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ONTOLOGY REPORT - ANNOTATIONS


Term:COP9 signalosome
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Accession:GO:0008180 term browser browse the term
Definition:A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
Synonyms:exact_synonym: CSN
 narrow_synonym: COP9 complex
 broad_synonym: signalosome


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COP9 signalosome term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amot angiomotin colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr  X:116,751,231...116,810,238
Ensembl chr  X:116,751,230...116,792,864
JBrowse link
G Amotl1 angiomotin-like 1 colocalizes_with ISO
IEA
(PMID:18850735)
GO_REF:0000107
RGD
Ensembl
PMID:18850735 GO_REF:0000107 NCBI chr 8:13,037,265...13,157,701
Ensembl chr 8:13,042,641...13,109,487
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr18:74,156,553...74,164,490
Ensembl chr18:74,156,553...74,164,495
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 colocalizes_with ISO
IEA
(PMID:18850735)
GO_REF:0000107
RGD
Ensembl
PMID:18850735 GO_REF:0000107 NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628
JBrowse link
G Cops2 COP9 signalosome subunit 2 ISO
IBA
(MGI:MGI:1298123|PMID:9707402)
PMID:21873635
(PMID:18850735), (PMID:9535219)
RGD PMID:9535219, PMID:9707402, PMID:18850735, PMID:21873635 MGI:MGI:1298123, RGD:13792537 NCBI chr 3:118,109,394...118,137,125
Ensembl chr 3:118,109,406...118,137,191
JBrowse link
G Cops3 COP9 signalosome subunit 3 ISO
IBA
(MGI:MGI:1298123|PMID:9707402)
PMID:21873635
(PMID:18850735)
RGD PMID:9707402, PMID:18850735, PMID:21873635 MGI:MGI:1298123, RGD:13792537 NCBI chr10:46,182,680...46,206,083
Ensembl chr10:46,182,687...46,206,135
JBrowse link
G Cops4 COP9 signalosome subunit 4 ISO
IBA
(MGI:MGI:1298123|PMID:9707402)
PMID:21873635
(PMID:18850735)
RGD PMID:9707402, PMID:18850735, PMID:21873635 MGI:MGI:1298123, RGD:13792537 NCBI chr14:10,718,863...10,749,134
Ensembl chr14:10,718,844...10,749,120
JBrowse link
G Cops5 COP9 signalosome subunit 5 ISO
IBA
(MGI:MGI:1298123|PMID:9707402)
PMID:21873635
(PMID:18850735), (PMID:19214193)
RGD PMID:9707402, PMID:18850735, PMID:19214193, PMID:21873635 MGI:MGI:1298123, RGD:13792537 NCBI chr 5:8,876,090...8,894,345
Ensembl chr 5:8,876,044...8,894,339
JBrowse link
G Cops6 COP9 signalosome subunit 6 ISO
IBA
(MGI:MGI:1298123|PMID:9707402)
PMID:21873635
(PMID:18850735)
RGD PMID:9707402, PMID:18850735, PMID:21873635 MGI:MGI:1298123, RGD:13792537 NCBI chr12:19,303,387...19,306,226
Ensembl chr12:19,303,387...19,306,226
JBrowse link
G Cops7a COP9 signalosome subunit 7A ISO
IBA
(PMID:18850735)
PMID:21873635
RGD PMID:18850735, PMID:21873635 RGD:13792537 NCBI chr 4:157,479,549...157,486,944
Ensembl chr 4:157,479,549...157,486,914
JBrowse link
G Cops7b COP9 signalosome subunit 7B ISO
IBA
(PMID:18850735)
PMID:21873635
RGD PMID:18850735, PMID:21873635 RGD:13792537 NCBI chr 9:93,607,199...93,633,064
Ensembl chr 9:93,607,477...93,633,064
JBrowse link
G Cops8 COP9 signalosome subunit 8 ISO
IBA
(MGI:MGI:1298123|PMID:9707402)
PMID:21873635
(PMID:18850735), (PMID:9535219)
RGD PMID:9535219, PMID:9707402, PMID:18850735, PMID:21873635 MGI:MGI:1298123, RGD:13792537 NCBI chr 9:97,772,224...97,782,055
Ensembl chr 9:97,772,184...97,782,067
JBrowse link
G Cops9 COP9 signalosome subunit 9 colocalizes_with ISO
IBA
(PMID:26456823)
(PMID:23776465)
PMID:21873635
RGD PMID:23776465, PMID:26456823, PMID:21873635 RGD:13792537 NCBI chr 9:99,813,332...99,818,262
Ensembl chr 9:99,813,332...99,818,262
JBrowse link
G Dcaf1 DDB1 and CUL4 associated factor 1 colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr 8:115,538,365...115,615,282
Ensembl chr 8:115,546,712...115,615,282
JBrowse link
G Dock7 dedicator of cytokinesis 7 colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr 5:117,595,194...117,780,844
