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ONTOLOGY REPORT - ANNOTATIONS


Term:cholesterol metabolic process
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Accession:GO:0008203 term browser browse the term
Definition:The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
Synonyms:exact_synonym: cholesterol metabolism
 never_in_taxon: NCBITaxon:4895 ! Schizosaccharomyces;   NCBITaxon:4930 ! Saccharomyces


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cholesterol metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 JBrowse link 4 53,030,789 53,159,988 RGD:2290270
G Abca2 ATP-binding cassette, sub-family A (ABC1), member 2 JBrowse link 2 25,428,599 25,448,544 RGD:2290270
G Abcg1 ATP binding cassette subfamily G member 1 JBrowse link 17 31,057,694 31,117,984 RGD:2290270
G Angptl3 angiopoietin-like 3 JBrowse link 4 99,030,954 99,038,192 RGD:2290270
G Aplp2 amyloid beta (A4) precursor-like protein 2 JBrowse link 9 31,149,557 31,211,848 RGD:2290270
G Apoa1 apolipoprotein A-I JBrowse link 9 46,228,630 46,230,469 RGD:2290270
G Apoa2 apolipoprotein A-II JBrowse link 1 171,221,564 171,226,379 RGD:2290270
G Apoa4 apolipoprotein A-IV JBrowse link 9 46,240,844 46,243,458 RGD:2290270
G Apob apolipoprotein B JBrowse link 12 7,977,629 8,016,839 RGD:2290270
G Apobr apolipoprotein B receptor JBrowse link 7 126,584,918 126,589,125 RGD:2290270
G Apoc1 apolipoprotein C-I JBrowse link 7 19,689,480 19,692,659 RGD:2290270
G Apoc3 apolipoprotein C-III JBrowse link 9 46,233,050 46,235,636 RGD:2290270
G Apoe apolipoprotein E JBrowse link 7 19,696,244 19,701,310 RGD:2290270
G Apof apolipoprotein F JBrowse link 10 128,268,699 128,271,250 RGD:2290270
G App amyloid beta (A4) precursor protein JBrowse link 16 84,952,666 85,175,255 RGD:2290270
G Arv1 ARV1 homolog, fatty acid homeostasis modulator JBrowse link 8 124,722,026 124,742,794 RGD:2290270
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:2290270
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha JBrowse link 7 35,119,293 35,121,928 RGD:2290270
G Ch25h cholesterol 25-hydroxylase JBrowse link 19 34,473,783 34,475,148 RGD:2290270
G Cln6 ceroid-lipofuscinosis, neuronal 6 JBrowse link 9 62,838,785 62,852,006 RGD:2290270
G Cln8 ceroid-lipofuscinosis, neuronal 8 JBrowse link 8 14,881,335 14,901,720 RGD:2290270
G Cubn cubilin (intrinsic factor-cobalamin receptor) JBrowse link 2 13,276,338 13,491,876 RGD:2290270
G Cyb5r3 cytochrome b5 reductase 3 JBrowse link 15 83,153,495 83,176,440 RGD:2290270
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 9 57,998,024 58,027,031 RGD:2290270
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 JBrowse link 15 74,834,892 74,841,643 RGD:2290270
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 15 74,850,618 74,856,231 RGD:2290270
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 JBrowse link 1 74,713,148 74,737,897 RGD:2290270
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 JBrowse link 12 108,334,268 108,362,234 RGD:2290270
G Cyp51 cytochrome P450, family 51 JBrowse link 5 4,080,674 4,104,697 RGD:2290270
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 JBrowse link 4 6,265,612 6,275,632 RGD:2290270
G Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 JBrowse link 3 18,071,944 18,243,890 RGD:2290270
G Dhcr24 24-dehydrocholesterol reductase JBrowse link 4 106,561,038 106,589,113 RGD:2290270
G Dhcr7 7-dehydrocholesterol reductase JBrowse link 7 143,823,167 143,848,410 RGD:2290270
G Disp3 dispatched RND transporter family member 3 JBrowse link 4 148,236,433 148,288,196 RGD:2290270
G Ebp phenylalkylamine Ca2+ antagonist (emopamil) binding protein JBrowse link X 8,185,329 8,193,512 RGD:2290270
