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ONTOLOGY REPORT - ANNOTATIONS


Term:bile acid metabolic process
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Accession:GO:0008206 term browser browse the term
Definition:The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
Synonyms:exact_synonym: bile acid metabolism


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bile acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 involved_in IEA
IDA
ISO
GO_REF:0000107
PMID:9545351
(PMID:20010382), (PMID:29507376), (PMID:32203132)
Ensembl
RGD
PMID:20010382 PMID:29507376 PMID:32203132 PMID:9545351 GO_REF:0000107, RGD:728120 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A involved_in IDA
ISO
PMID:9325339
(PMID:2318981)
RGD PMID:2318981 PMID:9325339 RGD:21201257 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Amacr alpha-methylacyl-CoA racemase involved_in IDA
IEA
ISO
GO_REF:0000107
(PMID:10655068)
Ensembl
RGD
PMID:10655068 PMID:8020470 GO_REF:0000107, RGD:2315634 NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255
JBrowse link
G Arv1 ARV1 homolog, fatty acid homeostasis modulator acts_upstream_of_or_within ISO (MGI:4849624|PMID:20663892) RGD PMID:20663892 MGI:4849624 NCBI chr19:52,692,337...52,704,156
Ensembl chr19:52,692,337...52,704,156
JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 acts_upstream_of_or_within ISO MGI:3043815 (MGI:3041693|PMID:14976163) RGD PMID:14976163 MGI:3041693 NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase acts_upstream_of_or_within ISO (MGI:893269|PMID:9215542) RGD PMID:9215542 MGI:893269 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEP chenodeoxycholic acid RGD PMID:20026603 RGD:4890374 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Gba2 glucosylceramidase beta 2 involved_in
NOT|involved_in
ISO
ISS
(PMID:17105727)
(MGI:3690511|PMID:17080196)
GO_REF:0000024
RGD
UniProt
PMID:17080196 PMID:17105727 GO_REF:0000024 MGI:3690511 NCBI chr 5:57,822,389...57,834,522
Ensembl chr 5:57,822,389...57,834,072
JBrowse link
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 TAS RGD PMID:12679481 RGD:1599971 NCBI chr 1:182,411,836...182,415,447
Ensembl chr 1:182,412,151...182,415,442
JBrowse link
G Lep leptin acts_upstream_of_or_within ISO (MGI:2386518|PMID:12114517) RGD PMID:12114517 MGI:2386518 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 acts_upstream_of_or_within IDA
ISO
IMP
MGI:2679472 (MGI:2678884|PMID:12917447) RGD PMID:12917447 PMID:12754200 PMID:27993716 MGI:2678884, RGD:1625079, RGD:14701034 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 acts_upstream_of_or_within ISO MGI:3050234 (MGI:3050203|PMID:15014077) RGD PMID:15014077 MGI:3050203 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326
JBrowse link
G Scp2 sterol carrier protein 2 involved_in IDA PMID:9325339 UniProt PMID:9325339 RGD:21201257 NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287
JBrowse link
G Slc10a2 solute carrier family 10 member 2 TAS RGD PMID:15304498 RGD:1624187 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
JBrowse link
G Slc27a5 solute carrier family 27 member 5 acts_upstream_of_or_within IMP
ISO
MGI:3757682 (MGI:3722950|PMID:16618417) RGD PMID:16618417 PMID:12454267 MGI:3722950, RGD:1302363 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
JBrowse link
G Slco1a6 solute carrier organic anion transporter family, member 1a6 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 4:175,072,143...175,107,950
Ensembl chr 4:175,072,143...175,117,263
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 involved_in ISO (PMID:23756265) RGD PMID:23756265 NCBI chr14:20,521,018...20,545,060
Ensembl chr14:20,517,951...20,545,531
JBrowse link
bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd3 ATP binding cassette subfamily D member 3 involved_in ISO
ISS
(MGI:5613029|PMID:25168382)
GO_REF:0000024
RGD
UniProt
PMID:25168382 GO_REF:0000024 MGI:5613029 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:7508385)
GO_REF:0000002
Ensembl
RGD
InterPro
PMID:7508385 GO_REF:0000002 GO_REF:0000107 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
G Amacr alpha-methylacyl-CoA racemase involved_in IDA
IEA
GO_REF:0000041 UniProt PMID:11964182 GO_REF:0000041, RGD:704372 NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase involved_in ISO (PMID:12810727), (PMID:8034703) RGD PMID:8034703 PMID:12810727 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in IEA
ISS
ISO
GO_REF:0000041
GO_REF:0000024
(PMID:11412116), (PMID:9660774)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:9660774 PMID:11412116 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 involved_in IBA
ISO
PMID:21873635
(MGI:1859119|PMID:10748047)
(PMID:10748047)
RGD PMID:10748047 PMID:21873635 MGI:1859119, RGD:13792537 NCBI chr 9:17,230,455...17,306,775
Ensembl chr 9:17,230,455...17,306,775
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 involved_in TAS
IEA
IDA
ISO
IBA
GO_REF:0000041
PMID:1694852
(PMID:19965590)
PMID:21873635
UniProt
RGD
PMID:19965590 PMID:2335522 PMID:1694852 PMID:21873635 GO_REF:0000041, RGD:70535, RGD:70534, RGD:13792537 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 involved_in TAS
ISO
IEA
IBA
(MGI:1859119|PMID:10748047)
GO_REF:0000041
GO_REF:0000107
PMID:21873635
RGD
UniProt
Ensembl
PMID:10748047 PMID:12029625 PMID:21873635 GO_REF:0000041 GO_REF:0000107 MGI:1859119, RGD:1298868, RGD:13792537 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 involved_in ISO (PMID:14643796)
