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ONTOLOGY REPORT - ANNOTATIONS

Term:cohesin complex
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Accession:GO:0008278 term browser browse the term
Definition:A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
Synonyms:exact_synonym: SMC/kleisin ring complex
 narrow_synonym: 14S cohesin;   9S cohesin;   Smc1-Smc3 complex
 related_synonym: SMC complex;   cohesin core heterodimer;   nuclear cohesin complex
 alt_id: GO:0000798;   GO:0008279;   GO:0008280;   GO:0043222


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cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21 RAD21 cohesin complex component part_of ISO (PMID:11590136), (PMID:22628566)
(MGI:1340883|PMID:10375619), (PMID:22419665)		 RGD PMID:10375619 PMID:11590136 PMID:22419665 PMID:22628566 MGI:1340883 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A part_of ISO (PMID:11590136), (PMID:22628566), (PMID:9789013)
(MGI:1340883|PMID:10375619)		 RGD PMID:9789013 PMID:10375619 PMID:11590136 PMID:22628566 MGI:1340883 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056 		JBrowse link
G Smc3 structural maintenance of chromosomes 3 part_of ISO (PMID:11590136), (PMID:22628566), (PMID:9789013)
(MGI:1340883|PMID:10375619)		 RGD PMID:9789013 PMID:10375619 PMID:11590136 PMID:22628566 MGI:1340883 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522 		JBrowse link
G Stag1 STAG1 cohesin complex component part_of ISO
IBA		 (PMID:11590136), (PMID:22628566)
GO_REF:0000033		 RGD
GO_Central		 PMID:11590136 PMID:22628566 GO_REF:0000033 NCBI chr 8:101,179,039...101,564,684
Ensembl chr 8:101,179,039...101,564,677 		JBrowse link
G Stag2 STAG2 cohesin complex component part_of ISO
IBA		 (PMID:11590136), (PMID:29263825)
GO_REF:0000033		 RGD
GO_Central		 PMID:11590136 PMID:29263825 GO_REF:0000033 NCBI chr  X:120,974,687...121,105,677
Ensembl chr  X:120,974,857...121,105,677 		JBrowse link
meiotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rad21 RAD21 cohesin complex component part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Rad21l1 RAD21 cohesin complex component like 1 part_of ISO
IBA		 (MGI:4942240|PMID:21242291), (MGI:5050018|PMID:21527826), (PMID:22164254)
GO_REF:0000033		 RGD
GO_Central		 PMID:21242291 PMID:21527826 PMID:22164254 GO_REF:0000033 MGI:4942240 MGI:5050018 NCBI chr 3:140,160,128...140,188,324
Ensembl chr 3:140,160,118...140,188,298 		JBrowse link
G Rec8 REC8 meiotic recombination protein part_of ISO
IBA		 (PMID:17696610), (PMID:21743440), (PMID:22164254), (PMID:22854038)
GO_REF:0000033		 RGD
GO_Central		 PMID:17696610 PMID:21743440 PMID:22164254 PMID:22854038 GO_REF:0000033 NCBI chr15:29,109,862...29,117,327
Ensembl chr15:29,109,863...29,117,326 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A part_of ISO
ISS
IEA
IBA		 (PMID:21242291)
GO_REF:0000024
(MGI:5050018|PMID:21527826)
GO_REF:0000107
GO_REF:0000033		 RGD
UniProt
Ensembl
GO_Central		 PMID:21242291 PMID:21527826 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:5050018 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056 		JBrowse link
G Smc1b structural maintenance of chromosomes 1B part_of ISO
IBA		 (PMID:21242291)
GO_REF:0000033
(MGI:5050018|PMID:21527826), (PMID:21743440), (PMID:22164254)		 RGD
GO_Central		 PMID:21242291 PMID:21527826 PMID:21743440 PMID:22164254 GO_REF:0000033 MGI:5050018 NCBI chr 7:116,180,987...116,242,778
Ensembl chr 7:116,180,987...116,242,744 		JBrowse link
G Smc3 structural maintenance of chromosomes 3 part_of ISS
ISO
IEA		 GO_REF:0000024
(PMID:21242291)
GO_REF:0000107
(MGI:5050018|PMID:21527826), (PMID:21743440), (PMID:22164254)		 UniProt
RGD
Ensembl		 PMID:21242291 PMID:21527826 PMID:21743440 PMID:22164254 GO_REF:0000024 GO_REF:0000107 MGI:5050018 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522 		JBrowse link
G Stag3 STAG3 cohesin complex component part_of ISO
IBA		 (PMID:21242291)
GO_REF:0000033
(MGI:5050018|PMID:21527826), (PMID:17696610), (PMID:22164254)		 RGD
GO_Central		 PMID:17696610 PMID:21242291 PMID:21527826 PMID:22164254 GO_REF:0000033 MGI:5050018 NCBI chr12:17,284,677...17,314,936
Ensembl chr12:17,284,794...17,314,935 		JBrowse link
mitotic cohesin complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddx11 DEAD/H-box helicase 11 NOT|located_in ISO (PMID:17105772) RGD PMID:17105772 NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550 		JBrowse link
G Rad21 RAD21 cohesin complex component part_of ISO (PMID:23242214) RGD PMID:23242214 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817 		JBrowse link
G Sgo2 shugoshin 2 part_of ISO (PMID:18084284) RGD PMID:18084284 NCBI chr 9:59,548,605...59,573,229
Ensembl chr 9:59,548,683...59,573,229 		JBrowse link
G Smc1a structural maintenance of chromosomes 1A part_of IEA
ISO		 GO_REF:0000107
(PMID:23242214)		 Ensembl
RGD		 PMID:23242214 GO_REF:0000107 NCBI chr  X:21,103,323...21,148,053
Ensembl chr  X:21,103,282...21,148,056 		JBrowse link
G Smc3 structural maintenance of chromosomes 3 part_of IEA
ISO
IBA		 GO_REF:0000107
(PMID:23242214)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:23242214 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522 		JBrowse link
G Stag2 STAG2 cohesin complex component part_of ISO (PMID:23242214) RGD PMID:23242214 NCBI chr  X:120,974,687...121,105,677
Ensembl chr  X:120,974,857...121,105,677 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20813
    protein-containing complex 6433
      cohesin complex 11
        meiotic cohesin complex 7
        mitotic cohesin complex 6
Path 2
Term Annotations click to browse term
  cellular_component 20813
    cellular anatomical entity 20576
      organelle 14001
        non-membrane-bounded organelle 5255
          intracellular non-membrane-bounded organelle 5255
            chromosome 1385
              cohesin complex 11
                meiotic cohesin complex 7
                mitotic cohesin complex 6
paths to the root