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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of G protein-coupled receptor signaling pathway
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Accession:GO:0008277 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.
Synonyms:exact_synonym: regulation of G protein coupled receptor protein signaling pathway;   regulation of G protein coupled receptor protein signalling pathway;   regulation of GPCR protein signaling pathway;   regulation of GPCR protein signalling pathway


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regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295
JBrowse link
G ARRB1 arrestin beta 1 acts_upstream_of_or_within ISO (MGI:1101531|PMID:9400383), (MGI:1930835|PMID:11171997) RGD
MGI
PMID:1517224 PMID:9400383 PMID:11171997 MGI:1101531 MGI:1930835 RGD:631708 NCBI chr 9:9,516,944...9,597,446
Ensembl chr 9:9,513,856...9,597,959
JBrowse link
G ARRB2 arrestin beta 2 acts_upstream_of_or_within ISO (MGI:1351102|PMID:10617462), (MGI:1927976|PMID:11130073), (MGI:1930835|PMID:11171997) RGD
MGI
PMID:1517224 PMID:10617462 PMID:11130073 PMID:11171997 MGI:1351102 MGI:1927976 MGI:1930835 RGD:631708 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,776...52,170,344
JBrowse link
G DGKQ diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:313,325...325,089
Ensembl chr 8:313,327...325,095
JBrowse link
G DYNLT1 dynein light chain Tctex-type 1 involved_in ISO (MGI:5788400|PMID:10559191) UniProt PMID:10559191 MGI:5788400 NCBI chr 1:8,556,083...8,562,865
Ensembl chr 1:8,556,059...8,563,679
JBrowse link
G FRMPD1 FERM and PDZ domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:238,371,311...238,511,714
Ensembl chr 1:238,371,336...238,511,716
JBrowse link
G GIT1 GIT ArfGAP 1 ISO RGD PMID:9826657 RGD:68782 NCBI chr12:45,768,172...45,783,652
Ensembl chr12:45,768,174...45,783,747
JBrowse link
G GPSM1 G protein signaling modulator 1 ISO RGD PMID:10559191 RGD:631950
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 RGD:61618 NCBI chr14:129,113,933...129,351,135
Ensembl chr14:129,113,602...129,347,153
JBrowse link
G HOMER2 homer scaffold protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3525625|PMID:12860966) Ensembl
MGI
PMID:12860966 GO_REF:0000107 MGI:3525625 NCBI chr 7:52,001,253...52,104,426
Ensembl chr 7:52,001,578...52,096,847
JBrowse link
G ITGB1 integrin subunit beta 1 ISO RGD PMID:17157995 RGD:1625132 NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,398...56,173,795
JBrowse link
G ITGB3 integrin subunit beta 3 ISO RGD PMID:17157995 RGD:1625132 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,505...16,752,292
JBrowse link
G KCTD12 potassium channel tetramerization domain containing 12 acts_upstream_of_or_within ISO (MGI:4462115|PMID:20400944) MGI PMID:20400944 MGI:4462115 NCBI chr11:49,025,134...49,033,208
Ensembl chr11:48,943,477...49,031,093
JBrowse link
G KCTD16 potassium channel tetramerization domain containing 16 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4462115|PMID:20400944) Ensembl
MGI
PMID:20400944 GO_REF:0000107 MGI:4462115 NCBI chr 2:145,704,702...145,992,830
Ensembl chr 2:145,707,460...145,980,908
JBrowse link
G KCTD8 potassium channel tetramerization domain containing 8 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:4462115|PMID:20400944)
GO_Central
MGI
PMID:20400944 PMID:21873635 MGI:4462115 NCBI chr 8:34,745,209...35,005,515
Ensembl chr 8:34,747,459...35,005,495
JBrowse link
G PDC phosducin involved_in IEA InterPro GO_REF:0000002 NCBI chr 9:127,600,114...127,619,759
Ensembl chr 9:127,601,385...127,608,367
JBrowse link
G PDCL phosducin like involved_in IEA InterPro GO_REF:0000002 NCBI chr 1:263,747,900...263,759,610
Ensembl chr 1:263,747,700...263,759,543
JBrowse link
G PDE4D phosphodiesterase 4D ISO RGD PMID:12552097 RGD:629543 NCBI chr16:37,897,300...39,406,534
Ensembl chr16:37,897,300...39,154,586
JBrowse link
G PHF24 PHD finger protein 24 acts_upstream_of_or_within ISO (MGI:5616490|PMID:25242222) MGI PMID:25242222 MGI:5616490 NCBI chr 1:235,757,499...235,783,053
Ensembl chr 1:235,757,797...235,783,051
JBrowse link
G PLCB1 phospholipase C beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:17,007,197...17,745,314
Ensembl chr17:17,007,261...17,745,312
