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ONTOLOGY REPORT - ANNOTATIONS

Term:NADH dehydrogenase (ubiquinone) activity
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Accession:GO:0008137 term browser browse the term
Definition:Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out).
Synonyms:exact_synonym: ubiquinone reductase activity
 narrow_synonym: mitochondrial electron transport complex 1 activity
 related_synonym: DPNH-coenzyme Q reductase activity;   DPNH-ubiquinone reductase activity;   NADH coenzyme Q1 reductase activity;   NADH-CoQ oxidoreductase activity;   NADH-CoQ reductase activity;   NADH-Q6 oxidoreductase activity;   NADH-coenzyme Q oxidoreductase activity;   NADH-coenzyme Q reductase activity;   NADH-ubiquinone oxidoreductase activity;   NADH-ubiquinone reductase activity;   NADH-ubiquinone-1 reductase activity;   NADH:ubiquinone oxidoreductase complex activity;   coenzyme Q reductase activity;   complex 1 dehydrogenase activity;   complex I (NADH:Q1 oxidoreductase) activity;   complex I (electron transport chain) activity;   complex I (mitochondrial electron transport) activity;   dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity;   electron transfer complex I activity;   reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity;   type 1 dehydrogenase activity
 xref: EC:7.1.1.2;   MetaCyc:NADH-DEHYDROG-A-RXN;   RHEA:29091;   Reactome:R-HSA-163217 "Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2"

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NADH dehydrogenase (ubiquinone) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ND1 NADH dehydrogenase subunit 1 enables IEA UniProt
Ensembl		 GO_REF:0000003 GO_REF:0000107 NCBI chr MT:2,748...3,703 JBrowse link
G ND2 NADH dehydrogenase subunit 2 enables IEA UniProt
Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000118 NCBI chr MT:3,914...4,955 JBrowse link
G ND3 NADH dehydrogenase subunit 3 enables IEA InterPro
Ensembl
UniProt
TreeGrafter		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 GO_REF:0000118 NCBI chr MT:9,481...9,827 JBrowse link
G ND4 NADH dehydrogenase subunit 4 enables IEA UniProt
InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 NCBI chr MT:10,186...11,563 JBrowse link
G ND4L NADH dehydrogenase subunit 4L enables IEA UniProt
Ensembl		 GO_REF:0000003 GO_REF:0000107 NCBI chr MT:9,896...10,192 JBrowse link
G ND5 NADH dehydrogenase subunit 5 enables IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 NCBI chr MT:11,763...13,580 JBrowse link
G ND6 NADH dehydrogenase subunit 6 enables IEA UniProt
Ensembl
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 NCBI chr MT:13,564...14,088 JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936745:1,436,257...1,471,785
Ensembl chrNW_004936745:1,436,234...1,471,843 		JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 enables IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:3,081,009...3,084,737
Ensembl chrNW_004936659:3,079,365...3,084,788 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 contributes_to
enables		 ISO
IEA		 (PMID:15824269), (PMID:16478720), (PMID:16870178) UniProtKB
InterPro
Ensembl
UniProt		 PMID:15824269 PMID:16478720 PMID:16870178 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 NCBI chrNW_004936631:2,503,353...2,538,957
Ensembl chrNW_004936631:2,499,062...2,538,801 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 contributes_to
enables		 ISO
IEA		 (PMID:22036843), (PMID:30922174) UniProt
Ensembl
UniProt		 PMID:22036843 PMID:30922174 GO_REF:0000003 GO_REF:0000107 RGD:42722001 NCBI chrNW_004936903:503,633...514,235
Ensembl chrNW_004936903:499,300...514,893 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 contributes_to
enables		 ISO
IEA		 (PMID:30140060) UniProt
InterPro
Ensembl		 PMID:30140060 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936562:1,667,780...1,674,670
Ensembl chrNW_004936562:1,664,293...1,674,670 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 contributes_to
enables		 ISO
IEA		 (PMID:15038602), (PMID:16870178) UniProtKB
Ensembl		 PMID:15038602 PMID:16870178 GO_REF:0000107 NCBI chrNW_004936480:13,829,093...13,932,202
Ensembl chrNW_004936480:13,827,743...13,932,238 		JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 enables IEA Ensembl
InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936588:715,093...720,035
Ensembl chrNW_004936588:715,162...719,968 		JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 contributes_to
enables		 ISO
IEA		 (PMID:9837812) UniProtKB
Ensembl		 PMID:9837812 GO_REF:0000107 NCBI chrNW_004936599:2,081,493...2,085,635
Ensembl chrNW_004936599:2,081,079...2,084,730 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 enables IEA RHEA
InterPro
UniProt
Ensembl		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chrNW_004936599:2,169,434...2,173,090
Ensembl chrNW_004936599:2,167,173...2,173,227 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 contributes_to
enables		 ISO
IEA		 (PMID:12754703) UniProt
Ensembl		 PMID:12754703 GO_REF:0000107 NCBI chrNW_004936670:2,742,553...2,772,697
Ensembl chrNW_004936670:2,742,553...2,772,697 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18185
    electron transfer activity 52
      NADH dehydrogenase (ubiquinone) activity 17
Path 2
Term Annotations click to browse term
  molecular_function 18185
    transporter activity 1151
      transmembrane transporter activity 1051
        active transmembrane transporter activity 388
          primary active transmembrane transporter activity 136
            oxidoreduction-driven active transmembrane transporter activity 31
              NADH dehydrogenase (ubiquinone) activity 17
paths to the root