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ONTOLOGY REPORT - ANNOTATIONS


Term:bile acid metabolic process
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Accession:GO:0008206 term browser browse the term
Definition:The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
Synonyms:exact_synonym: bile acid metabolism
 xref: Reactome:R-HSA-194068 "Bile acid and bile salt metabolism"



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bile acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 involved_in IEA
IDA
ISO
GO_REF:0000107
PMID:9545351
(PMID:20010382), (PMID:29507376), (PMID:32203132)
Ensembl
RGD
PMID:20010382 PMID:29507376 PMID:32203132 PMID:9545351 GO_REF:0000107, RGD:728120 NCBI chr 3:74,424,620...74,520,646 JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A involved_in IDA
ISO
PMID:9325339
(PMID:2318981)
RGD PMID:2318981 PMID:9325339 RGD:21201257 NCBI chr 8:127,956,126...127,966,348 JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 involved_in ISO (PMID:8486699) RGD PMID:8486699 NCBI chr17:70,720,397...70,747,285 JBrowse link
G Amacr alpha-methylacyl-CoA racemase involved_in IDA
IBA
IEA
ISO
GO_REF:0000033
GO_REF:0000107
(PMID:10655068)
GO_Central
Ensembl
RGD
PMID:10655068 PMID:8020470 GO_REF:0000033 GO_REF:0000107, RGD:2315634 NCBI chr 2:61,673,291...61,685,381 JBrowse link
G Arv1 ARV1 homolog, fatty acid homeostasis modulator acts_upstream_of_or_within ISO (PMID:20663892) RGD PMID:20663892 NCBI chr19:52,692,337...52,704,156 JBrowse link
G Atp8b1 ATPase phospholipid transporting 8B1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3043815 (PMID:14976163)
Ensembl
RGD
PMID:14976163 GO_REF:0000107 NCBI chr18:60,286,605...60,427,862 JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase acts_upstream_of_or_within ISO (PMID:9215542) RGD PMID:9215542 NCBI chr 5:68,647,166...68,656,137 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 IEP chenodeoxycholic acid RGD PMID:20026603 RGD:4890374 NCBI chr 8:63,449,148...63,476,534 JBrowse link
G Gba2 glucosylceramidase beta 2 involved_in
NOT|involved_in
ISO
IEA
ISS
(PMID:17105727)
(PMID:17080196)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17080196 PMID:17105727 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:57,822,389...57,834,522 JBrowse link
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 TAS RGD PMID:12679481 RGD:1599971 NCBI chr 1:191,842,688...191,845,919 JBrowse link
G Lep leptin acts_upstream_of_or_within ISO (PMID:12114517) RGD PMID:12114517 NCBI chr 4:58,626,529...58,640,663 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 acts_upstream_of_or_within
involved_in
IDA
ISO
IEA
IMP
MGI:2679472 (PMID:12917447)
GO_REF:0000107
RGD
Ensembl
PMID:12917447 PMID:12754200 PMID:27993716 GO_REF:0000107, RGD:1625079, RGD:14701034 NCBI chr 7:25,733,471...25,829,440 JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 acts_upstream_of_or_within ISO MGI:3050234 (PMID:15014077)
(PMID:21614002)
RGD PMID:15014077 PMID:21614002 NCBI chr13:50,865,253...50,985,107 JBrowse link
G Scp2 sterol carrier protein 2 involved_in IDA PMID:9325339 UniProt PMID:9325339 RGD:21201257 NCBI chr 5:128,035,714...128,110,015 JBrowse link
G Slc10a2 solute carrier family 10 member 2 TAS RGD PMID:15304498 RGD:1624187 NCBI chr16:91,088,089...91,111,025 JBrowse link
G Slc27a2 solute carrier family 27 member 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:113,804,728...113,842,208 JBrowse link
G Slc27a5 solute carrier family 27 member 5 acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
MGI:3757682 (PMID:16618417)
GO_REF:0000033
RGD
GO_Central
PMID:16618417 PMID:12454267 GO_REF:0000033, RGD:1302363 NCBI chr 1:82,688,742...82,699,335 JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 involved_in ISO
IEA
(PMID:23756265)
GO_REF:0000107
RGD
Ensembl
PMID:23756265 GO_REF:0000107 NCBI chr14:20,521,018...20,545,934 JBrowse link
bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd3 ATP binding cassette subfamily D member 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:25168382)
UniProt
RGD
PMID:25168382 GO_REF:0000024 NCBI chr 2:212,536,791...212,590,379 JBrowse link
G Acox2 acyl-CoA oxidase 2 involved_in ISO
IEA
ISS
(PMID:27884763)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:27884763 GO_REF:0000024 GO_REF:0000107 NCBI chr15:19,090,820...19,122,392 JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:7508385)
GO_REF:0000107
GO_REF:0000002
RGD
Ensembl
InterPro
PMID:7508385 GO_REF:0000002 GO_REF:0000107 NCBI chr 4:67,121,288...67,154,543 JBrowse link
G Amacr alpha-methylacyl-CoA racemase involved_in IDA
IEA
GO_REF:0000041 UniProt
RGD
PMID:11964182 GO_REF:0000041, RGD:704372 NCBI chr 2:61,673,291...61,685,381 JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase involved_in ISO (PMID:12810727), (PMID:8034703) RGD PMID:8034703 PMID:12810727 NCBI chr 5:68,647,166...68,656,137 JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 involved_in IEA
ISS
ISO
GO_REF:0000041
GO_REF:0000024
(PMID:11412116), (PMID:9660774)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:9660774 PMID:11412116 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr 9:83,712,402...83,743,222 JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 involved_in ISO
IBA
(PMID:10748047)
GO_REF:0000033
RGD
GO_Central
PMID:10748047 GO_REF:0000033 NCBI chr 9:24,727,817...24,804,060 JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 involved_in TAS
IBA
IEA
IDA
ISO
GO_REF:0000033
GO_REF:0000041
PMID:1694852
(PMID:19965590)
GO_Central
UniProt
RGD
PMID:19965590 PMID:2335522 PMID:1694852 GO_REF:0000033 GO_REF:0000041, RGD:70535, RGD:70534 NCBI chr 5:24,174,505...24,184,202 JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 involved_in TAS
ISO
IBA
IEA
(PMID:10748047)
GO_REF:0000033
GO_REF:0000041
GO_REF:0000107
RGD
GO_Central
UniProt
Ensembl
PMID:10748047 PMID:12029625 GO_REF:0000033 GO_REF:0000041 GO_REF:0000107, RGD:1298868 NCBI chr 2:102,419,011...102,586,047 JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 involved_in ISO (PMID:14643796)
(PMID:12393855)
RGD PMID:12393855 PMID:14643796 NCBI chr 8:130,455,622...130,457,592 JBrowse link
G Errfi1 ERBB receptor feedback inhibitor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3769404 (PMID:22912762)
Ensembl
RGD
PMID:22912762 GO_REF:0000107 NCBI chr 5:166,606,841...166,620,124 JBrowse link
G Hnf1a HNF1 homeobox A acts_upstream_of_or_within ISO MGI:2384427 (PMID:11279518) RGD PMID:11279518 NCBI chr12:47,299,171...47,333,457 JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 involved_in ISO
IEA
ISS
(PMID:12917011)
GO_REF:0000107
GO_REF:0000024
GO_REF:0000041
RGD
Ensembl
UniProt
PMID:12917011 GO_REF:0000024 GO_REF:0000041 GO_REF:0000107 NCBI chr  X:21,089,142...21,091,603 JBrowse link
G Pex2 peroxisomal biogenesis factor 2 acts_upstream_of_or_within ISO MGI:2180128 (PMID:14673138) RGD PMID:14673138 NCBI chr 2:96,050,380...96,072,928 JBrowse link
G Slc27a2 solute carrier family 27 member 2 involved_in ISO
IEA
(PMID:11980911)
GO_REF:0000107
RGD
Ensembl
PMID:11980911 GO_REF:0000107 NCBI chr 3:113,804,728...113,842,208 JBrowse link
G Slc27a5 solute carrier family 27 member 5 involved_in ISO (PMID:11980911) RGD PMID:11980911 NCBI chr 1:82,688,742...82,699,335 JBrowse link
G Star steroidogenic acute regulatory protein IDA RGD PMID:15382124 RGD:1600081 NCBI chr16:72,969,824...72,974,447 JBrowse link
bile acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:67,121,288...67,154,543 JBrowse link
bile acid conjugation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baat bile acid CoA:amino acid N-acyltransferase involved_in ISO
IDA
(PMID:12810727), (PMID:2037576), (PMID:8034703)
PMID:12951368
PMID:624713
RGD PMID:2037576 PMID:8034703 PMID:12810727 PMID:12951368 PMID:624713 RGD:2312798, RGD:14695068 NCBI chr 5:68,647,166...68,656,137 JBrowse link
