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ONTOLOGY REPORT - ANNOTATIONS


Term:cohesin complex
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Accession:GO:0008278 term browser browse the term
Definition:A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
Synonyms:exact_synonym: SMC/kleisin ring complex
 narrow_synonym: 14S cohesin;   9S cohesin;   Smc1-Smc3 complex
 related_synonym: SMC complex;   cohesin core heterodimer
 alt_id: GO:0008279;   GO:0008280;   GO:0043222


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cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21 RAD21 cohesin complex component part_of ISO (PMID:11590136), (PMID:22628566)
(MGI:1340883|PMID:10375619), (MGI:5429807|PMID:22419665)
RGD PMID:10375619 PMID:11590136 PMID:22419665 PMID:22628566 MGI:1340883 MGI:5429807 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
G Smc1a structural maintenance of chromosomes 1A part_of ISO
IBA
(PMID:11590136), (PMID:22628566), (PMID:9789013)
(MGI:1340883|PMID:10375619)
PMID:21873635
RGD PMID:9789013 PMID:10375619 PMID:11590136 PMID:22628566 PMID:21873635 MGI:1340883, RGD:13792537 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056
JBrowse link
G Smc1b structural maintenance of chromosomes 1B part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:116,180,987...116,242,778
Ensembl chr 7:116,180,987...116,242,744
JBrowse link
G Smc3 structural maintenance of chromosomes 3 part_of ISO (PMID:11590136), (PMID:22628566), (PMID:9789013)
(MGI:1340883|PMID:10375619)
RGD PMID:9789013 PMID:10375619 PMID:11590136 PMID:22628566 MGI:1340883 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
JBrowse link
G Stag1 stromal antigen 1 part_of IBA
ISO
PMID:21873635
(PMID:11590136), (PMID:22628566)
RGD PMID:11590136 PMID:22628566 PMID:21873635 RGD:13792537 NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677
JBrowse link
G Stag2 stromal antigen 2 part_of IBA
ISO
PMID:21873635
(PMID:11590136), (PMID:29263825)
RGD PMID:11590136 PMID:29263825 PMID:21873635 RGD:13792537 NCBI chr  X:120,974,687...121,105,677
Ensembl chr  X:120,974,857...121,105,677
JBrowse link
G Stag3 stromal antigen 3 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:17,284,677...17,314,936
Ensembl chr12:17,284,794...17,314,935
JBrowse link
meiotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21l1 RAD21 cohesin complex component like 1 part_of ISO (MGI:4942240|PMID:21242291), (MGI:5050018|PMID:21527826) RGD PMID:21242291 PMID:21527826 MGI:4942240 MGI:5050018 NCBI chr 3:140,160,128...140,188,324
Ensembl chr 3:140,160,118...140,188,298
JBrowse link
G Rec8 REC8 meiotic recombination protein part_of ISO (MGI:3719060|PMID:17696610) RGD PMID:17696610 MGI:3719060 NCBI chr15:29,109,862...29,117,327
Ensembl chr15:29,109,863...29,117,326
JBrowse link
G Smc1a structural maintenance of chromosomes 1A part_of IEA
ISO
ISS
IBA
GO_REF:0000107
(MGI:5050018|PMID:21527826)
GO_REF:0000024
PMID:21873635
(PMID:21242291)
Ensembl
RGD
UniProt
PMID:21242291 PMID:21527826 PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5050018, RGD:13792537 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056
JBrowse link
G Smc1b structural maintenance of chromosomes 1B part_of ISO
IBA
(PMID:21242291)
(MGI:5050018|PMID:21527826)
PMID:21873635
RGD PMID:21242291 PMID:21527826 PMID:21873635 MGI:5050018, RGD:13792537 NCBI chr 7:116,180,987...116,242,778
Ensembl chr 7:116,180,987...116,242,744
JBrowse link
G Smc3 structural maintenance of chromosomes 3 part_of ISS
ISO
GO_REF:0000024
(MGI:5050018|PMID:21527826)
