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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of G protein-coupled receptor signaling pathway
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Accession:GO:0008277 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms:exact_synonym: regulation of G protein coupled receptor protein signaling pathway;   regulation of G protein coupled receptor protein signalling pathway;   regulation of GPCR protein signaling pathway;   regulation of GPCR protein signalling pathway


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regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 involved_in ISO (PMID:11175907) UniProt PMID:11175907 NCBI chrNW_004936672:3,461,387...3,468,053 JBrowse link
G Arrb1 arrestin beta 1 acts_upstream_of_or_within ISO (MGI:1101531|PMID:9400383), (MGI:1930835|PMID:11171997) RGD
MGI
PMID:1517224 PMID:9400383 PMID:11171997 MGI:1101531 MGI:1930835 RGD:631708 NCBI chrNW_004936498:4,089,621...4,172,749 JBrowse link
G Arrb2 arrestin beta 2 acts_upstream_of_or_within ISO (MGI:1351102|PMID:10617462), (MGI:1927976|PMID:11130073), (MGI:1930835|PMID:11171997) RGD
MGI
PMID:1517224 PMID:10617462 PMID:11130073 PMID:11171997 MGI:1351102 MGI:1927976 MGI:1930835 RGD:631708 NCBI chrNW_004936677:3,173,054...3,181,475 JBrowse link
G Dgkq diacylglycerol kinase theta involved_in ISO (PMID:22732145) ParkinsonsUK-UCL PMID:22732145 NCBI chrNW_004936477:22,225,624...22,238,825 JBrowse link
G Dynlt1 dynein light chain Tctex-type 1 involved_in ISO (MGI:5788400|PMID:10559191) UniProt PMID:10559191 MGI:5788400 NCBI chrNW_004936489:10,329,223...10,335,758 JBrowse link
G Frmpd1 FERM and PDZ domain containing 1 involved_in ISO (PMID:18566450) UniProt PMID:18566450 NCBI chrNW_004936524:5,469,495...5,557,109 JBrowse link
G Git1 GIT ArfGAP 1 ISO RGD PMID:9826657 RGD:68782 NCBI chrNW_004936538:5,684,660...5,694,779 JBrowse link
G Gpsm1 G protein signaling modulator 1 ISO RGD PMID:10559191 RGD:631950 NCBI chrNW_004936669:1,442,550...1,469,563 JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 RGD:61618 NCBI chrNW_004936486:8,720,036...8,830,472 JBrowse link
G Homer2 homer scaffold protein 2 acts_upstream_of_or_within ISO (MGI:3525625|PMID:12860966) MGI PMID:12860966 MGI:3525625 NCBI chrNW_004936483:17,500,962...17,634,804 JBrowse link
G Itgb1 integrin subunit beta 1 ISO RGD PMID:17157995 RGD:1625132 NCBI chrNW_004936574:1,465,981...1,495,717 JBrowse link
G Itgb3 integrin subunit beta 3 ISO RGD PMID:17157995 RGD:1625132 NCBI chrNW_004936541:2,822,789...2,871,069 JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 acts_upstream_of_or_within ISO (MGI:4462115|PMID:20400944) MGI PMID:20400944 MGI:4462115 NCBI chrNW_004936511:4,389,558...4,395,630 JBrowse link
G Kctd16 potassium channel tetramerization domain containing 16 acts_upstream_of_or_within ISO (MGI:4462115|PMID:20400944) MGI PMID:20400944 MGI:4462115 NCBI chrNW_004936504:9,977,500...10,232,299 JBrowse link
G Kctd8 potassium channel tetramerization domain containing 8 acts_upstream_of_or_within ISO (MGI:4462115|PMID:20400944) MGI PMID:20400944 MGI:4462115 NCBI chrNW_004936482:10,941,599...11,180,776 JBrowse link
G Pde4d phosphodiesterase 4D ISO RGD PMID:12552097 RGD:629543 NCBI chrNW_004936480:8,123,437...9,235,586 JBrowse link
G Phf24 PHD finger protein 24 acts_upstream_of_or_within ISO (MGI:5616490|PMID:25242222) MGI PMID:25242222 MGI:5616490 NCBI chrNW_004936524:3,020,421...3,031,720 JBrowse link
