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ONTOLOGY REPORT - ANNOTATIONS

Term:glucocorticoid metabolic process
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Accession:GO:0008211 term browser browse the term
Definition:The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
Synonyms:exact_synonym: glucocorticoid metabolism;   glucocorticosteroid metabolic process;   glucocorticosteroid metabolism


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glucocorticoid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 acts_upstream_of_or_within ISO (PMID:27535620) MGI PMID:27535620 NCBI chr 3:28,360,868...28,472,940
Ensembl chr 3:28,360,873...28,473,456 		JBrowse link
G APOA1 apolipoprotein A1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713 		JBrowse link
G CBR1 carbonyl reductase 1 involved_in ISO (PMID:28878267) UniProt PMID:28878267 NCBI chr13:199,617,406...199,622,407
Ensembl chr13:199,617,199...199,622,407 		JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 involved_in ISO
IBA 		RGD
GO_Central		 PMID:11755176 PMID:16763064 GO_REF:0000033 RGD:1625084 RGD:727334 NCBI chr 6:28,084,087...28,089,256
Ensembl chr 6:28,083,955...28,089,671 		JBrowse link
G LOC110256483 carbonyl reductase [NADPH] 1-like involved_in ISO (PMID:28878267) UniProt PMID:28878267 NCBI chr13:199,713,741...199,719,535 JBrowse link
G MECP2 methyl-CpG binding protein 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr  X:124,735,523...124,789,063
Ensembl chr  X:124,735,656...124,738,659 		JBrowse link
G NR3C1 nuclear receptor subfamily 3 group C member 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,939...144,956,451 		JBrowse link
G SERPINA6 serpin family A member 6 acts_upstream_of_or_within ISO (PMID:16980625) MGI PMID:16980625 NCBI chr 7:115,535,552...115,554,536
Ensembl chr 7:115,535,697...115,554,570 		JBrowse link
G STAR steroidogenic acute regulatory protein acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:48,377,597...48,385,398
Ensembl chr15:48,377,521...48,385,462 		JBrowse link
cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:40,637,420...40,694,616
Ensembl chr 3:40,637,427...40,695,177 		JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in
NOT|involved_in 		ISO (PMID:19342457)
(PMID:9703385) 		UniProt
BHF-UCL		 PMID:9703385 PMID:19342457 NCBI chr 4:1,365,725...1,373,138 JBrowse link
cortisol metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478 		JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:1,365,725...1,373,138 JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:28,084,087...28,089,256
Ensembl chr 6:28,083,955...28,089,671 		JBrowse link
glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:68,481,696...68,486,122
Ensembl chr 4:68,484,053...68,486,121 		JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478 		JBrowse link
G CYP11B2 cytochrome P450 family 11 subfamily B member 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:1,365,725...1,373,138 JBrowse link
G CYP17A1 cytochrome P450 family 17 subfamily A member 1 involved_in
acts_upstream_of_or_within 		IEA UniProt
Ensembl		 GO_REF:0000041 GO_REF:0000107 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041 		JBrowse link
G CYP21A1 cytochrome P450 family 21 subfamily A member 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:24,086,138...24,089,364
Ensembl chr 7:24,086,218...24,089,370 		JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:12460758 RGD:1625060 NCBI chr 9:133,231,451...133,278,396
Ensembl chr 9:133,231,451...133,278,396 		JBrowse link
glucocorticoid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 ISO RGD PMID:12460758 RGD:1625060 NCBI chr 9:133,231,451...133,278,396
Ensembl chr 9:133,231,451...133,278,396 		JBrowse link
G YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:48,544,031...48,556,496
Ensembl chr14:48,544,173...48,556,490 		JBrowse link
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,195 		JBrowse link
G BMP5 bone morphogenetic protein 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470 		JBrowse link
G DKK3 dickkopf WNT signaling pathway inhibitor 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:47,385,244...47,444,664
Ensembl chr 2:47,385,192...47,444,660 		JBrowse link
G LOC100621006 RE1-silencing transcription factor-like involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:56,048,280...56,215,011
Ensembl chr 8:56,035,150...56,215,013 		JBrowse link
G REST RE1 silencing transcription factor involved_in ISS UniProt GO_REF:0000024 NCBI chr 8:56,035,182...56,061,140
Ensembl chr 8:56,035,150...56,215,013 		JBrowse link
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,680 		JBrowse link
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT4 Wnt family member 4 involved_in ISO (PMID:16981135) UniProt PMID:16981135 NCBI chr 6:80,110,238...80,138,165 JBrowse link
positive regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR5A2 nuclear receptor subfamily 5 group A member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:22,727,865...22,866,905
Ensembl chr10:22,715,735...22,865,364 		JBrowse link
regulation of cortisol biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DGKQ diacylglycerol kinase theta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:313,325...325,089
Ensembl chr 8:313,329...325,095 		JBrowse link
G H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:69,666,348...69,700,303
Ensembl chr 6:69,666,601...69,700,298 		JBrowse link
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR3C1 nuclear receptor subfamily 3 group C member 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 2:144,822,937...144,956,451
Ensembl chr 2:144,822,939...144,956,451 		JBrowse link
regulation of glucocorticoid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GAL galanin and GMAP prepropeptide ISO RGD PMID:17273801 RGD:1624340 NCBI chr 2:4,351,113...4,357,167
Ensembl chr 2:4,351,113...4,356,647 		JBrowse link
G STUB1 STIP1 homology and U-box containing protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:41,092,514...41,095,181
Ensembl chr 3:41,092,449...41,095,136 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18945
    cellular process 18488
      metabolic process 11687
        primary metabolic process 10342
          lipid metabolic process 1352
            steroid metabolic process 318
              glucocorticoid metabolic process 29
                cortisol metabolic process + 12
                glucocorticoid biosynthetic process + 18
                glucocorticoid catabolic process + 2
                negative regulation of glucocorticoid metabolic process + 6
                positive regulation of glucocorticoid metabolic process + 2
                regulation of glucocorticoid metabolic process + 13
paths to the root