JBrowse link
G PLCE1 phospholipase C epsilon 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:105,422,628...105,764,736
Ensembl chr14:105,458,916...105,764,731
JBrowse link
G RAMP1 receptor activity modifying protein 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr15:137,490,440...137,535,555
Ensembl chr15:137,490,087...137,535,555
JBrowse link
G RAMP2 receptor activity modifying protein 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr12:20,092,204...20,094,426
Ensembl chr12:20,092,193...20,094,474
JBrowse link
G RAMP3 receptor activity modifying protein 3 involved_in IEA InterPro GO_REF:0000002 NCBI chr18:50,319,795...50,366,757
Ensembl chr18:50,319,797...50,366,739
JBrowse link
G RGS1 regulator of G protein signaling 1 involved_in IEA InterPro GO_REF:0000002 NCBI chr10:1,147,439...1,151,733
Ensembl chr10:1,147,457...1,151,738
JBrowse link
G RGS10 regulator of G protein signaling 10 involved_in IEA InterPro GO_REF:0000002 NCBI chr14:129,386,717...129,424,150
Ensembl chr14:129,381,192...129,417,445
JBrowse link
G RGS14 regulator of G protein signaling 14 ISO RGD PMID:11976690 RGD:729762 NCBI chr 2:80,574,411...80,589,998
Ensembl chr 2:80,574,411...80,590,003
JBrowse link
G RGS18 regulator of G protein signaling 18 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1927493|PMID:11042171) Ensembl
MGI
PMID:11042171 GO_REF:0000107 MGI:1927493 NCBI chr10:1,520,866...1,539,776
Ensembl chr10:1,520,872...1,539,663
JBrowse link
G RGS2 regulator of G protein signaling 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr10:936,836...940,083
Ensembl chr10:936,789...940,098
JBrowse link
G RGS7 regulator of G protein signaling 7 acts_upstream_of_or_within ISO (MGI:5428056|PMID:22689652) RGD
MGI
PMID:10092682 PMID:22689652 MGI:5428056 RGD:69962 NCBI chr10:11,950,897...12,322,382
Ensembl chr10:11,950,900...12,322,360
JBrowse link
G RGS9 regulator of G protein signaling 9 ISO RGD PMID:9765512 RGD:69964 NCBI chr12:12,015,321...12,087,982
Ensembl chr12:11,996,417...12,089,466
JBrowse link
G RIC8B RIC8 guanine nucleotide exchange factor B acts_upstream_of_or_within ISO (PMID:12652642) MGI PMID:12652642 NCBI chr 5:13,468,933...13,580,497
Ensembl chr 5:13,468,937...13,585,781
JBrowse link
G SLC24A4 solute carrier family 24 member 4 involved_in
acts_upstream_of
IEA
ISO
(MGI:6716959|PMID:25096581) Ensembl
ARUK-UCL
PMID:25096581 GO_REF:0000107 MGI:6716959 NCBI chr 7:113,836,207...114,014,952
Ensembl chr 7:113,836,189...114,011,301
JBrowse link
G TUB TUB bipartite transcription factor involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5921791|PMID:28154160) Ensembl
MGI
PMID:28154160 GO_REF:0000107 MGI:5921791 NCBI chr 9:1,183,821...1,260,209
Ensembl chr 9:1,183,822...1,278,498
JBrowse link
G TULP3 TUB like protein 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:28154160)
(MGI:5921791|PMID:28154160)
Ensembl
MGI
PMID:28154160 GO_REF:0000107 MGI:5921791 NCBI chr 5:67,201,680...67,238,348
Ensembl chr 5:67,199,446...67,238,324
JBrowse link
G USP20 ubiquitin specific peptidase 20 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:269,995,532...270,037,499
Ensembl chr 1:269,995,520...270,086,780
JBrowse link
G USP33 ubiquitin specific peptidase 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:135,524,372...135,589,742
Ensembl chr 6:135,524,394...135,589,737
JBrowse link
G ZDHHC3 zinc finger DHHC-type palmitoyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:28,100,529...28,176,733
Ensembl chr13:28,098,004...28,176,754
JBrowse link
G ZDHHC7 zinc finger DHHC-type palmitoyltransferase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:3,786,330...3,817,960
Ensembl chr 6:3,786,325...3,899,139
JBrowse link
cross-receptor inhibition within G protein-coupled receptor heterodimer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALCR calcitonin receptor involved_in ISO (PMID:14722252) UniProt PMID:14722252 NCBI chr 9:73,279,874...73,403,516
Ensembl chr 9:73,279,911...73,403,434
JBrowse link
G RAMP3 receptor activity modifying protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:50,319,795...50,366,757
Ensembl chr18:50,319,797...50,366,739
JBrowse link
desensitization of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GIPR gastric inhibitory polypeptide receptor ISO RGD PMID:8928774 RGD:2312614 NCBI chr 6:52,022,667...52,033,959
