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ONTOLOGY REPORT - ANNOTATIONS


Term:isoprenoid biosynthetic process
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Accession:GO:0008299 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.
Synonyms:exact_synonym: isoprenoid anabolism;   isoprenoid biosynthesis;   isoprenoid formation;   isoprenoid synthesis
 narrow_synonym: polyisoprenoid anabolism;   polyisoprenoid biosynthesis;   polyisoprenoid biosynthetic process;   polyisoprenoid formation;   polyisoprenoid synthesis;   polyterpene biosynthesis;   polyterpene biosynthetic process
 alt_id: GO:0009241
 xref: MetaCyc:POLYISOPRENSYN-PWY


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isoprenoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coq2 coenzyme Q2, polyprenyltransferase involved_in IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr14:10,581,102...10,601,093
Ensembl chr14:10,581,136...10,600,566
JBrowse link
G Crppa CDP-L-ribitol pyrophosphorylase A involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:55,880,136...56,159,466
Ensembl chr 6:55,881,387...56,159,464
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fdps farnesyl diphosphate synthase involved_in IDA
IEA
GO_REF:0000043 UniProt PMID:10484604 GO_REF:0000043, RGD:2316922 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 involved_in IEA
IBA
GO_REF:0000043
PMID:21873635
UniProt PMID:21873635 GO_REF:0000043, RGD:13792537 NCBI chr17:53,956,185...53,971,039
Ensembl chr17:53,956,203...53,971,443
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:16140414, PMID:21873635, PMID:10484604 RGD:2316848, RGD:13792537, RGD:2316922 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 involved_in IEA
ISO
GO_REF:0000043
(PMID:8806705)
UniProt
RGD
PMID:8806705 GO_REF:0000043 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Idi2 isopentenyl-diphosphate delta isomerase 2 involved_in ISO (PMID:17202134) RGD PMID:17202134 NCBI chr17:63,107,152...63,107,469 JBrowse link
G Mvd mevalonate diphosphate decarboxylase involved_in ISO (PMID:11792727), (PMID:14680974) RGD PMID:11792727 PMID:14680974 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Mvk mevalonate kinase involved_in IDA
ISO
(PMID:14680974), (PMID:14730012) RGD PMID:14680974 PMID:14730012, PMID:7904598, PMID:10484604 RGD:2316851, RGD:2316922 NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400
JBrowse link
G Pdss1 decaprenyl diphosphate synthase subunit 1 involved_in IBA
ISO
PMID:21873635
(MGI:3607849|PMID:16262699)
(PMID:16262699)
RGD PMID:16262699, PMID:21873635 MGI:3607849, RGD:13792537 NCBI chr17:90,033,432...90,072,506
Ensembl chr17:90,033,539...90,071,408
JBrowse link
G Pdss2 decaprenyl diphosphate synthase subunit 2 involved_in ISO
IBA
(PMID:16262699)
(MGI:3607849|PMID:16262699)
PMID:21873635
RGD PMID:16262699, PMID:21873635 MGI:3607849, RGD:13792537 NCBI chr20:47,966,513...48,192,747
Ensembl chr20:47,966,583...48,192,743
JBrowse link
G Pex5 peroxisomal biogenesis factor 5 NOT|acts_upstream_of_or_within ISO MGI:2154454 (MGI:2136720|PMID:11420171) RGD PMID:11420171 MGI:2136720 NCBI chr 4:156,983,914...157,009,675
Ensembl chr 4:156,983,915...157,009,674
Ensembl chr 4:156,983,915...157,009,674
JBrowse link
G Pmvk phosphomevalonate kinase IDA RGD PMID:10484604 RGD:2316922 NCBI chr 2:188,784,329...188,793,890
Ensembl chr 2:188,784,222...188,793,895
JBrowse link
9-cis-retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2662611|PMID:11876656)
Ensembl
RGD
PMID:11876656 GO_REF:0000107 MGI:2662611 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 acts_upstream_of_or_within ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aldh8a1 aldehyde dehydrogenase 8 family, member A1 acts_upstream_of_or_within ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 1:16,910,043...16,929,465
Ensembl chr 1:16,910,069...16,930,481
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 IDA 9-cis- and all-trans-retinoic acid synthesized from 9-cis- and all-trans-retinal RGD PMID:8765131 RGD:2306683 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 involved_in ISO
ISS
(PMID:11304534)
GO_REF:0000024
RGD
UniProt
PMID:11304534 GO_REF:0000024 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
JBrowse link
G Rdh16 retinol dehydrogenase 16 acts_upstream_of_or_within ISO (MGI:2662611|PMID:11876656) RGD PMID:11876656 MGI:2662611 NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
JBrowse link
dolichol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 involved_in TAS PMID:10806397 UniProt PMID:10806397 RGD:2326086 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit involved_in IBA
ISO
PMID:21873635
(PMID:25066056)
RGD PMID:25066056, PMID:21873635 RGD:13792537 NCBI chr20:33,557,052...33,584,011
Ensembl chr20:33,557,052...33,584,010
JBrowse link
G Srd5a3 steroid 5 alpha-reductase 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:34,554,769...34,570,423
Ensembl chr14:34,556,220...34,570,356
JBrowse link
farnesyl diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdps farnesyl diphosphate synthase involved_in IDA
IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:8188698, PMID:21873635 GO_REF:0000041, RGD:2316305, RGD:13792537 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr17:53,956,185...53,971,039
Ensembl chr17:53,956,203...53,971,443
JBrowse link
farnesyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase TAS RGD PMID:12841361 RGD:1300058 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
geranyl diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fdps farnesyl diphosphate synthase involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr17:53,956,185...53,971,039
Ensembl chr17:53,956,203...53,971,443
JBrowse link
geranylgeranyl diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ggps1 geranylgeranyl diphosphate synthase 1 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr17:53,956,185...53,971,039
Ensembl chr17:53,956,203...53,971,443
JBrowse link
