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ONTOLOGY REPORT - ANNOTATIONS


Term:estrogen metabolic process
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Accession:GO:0008210 term browser browse the term
Definition:The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants.
Synonyms:exact_synonym: estrogen metabolism;   oestrogen metabolic process;   oestrogen metabolism


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estrogen metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase IMP RGD PMID:11071850 RGD:2289790 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:11555828), (PMID:12865317), (PMID:14559847)
UniProt
RGD
PMID:11555828 PMID:12865317 PMID:14559847 GO_REF:0000024 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 involved_in ISO
ISS
(PMID:11555828), (PMID:12865317)
GO_REF:0000024
RGD
UniProt
PMID:11555828 PMID:12865317 GO_REF:0000024 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 involved_in IMP
ISO
IEA
IDA
(MGI:5574571|PMID:23821647)
GO_REF:0000107
(PMID:11555828), (PMID:12865317), (PMID:23821647)
RGD
Ensembl
PMID:11555828 PMID:12865317 PMID:23821647 PMID:16893557 PMID:23821647 GO_REF:0000107 MGI:5574571, RGD:1599718, RGD:7829732 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 involved_in ISO (PMID:12865317), (PMID:14559847) RGD PMID:12865317 PMID:14559847
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 involved_in ISO (PMID:12865317) RGD PMID:12865317 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 involved_in ISO (PMID:11555828), (PMID:12865317), (PMID:14559847) RGD PMID:11555828 PMID:12865317 PMID:14559847 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 involved_in ISO (PMID:12865317) RGD PMID:12865317 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:12917011)
Ensembl
UniProt
RGD
PMID:12917011 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:21,089,152...21,091,597
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 involved_in ISO
IEA
(PMID:7487879)
GO_REF:0000107
RGD
Ensembl
PMID:7487879 GO_REF:0000107 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 acts_upstream_of_or_within ISO (MGI:3511120|PMID:9712896) RGD PMID:9712896 MGI:3511120 NCBI chr20:4,826,725...4,828,742
Ensembl chr20:4,822,026...4,828,742
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1914283 (MGI:3820330|PMID:19056881)
Ensembl
RGD
PMID:19056881 GO_REF:0000107 MGI:3820330 NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
JBrowse link
G Plekha1 pleckstrin homology domain containing A1 acts_upstream_of_or_within ISO MGI:97530 (MGI:3820330|PMID:19056881) RGD PMID:19056881 MGI:3820330 NCBI chr 1:185,427,982...185,479,157
Ensembl chr 1:185,428,048...185,479,156
JBrowse link
G Schip1 schwannomin interacting protein 1 acts_upstream_of_or_within ISO MGI:97530 (MGI:3820330|PMID:19056881) RGD PMID:19056881 MGI:3820330 NCBI chr 2:152,127,171...152,888,587
Ensembl chr 2:152,126,953...152,888,585
JBrowse link
G Sgpl1 sphingosine-1-phosphate lyase 1 acts_upstream_of_or_within ISO MGI:3526851 (MGI:3820330|PMID:19056881) RGD PMID:19056881 MGI:3820330 NCBI chr20:29,047,793...29,094,209
Ensembl chr20:29,047,796...29,094,084
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 involved_in IMP
ISO
estradiol sulfation
(PMID:16221673)
RGD PMID:16221673 PMID:14742143 RGD:2301073 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 involved_in
acts_upstream_of_or_within
TAS
ISO
ISS
(MGI:5447633|PMID:9765259)
MGI:3529586 (MGI:3528801|PMID:15685171)
GO_REF:0000024
(PMID:11884392)
RGD
UniProt
PMID:9765259 PMID:11884392 PMID:15685171 PMID:7857871 GO_REF:0000024 MGI:3528801 MGI:5447633, RGD:1299062 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase acts_upstream_of_or_within ISO MGI:3526866 (MGI:3820330|PMID:19056881) RGD PMID:19056881 MGI:3820330 NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 involved_in ISO (PMID:15472229), (PMID:18719240), (PMID:19830808) RGD PMID:15472229 PMID:18719240 PMID:19830808 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 involved_in ISO (PMID:18719240) RGD PMID:18719240 NCBI chr 9:88,791,216...88,808,465 JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 9:88,780,328...88,808,465 JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 involved_in ISO
IDA
(PMID:18719240) RGD PMID:18719240 PMID:18719240 RGD:40902964 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Ugt2b35 UDP glucuronosyltransferase 2 family, polypeptide B35 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr14:20,853,441...20,891,039
Ensembl chr14:20,853,587...20,891,037
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 involved_in ISS
ISO
GO_REF:0000024
(PMID:18719240)
UniProt
RGD
PMID:18719240 GO_REF:0000024 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
estrogen biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IDA estrone RGD PMID:19665544 RGD:4891164 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Hsd17b1 hydroxysteroid (17-beta) dehydrogenase 1 involved_in IDA
ISO
IEA
estradiol
(MGI:1267145|PMID:9658408)
GO_REF:0000041
(PMID:8994190)
RGD
UniProt
PMID:8994190 PMID:9658408 PMID:8612487 GO_REF:0000041 MGI:1267145, RGD:728619 NCBI chr10:86,009,728...86,011,928
Ensembl chr10:86,009,728...86,011,927
JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 IDA estrone RGD PMID:8612487 RGD:728619 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 involved_in IDA
ISO
IEA
PMID:9658408
(MGI:1267145|PMID:9658408), (MGI:2662631|PMID:12732193)
(PMID:12732193)
GO_REF:0000107
GO_REF:0000041
RGD
Ensembl
UniProt
PMID:9658408 PMID:12732193 PMID:9658408 GO_REF:0000041 GO_REF:0000107 MGI:1267145 MGI:2662631, RGD:30309934 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017
JBrowse link
G Hsd17b8 hydroxysteroid (17-beta) dehydrogenase 8 involved_in IBA
ISO
ISS
IEA
PMID:21873635
(PMID:17978863)
GO_REF:0000024
GO_REF:0000041
RGD
UniProt
PMID:17978863 PMID:21873635 GO_REF:0000024 GO_REF:0000041, RGD:13792537 NCBI chr20:4,826,725...4,828,742
Ensembl chr20:4,822,026...4,828,742
JBrowse link
G Rdh8 retinol dehydrogenase 8 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:19,353,191...19,360,462
Ensembl chr 8:19,353,191...19,360,462
JBrowse link
G Star steroidogenic acute regulatory protein IMP estradiol; positive regulation RGD PMID:16579833 RGD:1600078 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
estrogen catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sult1e1 sulfotransferase family 1E member 1 involved_in ISO (PMID:23207770) RGD PMID:23207770 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C IDA RGD PMID:15502008 RGD:2317077 NCBI chr 9:88,739,577...88,808,465 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11797
      hormone metabolic process 235
        cellular hormone metabolic process 145
          estrogen metabolic process 33
            estrogen biosynthetic process + 8
            estrogen catabolic process 2
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological quality 4181
        regulation of hormone levels 611
          hormone metabolic process 235
            cellular hormone metabolic process 145
              estrogen metabolic process 33
                estrogen biosynthetic process + 8
                estrogen catabolic process 2
paths to the root