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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphatidate phosphatase activity
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Accession:GO:0008195 term browser browse the term
Definition:Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Synonyms:exact_synonym: phosphatidate phosphohydrolase activity
 related_synonym: 3-sn-phosphatidate phosphohydrolase activity;   acid phosphatidyl phosphatase activity;   phosphatic acid phosphatase activity;   phosphatic acid phosphohydrolase activity;   phosphatidic acid phosphatase activity
 alt_id: GO:0004606
 xref: EC:3.1.3.4;   MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN;   RHEA:27429;   Reactome:R-HSA-164056 "Dephosphorylation of pChREBP (Ser 556) by PP2A";   reactome:R-HSA-1483203 "PA is dephosphorylated to DAG by LPIN";   reactome:R-HSA-163688 "Dephosphorylation of pChREBP (Thr 666) by PP2A";   reactome:R-HSA-2029468 "Conversion of PA into DAG by PAP-1";   reactome:R-HSA-390329 "Dephosphorylation of AKT by PP2A";   reactome:R-HSA-5221130 "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol";   reactome:R-HSA-6797630 "LRPP4(LRPP1-3,5) hydrolyse LPA";   reactome:R-HSA-75899 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate"


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phosphatidate phosphatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpin1 lipin 1 enables ISO
IBA		 (PMID:20231281)
GO_REF:0000033
MGI:1891341 (MGI:4943609|PMID:21397848), (PMID:17158099), (PMID:24133206)
(PMID:18694939), (PMID:23426360), (PMID:29765047), (PMID:31695197)		 RGD
GO_Central		 PMID:17158099 PMID:18694939 PMID:20231281 PMID:21397848 PMID:23426360 More... GO_REF:0000033 MGI:4943609 NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097 		JBrowse link
G Lpin2 lipin 2 enables ISO
IBA		 (PMID:18694939)
GO_REF:0000033
MGI:1891340 (MGI:4422152|PMID:19717560), (PMID:17158099), (PMID:24133206)		 RGD
GO_Central		 PMID:17158099 PMID:18694939 PMID:19717560 PMID:24133206 GO_REF:0000033 MGI:4422152 NCBI chr 9:111,083,378...111,158,193
Ensembl chr 9:111,083,745...111,158,193 		JBrowse link
G Lpin3 lipin 3 enables IBA
ISO		 GO_REF:0000033
(PMID:17158099)		 GO_Central
RGD		 PMID:17158099 GO_REF:0000033 NCBI chr 3:149,533,719...149,558,494
Ensembl chr 3:149,534,051...149,558,327 		JBrowse link
G Plpp1 phospholipid phosphatase 1 enables TAS
ISS
ISO
IDA
IEA
IBA		 GO_REF:0000024
(PMID:9305923), (PMID:9468526), (PMID:9705349)
(PMID:1334090), (PMID:8702556)
PMID:10359651
GO_REF:0000003
PMID:8663293
GO_REF:0000117
GO_REF:0000033
(MGI:3849130|PMID:19215222), (MGI:6383560|PMID:10359651), (PMID:8702556)		 UniProt
RGD
GO_Central		 PMID:1334090 PMID:8702556 PMID:9305923 PMID:9468526 PMID:9705349 More... GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000117 MGI:3849130 MGI:6383560, RGD:70566, RGD:15090857, RGD:15090855 NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268 		JBrowse link
G Plpp2 phospholipid phosphatase 2 enables NAS
ISS
ISO
IBA		 GO_REF:0000024
(PMID:16467304), (PMID:9705349)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:9705349 PMID:16467304 PMID:10992322 GO_REF:0000024 GO_REF:0000033, RGD:724585 NCBI chr 7:10,175,918...10,184,032
Ensembl chr 7:10,175,948...10,184,071 		JBrowse link
G Plpp3 phospholipid phosphatase 3 enables ISO
ISS
IBA		 (PMID:9305923), (PMID:9705349)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:9305923 PMID:9705349 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205 		JBrowse link
G Plpp4 phospholipid phosphatase 4 enables ISO
IBA		 (PMID:17590538)
GO_REF:0000033		 RGD
GO_Central		 PMID:17590538 GO_REF:0000033 NCBI chr 1:183,829,794...183,959,319
Ensembl chr 1:183,830,409...183,959,319 		JBrowse link
G Plpp5 phospholipid phosphatase 5 enables ISO
IBA		 (PMID:17590538)
GO_REF:0000033		 RGD
GO_Central		 PMID:17590538 GO_REF:0000033 NCBI chr16:66,349,483...66,353,887
Ensembl chr16:66,349,502...66,464,797 		JBrowse link
G Plpp6 phospholipid phosphatase 6 enables ISO (PMID:20110354) RGD PMID:20110354 NCBI chr 1:226,679,100...226,681,952
Ensembl chr 1:226,679,100...226,681,949 		JBrowse link
G Plppr1 phospholipid phosphatase related 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:63,437,457...63,725,286
Ensembl chr 5:63,437,816...63,763,835 		JBrowse link
G Plppr2 phospholipid phosphatase related 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:20,467,071...20,479,474
Ensembl chr 8:20,467,071...20,479,474 		JBrowse link
G Plppr3 phospholipid phosphatase related 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:9,831,162...9,842,434
Ensembl chr 7:9,831,162...9,845,296 		JBrowse link
G Plppr4 phospholipid phosphatase related 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:205,371,317...205,412,302
Ensembl chr 2:205,371,322...205,412,302 		JBrowse link
G Plppr5 phospholipid phosphatase related 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:205,525,466...205,737,892
Ensembl chr 2:205,458,176...205,717,599 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20733
    catalytic activity 6109
      hydrolase activity 2595
        hydrolase activity, acting on ester bonds 811
          phosphoric ester hydrolase activity 370
            phosphatase activity 280
              lipid phosphatase activity 18
                phosphatidate phosphatase activity 14
paths to the root