G Plcb1 phospholipase C beta 1 involved_in ISO (MGI:4943665|PMID:18493969) BHF-UCL PMID:18493969 MGI:4943665 NCBI chrNW_004936485:10,548,966...11,254,139 JBrowse link
G Plce1 phospholipase C epsilon 1 involved_in ISO (PMID:11022047) UniProt PMID:11022047 NCBI chrNW_004936601:817,151...1,105,824 JBrowse link
G Rgs14 regulator of G protein signaling 14 ISO RGD PMID:11976690 RGD:729762 NCBI chrNW_004936597:1,650,480...1,658,823 JBrowse link
G Rgs18 regulator of G protein signaling 18 acts_upstream_of_or_within ISO (MGI:1927493|PMID:11042171) MGI PMID:11042171 MGI:1927493 NCBI chrNW_004936638:514,412...535,417 JBrowse link
G Rgs2 regulator of G protein signaling 2 involved_in ISO (PMID:19478087) UniProt PMID:19478087 NCBI chrNW_004936638:1,065,866...1,068,649 JBrowse link
G Rgs7 regulator of G protein signaling 7 acts_upstream_of_or_within ISO (MGI:5428056|PMID:22689652) RGD
MGI
PMID:10092682 PMID:22689652 MGI:5428056 RGD:69962 NCBI chrNW_004936526:9,087,820...9,552,482 JBrowse link
G Rgs9 regulator of G protein signaling 9 ISO RGD PMID:9765512 RGD:69964 NCBI chrNW_004936541:7,472,195...7,525,220 JBrowse link
G Ric8b RIC8 guanine nucleotide exchange factor B acts_upstream_of_or_within ISO (PMID:12652642) MGI PMID:12652642 NCBI chrNW_004936492:8,081,821...8,190,681 JBrowse link
G Slc24a4 solute carrier family 24 member 4 acts_upstream_of ISO (MGI:6716959|PMID:25096581) ARUK-UCL PMID:25096581 MGI:6716959 NCBI chrNW_004936733:515,546...639,699 JBrowse link
G Tub TUB bipartite transcription factor acts_upstream_of_or_within ISO (MGI:5921791|PMID:28154160) MGI PMID:28154160 MGI:5921791 NCBI chrNW_004936528:9,829,889...9,912,645 JBrowse link
G Tulp3 TUB like protein 3 acts_upstream_of_or_within
involved_in
ISO (MGI:5921791|PMID:28154160)
(PMID:28154160)
(PMID:20889716)
MGI
UniProt
PMID:20889716 PMID:28154160 MGI:5921791 NCBI chrNW_004936606:3,209,170...3,278,809 JBrowse link
G Usp20 ubiquitin specific peptidase 20 involved_in ISO (PMID:19424180) UniProt PMID:19424180 NCBI chrNW_004936487:17,030,397...17,069,165 JBrowse link
G Usp33 ubiquitin specific peptidase 33 involved_in ISO (PMID:19363159), (PMID:19424180) UniProt PMID:19363159 PMID:19424180 NCBI chrNW_004936571:4,537,461...4,600,238 JBrowse link
G Zdhhc3 zinc finger DHHC-type palmitoyltransferase 3 involved_in ISO (PMID:19001095)
(MGI:3831644|PMID:19001095)
UniProt PMID:19001095 MGI:3831644 NCBI chrNW_004936695:776,822...830,693 JBrowse link
G Zdhhc7 zinc finger DHHC-type palmitoyltransferase 7 involved_in ISO (PMID:19001095) UniProt PMID:19001095 NCBI chrNW_004936641:3,175,338...3,199,487 JBrowse link
cross-receptor inhibition within G protein-coupled receptor heterodimer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calcr calcitonin receptor involved_in ISO (PMID:14722252) UniProt PMID:14722252 NCBI chrNW_004936803:423,558...466,762 JBrowse link
G Ramp3 receptor activity modifying protein 3 involved_in ISO (PMID:14722252) UniProt PMID:14722252 NCBI chrNW_004936478:19,977,618...20,001,366 JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gipr gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chrNW_004936706:2,052,069...2,062,722 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within
ISO (PMID:15102938)
(MGI:1337704|PMID:10338466)
(MGI:84440|PMID:7761854)
PMID:18223549
RGD
UniProt
MGI
BHF-UCL
PMID:7761854 PMID:10338466 PMID:15102938 PMID:17908240 PMID:18223549 PMID:30075183 MGI:1337704 MGI:84440 RGD:13792694 RGD:7242040 RGD:8553863 NCBI chrNW_004936599:2,437,061...2,456,141 JBrowse link