(MGI:3588413|PMID:12393855)
RGD PMID:12393855 PMID:14643796 MGI:3588413 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within ISO MGI:2384427 (MGI:1933035|PMID:11279518) RGD PMID:11279518 MGI:1933035 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 involved_in ISO
ISS
IEA
(PMID:12917011)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000041
RGD
UniProt
Ensembl
PMID:12917011 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr  X:21,089,152...21,091,597
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Pex2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO MGI:2180128 (MGI:3027293|PMID:14673138) RGD PMID:14673138 MGI:3027293 NCBI chr 2:96,050,380...96,072,928
Ensembl chr 2:96,045,958...96,073,404
JBrowse link
G Slc27a2 solute carrier family 27 member 2 involved_in IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:11980911)
Ensembl
RGD
PMID:11980911 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Slc27a5 solute carrier family 27 member 5 involved_in ISO
IBA
(PMID:11980911)
PMID:21873635
RGD PMID:11980911 PMID:21873635 RGD:13792537 NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
JBrowse link
G Star steroidogenic acute regulatory protein IDA RGD PMID:15382124 RGD:1600081 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
bile acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372
JBrowse link
bile acid conjugation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baat bile acid CoA:amino acid N-acyltransferase involved_in ISO
IDA
(PMID:12810727), (PMID:2037576), (PMID:8034703)
PMID:12951368
PMID:624713
RGD PMID:2037576 PMID:8034703 PMID:12810727 PMID:12951368 PMID:624713 RGD:2312798, RGD:14695068 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf19 fibroblast growth factor 19 involved_in
acts_upstream_of_or_within
ISO (PMID:12815072)
MGI:1928271 (MGI:5501367|PMID:23747249)
RGD PMID:12815072 PMID:23747249 MGI:5501367 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Malrd1 MAM and LDL receptor class A domain containing 1 acts_upstream_of_or_within ISO MGI:1096383|MGI:2154956 (MGI:5501367|PMID:23747249) RGD PMID:23747249 MGI:5501367 NCBI chr17:78,418,819...79,131,016
Ensembl chr17:78,418,819...79,131,016
JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (PMID:16488887) RGD PMID:16488887 NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
JBrowse link
positive regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3819720|PMID:18565334), (MGI:4360821|PMID:19721697)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:18565334 PMID:19721697 GO_REF:0000024 GO_REF:0000107 MGI:3819720 MGI:4360821 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Star steroidogenic acute regulatory protein involved_in ISO (PMID:18403318) RGD PMID:18403318 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) RGD PMID:18403318 NCBI chr18:24,814,683...24,830,024
Ensembl chr18:24,817,107...24,830,024
JBrowse link
regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D involved_in ISO (PMID:18599737) RGD PMID:18599737 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 involved_in ISO
IDA
(PMID:19965590)
PMID:1694852
RGD PMID:19965590 PMID:1694852 RGD:70534 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 involved_in IBA
ISO
ISS
PMID:21873635
(MGI:1858658|PMID:10809780)
GO_REF:0000024
(PMID:17623664), (PMID:20683963)
RGD
UniProt
PMID:10809780 PMID:17623664 PMID:20683963 PMID:21873635 GO_REF:0000024 MGI:1858658, RGD:13792537 NCBI chr17:9,461,541...9,476,268
Ensembl chr17:9,461,547...9,476,242
JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (MGI:5014028|PMID:20375098) RGD PMID:20375098 MGI:5014028 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
regulation of bile acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5543985|PMID:23764895)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:23764895 GO_REF:0000024 GO_REF:0000107 MGI:5543985 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase IMP RGD PMID:7542218 RGD:12910748 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Pank2 pantothenate kinase 2 involved_in ISO (PMID:22221393) RGD PMID:22221393 NCBI chr 3:118,483,382...118,519,551
Ensembl chr 3:118,483,444...118,518,320
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      organic substance metabolic process 11335
        organic hydroxy compound metabolic process 556
          bile acid metabolic process 39
            bile acid biosynthetic process + 23
            bile acid catabolic process 1
            bile acid conjugation 1
            negative regulation of bile acid metabolic process + 3
            positive regulation of bile acid metabolic process + 3
            regulation of bile acid metabolic process + 13
Path 2
Term Annotations click to browse term
  biological_process 19492
    metabolic process 11795
      cellular metabolic process 10721
        organic acid metabolic process 1011
          oxoacid metabolic process 979
            carboxylic acid metabolic process 960
              monocarboxylic acid metabolic process 660
                bile acid metabolic process 39
                  bile acid biosynthetic process + 23
                  bile acid catabolic process 1
                  bile acid conjugation 1
                  negative regulation of bile acid metabolic process + 3
                  positive regulation of bile acid metabolic process + 3
                  regulation of bile acid metabolic process + 13
paths to the root