Ensembl chr 6:52,022,681...52,033,954
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 involved_in
acts_upstream_of_or_within
IEA
IBA
ISO
(PMID:21873635)
(MGI:1337704|PMID:10338466)
(MGI:84440|PMID:7761854)
Ensembl
GO_Central
MGI
RGD
PMID:7761854 PMID:10338466 PMID:17908240 PMID:21873635 PMID:30075183 GO_REF:0000107 MGI:1337704 MGI:84440 RGD:13792694 RGD:7242040 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,436...5,227,748
JBrowse link
G GRK3 G protein-coupled receptor kinase 3 involved_in ISO
IBA
(PMID:21873635) RGD
GO_Central
PMID:8381966 PMID:20837135 PMID:21873635 RGD:5685022 RGD:5685621 NCBI chr14:43,305,255...43,445,626
Ensembl chr14:43,224,930...43,442,985
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:15166006 RGD:1598508 NCBI chr 8:1,737,960...1,792,390
Ensembl chr 8:1,738,135...1,792,861
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:8626574 PMID:30075183 RGD:13792694 RGD:61618 NCBI chr14:129,113,933...129,351,135
Ensembl chr14:129,113,602...129,347,153
JBrowse link
G GRK6 G protein-coupled receptor kinase 6 ISO RGD PMID:12810562 PMID:17908240 RGD:1299124 RGD:7242040 NCBI chr 2:80,496,105...80,527,208
Ensembl chr 2:80,507,009...80,527,210
JBrowse link
G GRM5 glutamate metabotropic receptor 5 involved_in ISO PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 9:21,914,422...22,438,200
Ensembl chr 9:21,916,815...22,436,063
JBrowse link
G LOC110261493 sperm acrosome membrane-associated protein 4-like involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:5694852|PMID:26276394)
GO_Central
MGI
PMID:21873635 PMID:26276394 MGI:5694852 NCBI chr 7:23,823,392...23,825,431 JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9350980 RGD:9850278 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,954...142,161,292
JBrowse link
desensitization of G protein-coupled receptor signaling pathway by arrestin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 involved_in IEA
ISS
Ensembl
HGNC-UCL
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:150,032,649...150,035,591
Ensembl chr 2:150,032,782...150,035,591
JBrowse link
G ADRB3 adrenoceptor beta 3 NOT|involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chr15:48,468,803...48,478,370 JBrowse link
G ARRB2 arrestin beta 2 involved_in ISO
IEA
RGD
Ensembl
PMID:20705669 GO_REF:0000107 RGD:5509896 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,776...52,170,344
JBrowse link
G protein-coupled receptor catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BECN2 beclin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23954414)
(MGI:5528919|PMID:23954414)
Ensembl
MGI
PMID:23954414 GO_REF:0000107 MGI:5528919 NCBI chr10:15,388,712...15,390,250
Ensembl chr10:15,388,605...15,390,226
JBrowse link
G GPRASP1 G protein-coupled receptor associated sorting protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(PMID:23954414) Ensembl
MGI
PMID:23954414 GO_REF:0000107 NCBI chr  X:83,765,210...83,810,090
Ensembl chr  X:83,765,255...83,811,026
JBrowse link
G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADM adrenomedullin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:49,229,223...49,231,521
Ensembl chr 2:49,229,223...49,231,866
JBrowse link
G ARR3 arrestin 3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:56,295,107...56,310,507
Ensembl chr  X:56,296,596...56,310,504
JBrowse link
G ARRB1 arrestin beta 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:9,516,944...9,597,446
Ensembl chr 9:9,513,856...9,597,959
JBrowse link
G ARRB2 arrestin beta 2 involved_in IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,776...52,170,344
JBrowse link
G CALCB calcitonin-related polypeptide beta involved_in ISO (PMID:10882736) UniProt PMID:10882736 NCBI chr 2:44,043,135...44,048,651 JBrowse link
G DNM1 dynamin 1 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 1:268,653,045...268,702,233
Ensembl chr 1:268,653,039...268,702,223
JBrowse link
G DNM2 dynamin 2 ISO RGD PMID:14709338 RGD:9685157 NCBI chr 2:69,474,011...69,574,427
Ensembl chr 2:69,474,031...69,574,424
JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:14617818 RGD:1581465 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599
JBrowse link
