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ONTOLOGY REPORT - ANNOTATIONS

Term:bile acid metabolic process
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Accession:GO:0008206 term browser browse the term
Definition:The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
Synonyms:exact_synonym: bile acid metabolism


show annotations for term's descendants           Sort by:
bile acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 involved_in IEA
IMP
ISS
IDA		 (PMID:20010382), (PMID:29507376)
(PMID:32203132)		 Ensembl
UniProt		 PMID:20010382 PMID:29507376 PMID:32203132 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ACAA1 acetyl-CoA acyltransferase 1 involved_in IMP
ISS		 (PMID:2318981) UniProt PMID:2318981 GO_REF:0000024 NCBI chr 3:38,122,715...38,137,127
Ensembl chr 3:38,103,129...38,137,242 		JBrowse link
G AKR1C1 aldo-keto reductase family 1 member C1 involved_in IDA (PMID:8486699) UniProt PMID:8486699 NCBI chr10:4,963,415...4,983,283
Ensembl chr10:4,963,253...4,983,283 		JBrowse link
G AMACR alpha-methylacyl-CoA racemase involved_in ISO
IEA
IBA
IDA		 (PMID:10655068) RGD
TreeGrafter
GO_Central
UniProt		 PMID:8020470 PMID:10655068 GO_REF:0000033 GO_REF:0000118 RGD:2315634 NCBI chr 5:33,986,165...34,008,050
Ensembl chr 5:33,986,165...34,008,104 		JBrowse link
G ARV1 ARV1 homolog, fatty acid homeostasis modulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20663892) Ensembl
MGI		 PMID:20663892 GO_REF:0000107 NCBI chr 1:230,979,094...231,000,733
Ensembl chr 1:230,978,981...231,000,733 		JBrowse link
G ATP8B1 ATPase phospholipid transporting 8B1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14976163) Ensembl
MGI		 PMID:14976163 GO_REF:0000107 NCBI chr18:57,646,426...57,803,315
Ensembl chr18:57,646,426...57,803,315 		JBrowse link
G BAAT bile acid-CoA:amino acid N-acyltransferase involved_in
acts_upstream_of_or_within		 IEA
ISO
TAS		 (PMID:9215542) Ensembl
MGI
Reactome		 PMID:9215542 GO_REF:0000107 Reactome:R-HSA-159431 NCBI chr 9:101,360,417...101,385,006
Ensembl chr 9:101,354,182...101,385,400 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 ISO chenodeoxycholic acid RGD PMID:20026603 RGD:4890374 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G GBA2 glucosylceramidase beta 2 NOT|involved_in ISO
TAS
IDA		 (MGI:3690511|PMID:17080196)
(PMID:11489889)
(PMID:17105727)		 UniProt
UniProt		 PMID:11489889 PMID:17080196 PMID:17105727 MGI:3690511 NCBI chr 9:35,736,866...35,749,228
Ensembl chr 9:35,736,866...35,749,228 		JBrowse link
G LEP leptin involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12114517) Ensembl
MGI		 PMID:12114517 GO_REF:0000107 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G NPC1 NPC intracellular cholesterol transporter 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr18:23,506,184...23,586,506
Ensembl chr18:23,506,184...23,586,506 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:12917447) RGD
MGI
Ensembl		 PMID:12754200 PMID:12917447 PMID:27993716 GO_REF:0000107 RGD:14701034 RGD:1625079 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR5A2 nuclear receptor subfamily 5 group A member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15014077) Ensembl
MGI		 PMID:15014077 GO_REF:0000107 NCBI chr 1:200,027,710...200,177,415
Ensembl chr 1:200,027,614...200,177,420 		JBrowse link
G SCP2 sterol carrier protein 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:52,927,276...53,051,698
Ensembl chr 1:52,927,276...53,051,698 		JBrowse link
G SLC27A2 solute carrier family 27 member 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:50,182,196...50,236,385
Ensembl chr15:50,182,196...50,236,385 		JBrowse link
G SLC27A5 solute carrier family 27 member 5 acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (PMID:16618417) RGD
MGI
GO_Central
Ensembl		 PMID:12454267 PMID:16618417 GO_REF:0000033 GO_REF:0000107 RGD:1302363 NCBI chr19:58,498,333...58,511,992
Ensembl chr19:58,479,512...58,512,413 		JBrowse link
G UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus involved_in IDA (PMID:23756265) UniProt PMID:23756265 NCBI chr 4:69,588,417...69,653,247
Ensembl chr 4:69,588,417...69,653,249 		JBrowse link
G UGT2A2 UDP glucuronosyltransferase family 2 member A2 involved_in IDA (PMID:23756265) UniProt PMID:23756265 NCBI chr 4:69,588,417...69,639,642
Ensembl chr 4:69,588,417...69,639,642 		JBrowse link
bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 involved_in TAS Reactome Reactome:R-HSA-193368 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G ABCD3 ATP binding cassette subfamily D member 3 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:94,385,131...94,518,663
Ensembl chr 1:94,418,389...94,518,666 		JBrowse link
G ACOT8 acyl-CoA thioesterase 8 involved_in TAS Reactome Reactome:R-HSA-193368 NCBI chr20:45,841,721...45,857,392
Ensembl chr20:45,841,721...45,857,405 		JBrowse link
G ACOX2 acyl-CoA oxidase 2 involved_in IDA (PMID:27884763) UniProt PMID:27884763 NCBI chr 3:58,505,136...58,537,190
Ensembl chr 3:58,505,136...58,537,283 		JBrowse link
G AKR1C4 aldo-keto reductase family 1 member C4 involved_in TAS Reactome Reactome:R-HSA-193368 Reactome:R-HSA-193775 Reactome:R-HSA-193807 NCBI chr10:5,196,837...5,218,949
Ensembl chr10:5,195,462...5,218,949 		JBrowse link
G AKR1D1 aldo-keto reductase family 1 member D1 acts_upstream_of_or_within
involved_in		 IDA
TAS
IEA		 (PMID:7508385) MGI
UniProt
Reactome
InterPro		 PMID:7508385 GO_REF:0000002 Reactome:R-HSA-193368 Reactome:R-HSA-193775 Reactome:R-HSA-193807 NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305 		JBrowse link
G AMACR alpha-methylacyl-CoA racemase involved_in ISO
TAS
IEA		 RGD
Reactome
UniProt		 PMID:11964182 GO_REF:0000041 RGD:704372 Reactome:R-HSA-193368 Reactome:R-HSA-193775 NCBI chr 5:33,986,165...34,008,050
Ensembl chr 5:33,986,165...34,008,104 		JBrowse link
G BAAT bile acid-CoA:amino acid N-acyltransferase involved_in TAS
IDA		 (PMID:12810727), (PMID:8034703) Reactome
UniProt		 PMID:8034703 PMID:12810727 Reactome:R-HSA-193368 NCBI chr 9:101,360,417...101,385,006
Ensembl chr 9:101,354,182...101,385,400 		JBrowse link
G CYP27A1 cytochrome P450 family 27 subfamily A member 1 involved_in IEA
TAS
IDA		 (PMID:11412116), (PMID:9660774) UniProt
Reactome		 PMID:9660774 PMID:11412116 GO_REF:0000041 Reactome:R-HSA-193368 Reactome:R-HSA-193775 Reactome:R-HSA-193807 NCBI chr 2:218,782,147...218,815,293
Ensembl chr 2:218,781,749...218,815,293 		JBrowse link
G CYP39A1 cytochrome P450 family 39 subfamily A member 1 involved_in IEA
IBA
TAS
IDA		 (PMID:10748047) UniProt
TreeGrafter
GO_Central
Reactome
Ensembl		 PMID:10748047 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 Reactome:R-HSA-193775 NCBI chr 6:46,549,580...46,652,818
Ensembl chr 6:46,549,580...46,652,830 		JBrowse link
G CYP46A1 cytochrome P450 family 46 subfamily A member 1 involved_in TAS Reactome Reactome:R-HSA-193775 NCBI chr14:99,684,298...99,727,301
Ensembl chr14:99,684,298...99,727,301 		JBrowse link
G CYP51A1 cytochrome P450 family 51 subfamily A member 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 7:92,112,153...92,134,803
Ensembl chr 7:92,084,987...92,134,803 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 involved_in IEA
IBA
TAS
IDA
ISS		 (PMID:19965590) UniProt
TreeGrafter
GO_Central
Reactome
InterPro
Ensembl		 PMID:19965590 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 Reactome:R-HSA-193368 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G CYP7B1 cytochrome P450 family 7 subfamily B member 1 involved_in IEA
IBA
TAS		 (PMID:9802883) Ensembl
GO_Central
TreeGrafter
PINC
UniProt		 PMID:9802883 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107 GO_REF:0000118 Reactome:R-HSA-192105 Reactome:R-HSA-193807 NCBI chr 8:64,586,575...64,798,737
Ensembl chr 8:64,587,763...64,798,737 		JBrowse link
G CYP8B1 cytochrome P450 family 8 subfamily B member 1 involved_in ISS
TAS
IEA		 UniProt
Reactome		 GO_REF:0000024 GO_REF:0000041 Reactome:R-HSA-193368 Reactome:R-HSA-193775 Reactome:R-HSA-193807 NCBI chr 3:42,872,192...42,875,879