isopentenyl diphosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07028137.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr17:57,755,210...57,765,652 JBrowse link
G AABR07028157.1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr17:57,906,050...57,908,621 JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G LOC102551575 isopentenyl-diphosphate delta-isomerase 2-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:57,864,652...57,866,201
Ensembl chr17:57,864,244...57,865,804
JBrowse link
G LOC103694120 isopentenyl-diphosphate delta-isomerase 2-like involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:57,814,239...57,816,277
Ensembl chr17:57,814,539...57,816,256
JBrowse link
G LOC291276 similar to isopentenyl diphosphate delta-isomerase type 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:57,701,861...57,705,698
Ensembl chr17:57,701,861...57,704,293
JBrowse link
G RGD1564347 similar to isopentenyl diphosphate delta-isomerase type 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:57,674,146...57,688,350
Ensembl chr17:57,676,569...57,687,379
JBrowse link
isopentenyl diphosphate biosynthetic process, mevalonate pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvd mevalonate diphosphate decarboxylase involved_in IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:197206, PMID:21873635 RGD:2316852, RGD:13792537 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Mvk mevalonate kinase involved_in IDA
IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:197206, PMID:21873635 GO_REF:0000041, RGD:2316852, RGD:13792537 NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400
JBrowse link
G Pmvk phosphomevalonate kinase involved_in IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:197206, PMID:21873635 GO_REF:0000041, RGD:2316852, RGD:13792537 NCBI chr 2:188,784,329...188,793,890
Ensembl chr 2:188,784,222...188,793,895
JBrowse link
negative regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c3 aldo-keto reductase family 1, member C3 involved_in ISO (PMID:21851338) RGD PMID:21851338 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
polyprenol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhdds dehydrodolichyl diphosphate synthase subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:152,200,681...152,227,669
Ensembl chr 5:152,199,584...152,227,677
JBrowse link
positive regulation of retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rdh10 retinol dehydrogenase 10 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030
JBrowse link
G Rdh16 retinol dehydrogenase 16 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
JBrowse link
retinoic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 IMP RGD PMID:21138835 RGD:6771354 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 involved_in IEP
ISO
ISS
IMP
(PMID:29240402)
GO_REF:0000024
RGD
UniProt
PMID:29240402, PMID:15950969, PMID:21138835 GO_REF:0000024, RGD:6771322, RGD:6771354 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 acts_upstream_of_or_within
involved_in
IEP
ISO
ISS
IEA
IMP
(MGI:1927016|PMID:11044606), (MGI:3055622|PMID:11013254), (MGI:3692370|PMID:16241904)
(MGI:3042765|PMID:14623956)
(PMID:27759097)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:11013254 PMID:11044606 PMID:14623956 PMID:16241904 PMID:27759097, PMID:15950969, PMID:21138835 GO_REF:0000024 GO_REF:0000107 MGI:1927016 MGI:3042765 MGI:3055622 MGI:3692370, RGD:6771322, RGD:6771354 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Crabp2 cellular retinoic acid binding protein 2 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 2:187,322,416...187,326,794
Ensembl chr 2:184,882,969...184,883,505
JBrowse link
G Dhrs9 dehydrogenase/reductase 9 IEP
IDA
RGD PMID:15950969, PMID:21138835 RGD:6771322, RGD:6771354 NCBI chr 3:55,623,671...55,645,883
Ensembl chr 3:55,623,634...55,648,325
JBrowse link
G Rbp1 retinol binding protein 1 IEP RGD PMID:15950969 RGD:6771322 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842
JBrowse link
G Rdh10 retinol dehydrogenase 10 acts_upstream_of_or_within ISO (MGI:3709664|PMID:17473173) RGD PMID:17473173 MGI:3709664 NCBI chr 5:2,605,265...2,631,905
Ensembl chr 5:2,603,505...2,632,030
JBrowse link
triterpenoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lss lanosterol synthase involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
zeaxanthin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpe65 retinoid isomerohydrolase RPE65 involved_in ISS
ISO
IBA
GO_REF:0000024
(PMID:28874556)
PMID:21873635
UniProt
RGD
PMID:28874556, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:266,141,581...266,169,197
Ensembl chr 2:266,141,581...266,169,197
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19634
    metabolic process 11911
      cellular metabolic process 10866
        cellular biosynthetic process 6026
          isoprenoid biosynthetic process 39
            apocarotenoid biosynthetic process + 0
            isopentenyl diphosphate biosynthetic process + 10
            isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate 0
            isoprenoid biosynthetic process via mevalonate + 3
            polyprenol biosynthetic process + 4
            prenol biosynthetic process 0
            terpene biosynthetic process + 0
            terpenoid biosynthetic process + 18
Path 2
Term Annotations click to browse term
  biological_process 19634
    metabolic process 11911
      primary metabolic process 10648
        lipid metabolic process 1364
          cellular lipid metabolic process 1013
            isoprenoid metabolic process 117
              isoprenoid biosynthetic process 39
                apocarotenoid biosynthetic process + 0
                isopentenyl diphosphate biosynthetic process + 10
                isoprenoid biosynthetic process via 1-deoxy-D-xylulose 5-phosphate 0
                isoprenoid biosynthetic process via mevalonate + 3
                polyprenol biosynthetic process + 4
                prenol biosynthetic process 0
                terpene biosynthetic process + 0
                terpenoid biosynthetic process + 18
paths to the root