G DRD3 dopamine receptor D3 involved_in IEA
ISO
Ensembl
RGD
PMID:14617818 GO_REF:0000107 RGD:1581465 NCBI chr13:145,769,294...145,817,997
Ensembl chr13:145,771,510...145,819,173
JBrowse link
G GRK4 G protein-coupled receptor kinase 4 ISO RGD PMID:12519791 RGD:1304268 NCBI chr 8:1,737,960...1,792,390
Ensembl chr 8:1,738,135...1,792,861
JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:88,597,510...88,598,682
Ensembl chr 1:88,596,215...88,601,047
JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:131,844,578...131,860,417
Ensembl chr15:131,844,928...131,860,392
JBrowse link
G PLD2 phospholipase D2 acts_upstream_of_or_within ISO (MGI:3042801|PMID:14718562) MGI PMID:14718562 MGI:3042801 NCBI chr12:52,073,913...52,087,804
Ensembl chr12:52,073,896...52,087,809
JBrowse link
G SAG S-antigen visual arrestin involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:133,704,975...133,741,844
Ensembl chr15:133,691,886...133,741,798
JBrowse link
inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chr18:50,862,225...50,956,263
Ensembl chr18:50,861,466...50,957,945
JBrowse link
negative regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase involved_in IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,495...47,072,245
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRDC3 arrestin domain containing 3 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5302794|PMID:21982743) Ensembl
MGI
PMID:21982743 GO_REF:0000107 MGI:5302794 NCBI chr 2:98,430,451...98,444,835
Ensembl chr 2:98,430,465...98,444,647
JBrowse link
G CRTC3 CREB regulated transcription coactivator 3 acts_upstream_of_or_within ISO (MGI:4867567|PMID:21164481) MGI PMID:21164481 MGI:4867567 NCBI chr 7:53,146,317...53,255,985
Ensembl chr 7:53,146,403...53,255,977
JBrowse link
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:64,336,354...64,445,669
Ensembl chr 9:64,336,499...64,445,663
JBrowse link
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:12631586 RGD:13508593 NCBI chr13:32,705,326...32,733,804
Ensembl chr13:32,705,321...32,733,363
JBrowse link
G PDE4B phosphodiesterase 4B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:146,167,262...146,720,105
Ensembl chr 6:146,166,681...146,720,127
JBrowse link
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLP1 amyloid beta precursor like protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:45,285,698...45,295,355
Ensembl chr 6:45,285,698...45,295,352
JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 acts_upstream_of_or_within ISO (MGI:3850921|PMID:19246489) MGI PMID:19246489 MGI:3850921 NCBI chr18:42,251,755...42,296,457
Ensembl chr18:42,251,749...42,295,468
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:30075183 RGD:13792694 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,436...5,227,748
JBrowse link
G GRK5 G protein-coupled receptor kinase 5 ISO RGD PMID:30075183 RGD:13792694 NCBI chr14:129,113,933...129,351,135
Ensembl chr14:129,113,602...129,347,153
JBrowse link
G MRAP melanocortin 2 receptor accessory protein involved_in ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chr13:195,950,949...195,973,501 JBrowse link
G MRAP2 melanocortin 2 receptor accessory protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:53,248,311...53,318,111
Ensembl chr 1:53,256,006...53,318,107
JBrowse link
G OPRL1 opioid related nociceptin receptor 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chr17:62,905,700...62,913,018
Ensembl chr17:62,897,727...62,913,754
JBrowse link
G OPRM1 opioid receptor mu 1 ISO RGD PMID:15748148 RGD:9835006 NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443
JBrowse link
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:9013884 RGD:9850263 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,954...142,161,292
JBrowse link
negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGS2 regulator of G protein signaling 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:936,836...940,083
Ensembl chr10:936,789...940,098
JBrowse link
negative regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chr 6:4,598,752...4,641,450 JBrowse link
G UBQLN2 ubiquilin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:48,948,062...48,951,392
Ensembl chr  X:48,948,389...48,950,263
JBrowse link