negative regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf19 fibroblast growth factor 19 involved_in
acts_upstream_of_or_within
ISO (PMID:12815072)
MGI:1928271 (PMID:23747249)
RGD PMID:12815072 PMID:23747249 NCBI chr 1:209,485,813...209,490,267 JBrowse link
G Malrd1 MAM and LDL receptor class A domain containing 1 acts_upstream_of_or_within ISO MGI:1096383|MGI:2154956 (PMID:23747249) RGD PMID:23747249 NCBI chr17:83,327,372...84,039,558 JBrowse link
G Mir33 microRNA 33 involved_in ISO (PMID:23536474) RGD PMID:23536474 NCBI chr 7:115,593,952...115,594,020 JBrowse link
G Prox1 prospero homeobox 1 involved_in ISO (PMID:16488887) RGD PMID:16488887 NCBI chr13:104,196,615...104,251,007 JBrowse link
positive regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:18565334), (PMID:19721697)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:18565334 PMID:19721697 GO_REF:0000024 GO_REF:0000107 NCBI chr10:84,224,599...84,231,812 JBrowse link
G Star steroidogenic acute regulatory protein involved_in ISO (PMID:18403318) RGD PMID:18403318 NCBI chr16:72,969,824...72,974,447 JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 involved_in ISO (PMID:18403318) RGD PMID:18403318 NCBI chr18:24,814,683...24,830,024 JBrowse link
regulation of bile acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D involved_in ISO (PMID:18599737) RGD PMID:18599737 NCBI chr19:30,046,494...30,085,039 JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 involved_in ISO
IDA
(PMID:19965590)
PMID:1694852
RGD PMID:19965590 PMID:1694852 RGD:70534 NCBI chr 5:24,174,505...24,184,202 JBrowse link
G Fgfr4 fibroblast growth factor receptor 4 involved_in ISO
ISS
IEA
IBA
(PMID:17623664), (PMID:20683963)
GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:10809780)
RGD
UniProt
Ensembl
GO_Central
PMID:10809780 PMID:17623664 PMID:20683963 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr17:9,466,686...9,481,423 JBrowse link
G Sirt1 sirtuin 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:20375098)
Ensembl
RGD
PMID:20375098 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000 JBrowse link
regulation of bile acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:23764895)
UniProt
Ensembl
RGD
PMID:23764895 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:74,424,620...74,520,646 JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase IMP RGD PMID:7542218 RGD:12910748 NCBI chr14:32,901,615...32,978,895 JBrowse link
G Pank2 pantothenate kinase 2 involved_in ISO (PMID:22221393) RGD PMID:22221393 NCBI chr 3:138,936,448...138,974,196 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      metabolic process 12157
        primary metabolic process 10741
          lipid metabolic process 1458
            steroid metabolic process 366
              bile acid metabolic process 42
                bile acid biosynthetic process + 26
                bile acid catabolic process 1
                bile acid conjugation 1
                negative regulation of bile acid metabolic process + 4
                positive regulation of bile acid metabolic process + 3
                regulation of bile acid metabolic process + 14
Path 2
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      metabolic process 12157
        small molecule metabolic process 1918
          organic acid metabolic process 1043
            oxoacid metabolic process 1022
              carboxylic acid metabolic process 1007
                monocarboxylic acid metabolic process 739
                  bile acid metabolic process 42
                    bile acid biosynthetic process + 26
                    bile acid catabolic process 1
                    bile acid conjugation 1
                    negative regulation of bile acid metabolic process + 4
                    positive regulation of bile acid metabolic process + 3
                    regulation of bile acid metabolic process + 14
paths to the root