Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:IkappaB kinase activity
go back to main search page
Accession:GO:0008384 term browser browse the term
Definition:Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein.
Comment:Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB.
Synonyms:narrow_synonym: TANK-binding kinase 1 activity
 related_synonym: ATP:IkappaB protein phosphotransferase activity;   CHUK;   IKBKA;   IKBKB;   IKK;   IKK-1;   IKK-2;   STK12;   TBK1;   inhibitor of NF-kappaB kinase activity;   inhibitor of NFkappaB kinase activity
 xref: EC:2.7.11.10;   MetaCyc:2.7.11.10-RXN;   RHEA:19073;   reactome:R-HSA-5684267 "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex";   reactome:R-HSA-5684275 "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400"


show annotations for term's descendants           Sort by:
IkappaB kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHUK component of inhibitor of nuclear factor kappa B kinase complex enables IEA InterPro
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr28:12,964,670...13,001,557
Ensembl chr28:12,965,479...13,001,512 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta enables
contributes_to		 IEA
ISO		 InterPro
RGD
Ensembl
TreeGrafter		 PMID:12592100 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 RGD:13801014 NCBI chr16:23,359,551...23,419,114
Ensembl chr16:23,359,813...23,419,075 		JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon enables IEA Ensembl GO_REF:0000107 NCBI chr38:2,747,303...2,772,574
Ensembl chr38:2,747,297...2,772,587 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18797
    catalytic activity 5736
      catalytic activity, acting on a protein 2372
        protein kinase activity 603
          protein serine/threonine kinase activity 420
            IkappaB kinase activity 3
Path 2
Term Annotations click to browse term
  molecular_function 18797
    catalytic activity 5736
      transferase activity 2354
        transferase activity, transferring phosphorus-containing groups 945
          kinase activity 792
            protein kinase activity 603
              protein serine/threonine kinase activity 420
                IkappaB kinase activity 3
paths to the root