negative regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL5 C-C motif chemokine ligand 5 involved_in ISO (PMID:10734056) UniProt PMID:10734056 NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118
JBrowse link
G CRY1 cryptochrome circadian regulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:13,275,265...13,429,566
Ensembl chr 5:13,275,544...13,364,594
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:1403099 RGD:632163 NCBI chr 2:5,209,435...5,227,543
Ensembl chr 2:5,209,436...5,227,748
JBrowse link
G KLK14 kallikrein related peptidase 14 involved_in ISO (PMID:16885167) UniProt PMID:16885167 NCBI chr 6:55,719,698...55,726,099
Ensembl chr 6:55,719,728...55,725,473
JBrowse link
G MGRN1 mahogunin ring finger 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:37,694,798...37,748,106
Ensembl chr 3:37,689,708...37,748,068
JBrowse link
G PLEK pleckstrin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:73,877,741...73,910,163
Ensembl chr 3:73,877,743...74,005,519
JBrowse link
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:9651375 RGD:69959 NCBI chr 8:1,971,390...2,074,970
Ensembl chr 8:1,963,313...2,076,963
JBrowse link
G RGS13 regulator of G protein signaling 13 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2385407|PMID:12193720) Ensembl
MGI
PMID:12193720 GO_REF:0000107 MGI:2385407 NCBI chr10:1,056,920...1,082,394
Ensembl chr10:1,057,622...1,082,222
JBrowse link
G RGS14 regulator of G protein signaling 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:80,574,411...80,589,998
Ensembl chr 2:80,574,411...80,590,003
JBrowse link
G RGS2 regulator of G protein signaling 2 involved_in ISO (MGI:3836877|PMID:19127022) RGD
BHF-UCL
PMID:11968023 PMID:19127022 PMID:21798518 MGI:3836877 RGD:633858 RGD:7207364 NCBI chr10:936,836...940,083
Ensembl chr10:936,789...940,098
JBrowse link
G RGS4 regulator of G protein signaling 4 ISO RGD PMID:9918533 PMID:21798518 RGD:7207364 RGD:7207376 NCBI chr 4:87,383,336...87,390,478
Ensembl chr 4:87,381,386...87,390,467
JBrowse link
G RNF157 ring finger protein 157 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:5,225,978...5,306,197
Ensembl chr12:5,226,135...5,307,061
JBrowse link
G RPGRIP1L RPGRIP1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:31,564,937...31,660,540
Ensembl chr 6:31,564,986...31,661,194
JBrowse link
G RPH3AL rabphilin 3A like (without C2 domains) involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3044444|PMID:15159548) Ensembl
MGI
PMID:15159548 GO_REF:0000107 MGI:3044444 NCBI chr12:47,322,505...47,497,904
Ensembl chr12:47,346,977...47,500,525
JBrowse link
G YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:47,298,020...47,317,826
Ensembl chr17:47,298,015...47,319,275
JBrowse link
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BICD1 BICD cargo adaptor 1 involved_in ISO PMID:20164183
(MGI:4887309|PMID:20164183)
BHF-UCL PMID:20164183 MGI:4887309 RGD:8693367 NCBI chr 5:41,897,611...42,143,668
Ensembl chr 5:41,897,376...42,143,641
JBrowse link
negative regulation of thrombin-activated receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MET MET proto-oncogene, receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,044...29,541,512
JBrowse link
G SNCA synuclein alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:129,247,724...129,388,307
Ensembl chr 8:129,248,819...129,388,307
JBrowse link
G STMN1 stathmin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:83,356,404...83,362,546
Ensembl chr 6:83,356,411...83,362,500
JBrowse link
positive regulation of adenosine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP3 acid phosphatase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:73,471,837...73,530,778
Ensembl chr13:73,471,881...73,571,052
JBrowse link
G CNTN2 contactin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:1930847|PMID:11178983) Ensembl
MGI
PMID:11178983 GO_REF:0000107 MGI:1930847 NCBI chr 9:65,737,488...65,776,412
Ensembl chr 9:65,737,719...65,776,308
JBrowse link
G NECAB2 N-terminal EF-hand calcium binding protein 2 involved_in ISO (PMID:17689978) UniProt PMID:17689978 NCBI chr 6:4,598,752...4,641,450 JBrowse link
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:49,690,319...49,700,735
Ensembl chr 6:49,690,370...49,700,735
JBrowse link