Ensembl chr 3:42,856,005...42,875,898 		JBrowse link
G ERRFI1 ERBB receptor feedback inhibitor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22912762) Ensembl
MGI		 PMID:22912762 GO_REF:0000107 NCBI chr 1:8,011,727...8,026,309
Ensembl chr 1:8,004,404...8,026,309 		JBrowse link
G HNF1A HNF1 homeobox A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11279518) Ensembl
MGI		 PMID:11279518 GO_REF:0000107 NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512 		JBrowse link
G HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 involved_in IEA
IDA		 (PMID:12917011) UniProt PMID:12917011 GO_REF:0000041 NCBI chr  X:53,431,258...53,434,376
Ensembl chr  X:53,431,258...53,434,370 		JBrowse link
G HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 involved_in TAS (PMID:11067870) Reactome PMID:11067870 Reactome:R-HSA-193368 Reactome:R-HSA-193775 Reactome:R-HSA-193807 NCBI chr16:30,985,207...30,989,147
Ensembl chr16:30,985,207...30,989,147 		JBrowse link
G OSBP oxysterol binding protein involved_in TAS Reactome Reactome:R-HSA-192105 NCBI chr11:59,574,398...59,615,774
Ensembl chr11:59,574,398...59,615,774 		JBrowse link
G OSBPL1A oxysterol binding protein like 1A involved_in TAS Reactome Reactome:R-HSA-192105 NCBI chr18:24,162,045...24,397,824
Ensembl chr18:24,162,045...24,397,880 		JBrowse link
G OSBPL2 oxysterol binding protein like 2 involved_in TAS Reactome Reactome:R-HSA-192105 NCBI chr20:62,238,521...62,296,183
Ensembl chr20:62,231,922...62,296,213 		JBrowse link
G OSBPL3 oxysterol binding protein like 3 involved_in TAS Reactome Reactome:R-HSA-192105 NCBI chr 7:24,796,537...24,981,845
Ensembl chr 7:24,796,540...24,981,634 		JBrowse link
G OSBPL6 oxysterol binding protein like 6 involved_in TAS Reactome Reactome:R-HSA-192105 NCBI chr 2:178,193,774...178,402,893
Ensembl chr 2:178,194,481...178,402,893 		JBrowse link
G OSBPL7 oxysterol binding protein like 7 involved_in TAS Reactome Reactome:R-HSA-192105 NCBI chr17:47,807,372...47,821,794
Ensembl chr17:47,807,372...47,821,803 		JBrowse link
G OSBPL9 oxysterol binding protein like 9 involved_in TAS Reactome Reactome:R-HSA-192105 NCBI chr 1:51,518,272...51,789,219
Ensembl chr 1:51,577,179...51,798,427 		JBrowse link
G PEX2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO (PMID:14673138) MGI PMID:14673138 NCBI chr 8:76,980,258...77,001,044
Ensembl chr 8:76,980,258...77,001,044 		JBrowse link
G SCP2 sterol carrier protein 2 involved_in TAS Reactome Reactome:R-HSA-193368 NCBI chr 1:52,927,276...53,051,698
Ensembl chr 1:52,927,276...53,051,698 		JBrowse link
G SLC27A2 solute carrier family 27 member 2 involved_in IDA
IEA
TAS		 (PMID:11980911) UniProt
TreeGrafter
Reactome		 PMID:11980911 GO_REF:0000118 Reactome:R-HSA-193368 Reactome:R-HSA-193775 NCBI chr15:50,182,196...50,236,385
Ensembl chr15:50,182,196...50,236,385 		JBrowse link
G SLC27A5 solute carrier family 27 member 5 involved_in IDA
TAS		 (PMID:11980911) UniProt
Reactome		 PMID:11980911 Reactome:R-HSA-193368 Reactome:R-HSA-193775 NCBI chr19:58,498,333...58,511,992
Ensembl chr19:58,479,512...58,512,413 		JBrowse link
G STAR steroidogenic acute regulatory protein ISO RGD PMID:15382124 RGD:1600081 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
bile acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1D1 aldo-keto reductase family 1 member D1 involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305 		JBrowse link
G SULT2A1 sulfotransferase family 2A member 1 involved_in IEA UniProt GO_REF:0000043 NCBI chr19:47,870,467...47,886,315
Ensembl chr19:47,870,467...47,886,315 		JBrowse link
bile acid conjugation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAAT bile acid-CoA:amino acid N-acyltransferase involved_in IDA
IEA		 (PMID:12810727), (PMID:2037576), (PMID:8034703) UniProt
Ensembl		 PMID:2037576 PMID:8034703 PMID:12810727 GO_REF:0000107 NCBI chr 9:101,360,417...101,385,006
Ensembl chr 9:101,354,182...101,385,400 		JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF19 fibroblast growth factor 19 involved_in