G Grk3 G protein-coupled receptor kinase 3 ISO RGD PMID:8381966 PMID:20837135 RGD:5685022 RGD:5685621 NCBI chrNW_004936657:425,902...522,331 JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chrNW_004936486:8,720,036...8,830,472 JBrowse link
G Grk6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chrNW_004936597:1,706,671...1,722,370 JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chrNW_004936736:623,118...1,060,273 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chrNW_004936591:1,174,364...1,250,233 JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb2 adrenoceptor beta 2 involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chrNW_004936504:5,985,407...5,987,453 JBrowse link
G Adrb3 adrenoceptor beta 3 NOT|involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chrNW_004936710:1,410,589...1,413,279 JBrowse link
G Arrb2 arrestin beta 2 involved_in ISO (PMID:12582207) RGD
UniProt
PMID:12582207 PMID:20705669 RGD:5509896 NCBI chrNW_004936677:3,173,054...3,181,475 JBrowse link
G protein-coupled receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn2 beclin 2 involved_in
acts_upstream_of_or_within
ISO (PMID:23954414)
(MGI:5528919|PMID:23954414)
UniProt
MGI
PMID:23954414 MGI:5528919 NCBI chrNW_004936526:8,532,991...8,534,271 JBrowse link
G Gprasp1 G protein-coupled receptor associated sorting protein 1 involved_in
acts_upstream_of_or_within
ISO (PMID:23954414) UniProt
MGI
PMID:23954414 NCBI chrNW_004936813:1,208,018...1,213,224 JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chrNW_004936528:8,005,223...8,007,586 JBrowse link
G Arrb1 arrestin beta 1 involved_in ISO (PMID:10521508), (PMID:12582207) UniProt PMID:10521508 PMID:12582207 NCBI chrNW_004936498:4,089,621...4,172,749 JBrowse link
G Arrb2 arrestin beta 2 involved_in ISO (PMID:10644702)
(PMID:12582207)
UniProt PMID:10644702 PMID:12582207 NCBI chrNW_004936677:3,173,054...3,181,475 JBrowse link
G Calca calcitonin related polypeptide alpha involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chrNW_004936528:3,800,801...3,806,000 JBrowse link
G Dnm1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004936487:15,767,897...15,797,722 JBrowse link
G Dnm2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chrNW_004936659:957,408...1,046,393 JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chrNW_004936612:1,094,686...1,154,149 JBrowse link
G Drd3 dopamine receptor D3 involved_in ISO (PMID:18424554) RGD
BHF-UCL
PMID:14617818 PMID:18424554 RGD:1581465 NCBI chrNW_004936536:1,580,732...1,616,726 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B involved_in ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chrNW_004936890:154,252...157,044 JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in ISO (MGI:4821070|PMID:17325130) UniProt PMID:17325130 MGI:4821070 NCBI chrNW_004936525:5,711,894...5,729,074 JBrowse link
G Pld2 phospholipase D2 acts_upstream_of_or_within ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chrNW_004936677:2,870,664...2,883,545 JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chrNW_004936478:19,183,493...19,278,457 JBrowse link
negative regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ada adenosine deaminase involved_in ISO (PMID:16670267) UniProt PMID:16670267 NCBI chrNW_004936530:2,217,713...2,224,070 JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrdc3 arrestin domain containing 3 acts_upstream_of_or_within ISO (MGI:5302794|PMID:21982743) MGI PMID:21982743 MGI:5302794 NCBI chrNW_004936469:9,364,291...9,377,504 JBrowse link