G Erlin1 ER lipid raft associated 1 JBrowse link 19 44,034,943 44,070,164 RGD:2290270
G Erlin2 ER lipid raft associated 2 JBrowse link 8 27,022,408 27,039,437 RGD:2290270
G Fdft1 farnesyl diphosphate farnesyl transferase 1 JBrowse link 14 63,145,150 63,181,687 RGD:2290270
G Fdps farnesyl diphosphate synthetase JBrowse link 3 89,093,588 89,101,967 RGD:2290270
G Fdx1 ferredoxin 1 JBrowse link 9 51,943,023 51,963,602 RGD:2290270
G Fdxr ferredoxin reductase JBrowse link 11 115,268,024 115,277,101 RGD:2290270
G Fech ferrochelatase JBrowse link 18 64,456,542 64,489,098 RGD:2290270
G Fgl1 fibrinogen-like protein 1 JBrowse link 8 41,191,434 41,217,978 RGD:2290270
G Gba glucosidase, beta, acid JBrowse link 3 89,202,905 89,208,873 RGD:2290270
G Gba2 glucosidase beta 2 JBrowse link 4 43,566,928 43,578,886 RGD:2290270
G Gm9745 predicted gene 9745 JBrowse link 13 8,940,986 8,948,243 RGD:2290270
G Hdlbp high density lipoprotein (HDL) binding protein JBrowse link 1 93,405,940 93,478,917 RGD:2290270
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase JBrowse link 13 96,648,962 96,670,936 RGD:2290270
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 JBrowse link 13 119,690,351 119,708,260 RGD:2290270
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 JBrowse link 3 98,280,431 98,310,738 RGD:2290270
G Hnf1a HNF1 homeobox A JBrowse link 5 114,948,980 114,971,062 RGD:2290270
G Idi2 isopentenyl-diphosphate delta isomerase 2 JBrowse link 13 8,952,863 8,960,935 RGD:2290270
G Il4 interleukin 4 JBrowse link 11 53,612,460 53,618,665 RGD:2290270
G Insig1 insulin induced gene 1 JBrowse link 5 28,071,412 28,078,662 RGD:2290270
G Insig2 insulin induced gene 2 JBrowse link 1 121,304,353 121,332,662 RGD:2290270
G Lbr lamin B receptor JBrowse link 1 181,815,315 181,842,401 RGD:2290270
G Lcat lecithin cholesterol acyltransferase JBrowse link 8 105,939,551 105,943,402 RGD:2290270
G Ldlr low density lipoprotein receptor JBrowse link 9 21,723,576 21,749,919 RGD:2290270
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 JBrowse link 4 134,741,554 134,768,032 RGD:2290270
G Lep leptin JBrowse link 6 29,060,221 29,073,876 RGD:2290270
G Lepr leptin receptor JBrowse link 4 101,717,137 101,815,352 RGD:2290270
G Lima1 LIM domain and actin binding 1 JBrowse link 15 99,778,468 99,875,477 RGD:2290270
G Lipc lipase, hepatic JBrowse link 9 70,798,128 70,952,221 RGD:2290270
G Lipe lipase, hormone sensitive JBrowse link 7 25,379,527 25,398,486 RGD:2290270
G Lrp1 low density lipoprotein receptor-related protein 1 JBrowse link 10 127,538,157 127,621,148 RGD:2290270
G Lrp5 low density lipoprotein receptor-related protein 5 JBrowse link 19 3,584,825 3,686,585 RGD:2290270
G Mbtps1 membrane-bound transcription factor peptidase, site 1 JBrowse link 8 119,508,151 119,558,864 RGD:2290270
G Mttp microsomal triglyceride transfer protein JBrowse link 3 138,089,855 138,143,418 RGD:2290270
G Mvd mevalonate (diphospho) decarboxylase JBrowse link 8 122,433,596 122,443,422 RGD:2290270
G Mvk mevalonate kinase JBrowse link 5 114,444,264 114,460,591 RGD:2290270
G Nfe2l1 nuclear factor, erythroid derived 2,-like 1 JBrowse link 11 96,817,414 96,829,968 RGD:2290270
G Npc1 NPC intracellular cholesterol transporter 1 JBrowse link 18 12,189,694 12,236,506 RGD:2290270
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 JBrowse link 11 6,211,011 6,230,245 RGD:2290270
G Npc2 NPC intracellular cholesterol transporter 2 JBrowse link 12 84,754,559 84,773,112 RGD:2290270
G Nsdhl NAD(P) dependent steroid dehydrogenase-like JBrowse link X 72,918,521 72,958,528 RGD:2290270