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS1 nitric oxide synthase 1 involved_in ISO (MGI:3771112|PMID:17242280) BHF-UCL PMID:17242280 MGI:3771112 NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,972
JBrowse link
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 ISO RGD PMID:18202135 RGD:5129138 NCBI chr14:124,400,330...124,401,739
Ensembl chr14:124,400,189...124,401,739
JBrowse link
G CRHR2 corticotropin releasing hormone receptor 2 acts_upstream_of_or_within ISO (MGI:3850921|PMID:19246489) MGI PMID:19246489 MGI:3850921 NCBI chr18:42,251,755...42,296,457
Ensembl chr18:42,251,749...42,295,468
JBrowse link
G GSK3A glycogen synthase kinase 3 alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:49,690,319...49,700,735
Ensembl chr 6:49,690,370...49,700,735
JBrowse link
G MRAP melanocortin 2 receptor accessory protein involved_in ISO (PMID:19329486) BHF-UCL PMID:19329486 NCBI chr13:195,950,949...195,973,501 JBrowse link
G MRAP2 melanocortin 2 receptor accessory protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:53,248,311...53,318,111
Ensembl chr 1:53,256,006...53,318,107
JBrowse link
positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRMT5 protein arginine methyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:76,110,956...76,119,619
Ensembl chr 7:76,110,951...76,136,597
JBrowse link
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ITGB3 integrin subunit beta 3 ISO RGD PMID:17157995 RGD:1625132 NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,505...16,752,292
JBrowse link
positive regulation of G protein-coupled receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APELA apelin receptor early endogenous ligand involved_in ISO (PMID:25639753) UniProt PMID:25639753 NCBI chr 8:53,703,735...53,736,989 JBrowse link
G APLN apelin involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:106,236,746...106,246,563
Ensembl chr  X:106,236,748...106,246,378
JBrowse link
G APP amyloid beta precursor protein involved_in ISO (PMID:18723082) ARUK-UCL PMID:18723082 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,434,869...189,716,057
JBrowse link
positive regulation of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein involved_in ISO (PMID:11316806) ARUK-UCL PMID:11316806 NCBI chr13:189,434,854...189,716,120
Ensembl chr13:189,434,869...189,716,057
JBrowse link
G C3 complement C3 involved_in IEA
ISS
Ensembl
UniProt
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:72,431,470...72,471,622
Ensembl chr 2:72,431,499...72,528,112
JBrowse link
G DRD2 dopamine receptor D2 ISO RGD PMID:18809670 RGD:2311559 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599
JBrowse link
G ECE1 endothelin converting enzyme 1 ISO RGD PMID:15733912 RGD:1581735 NCBI chr 6:79,408,322...79,465,827
Ensembl chr 6:79,408,328...79,466,106
JBrowse link
G FGF8 fibroblast growth factor 8 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3847828|PMID:19307307) Ensembl
MGI
PMID:19307307 GO_REF:0000107 MGI:3847828 NCBI chr14:112,808,215...112,814,225
Ensembl chr14:112,808,210...112,814,134
JBrowse link
G GAS2L2 growth arrest specific 2 like 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:39,772,070...39,785,159
Ensembl chr12:39,768,014...39,785,159
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,982
JBrowse link
G KLK14 kallikrein related peptidase 14 involved_in ISO (PMID:16885167) UniProt PMID:16885167 NCBI chr 6:55,719,698...55,726,099
Ensembl chr 6:55,719,728...55,725,473
JBrowse link
G KLK5 kallikrein related peptidase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:55,618,094...55,627,518
Ensembl chr 6:55,618,377...55,627,079
JBrowse link
G KLK6 kallikrein related peptidase 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:55,629,983...55,639,215
Ensembl chr 6:55,630,059...55,638,883
JBrowse link
G MYH9 myosin heavy chain 9 ISO RGD PMID:20068007 RGD:6902910 NCBI chr 5:11,365,603...11,456,475 JBrowse link
G PDE6G phosphodiesterase 6G acts_upstream_of_or_within ISO (MGI:2156093|PMID:11502744) MGI PMID:11502744 MGI:2156093 NCBI chr12:1,235,886...1,239,808 JBrowse link
G PDE6H phosphodiesterase 6H acts_upstream_of_or_within ISO (MGI:2156093|PMID:11502744) MGI PMID:11502744 MGI:2156093 NCBI chr 5:57,555,448...57,582,324 JBrowse link