(PMID:21242291)
UniProt
RGD
PMID:21242291 PMID:21527826 GO_REF:0000024 MGI:5050018 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
JBrowse link
G Stag3 stromal antigen 3 part_of ISO (PMID:21242291)
(MGI:3719060|PMID:17696610), (MGI:5050018|PMID:21527826)
RGD PMID:17696610 PMID:21242291 PMID:21527826 MGI:3719060 MGI:5050018 NCBI chr12:17,284,677...17,314,936
Ensembl chr12:17,284,794...17,314,935
JBrowse link
mitotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx11 DEAD/H-box helicase 11 NOT|colocalizes_with ISO (PMID:17105772) RGD PMID:17105772 NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550
JBrowse link
G Sgo2 shugoshin 2 part_of ISO (PMID:18084284) RGD PMID:18084284 NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:59,548,683...59,573,229
JBrowse link
nuclear meiotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21 RAD21 cohesin complex component part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
G Rad21l1 RAD21 cohesin complex component like 1 part_of IBA
ISO
PMID:21873635
(MGI:5315075|PMID:22164254)
RGD PMID:22164254 PMID:21873635 MGI:5315075, RGD:13792537 NCBI chr 3:140,160,128...140,188,324
Ensembl chr 3:140,160,118...140,188,298
JBrowse link
G Rec8 REC8 meiotic recombination protein part_of IBA
ISO
PMID:21873635
(MGI:5288570|PMID:21743440), (MGI:5315075|PMID:22164254), (MGI:5504589|PMID:22854038)
RGD PMID:21743440 PMID:22164254 PMID:22854038 PMID:21873635 MGI:5288570 MGI:5315075 MGI:5504589, RGD:13792537 NCBI chr15:29,109,862...29,117,327
Ensembl chr15:29,109,863...29,117,326
JBrowse link
G Smc1b structural maintenance of chromosomes 1B part_of ISO (MGI:5288570|PMID:21743440), (MGI:5315075|PMID:22164254) RGD PMID:21743440 PMID:22164254 MGI:5288570 MGI:5315075 NCBI chr 7:116,180,987...116,242,778
Ensembl chr 7:116,180,987...116,242,744
JBrowse link
G Smc3 structural maintenance of chromosomes 3 part_of IEA
ISO
GO_REF:0000107
(MGI:5288570|PMID:21743440), (MGI:5315075|PMID:22164254)
Ensembl
RGD
PMID:21743440 PMID:22164254 GO_REF:0000107 MGI:5288570 MGI:5315075 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
JBrowse link
G Stag3 stromal antigen 3 part_of ISO (MGI:5315075|PMID:22164254) RGD PMID:22164254 MGI:5315075 NCBI chr12:17,284,677...17,314,936
Ensembl chr12:17,284,794...17,314,935
JBrowse link
nuclear mitotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21 RAD21 cohesin complex component part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
G Rad21l1 RAD21 cohesin complex component like 1 part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:140,160,128...140,188,324
Ensembl chr 3:140,160,118...140,188,298
JBrowse link
G Rec8 REC8 meiotic recombination protein part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:29,109,862...29,117,327
Ensembl chr15:29,109,863...29,117,326
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20010
    protein-containing complex 6011
      cohesin complex 11
        meiotic cohesin complex + 7
        mitotic cohesin complex + 5
        nuclear cohesin complex + 6
Path 2
Term Annotations click to browse term
  cellular_component 20010
    cellular anatomical entity 19714
      organelle 13093
        non-membrane-bounded organelle 4903
          intracellular non-membrane-bounded organelle 4903
            chromosome 1168
              condensed chromosome 240
                cohesin complex 11
                  meiotic cohesin complex + 7
                  mitotic cohesin complex + 5
                  nuclear cohesin complex + 6
paths to the root