G Pcsk9 proprotein convertase subtilisin/kexin type 9 JBrowse link 4 106,442,334 106,464,325 RGD:2290270
G Pctp phosphatidylcholine transfer protein JBrowse link 11 89,982,544 90,002,894 RGD:2290270
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 JBrowse link 14 50,927,215 50,931,010 RGD:2290270
G Pmp22 peripheral myelin protein 22 JBrowse link 11 63,128,982 63,159,547 RGD:2290270
G Pmvk phosphomevalonate kinase JBrowse link 3 89,454,541 89,469,014 RGD:2290270
G Pon1 paraoxonase 1 JBrowse link 6 5,168,090 5,193,987 RGD:2290270
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit JBrowse link 15 5,143,861 5,181,899 RGD:2290270
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit JBrowse link 4 105,029,649 105,109,898 RGD:2290270
G Saa1 serum amyloid A 1 JBrowse link 7 46,740,497 46,743,181 RGD:2290270
G Scap SREBF chaperone JBrowse link 9 110,333,288 110,384,949 RGD:2290270
G Smpd1 sphingomyelin phosphodiesterase 1, acid lysosomal JBrowse link 7 105,554,360 105,558,389 RGD:2290270
G Soat1 sterol O-acyltransferase 1 JBrowse link 1 156,428,108 156,474,328 RGD:2290270
G Soat2 sterol O-acyltransferase 2 JBrowse link 15 102,150,415 102,163,469 RGD:2290270
G Sorl1 sortilin-related receptor, LDLR class A repeats-containing JBrowse link 9 41,964,709 42,124,297 RGD:2290270
G Sqle squalene epoxidase JBrowse link 15 59,315,092 59,331,193 RGD:2290270
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 11 60,199,084 60,224,186 RGD:2290270
G Srebf2 sterol regulatory element binding factor 2 JBrowse link 15 82,147,269 82,205,379 RGD:2290270
G Sult2b1 sulfotransferase family, cytosolic, 2B, member 1 JBrowse link 7 45,729,981 45,759,672 RGD:2290270
G Tm7sf2 transmembrane 7 superfamily member 2 JBrowse link 19 6,062,821 6,067,850 RGD:2290270
G Tnfsf4 tumor necrosis factor (ligand) superfamily, member 4 JBrowse link 1 161,395,438 161,418,206 RGD:2290270
G Vldlr very low density lipoprotein receptor JBrowse link 19 27,216,480 27,254,231 RGD:2290270
cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoa1 apolipoprotein A-I JBrowse link 9 46,228,630 46,230,469 RGD:2290270
G Apoa4 apolipoprotein A-IV JBrowse link 9 46,240,844 46,243,458 RGD:2290270
G Apoa5 apolipoprotein A-V JBrowse link 9 46,268,608 46,271,921 RGD:2290270
G Apoe apolipoprotein E JBrowse link 7 19,696,244 19,701,310 RGD:2290270
G Ces1d carboxylesterase 1D JBrowse link 8 93,166,072 93,197,804 RGD:2290270
G Cftr cystic fibrosis transmembrane conductance regulator JBrowse link 6 18,170,687 18,322,770 RGD:2290270
G Cyb5r3 cytochrome b5 reductase 3 JBrowse link 15 83,153,495 83,176,440 RGD:2290270
G Cyp51 cytochrome P450, family 51 JBrowse link 5 4,080,674 4,104,697 RGD:2290270
G Dhcr24 24-dehydrocholesterol reductase JBrowse link 4 106,561,038 106,589,113 RGD:2290270
G Dhcr7 7-dehydrocholesterol reductase JBrowse link 7 143,823,167 143,848,410 RGD:2290270
G Ebp phenylalkylamine Ca2+ antagonist (emopamil) binding protein JBrowse link X 8,185,329 8,193,512 RGD:2290270
G Fdft1 farnesyl diphosphate farnesyl transferase 1 JBrowse link 14 63,145,150 63,181,687 RGD:2290270
G Fdps farnesyl diphosphate synthetase JBrowse link 3 89,093,588 89,101,967 RGD:2290270
G G6pdx glucose-6-phosphate dehydrogenase X-linked JBrowse link X 74,409,483 74,428,880 RGD:2290270
G Gm9745 predicted gene 9745 JBrowse link 13 8,940,986 8,948,243 RGD:2290270
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase JBrowse link 13 96,648,962 96,670,936 RGD:2290270
G Hmgcs1 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 JBrowse link 13 119,690,351 119,708,260 RGD:2290270
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 JBrowse link 3 98,280,431 98,310,738 RGD:2290270