G PHB prohibitin involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:25,596,520...25,609,693
Ensembl chr12:25,584,443...25,609,656
JBrowse link
G PTGDR2 prostaglandin D2 receptor 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2670839|PMID:12878180) Ensembl
MGI
PMID:12878180 GO_REF:0000107 MGI:2670839 NCBI chr 2:10,891,280...10,897,194
Ensembl chr 2:10,880,901...10,903,017
JBrowse link
G SLC39A14 solute carrier family 39 member 14 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:6,639,485...6,687,929
Ensembl chr14:6,639,206...6,803,670
JBrowse link
G TMOD2 tropomodulin 2 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2663390|PMID:12799133) Ensembl
MGI
PMID:12799133 GO_REF:0000107 MGI:2663390 NCBI chr 1:119,956,583...120,009,372
Ensembl chr 1:119,956,588...120,009,364
JBrowse link
positive regulation of inhibitory G protein-coupled receptor phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APLNR apelin receptor involved_in IEA Ensembl GO_REF:0000107
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,954...142,161,292
JBrowse link
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHGA chromogranin A ISO RGD PMID:11257446 RGD:6907050 NCBI chr 7:114,345,542...114,357,799
Ensembl chr 7:114,345,091...114,358,571
JBrowse link
G F2 coagulation factor II, thrombin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:15,793,257...15,819,151
Ensembl chr 2:15,791,451...15,819,138
JBrowse link
G GPR27 G protein-coupled receptor 27 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:5311513|PMID:22253604) Ensembl
MGI
PMID:22253604 GO_REF:0000107 MGI:5311513 NCBI chr13:53,152,038...53,154,537
Ensembl chr13:53,152,062...53,153,192
JBrowse link
G GRP gastrin releasing peptide involved_in ISS
IEA
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 1:161,708,815...161,721,986
Ensembl chr 1:161,708,807...161,721,782
JBrowse link
prostaglandin receptor internalization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGER3 prostaglandin E receptor 3 ISO RGD PMID:15937517 RGD:10043344 NCBI chr 6:141,958,955...142,160,437
Ensembl chr 6:141,958,954...142,161,292
JBrowse link
protein kinase C deactivation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MRAP melanocortin 2 receptor accessory protein involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:195,950,949...195,973,501 JBrowse link
G MRAP2 melanocortin 2 receptor accessory protein 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:53,248,311...53,318,111
Ensembl chr 1:53,256,006...53,318,107
JBrowse link
G PDE10A phosphodiesterase 10A acts_upstream_of_or_within ISO (MGI:3815363|PMID:18923023) MGI PMID:18923023 MGI:3815363 NCBI chr 1:3,120,418...3,394,236
Ensembl chr 1:3,120,223...3,392,651
JBrowse link
G PDE4A phosphodiesterase 4A acts_upstream_of_or_within ISO (MGI:3815363|PMID:18923023) MGI PMID:18923023 MGI:3815363 NCBI chr 2:69,225,403...69,268,327
Ensembl chr 2:69,225,395...69,267,971
JBrowse link
regulation of angiotensin-activated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ROCK1 Rho associated coiled-coil containing protein kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:106,163,899...106,314,998
Ensembl chr 6:106,163,903...106,314,944
JBrowse link
G ROCK2 Rho associated coiled-coil containing protein kinase 2 involved_in ISO (MGI:6158813|PMID:28679962) ARUK-UCL PMID:28679962 MGI:6158813 NCBI chr 3:125,353,063...125,493,368
Ensembl chr 3:125,353,119...125,491,963
JBrowse link
regulation of endocannabinoid signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD6 abhydrolase domain containing 6, acylglycerol lipase involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:4829719|PMID:20657592) Ensembl
MGI
PMID:20657592 GO_REF:0000107 MGI:4829719 NCBI chr13:39,982,536...40,055,467
Ensembl chr13:40,009,737...40,055,490
JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha involved_in ISO (MGI:5494205|PMID:23502535) UniProt PMID:23502535 MGI:5494205 NCBI chr 2:151,248,356...151,353,907
Ensembl chr 2:151,248,356...151,308,658
JBrowse link
G MGLL monoglyceride lipase involved_in ISO (MGI:4836780|PMID:20729846) UniProt PMID:20729846 MGI:4836780 NCBI chr13:72,480,395...72,568,964
Ensembl chr13:72,479,337...72,568,962
JBrowse link
