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ONTOLOGY REPORT - ANNOTATIONS

Term:mineralocorticoid metabolic process
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Accession:GO:0008212 term browser browse the term
Definition:The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance.
Synonyms:exact_synonym: mineralocorticoid metabolism


show annotations for term's descendants           Sort by:
mineralocorticoid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IDA RGD PMID:2808402 RGD:728825 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IMP
IEA
ISO		 PMID:19342457
GO_REF:0000107
(PMID:19342457)		 Ensembl
RGD		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr10:14,894,630...14,952,317
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IMP
IBA		 PMID:19342457
GO_REF:0000033		 GO_Central PMID:19342457 GO_REF:0000033, RGD:4891166 NCBI chr 7:108,653,385...108,660,062
Ensembl chr 7:106,718,274...106,779,278 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 acts_upstream_of_or_within
involved_in		 IDA
IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:19342457), (PMID:2256920)		 Ensembl
GO_Central
RGD		 PMID:2256920 PMID:19342457 PMID:11832364 GO_REF:0000033 GO_REF:0000107, RGD:727991 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:1741400), (PMID:19342457), (PMID:2256920), (PMID:23322723)
GO_REF:0000107
(PMID:1686470), (PMID:8645611)		 RGD
Ensembl		 PMID:1686470 PMID:1741400 PMID:2256920 PMID:8645611 PMID:19342457 More... GO_REF:0000107 NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
aldosterone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ednrb endothelin receptor type B involved_in ISO
IEA		 MGI:3693642 (PMID:16868309)
GO_REF:0000107		 RGD
Ensembl		 PMID:16868309 GO_REF:0000107 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Scnn1b sodium channel epithelial 1 subunit beta acts_upstream_of_or_within ISO (PMID:28567665) RGD PMID:28567665 NCBI chr 1:185,861,326...185,915,717
Ensembl chr 1:176,430,103...176,484,451 		JBrowse link
mineralocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 IDA 11-deoxycorticosterone RGD PMID:19665544 RGD:4891164 NCBI chr20:4,028,323...4,031,549
Ensembl chr20:4,023,767...4,026,923 		JBrowse link
negative regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in IEA
ISO		 GO_REF:0000107
(PMID:19584291)		 Ensembl
RGD		 PMID:19584291 GO_REF:0000107 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:85,397,629...85,520,374
Ensembl chr 8:76,517,164...76,639,925 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:175,672,834...175,715,867
Ensembl chr 1:166,238,238...166,280,590 		JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO
IEA
IMP		 (PMID:19342457)
GO_REF:0000107		 RGD
Ensembl		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr14:31,213,415...31,233,451
Ensembl chr14:30,862,553...30,894,354 		JBrowse link
positive regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 involved_in ISO
IEA		 (PMID:16527843)
GO_REF:0000107		 RGD
Ensembl		 PMID:16527843 GO_REF:0000107 NCBI chr17:26,523,704...26,785,558
Ensembl chr17:26,318,569...26,470,365 		JBrowse link
G Dab2 DAB adaptor protein 2 IDA RGD PMID:17303656 RGD:7243836 NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Wnt4 Wnt family member 4 involved_in ISO
IEA		 (PMID:16981135)
GO_REF:0000107		 RGD
Ensembl		 PMID:16981135 GO_REF:0000107 NCBI chr 5:154,797,245...154,818,565
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
regulation of aldosterone biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in ISO
IEA
ISS		 (PMID:29403011)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:29403011 GO_REF:0000024 GO_REF:0000107 NCBI chr11:93,702,382...93,716,059
Ensembl chr11:80,198,153...80,211,657 		JBrowse link
regulation of aldosterone metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 acts_upstream_of_or_within ISO MGI:3050114 (PMID:17122062) RGD PMID:17122062 NCBI chr15:351,065...1,057,117
Ensembl chr15:302,214...1,001,198 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20567
    cellular process 19557
      metabolic process 12206
        hormone metabolic process 268
          mineralocorticoid metabolic process 17
            aldosterone metabolic process + 15
            mineralocorticoid biosynthetic process + 13
            mineralocorticoid catabolic process + 0
Path 2
Term Annotations click to browse term
  biological_process 20567
    cellular process 19557
      metabolic process 12206
        primary metabolic process 10763
          lipid metabolic process 1485
            steroid metabolic process 374
              mineralocorticoid metabolic process 17
                aldosterone metabolic process + 15
                mineralocorticoid biosynthetic process + 13
                mineralocorticoid catabolic process + 0
paths to the root