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 JBrowse link 1 169,949,535 169,969,242 RGD:2290270
G Idi2 isopentenyl-diphosphate delta isomerase 2 JBrowse link 13 8,952,863 8,960,935 RGD:2290270
G Insig1 insulin induced gene 1 JBrowse link 5 28,071,412 28,078,662 RGD:2290270
G Insig2 insulin induced gene 2 JBrowse link 1 121,304,353 121,332,662 RGD:2290270
G Lbr lamin B receptor JBrowse link 1 181,815,315 181,842,401 RGD:2290270
G Lss lanosterol synthase JBrowse link 10 76,531,565 76,557,139 RGD:2290270
G Mvd mevalonate (diphospho) decarboxylase JBrowse link 8 122,433,596 122,443,422 RGD:2290270
G Mvk mevalonate kinase JBrowse link 5 114,444,264 114,460,591 RGD:2290270
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 JBrowse link 11 6,211,011 6,230,245 RGD:2290270
G Nsdhl NAD(P) dependent steroid dehydrogenase-like JBrowse link X 72,918,521 72,958,528 RGD:2290270
G Pmvk phosphomevalonate kinase JBrowse link 3 89,454,541 89,469,014 RGD:2290270
G Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit JBrowse link 15 5,143,861 5,181,899 RGD:2290270
G Prkaa2 protein kinase, AMP-activated, alpha 2 catalytic subunit JBrowse link 4 105,029,649 105,109,898 RGD:2290270
G Tm7sf2 transmembrane 7 superfamily member 2 JBrowse link 19 6,062,821 6,067,850 RGD:2290270
cholesterol biosynthetic process via 24,25-dihydrolanosterol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp51 cytochrome P450, family 51 JBrowse link 5 4,080,674 4,104,697 RGD:2290270
cholesterol biosynthetic process via lathosterol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sc5d sterol-C5-desaturase JBrowse link 9 42,251,592 42,264,300 RGD:2290270
cholesterol catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1d1 aldo-keto reductase family 1, member D1 JBrowse link 6 37,529,978 37,574,921 RGD:2290270
G Apoe apolipoprotein E JBrowse link 7 19,696,244 19,701,310 RGD:2290270
G Cel carboxyl ester lipase JBrowse link 2 28,555,819 28,563,403 RGD:2290270
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 JBrowse link 1 74,713,148 74,737,897 RGD:2290270
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 JBrowse link 17 43,667,372 43,751,431 RGD:2290270
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 JBrowse link 12 108,334,268 108,362,234 RGD:2290270
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 JBrowse link 4 6,265,612 6,275,632 RGD:2290270
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 JBrowse link 7 127,800,609 127,803,802 RGD:2290270
G Mt3 metallothionein 3 JBrowse link 8 94,152,607 94,154,148 RGD:2290270
G Scarb1 scavenger receptor class B, member 1 JBrowse link 5 125,277,087 125,341,094 RGD:2290270
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 7 19,696,244 19,701,310 RGD:2290270
G Erlin1 ER lipid raft associated 1 JBrowse link 19 44,034,943 44,070,164 RGD:2290270
G Erlin2 ER lipid raft associated 2 JBrowse link 8 27,022,408 27,039,437 RGD:2290270
G Idi2 isopentenyl-diphosphate delta isomerase 2 JBrowse link 13 8,952,863 8,960,935 RGD:2290270
G Sod1 superoxide dismutase 1, soluble JBrowse link 16 90,220,762 90,226,333 RGD:2290270
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg1 ATP binding cassette subfamily G member 1 JBrowse link 17 31,057,694 31,117,984 RGD:2290270
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 JBrowse link 4 6,265,612 6,275,632 RGD:2290270
G Fdps farnesyl diphosphate synthetase JBrowse link 3 89,093,588 89,101,967 RGD:2290270
G Fgf1 fibroblast growth factor 1 JBrowse link 18 38,838,672 38,929,470 RGD:2290270
G Por P450 (cytochrome) oxidoreductase JBrowse link 5 135,670,040 135,735,326 RGD:2290270
G Scp2 sterol carrier protein 2, liver JBrowse link 4 108,043,830 108,144,971 RGD:2290270
