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ONTOLOGY REPORT - ANNOTATIONS


Term:cohesin complex
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Accession:GO:0008278 term browser browse the term
Definition:A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
Synonyms:exact_synonym: SMC/kleisin ring complex
 narrow_synonym: 14S cohesin;   9S cohesin;   Smc1-Smc3 complex
 related_synonym: SMC complex;   cohesin core heterodimer
 alt_id: GO:0008279;   GO:0008280;   GO:0043222


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cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21 RAD21 cohesin complex component ISO (PMID:11590136), (PMID:22628566)
(MGI:MGI:1340883|PMID:10375619), (MGI:MGI:5429807|PMID:22419665)
RGD PMID:10375619, PMID:11590136, PMID:22419665, PMID:22628566 MGI:MGI:1340883, MGI:MGI:5429807 NCBI chr 7:91,511,755...91,538,673
Ensembl chr 7:91,511,756...91,538,673
JBrowse link
G Smc1a structural maintenance of chromosomes 1A ISO (MGI:MGI:1340883|PMID:10375619)
(PMID:11590136), (PMID:22628566), (PMID:9789013)
RGD PMID:9789013, PMID:10375619, PMID:11590136, PMID:22628566 MGI:MGI:1340883 NCBI chr  X:21,710,976...21,755,708
Ensembl chr  X:21,711,019...21,755,525
JBrowse link
G Smc3 structural maintenance of chromosomes 3 ISO (MGI:MGI:1340883|PMID:10375619)
(PMID:11590136), (PMID:22628566), (PMID:9789013)
RGD PMID:9789013, PMID:10375619, PMID:11590136, PMID:22628566 MGI:MGI:1340883 NCBI chr 1:274,310,120...274,352,856
Ensembl chr 1:274,309,758...274,352,854
JBrowse link
G Stag1 stromal antigen 1 ISO
IBA
(PMID:11590136), (PMID:22628566)
PMID:21873635
RGD PMID:11590136, PMID:22628566, PMID:21873635 RGD:13792537 NCBI chr 8:108,958,099...109,342,738
Ensembl chr 8:108,958,046...109,342,738
JBrowse link
G Stag2 stromal antigen 2 IBA
ISO
PMID:21873635
(PMID:11590136), (PMID:29263825)
RGD PMID:11590136, PMID:29263825, PMID:21873635 RGD:13792537 NCBI chr  X:128,493,603...128,624,418
Ensembl chr  X:128,493,614...128,624,418
JBrowse link
G Stag3 stromal antigen 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:19,599,741...19,630,775
Ensembl chr12:19,599,834...19,630,780
JBrowse link
meiotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21l1 RAD21 cohesin complex component like 1 ISO (MGI:MGI:4942240|PMID:21242291), (MGI:MGI:5050018|PMID:21527826) RGD PMID:21242291, PMID:21527826 MGI:MGI:4942240, MGI:MGI:5050018 NCBI chr 3:147,163,335...147,191,008
Ensembl chr 3:147,163,838...147,188,929
JBrowse link
G Rec8 REC8 meiotic recombination protein ISO (MGI:MGI:3719060|PMID:17696610) RGD PMID:17696610 MGI:MGI:3719060 NCBI chr15:34,296,922...34,304,387
Ensembl chr15:34,296,922...34,304,552
JBrowse link
G Smc1a structural maintenance of chromosomes 1A IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5050018|PMID:21527826)
(PMID:21242291)
Ensembl
UniProt
RGD
PMID:21242291, PMID:21527826 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5050018 NCBI chr  X:21,710,976...21,755,708
Ensembl chr  X:21,711,019...21,755,525
JBrowse link
G Smc1b structural maintenance of chromosomes 1B ISO (PMID:21242291)
(MGI:MGI:5050018|PMID:21527826)
RGD PMID:21242291, PMID:21527826 MGI:MGI:5050018 NCBI chr 7:125,966,480...126,028,287
Ensembl chr 7:125,966,480...126,028,279
JBrowse link
G Smc3 structural maintenance of chromosomes 3 ISO
ISS
(PMID:21242291)
GO_REF:0000024
(MGI:MGI:5050018|PMID:21527826)
RGD
UniProt
PMID:21242291, PMID:21527826 GO_REF:0000024, MGI:MGI:5050018 NCBI chr 1:274,310,120...274,352,856
Ensembl chr 1:274,309,758...274,352,854
JBrowse link