Ensembl chr 5:117,596,136...117,780,777
JBrowse link
G Dynll1 dynein light chain LC8-type 1 colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G Epb41l2 erythrocyte membrane protein band 4.1-like 2 colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr 1:20,881,820...21,067,713
Ensembl chr 1:20,893,995...20,962,526
JBrowse link
G Flot1 flotillin 1 colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr20:3,427,890...3,438,418
Ensembl chr20:3,427,880...3,438,396
JBrowse link
G Gps1 G protein pathway suppressor 1 ISO
IBA
IEA
(MGI:MGI:1298123|PMID:9707402)
PMID:21873635
(PMID:18850735)
GO_REF:0000107
GO_REF:0000002
RGD
Ensembl
InterPro
PMID:9707402, PMID:18850735, PMID:21873635 GO_REF:0000002, GO_REF:0000107, MGI:MGI:1298123, RGD:13792537 NCBI chr10:109,966,875...109,971,912
Ensembl chr10:109,966,904...109,971,911
JBrowse link
G Grb2 growth factor receptor bound protein 2 ISO
ISS
(PMID:22561606)
GO_REF:0000024
(MGI:MGI:5432321|PMID:22561606)
RGD
UniProt
PMID:22561606 GO_REF:0000024, MGI:MGI:5432321 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A colocalizes_with ISO
IBA
(PMID:18850735)
PMID:21873635
RGD PMID:18850735, PMID:21873635 RGD:13792537 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B colocalizes_with ISO
IBA
(PMID:18850735)
PMID:21873635
RGD PMID:18850735, PMID:21873635 RGD:13792537 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like colocalizes_with ISO
IBA
(PMID:18850735)
PMID:21873635
RGD PMID:18850735, PMID:21873635 RGD:13792537 NCBI chr20:4,879,998...4,965,191
Ensembl chr20:4,959,294...4,964,963
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Lat linker for activation of T cells ISO
ISS
(MGI:MGI:5432321|PMID:22561606)
GO_REF:0000024
RGD
UniProt
PMID:22561606 GO_REF:0000024, MGI:MGI:5432321 NCBI chr 1:197,765,644...197,770,669
Ensembl chr 1:197,765,644...197,770,669
JBrowse link
G LOC108348108 heat shock 70 kDa protein 1A colocalizes_with IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:2,699,707...2,701,856
Ensembl chr20:4,877,324...4,879,779
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Myh9 myosin, heavy chain 9 colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr 7:118,740,005...118,792,507
Ensembl chr 7:118,741,110...118,792,625
JBrowse link
G Nckipsd NCK interacting protein with SH3 domain colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr 8:117,601,035...117,612,302
Ensembl chr 8:117,600,749...117,611,922
JBrowse link
G Plcg1 phospholipase C, gamma 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:22561606)
Ensembl
UniProt
RGD
PMID:22561606 GO_REF:0000024, GO_REF:0000107 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Stoml2 stomatin like 2 colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr 5:58,472,561...58,476,158
Ensembl chr 5:58,472,550...58,476,251
JBrowse link
G Themis thymocyte selection associated ISO (MGI:MGI:5432321|PMID:22561606) RGD PMID:22561606 MGI:MGI:5432321 NCBI chr 1:17,152,973...17,378,225
Ensembl chr 1:17,171,631...17,378,047
JBrowse link
G Tmod1 tropomodulin 1 colocalizes_with IEA
ISO
GO_REF:0000107
(PMID:18850735)
Ensembl
RGD
PMID:18850735 GO_REF:0000107 NCBI chr 5:61,635,244...61,712,052
Ensembl chr 5:61,657,507...61,712,051
JBrowse link
G Wdr6 WD repeat domain 6 colocalizes_with ISO (PMID:18850735) RGD PMID:18850735 NCBI chr 8:117,358,345...117,364,761
Ensembl chr 8:117,358,787...117,366,096
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20609
    protein-containing complex 6092
      COP9 signalosome 34
Path 2
Term Annotations click to browse term
  cellular_component 20609
    cellular anatomical entity 20358
      organelle 13257
        membrane-bounded organelle 11448
          intracellular membrane-bounded organelle 10704
            nucleus 7183
              COP9 signalosome 34
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.