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ONTOLOGY REPORT - ANNOTATIONS


Term:bile acid metabolic process
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Accession:GO:0008206 term browser browse the term
Definition:The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
Synonyms:exact_synonym: bile acid metabolism


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bile acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 IDA
IEA
ISO
PMID:9545351
GO_REF:0000107
(PMID:20010382), (PMID:29507376), (PMID:32203132)
Ensembl
RGD
PMID:20010382, PMID:29507376, PMID:32203132, PMID:9545351 GO_REF:0000107, RGD:728120 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A ISO
IDA
(PMID:2318981)
PMID:9325339
RGD PMID:2318981, PMID:9325339 RGD:21201257 NCBI chr 8:128,027,880...128,036,471
Ensembl chr 8:128,027,958...128,036,236
JBrowse link
G Amacr alpha-methylacyl-CoA racemase IDA
ISO
IEA
(PMID:10655068)
GO_REF:0000107
RGD
Ensembl
PMID:10655068, PMID:8020470 GO_REF:0000107, RGD:2315634 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326
JBrowse link
G Arv1 ARV1 homolog, fatty acid homeostasis modulator ISO (MGI:MGI:4849624|PMID:20663892) RGD PMID:20663892 MGI:MGI:4849624 NCBI chr19:57,484,720...57,496,539
Ensembl chr19:57,484,634...57,496,695
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 ISO MGI:MGI:3043815 (MGI:MGI:3041693|PMID:14976163) RGD PMID:14976163 MGI:MGI:3041693 NCBI chr18:60,013,388...60,152,920
Ensembl chr18:60,013,382...60,095,354
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase ISO (MGI:MGI:893269|PMID:9215542) RGD PMID:9215542 MGI:MGI:893269 NCBI chr 5:64,768,397...64,777,368
Ensembl chr 5:64,768,401...64,777,368
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEP chenodeoxycholic acid RGD PMID:20026603 RGD:4890374 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Gba2 glucosylceramidase beta 2 NOT ISO
ISS
(PMID:17105727)
(MGI:MGI:3690511|PMID:17080196)
GO_REF:0000024
RGD
UniProt
PMID:17080196, PMID:17105727 GO_REF:0000024, MGI:MGI:3690511 NCBI chr 5:59,068,081...59,079,719
Ensembl chr 5:59,068,081...59,079,719
JBrowse link
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 TAS RGD PMID:12679481 RGD:1599971 NCBI chr 1:199,248,084...199,251,745
Ensembl chr 1:199,248,470...199,251,740
JBrowse link
G Lep leptin ISO (MGI:MGI:2386518|PMID:12114517) RGD PMID:12114517 MGI:MGI:2386518 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 IDA
IMP
IEA
ISO
GO_REF:0000107
MGI:MGI:2679472 (MGI:MGI:2678884|PMID:12917447)
Ensembl
RGD
PMID:12917447, PMID:12754200, PMID:27993716 GO_REF:0000107, MGI:MGI:2678884, RGD:1625079, RGD:14701034 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 ISO MGI:MGI:3050234 (MGI:MGI:3050203|PMID:15014077) RGD PMID:15014077 MGI:MGI:3050203 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428
JBrowse link
G Scp2 sterol carrier protein 2 IDA PMID:9325339 UniProt PMID:9325339 RGD:21201257 NCBI chr 5:127,647,934...127,735,703
Ensembl chr 5:127,620,274...127,735,739
JBrowse link
G Slc10a2 solute carrier family 10 member 2 TAS RGD PMID:15304498 RGD:1624187 NCBI chr16:90,324,420...90,350,254
Ensembl chr16:90,324,361...90,345,865
JBrowse link
G Slc27a5 solute carrier family 27 member 5 IMP
IBA
ISO
PMID:21873635
MGI:MGI:3757682 (MGI:MGI:3722950|PMID:16618417)
RGD PMID:16618417, PMID:12454267, PMID:21873635 MGI:MGI:3722950, RGD:1302363, RGD:13792537 NCBI chr 1:65,576,599...65,587,192
Ensembl chr 1:65,576,535...65,587,186
JBrowse link
G Slco1a6 solute carrier organic anion transporter family, member 1a6 IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:176,345,671...176,390,729
Ensembl chr 4:176,345,671...176,381,477
JBrowse link
bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 ISO
IEA
(PMID:7508385)
GO_REF:0000107
RGD
Ensembl
PMID:7508385 GO_REF:0000107 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Amacr alpha-methylacyl-CoA racemase IDA
IEA
GO_REF:0000041 UniProt PMID:11964182 GO_REF:0000041, RGD:704372 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase ISO (PMID:12810727), (PMID:8034703) RGD PMID:8034703, PMID:12810727 NCBI chr 5:64,768,397...64,777,368
Ensembl chr 5:64,768,401...64,777,368
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000041
(PMID:11412116), (PMID:9660774)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:9660774, PMID:11412116 GO_REF:0000024, GO_REF:0000041, GO_REF:0000107 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 ISO
IBA
(PMID:10748047)
PMID:21873635
(MGI:MGI:1859119|PMID:10748047)
RGD PMID:10748047, PMID:21873635 MGI:MGI:1859119, RGD:13792537 NCBI chr 9:19,804,079...19,880,346
Ensembl chr 9:19,804,079...19,880,346
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 TAS
IBA
ISO
IDA
IEA
PMID:21873635
(PMID:19965590)
PMID:1694852
GO_REF:0000041
RGD
UniProt
PMID:19965590, PMID:2335522, PMID:21873635, PMID:1694852 GO_REF:0000041, RGD:70535, RGD:13792537, RGD:70534 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 TAS
IBA
ISO
IEA
PMID:21873635
(MGI:MGI:1859119|PMID:10748047)
GO_REF:0000107
GO_REF:0000041
RGD
Ensembl
UniProt
PMID:10748047, PMID:12029625, PMID:21873635 GO_REF:0000041, GO_REF:0000107, MGI:MGI:1859119, RGD:1298868, RGD:13792537 NCBI chr 2:102,701,903...102,871,257
Ensembl chr 2:102,701,903...102,871,257
JBrowse link