G Sec14l2 SEC14-like lipid binding 2 JBrowse link 11 4,097,039 4,118,729 RGD:2290270
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 11 60,199,084 60,224,186 RGD:2290270
regulation of cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apob apolipoprotein B JBrowse link 12 7,977,629 8,016,839 RGD:2290270
G Dhcr7 7-dehydrocholesterol reductase JBrowse link 7 143,823,167 143,848,410 RGD:2290270
G Pex2 peroxisomal biogenesis factor 2 JBrowse link 3 5,560,188 5,578,596 RGD:2290270
G Scap SREBF chaperone JBrowse link 9 110,333,288 110,384,949 RGD:2290270
regulation of cholesterol metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acadl acyl-Coenzyme A dehydrogenase, long-chain JBrowse link 1 66,830,839 66,863,309 RGD:2290270
G Acadvl acyl-Coenzyme A dehydrogenase, very long chain JBrowse link 11 70,010,183 70,015,428 RGD:2290270
G Apoe apolipoprotein E JBrowse link 7 19,696,244 19,701,310 RGD:2290270
G Arv1 ARV1 homolog, fatty acid homeostasis modulator JBrowse link 8 124,722,026 124,742,794 RGD:2290270
G Dgat2 diacylglycerol O-acyltransferase 2 JBrowse link 7 99,153,663 99,182,713 RGD:2290270
G Dgkq diacylglycerol kinase, theta JBrowse link 5 108,647,044 108,660,830 RGD:2290270
G Ephx2 epoxide hydrolase 2, cytoplasmic JBrowse link 14 66,084,372 66,124,522 RGD:2290270
G Gnb3 guanine nucleotide binding protein (G protein), beta 3 JBrowse link 6 124,834,240 124,840,275 RGD:2290270
G Ldlr low density lipoprotein receptor JBrowse link 9 21,723,576 21,749,919 RGD:2290270
G Lmf1 lipase maturation factor 1 JBrowse link 17 25,579,174 25,662,831 RGD:2290270
G Por P450 (cytochrome) oxidoreductase JBrowse link 5 135,670,040 135,735,326 RGD:2290270
G Serpina12 serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 JBrowse link 12 104,028,769 104,044,443 RGD:2290270
G Thrb thyroid hormone receptor beta JBrowse link 14 17,659,225 18,040,097 RGD:2290270
G Ttc39b tetratricopeptide repeat domain 39B JBrowse link 4 83,220,300 83,324,309 RGD:2290270
G Ttc39d tetratricopeptide repeat domain 39D JBrowse link 17 80,215,914 80,217,936 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23109
    metabolic process 10387
      small molecule metabolic process 1665
        alcohol metabolic process 326
          secondary alcohol metabolic process 141
            cholesterol metabolic process 126
              cholesterol biosynthetic process + 46
              cholesterol catabolic process 10
              cholesterol ester hydrolysis involved in cholesterol transport 0
              negative regulation of cholesterol metabolic process + 5
              peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine 0
              positive regulation of cholesterol metabolic process + 8
              regulation of cholesterol metabolic process + 30
Path 2
Term Annotations click to browse term
  biological_process 23109
    metabolic process 10387
      primary metabolic process 9241
        lipid metabolic process 1267
          steroid metabolic process 307
            sterol metabolic process 141
              cholesterol metabolic process 126
                cholesterol biosynthetic process + 46
                cholesterol catabolic process 10
                cholesterol ester hydrolysis involved in cholesterol transport 0
                negative regulation of cholesterol metabolic process + 5
                peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine 0
                positive regulation of cholesterol metabolic process + 8
                regulation of cholesterol metabolic process + 30
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.