G Stag3 stromal antigen 3 ISO (PMID:21242291)
(MGI:MGI:3719060|PMID:17696610), (MGI:MGI:5050018|PMID:21527826)
RGD PMID:17696610, PMID:21242291, PMID:21527826 MGI:MGI:3719060, MGI:MGI:5050018 NCBI chr12:19,599,741...19,630,775
Ensembl chr12:19,599,834...19,630,780
JBrowse link
mitotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx11 DEAD/H-box helicase 11 NOT|colocalizes_with ISO (PMID:17105772) RGD PMID:17105772 NCBI chr 9:114,113,642...114,133,908
Ensembl chr 9:114,111,580...114,132,492
JBrowse link
G Sgo2 shugoshin 2 ISO (PMID:18084284) RGD PMID:18084284 NCBI chr 9:64,898,380...64,923,023
Ensembl chr 9:64,898,459...64,923,012
JBrowse link
nuclear meiotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21 RAD21 cohesin complex component IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:91,511,755...91,538,673
Ensembl chr 7:91,511,756...91,538,673
JBrowse link
G Rad21l1 RAD21 cohesin complex component like 1 ISO
IBA
(MGI:MGI:5315075|PMID:22164254)
PMID:21873635
RGD PMID:22164254, PMID:21873635 MGI:MGI:5315075, RGD:13792537 NCBI chr 3:147,163,335...147,191,008
Ensembl chr 3:147,163,838...147,188,929
JBrowse link
G Rec8 REC8 meiotic recombination protein ISO
IBA
(MGI:MGI:5288570|PMID:21743440), (MGI:MGI:5315075|PMID:22164254), (MGI:MGI:5504589|PMID:22854038)
PMID:21873635
RGD PMID:21743440, PMID:22164254, PMID:22854038, PMID:21873635 MGI:MGI:5288570, MGI:MGI:5315075, MGI:MGI:5504589, RGD:13792537 NCBI chr15:34,296,922...34,304,387
Ensembl chr15:34,296,922...34,304,552
JBrowse link
G Smc1b structural maintenance of chromosomes 1B ISO (MGI:MGI:5288570|PMID:21743440), (MGI:MGI:5315075|PMID:22164254) RGD PMID:21743440, PMID:22164254 MGI:MGI:5288570, MGI:MGI:5315075 NCBI chr 7:125,966,480...126,028,287
Ensembl chr 7:125,966,480...126,028,279
JBrowse link
G Smc3 structural maintenance of chromosomes 3 IEA
ISO
GO_REF:0000107
(MGI:MGI:5288570|PMID:21743440), (MGI:MGI:5315075|PMID:22164254)
Ensembl
RGD
PMID:21743440, PMID:22164254 GO_REF:0000107, MGI:MGI:5288570, MGI:MGI:5315075 NCBI chr 1:274,310,120...274,352,856
Ensembl chr 1:274,309,758...274,352,854
JBrowse link
G Stag3 stromal antigen 3 ISO (MGI:MGI:5315075|PMID:22164254) RGD PMID:22164254 MGI:MGI:5315075 NCBI chr12:19,599,741...19,630,775
Ensembl chr12:19,599,834...19,630,780
JBrowse link
nuclear mitotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21 RAD21 cohesin complex component IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:91,511,755...91,538,673
Ensembl chr 7:91,511,756...91,538,673
JBrowse link
G Rad21l1 RAD21 cohesin complex component like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:147,163,335...147,191,008
Ensembl chr 3:147,163,838...147,188,929
JBrowse link
G Rec8 REC8 meiotic recombination protein IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:34,296,922...34,304,387
Ensembl chr15:34,296,922...34,304,552
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6093
      cohesin complex 11
        meiotic cohesin complex + 7
        mitotic cohesin complex + 5
        nuclear cohesin complex + 6
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      organelle 13258
        non-membrane-bounded organelle 5183
          intracellular non-membrane-bounded organelle 5172
            chromosome 1419
              condensed chromosome 202
                cohesin complex 11
                  meiotic cohesin complex + 7
                  mitotic cohesin complex + 5
                  nuclear cohesin complex + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.