G Crtc3 CREB regulated transcription coactivator 3 acts_upstream_of_or_within ISO (MGI:4867567|PMID:21164481) MGI PMID:21164481 MGI:4867567 NCBI chrNW_004936483:16,356,663...16,465,128 JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 involved_in ISO (PMID:17242280) BHF-UCL PMID:17242280 NCBI chrNW_004936567:944,825...1,039,920 JBrowse link
G Gnai2 G protein subunit alpha i2 ISO RGD PMID:12631586 RGD:13508593 NCBI chrNW_004936529:1,779,582...1,801,251 JBrowse link
G Pde4b phosphodiesterase 4B involved_in ISO (MGI:5286798|PMID:21670503) BHF-UCL PMID:21670503 MGI:5286798 NCBI chrNW_004936591:5,152,491...5,666,728 JBrowse link
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplp1 amyloid beta precursor like protein 1 involved_in ISO (PMID:16531006) BHF-UCL PMID:16531006 NCBI chrNW_004936570:475,446...484,379 JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 acts_upstream_of_or_within ISO (MGI:3850921|PMID:19246489) MGI PMID:19246489 MGI:3850921 NCBI chrNW_004936478:6,901,098...6,947,719 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:30075183 RGD:13792694 NCBI chrNW_004936599:2,437,061...2,456,141 JBrowse link
G Grk5 G protein-coupled receptor kinase 5 ISO RGD PMID:30075183 RGD:13792694 NCBI chrNW_004936486:8,720,036...8,830,472 JBrowse link
G LOC101964652 melanocortin 2 receptor accessory protein involved_in ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chrNW_004936500:9,790,435...9,807,101 JBrowse link
G Mrap2 melanocortin 2 receptor accessory protein 2 involved_in ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chrNW_004936510:6,905,870...6,945,583 JBrowse link
G Oprl1 opioid related nociceptin receptor 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chrNW_004936514:11,264,392...11,273,584 JBrowse link
G Oprm1 opioid receptor mu 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chrNW_004936489:6,506,207...6,567,136 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:9013884 RGD:9850263 NCBI chrNW_004936591:1,174,364...1,250,233 JBrowse link
G Sstr4 somatostatin receptor 4 ISO RGD PMID:8175684 RGD:2325010 NCBI chrNW_004936620:2,575,880...2,577,761 JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs2 regulator of G protein signaling 2 involved_in ISO (MGI:5009116|PMID:21291891) BHF-UCL PMID:21291891 MGI:5009116 NCBI chrNW_004936638:1,065,866...1,068,649 JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chrNW_004936641:3,779,024...3,802,883 JBrowse link
G Ubqln2 ubiquilin 2 involved_in ISO (PMID:18199683) UniProt PMID:18199683 NCBI chrNW_004936819:530,833...534,185 JBrowse link
negative regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 involved_in ISO (PMID:10734056) UniProt PMID:10734056 NCBI chrNW_004936490:253,279...259,947 JBrowse link
G Cry1 cryptochrome circadian regulator 1 involved_in ISO (MGI:5567906|PMID:20852621) UniProt PMID:20852621 MGI:5567906 NCBI chrNW_004936492:7,929,138...7,994,797 JBrowse link
G Grk2 G protein-coupled receptor kinase 2 ISO RGD PMID:1403099 RGD:632163 NCBI chrNW_004936599:2,437,061...2,456,141 JBrowse link
G Klk14 kallikrein related peptidase 14 involved_in ISO (PMID:16885167) UniProt PMID:16885167 NCBI chrNW_004936889:714,933...719,305 JBrowse link
G LOC101964975 interleukin-8 involved_in ISO (PMID:10734056) UniProt PMID:10734056 NCBI chrNW_004936598:1,779,471...1,781,353 JBrowse link
G Mgrn1 mahogunin ring finger 1 involved_in ISO (PMID:19737927) UniProt PMID:19737927 NCBI chrNW_004936530:4,647,550...4,693,143 JBrowse link
G Plek pleckstrin involved_in ISO (PMID:7782310) BHF-UCL PMID:7782310 NCBI chrNW_004936491:12,762,421...12,818,249 JBrowse link