regulation of opioid receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPP1R9B protein phosphatase 1 regulatory subunit 9B involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:26,319,123...26,337,089
Ensembl chr12:26,319,124...26,336,562
JBrowse link
G SYP synaptophysin involved_in ISO PMID:17005904 UniProt PMID:17005904 RGD:8554727 NCBI chr  X:43,232,190...43,246,764
Ensembl chr  X:43,232,195...43,246,682
JBrowse link
regulation of rhodopsin mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIPL1 aryl hydrocarbon receptor interacting protein like 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3054118|PMID:15365173)
(MGI:3054134|PMID:15365178)
Ensembl
MGI
PMID:15365173 PMID:15365178 GO_REF:0000107 MGI:3054118 MGI:3054134 NCBI chr12:50,903,358...50,917,187
Ensembl chr12:50,903,438...50,920,437
JBrowse link
G GRK1 G protein-coupled receptor kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:78,793,670...78,803,291
Ensembl chr11:78,793,777...78,803,297
JBrowse link
termination of G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RGS12 regulator of G protein signaling 12 ISO RGD PMID:11130074 RGD:7207399 NCBI chr 8:1,971,390...2,074,970
Ensembl chr 8:1,963,313...2,076,963
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16576
    signaling 6563
      regulation of signaling 3354
        regulation of signal transduction 2843
          regulation of G protein-coupled receptor signaling pathway 135
            cross-receptor inhibition within G protein-coupled receptor heterodimer 2
            modulation by symbiont of host G protein-coupled receptor signal transduction + 0
            negative regulation of G protein-coupled receptor signaling pathway + 64
            positive regulation of G protein-coupled receptor signaling pathway + 32
            protein kinase C deactivation 1
            regulation of G protein-coupled receptor internalization + 5
            regulation of adenosine receptor signaling pathway + 4
            regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 19
            regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway + 1
            regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway + 1
            regulation of angiotensin-activated signaling pathway + 2
            regulation of endocannabinoid signaling pathway 3
            regulation of octopamine or tyramine signaling pathway + 0
            regulation of opioid receptor signaling pathway + 3
            regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 5
            regulation of rhodopsin mediated signaling pathway + 2
            regulation of thrombin-activated receptor signaling pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 16576
    biological regulation 12075
      regulation of biological process 11450
        regulation of cellular process 11009
          signal transduction 6026
            G protein-coupled receptor signaling pathway 1826
              regulation of G protein-coupled receptor signaling pathway 135
                cross-receptor inhibition within G protein-coupled receptor heterodimer 2
                modulation by symbiont of host G protein-coupled receptor signal transduction + 0
                negative regulation of G protein-coupled receptor signaling pathway + 64
                positive regulation of G protein-coupled receptor signaling pathway + 32
                protein kinase C deactivation 1
                regulation of G protein-coupled receptor internalization + 5
                regulation of adenosine receptor signaling pathway + 4
                regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway + 19
                regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway + 1
                regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway + 1
                regulation of angiotensin-activated signaling pathway + 2
                regulation of endocannabinoid signaling pathway 3
                regulation of octopamine or tyramine signaling pathway + 0
                regulation of opioid receptor signaling pathway + 3
                regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 5
                regulation of rhodopsin mediated signaling pathway + 2
                regulation of thrombin-activated receptor signaling pathway + 3
paths to the root