acts_upstream_of_or_within		 IDA
ISO		 (PMID:12815072)
(PMID:23747249)		 UniProt
MGI		 PMID:12815072 PMID:23747249 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022 		JBrowse link
G MALRD1 MAM and LDL receptor class A domain containing 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23747249) Ensembl
MGI		 PMID:23747249 GO_REF:0000107 NCBI chr10:19,046,927...19,734,478
Ensembl chr10:19,048,801...19,790,401 		JBrowse link
G MIR33A microRNA 33a involved_in IDA (PMID:23536474) BHF-UCL PMID:23536474 NCBI chr22:41,900,944...41,901,012
Ensembl chr22:41,900,944...41,901,012 		JBrowse link
G PROX1 prospero homeobox 1 involved_in IMP (PMID:16488887) BHF-UCL PMID:16488887 NCBI chr 1:213,983,151...214,041,510
Ensembl chr 1:213,983,181...214,041,510 		JBrowse link
positive regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1D1 nuclear receptor subfamily 1 group D member 1 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589 		JBrowse link
G STAR steroidogenic acute regulatory protein involved_in IDA (PMID:18403318) BHF-UCL PMID:18403318 NCBI chr 8:38,142,700...38,150,952
Ensembl chr 8:38,142,700...38,150,992 		JBrowse link
G STARD4 StAR related lipid transfer domain containing 4 involved_in IDA (PMID:18403318) BHF-UCL PMID:18403318 NCBI chr 5:111,496,033...111,512,535
Ensembl chr 5:111,496,033...111,512,590 		JBrowse link
regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CES1 carboxylesterase 1 involved_in IMP (PMID:18599737) UniProt PMID:18599737 NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337 		JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 involved_in IDA
ISS
IEA		 (PMID:19965590) UniProt
Ensembl		 PMID:19965590 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163 		JBrowse link
G FGFR4 fibroblast growth factor receptor 4 involved_in IMP
IBA
IEA		 (PMID:17623664), (PMID:20683963) UniProt
GO_Central
TreeGrafter		 PMID:17623664 PMID:20683963 GO_REF:0000033 GO_REF:0000118 NCBI chr 5:177,086,915...177,098,144
Ensembl chr 5:177,086,905...177,098,144 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 involved_in TAS (PMID:21757002) BHF-UCL PMID:21757002 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G SIRT1 sirtuin 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
regulation of bile acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase involved_in ISO
IEA		 RGD
Ensembl		 PMID:7542218 GO_REF:0000107 RGD:12910748 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783 		JBrowse link
G PANK2 pantothenate kinase 2 involved_in IMP (PMID:22221393) ParkinsonsUK-UCL PMID:22221393 NCBI chr20:3,888,781...3,929,887
Ensembl chr20:3,888,839...3,929,887 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19770
    metabolic process 12509
      organic substance metabolic process 12005
        organic hydroxy compound metabolic process 647
          bile acid metabolic process 55
            bile acid biosynthetic process + 41
            bile acid catabolic process 2
            bile acid conjugation 1
            negative regulation of bile acid metabolic process + 4
            positive regulation of bile acid metabolic process + 3
            regulation of bile acid metabolic process + 15
Path 2
Term Annotations click to browse term
  biological_process 19770
    metabolic process 12509
      cellular metabolic process 11168
        organic acid metabolic process 1059
          oxoacid metabolic process 1049
            carboxylic acid metabolic process 1022
              monocarboxylic acid metabolic process 720
                bile acid metabolic process 55
                  bile acid biosynthetic process + 41
                  bile acid catabolic process 2
                  bile acid conjugation 1
                  negative regulation of bile acid metabolic process + 4
                  positive regulation of bile acid metabolic process + 3
                  regulation of bile acid metabolic process + 15
paths to the root