G Rgs12 regulator of G protein signaling 12 ISO RGD PMID:9651375 RGD:69959 NCBI chrNW_004936477:20,300,528...20,388,212 JBrowse link
G Rgs13 regulator of G protein signaling 13 acts_upstream_of_or_within ISO (MGI:2385407|PMID:12193720) MGI PMID:12193720 MGI:2385407 NCBI chrNW_004936638:940,691...963,585 JBrowse link
G Rgs14 regulator of G protein signaling 14 involved_in ISO (MGI:5009199|PMID:10926822) UniProt PMID:10926822 MGI:5009199 NCBI chrNW_004936597:1,650,480...1,658,823 JBrowse link
G Rgs2 regulator of G protein signaling 2 involved_in ISO (MGI:3836877|PMID:19127022) RGD
BHF-UCL
PMID:11968023 PMID:19127022 PMID:21798518 MGI:3836877 RGD:633858 RGD:7207364 NCBI chrNW_004936638:1,065,866...1,068,649 JBrowse link
G Rgs4 regulator of G protein signaling 4 ISO RGD PMID:9918533 PMID:21798518 RGD:7207364 RGD:7207376 NCBI chrNW_004937238:101,948...109,513 JBrowse link
G Rpgrip1l RPGRIP1 like involved_in ISO (PMID:19464661) UniProt PMID:19464661 NCBI chrNW_004936475:6,219,187...6,321,612 JBrowse link
G Rph3al rabphilin 3A like (without C2 domains) acts_upstream_of_or_within ISO (MGI:3044444|PMID:15159548) MGI PMID:15159548 MGI:3044444 NCBI chrNW_004936538:7,325,458...7,426,821 JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta involved_in ISO (PMID:21224381) UniProt PMID:21224381 NCBI chrNW_004936514:7,832,094...7,853,170 JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bicd1 BICD cargo adaptor 1 involved_in ISO PMID:20164183
(MGI:4887309|PMID:20164183)
BHF-UCL PMID:20164183 MGI:4887309 RGD:8693367 NCBI chrNW_004936607:3,893,350...4,126,813 JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Met MET proto-oncogene, receptor tyrosine kinase involved_in ISO (PMID:25198505) CAFA PMID:25198505 NCBI chrNW_004936589:2,280,803...2,390,179 JBrowse link
G Snca synuclein alpha involved_in ISO (PMID:12239163) UniProt PMID:12239163 NCBI chrNW_004936685:2,077,017...2,175,298 JBrowse link
G Stmn1 stathmin 1 involved_in ISO (PMID:25198505) CAFA PMID:25198505 NCBI chrNW_004936474:10,470,006...10,475,557 JBrowse link
positive regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 involved_in ISO (PMID:18940592), (PMID:22389722) UniProt PMID:18940592 PMID:22389722 NCBI chrNW_004936529:5,661,772...5,723,108 JBrowse link
G Cntn2 contactin 2 acts_upstream_of_or_within ISO (MGI:1930847|PMID:11178983) MGI PMID:11178983 MGI:1930847 NCBI chrNW_004936557:7,297,429...7,320,666 JBrowse link
G Necab2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chrNW_004936641:3,779,024...3,802,883 JBrowse link
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (MGI:4829580|PMID:20516643) BHF-UCL PMID:20516643 MGI:4829580 NCBI chrNW_004936706:266,462...277,256 JBrowse link
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nos1 nitric oxide synthase 1 involved_in ISO (MGI:3771112|PMID:17242280) BHF-UCL PMID:17242280 MGI:3771112 NCBI chrNW_004936558:5,162,471...5,302,488 JBrowse link
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 ISO RGD PMID:18202135 RGD:5129138 NCBI chrNW_004936486:4,400,467...4,401,588 JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 acts_upstream_of_or_within ISO (MGI:3850921|PMID:19246489) MGI PMID:19246489 MGI:3850921 NCBI chrNW_004936478:6,901,098...6,947,719 JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha involved_in ISO (MGI:4829580|PMID:20516643) BHF-UCL PMID:20516643 MGI:4829580 NCBI chrNW_004936706:266,462...277,256 JBrowse link
G LOC101964652 melanocortin 2 receptor accessory protein involved_in ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chrNW_004936500:9,790,435...9,807,101 JBrowse link
