProtKB:O15111 (PMID:10094049) RGD PMID:10094049 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Pycard PYD and CARD domain containing colocalizes_with
part_of
ISO
IEA
(PMID:12486103)
GO_REF:0000107
RGD
Ensembl
PMID:12486103 GO_REF:0000107 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Trim40 tripartite motif-containing 40 part_of ISO (PMID:21474709) RGD PMID:21474709 NCBI chr20:1,676,188...1,685,906
Ensembl chr20:1,676,270...1,685,214
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20010
    cellular anatomical entity 19714
      cytosol 4227
        IkappaB kinase complex 7
Path 2
Term Annotations click to browse term
  cellular_component 20010
    protein-containing complex 6011
      catalytic complex 1464
        transferase complex 801
          transferase complex, transferring phosphorus-containing groups 259
            protein kinase complex 104
              serine/threonine protein kinase complex 86
                IkappaB kinase complex 7
paths to the root