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ONTOLOGY REPORT - ANNOTATIONS

Term:glucocorticoid metabolic process
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Accession:GO:0008211 term browser browse the term
Definition:The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
Synonyms:exact_synonym: glucocorticoid metabolism;   glucocorticosteroid metabolic process;   glucocorticosteroid metabolism


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glucocorticoid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 acts_upstream_of_or_within ISO MGI:2180783 (PMID:8647961) RGD PMID:8647961 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Cbr1 carbonyl reductase 1 involved_in ISO (MGI:6109036|PMID:28878267)
(PMID:28878267)		 RGD PMID:28878267 MGI:6109036 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 involved_in IDA
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:16763064 PMID:11755176 GO_REF:0000033, RGD:1625084, RGD:727334 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Mecp2 methyl CpG binding protein 2 acts_upstream_of_or_within ISO MGI:2183727 (PMID:17108082) RGD PMID:17108082 NCBI chr  X:151,781,177...151,844,687
Ensembl chr  X:151,789,930...151,844,689 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857745 (PMID:10509797)		 Ensembl
RGD		 PMID:10509797 GO_REF:0000107 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Serpina6 serpin family A member 6 acts_upstream_of_or_within ISO MGI:3664470 (PMID:16980625) RGD PMID:16980625 NCBI chr 6:122,780,040...122,790,274
Ensembl chr 6:122,780,043...122,790,349 		JBrowse link
G Star steroidogenic acute regulatory protein acts_upstream_of_or_within ISO MGI:2388706 (PMID:9326645) RGD PMID:9326645 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IMP
IEA
ISO		 PMID:19342457
GO_REF:0000107
(PMID:19342457)		 Ensembl
RGD		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IMP PMID:19342457 UniProt PMID:19342457 RGD:4891166 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in ISO (PMID:19342457), (PMID:2022736), (PMID:8506298) RGD PMID:2022736 PMID:8506298 PMID:19342457 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 NOT|involved_in ISO (PMID:9703385)
(PMID:19342457)		 RGD PMID:9703385 PMID:19342457 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
cortisol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278 		JBrowse link
G Cyp11b1-ps1 cytochrome P450, family 11, subfamily b, polypeptide 1, pseudogene 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 7:106,718,410...106,724,483 JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IEA
IBA		 GO_REF:0000118
GO_REF:0000033		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b2l1 cytochrome P450, family 11, subfamily b, polypeptide 2 like 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 7:106,724,638...106,751,822
Ensembl chr 7:106,718,274...106,779,278 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 involved_in ISO (PMID:8538347) RGD PMID:8538347 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone acts_upstream_of_or_within ISO MGI:1857392 (PMID:10861000) RGD PMID:10861000 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 involved_in IBA
IEA		 GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 involved_in IDA
IEA
IBA		 corticosterone
GO_REF:0000107
GO_REF:0000118
GO_REF:0000033		 Ensembl
TreeGrafter
GO_Central
RGD		 PMID:19665544 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118, RGD:4891164 NCBI chr 7:106,772,597...106,780,536
Ensembl chr 7:106,718,274...106,779,278 		JBrowse link
G Cyp11b1-ps1 cytochrome P450, family 11, subfamily b, polypeptide 1, pseudogene 1 involved_in IEA GO_REF:0000118
GO_REF:0000107		 TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:106,718,410...106,724,483 JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 involved_in IDA
IBA
IEA		 corticosterone, 18-hydroxycorticosterone
GO_REF:0000033
GO_REF:0000118		 GO_Central
TreeGrafter
RGD		 PMID:11832364 GO_REF:0000033 GO_REF:0000118, RGD:727991 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp11b2l1 cytochrome P450, family 11, subfamily b, polypeptide 2 like 1 involved_in IEA GO_REF:0000107
GO_REF:0000118		 Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 7:106,724,638...106,751,822
Ensembl chr 7:106,718,274...106,779,278 		JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:7588219)
GO_REF:0000041		 Ensembl
RGD
UniProt		 PMID:7588219 GO_REF:0000041 GO_REF:0000107 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:4,020,217...4,026,923
Ensembl chr20:4,023,767...4,026,923 		JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 involved_in IEA GO_REF:0000118 TreeGrafter GO_REF:0000118 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IDA RGD PMID:12460758 RGD:1625060 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
glucocorticoid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 IDA RGD PMID:12460758 RGD:1625060 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta involved_in ISO
IEA		 (PMID:15790729)
GO_REF:0000107		 RGD
Ensembl		 PMID:15790729 GO_REF:0000107 NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741 		JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp2 bone morphogenetic protein 2 involved_in ISO
IEA		 (PMID:19584291)
GO_REF:0000107		 RGD
Ensembl		 PMID:19584291 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp5 bone morphogenetic protein 5 involved_in ISO (PMID:19584291) RGD PMID:19584291 NCBI chr 8:76,517,164...76,639,925
Ensembl chr 8:76,517,164...76,639,925 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 1:166,237,969...166,281,271
Ensembl chr 1:166,238,238...166,280,590 		JBrowse link
G Rest RE1-silencing transcription factor involved_in ISO
IMP
IEA		 (PMID:19342457)
GO_REF:0000107		 RGD
Ensembl		 PMID:19342457 PMID:19342457 GO_REF:0000107, RGD:4891166 NCBI chr14:30,859,109...30,879,828
Ensembl chr14:30,862,553...30,894,354 		JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2451290 (PMID:17234593)		 Ensembl
RGD		 PMID:17234593 GO_REF:0000107 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837 		JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt4 Wnt family member 4 involved_in ISO (PMID:16981135) RGD PMID:16981135 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859 		JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dgkq diacylglycerol kinase, theta involved_in ISO (PMID:24369117) RGD PMID:24369117 NCBI chr14:1,059,125...1,073,131
Ensembl chr14:1,059,170...1,073,131 		JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) involved_in ISO (PMID:18628520), (PMID:23132696)
(MGI:3623644|PMID:16356929)		 RGD PMID:16356929 PMID:18628520 PMID:23132696 MGI:3623644 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171 		JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1857745 (PMID:7628695)		 Ensembl
RGD		 PMID:7628695 GO_REF:0000107 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
regulation of glucocorticoid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gal galanin and GMAP prepropeptide IMP RGD PMID:17273801 RGD:1624340 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Stub1 STIP1 homology and U-box containing protein 1 involved_in ISO (PMID:11146632) RGD PMID:11146632 NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      primary metabolic process 10352
        lipid metabolic process 1489
          steroid metabolic process 366
            glucocorticoid metabolic process 32
              cortisol metabolic process + 18
              glucocorticoid biosynthetic process + 23
              glucocorticoid catabolic process + 2
              negative regulation of glucocorticoid metabolic process + 5
              positive regulation of glucocorticoid metabolic process + 1
              regulation of glucocorticoid metabolic process + 11
paths to the root