G Mrap2 melanocortin 2 receptor accessory protein 2 involved_in ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chrNW_004936510:6,905,870...6,945,583 JBrowse link
positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prmt5 protein arginine methyltransferase 5 involved_in ISO (PMID:26554819) WB PMID:26554819 NCBI chrNW_004936722:1,379,515...1,388,538 JBrowse link
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgb3 integrin subunit beta 3 ISO RGD PMID:17157995 RGD:1625132 NCBI chrNW_004936541:2,822,789...2,871,069 JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apela apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chrNW_004936555:969,902...978,736 JBrowse link
G Apln apelin involved_in ISO (PMID:11359874)
(MGI:5902690|PMID:11359874)
UniProt PMID:11359874 MGI:5902690 RGD:12907555 NCBI chrNW_004936479:1,889,930...1,899,811 JBrowse link
G LOC101959175 amyloid beta precursor protein involved_in ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
positive regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 involved_in ISO (PMID:15833747) UniProt PMID:15833747 NCBI chrNW_004936588:3,985,732...4,023,221 JBrowse link
G Drd2 dopamine receptor D2 ISO RGD PMID:18809670 RGD:2311559 NCBI chrNW_004936612:1,094,686...1,154,149 JBrowse link
G Ece1 endothelin converting enzyme 1 ISO RGD PMID:15733912 RGD:1581735 NCBI chrNW_004936474:7,034,134...7,083,005 JBrowse link
G Fgf8 fibroblast growth factor 8 acts_upstream_of_or_within ISO (MGI:3847828|PMID:19307307) MGI PMID:19307307 MGI:3847828 NCBI chrNW_004936600:4,004,847...4,010,626 JBrowse link
G Gas2l2 growth arrest specific 2 like 2 involved_in ISO PMID:23994616
(MGI:6355742|PMID:23994616)
UniProt PMID:23994616 MGI:6355742 RGD:14697711 NCBI chrNW_004936490:144,824...153,790 JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in ISO (PMID:15539556) UniProt PMID:15539556 NCBI chrNW_004936754:1,288,891...1,293,555 JBrowse link
G Klk14 kallikrein related peptidase 14 involved_in ISO (PMID:16885167) UniProt PMID:16885167 NCBI chrNW_004936889:714,933...719,305 JBrowse link
G Klk5 kallikrein related peptidase 5 involved_in ISO (PMID:16885167) UniProt PMID:16885167 NCBI chrNW_004936889:609,807...616,777 JBrowse link
G Klk6 kallikrein related peptidase 6 involved_in ISO (PMID:16885167) UniProt PMID:16885167 NCBI chrNW_004936889:621,645...628,454 JBrowse link
G LOC101959175 amyloid beta precursor protein involved_in ISO (PMID:11316806) ARUK-UCL PMID:11316806 NCBI chrNW_004936640:1,549,977...1,787,436 JBrowse link
G Myh9 myosin heavy chain 9 ISO RGD PMID:20068007 RGD:6902910 NCBI chrNW_004936492:4,384,215...4,466,229 JBrowse link
G Pde6g phosphodiesterase 6G acts_upstream_of_or_within ISO (MGI:2156093|PMID:11502744) MGI PMID:11502744 MGI:2156093 NCBI chrNW_004936594:5,263,345...5,267,240 JBrowse link
G Pde6h phosphodiesterase 6H acts_upstream_of_or_within ISO (MGI:2156093|PMID:11502744) MGI PMID:11502744 MGI:2156093 NCBI chrNW_004936587:2,505,755...2,514,103 JBrowse link
G Phb prohibitin involved_in ISO (PMID:24732013) UniProt PMID:24732013 NCBI chrNW_004936490:12,127,065...12,138,870 JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 acts_upstream_of_or_within ISO (MGI:2670839|PMID:12878180) MGI PMID:12878180 MGI:2670839 NCBI chrNW_004936581:2,069,355...2,072,535 JBrowse link
G Slc39a14 solute carrier family 39 member 14 involved_in ISO (MGI:4950776|PMID:21445361) UniProt PMID:21445361 MGI:4950776 NCBI chrNW_004939045:1...7,491 JBrowse link