G Hnf1a HNF1 homeobox A ISO MGI:MGI:2384427 (MGI:MGI:1933035|PMID:11279518) RGD PMID:11279518 MGI:MGI:1933035 NCBI chr12:47,407,811...47,433,342
Ensembl chr12:47,407,811...47,433,342
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 ISO
ISS
(PMID:12917011)
GO_REF:0000024
RGD
UniProt
PMID:12917011 GO_REF:0000024 NCBI chr  X:21,696,796...21,699,241
Ensembl chr  X:21,696,772...21,699,241
JBrowse link
G Pex2 peroxisomal biogenesis factor 2 ISO MGI:MGI:2180128 (MGI:MGI:3027293|PMID:14673138) RGD PMID:14673138 MGI:MGI:3027293 NCBI chr 2:98,251,756...98,269,185
Ensembl chr 2:98,252,925...98,269,184
JBrowse link
G Slc27a2 solute carrier family 27 member 2 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:11980911)
Ensembl
RGD
PMID:11980911, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Slc27a5 solute carrier family 27 member 5 ISO
IBA
(PMID:11980911)
PMID:21873635
RGD PMID:11980911, PMID:21873635 RGD:13792537 NCBI chr 1:65,576,599...65,587,192
Ensembl chr 1:65,576,535...65,587,186
JBrowse link
G Star steroidogenic acute regulatory protein IDA RGD PMID:15382124 RGD:1600081 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
bile acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
bile acid conjugation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baat bile acid CoA:amino acid N-acyltransferase IDA
ISO
PMID:12951368
(PMID:12810727), (PMID:2037576), (PMID:8034703)
PMID:624713
RGD PMID:2037576, PMID:8034703, PMID:12810727, PMID:12951368, PMID:624713 RGD:2312798, RGD:14695068 NCBI chr 5:64,768,397...64,777,368
Ensembl chr 5:64,768,401...64,777,368
JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf19 fibroblast growth factor 19 ISO MGI:MGI:1928271 (MGI:MGI:5501367|PMID:23747249)
(PMID:12815072)
RGD PMID:12815072, PMID:23747249 MGI:MGI:5501367 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693
JBrowse link
G Malrd1 MAM and LDL receptor class A domain containing 1 ISO MGI:MGI:1096383|MGI:MGI:2154956 (MGI:MGI:5501367|PMID:23747249) RGD PMID:23747249 MGI:MGI:5501367 NCBI chr17:82,430,836...83,156,696
Ensembl chr17:82,430,836...82,953,864
JBrowse link
G Prox1 prospero homeobox 1 ISO (PMID:16488887) RGD PMID:16488887 NCBI chr13:108,382,536...108,444,107
Ensembl chr13:108,382,399...108,443,294
JBrowse link
positive regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:3819720|PMID:18565334), (MGI:MGI:4360821|PMID:19721697)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:18565334, PMID:19721697 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3819720, MGI:MGI:4360821 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
JBrowse link
G Star steroidogenic acute regulatory protein ISO (PMID:18403318) RGD PMID:18403318 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 ISO (PMID:18403318) RGD PMID:18403318 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555
JBrowse link
regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D ISO (PMID:18599737) RGD PMID:18599737 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 IDA
ISO
PMID:1694852
(PMID:19965590)
RGD PMID:19965590, PMID:1694852 RGD:70534 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 ISO
IBA
ISS
(MGI:MGI:1858658|PMID:10809780)
PMID:21873635
(PMID:17623664), (PMID:20683963)
GO_REF:0000024
RGD
UniProt
PMID:10809780, PMID:17623664, PMID:20683963, PMID:21873635 GO_REF:0000024, MGI:MGI:1858658, RGD:13792537 NCBI chr17:9,990,072...10,004,339
Ensembl chr17:9,990,078...10,004,321
JBrowse link
G Sirt1 sirtuin 1 ISO (MGI:MGI:5014028|PMID:20375098) RGD PMID:20375098 MGI:MGI:5014028 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
regulation of bile acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:MGI:5543985|PMID:23764895)
UniProt
Ensembl
RGD
PMID:23764895 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5543985 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase IMP RGD PMID:7542218 RGD:12910748 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Pank2 pantothenate kinase 2 ISO (PMID:22221393) RGD PMID:22221393 NCBI chr 3:123,807,911...123,841,797
Ensembl chr 3:123,807,952...123,841,797
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      organic substance metabolic process 11636
        organic hydroxy compound metabolic process 538
          bile acid metabolic process 36
            bile acid biosynthetic process + 21
            bile acid catabolic process 1
            bile acid conjugation 1
            negative regulation of bile acid metabolic process + 3
            positive regulation of bile acid metabolic process + 3
            regulation of bile acid metabolic process + 13
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      cellular metabolic process 11065
        organic acid metabolic process 1090
          oxoacid metabolic process 1061
            carboxylic acid metabolic process 1005
              monocarboxylic acid metabolic process 665
                bile acid metabolic process 36
                  bile acid biosynthetic process + 21
                  bile acid catabolic process 1
                  bile acid conjugation 1
                  negative regulation of bile acid metabolic process + 3
                  positive regulation of bile acid metabolic process + 3
                  regulation of bile acid metabolic process + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.