G Tmod2 tropomodulin 2 acts_upstream_of_or_within ISO (MGI:2663390|PMID:12799133) MGI PMID:12799133 MGI:2663390 NCBI chrNW_004936471:13,602,769...13,636,258 JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aplnr apelin receptor involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chrNW_004936581:5,230,836...5,234,562 JBrowse link
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004936591:1,174,364...1,250,233 JBrowse link
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chga chromogranin A ISO RGD PMID:11257446 RGD:6907050 NCBI chrNW_004936733:915,700...927,220 JBrowse link
G F2 coagulation factor II, thrombin involved_in ISO (PMID:20164183) BHF-UCL PMID:20164183 NCBI chrNW_004936562:2,371,725...2,388,617 JBrowse link
G Gpr27 G protein-coupled receptor 27 acts_upstream_of_or_within ISO (MGI:5311513|PMID:22253604) MGI PMID:22253604 MGI:5311513 NCBI chrNW_004936603:3,241,741...3,289,996 JBrowse link
G LOC101977540 gastrin releasing peptide involved_in ISO (MGI:5704231|PMID:26658875) UniProt PMID:26658875 MGI:5704231 NCBI chrNW_004936497:5,473,293...5,487,344 JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptger3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chrNW_004936591:1,174,364...1,250,233 JBrowse link
protein kinase C deactivation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 involved_in ISO (PMID:16820593) BHF-UCL PMID:16820593 NCBI chrNW_004936534:885,489...892,292 JBrowse link
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A acts_upstream_of_or_within ISO (MGI:3815363|PMID:18923023) MGI PMID:18923023 MGI:3815363 NCBI chrNW_004936489:15,401,248...15,671,594 JBrowse link
G Pde4a phosphodiesterase 4A acts_upstream_of_or_within ISO (MGI:3815363|PMID:18923023) MGI PMID:18923023 MGI:3815363 NCBI chrNW_004936659:742,969...770,473 JBrowse link
regulation of angiotensin-activated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rock1 Rho associated coiled-coil containing protein kinase 1 involved_in ISO (PMID:28679962) ARUK-UCL PMID:28679962 NCBI chrNW_004936550:730,462...874,601 JBrowse link
G Rock2 Rho associated coiled-coil containing protein kinase 2 involved_in ISO (MGI:6158813|PMID:28679962) ARUK-UCL PMID:28679962 MGI:6158813 NCBI chrNW_004936532:7,142,580...7,284,722 JBrowse link
regulation of endocannabinoid signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd6 abhydrolase domain containing 6, acylglycerol lipase acts_upstream_of_or_within ISO (MGI:4829719|PMID:20657592) MGI PMID:20657592 MGI:4829719 NCBI chrNW_004936473:2,687,784...2,732,413 JBrowse link
G Camk2a calcium/calmodulin dependent protein kinase II alpha involved_in ISO (MGI:5494205|PMID:23502535) UniProt PMID:23502535 MGI:5494205 NCBI chrNW_004936504:4,636,863...4,700,887 JBrowse link
G Mgll monoglyceride lipase involved_in ISO (MGI:4836780|PMID:20729846) UniProt PMID:20729846 MGI:4836780 NCBI chrNW_004936798:681,549...721,645 JBrowse link
regulation of opioid receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC101975550 synaptophysin involved_in ISO PMID:17005904 UniProt PMID:17005904 RGD:8554727 NCBI chrNW_004936721:1,062,206...1,075,935 JBrowse link
G Ppp1r9b protein phosphatase 1 regulatory subunit 9B involved_in ISO (MGI:3834288|PMID:18439408) UniProt PMID:18439408 MGI:3834288 NCBI chrNW_004936490:11,497,389...11,514,191 JBrowse link
regulation of rhodopsin mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aipl1 aryl hydrocarbon receptor interacting protein like 1 acts_upstream_of_or_within ISO (MGI:3054134|PMID:15365178)
(MGI:3054118|PMID:15365173)
MGI PMID:15365173 PMID:15365178 MGI:3054118 MGI:3054134 NCBI chrNW_004936677:1,539,502...1,548,343 JBrowse link
G Grk1 G protein-coupled receptor kinase 1 involved_in ISO (PMID:15946941) UniProt PMID:15946941 NCBI chrNW_004936472:152,202...165,134 JBrowse link
termination of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgs12 regulator of G protein signaling 12 ISO RGD PMID:11130074 RGD:7207399 NCBI chrNW_004936477:20,300,528...20,388,212 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12168
    signaling 4318
      regulation of signaling 2975
        regulation of signal transduction 2556
          regulation of G protein-coupled receptor signaling pathway 125
            cross-receptor inhibition within G protein-coupled receptor heterodimer 2
            modulation by symbiont of host G protein-coupled receptor signal transduction + 0
            negative regulation of G protein-coupled receptor signaling pathway + 60
            positive regulation of G protein-coupled receptor signaling pathway + 32
            protein kinase C deactivation 1
            regulation of G protein-coupled receptor internalization + 5
            regulation of adenosine receptor signaling pathway + 4
            regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 20
            regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway + 1
            regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway + 1
            regulation of angiotensin-activated signaling pathway + 2
            regulation of endocannabinoid signaling pathway 3
            regulation of octopamine or tyramine signaling pathway + 0
            regulation of opioid receptor signaling pathway + 3
            regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 5
            regulation of rhodopsin mediated signaling pathway + 2
            regulation of thrombin-activated receptor signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 12168
    biological regulation 8886
      regulation of biological process 8417
        regulation of cellular process 7987
          signal transduction 3832
            G protein-coupled receptor signaling pathway 453
              regulation of G protein-coupled receptor signaling pathway 125
                cross-receptor inhibition within G protein-coupled receptor heterodimer 2
                modulation by symbiont of host G protein-coupled receptor signal transduction + 0
                negative regulation of G protein-coupled receptor signaling pathway + 60
                positive regulation of G protein-coupled receptor signaling pathway + 32
                protein kinase C deactivation 1
                regulation of G protein-coupled receptor internalization + 5
                regulation of adenosine receptor signaling pathway + 4
                regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 20
                regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway + 1
                regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway + 1
                regulation of angiotensin-activated signaling pathway + 2
                regulation of endocannabinoid signaling pathway 3
                regulation of octopamine or tyramine signaling pathway + 0
                regulation of opioid receptor signaling pathway + 3
                regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 5
                regulation of rhodopsin mediated signaling pathway + 2
                regulation of thrombin-activated receptor signaling pathway + 3
paths to the root