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ONTOLOGY REPORT - ANNOTATIONS

Term:NADH dehydrogenase (ubiquinone) activity
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Accession:GO:0008137 term browser browse the term
Definition:Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out).
Synonyms:exact_synonym: ubiquinone reductase activity
 narrow_synonym: mitochondrial electron transport complex 1 activity
 related_synonym: DPNH-coenzyme Q reductase activity;   DPNH-ubiquinone reductase activity;   NADH coenzyme Q1 reductase activity;   NADH-CoQ oxidoreductase activity;   NADH-CoQ reductase activity;   NADH-Q6 oxidoreductase activity;   NADH-coenzyme Q oxidoreductase activity;   NADH-coenzyme Q reductase activity;   NADH-ubiquinone oxidoreductase activity;   NADH-ubiquinone reductase activity;   NADH-ubiquinone-1 reductase activity;   NADH:ubiquinone oxidoreductase complex activity;   coenzyme Q reductase activity;   complex 1 dehydrogenase activity;   complex I (NADH:Q1 oxidoreductase) activity;   complex I (electron transport chain) activity;   complex I (mitochondrial electron transport) activity;   dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity;   electron transfer complex I activity;   reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity;   type 1 dehydrogenase activity
 xref: EC:7.1.1.2;   MetaCyc:NADH-DEHYDROG-A-RXN;   RHEA:29091;   Reactome:R-HSA-163217 "Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2"

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NADH dehydrogenase (ubiquinone) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 enables ISO (PMID:24652937) MGI PMID:24652937 NCBI chrNW_004955542:1,329,802...1,370,109
Ensembl chrNW_004955542:1,329,212...1,370,695 		JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 enables ISO (PMID:33502047) UniProt PMID:33502047 NCBI chrNW_004955415:33,138,888...33,142,663
Ensembl chrNW_004955415:33,134,474...33,143,145 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 enables
contributes_to		 ISO (PMID:27799543), (PMID:32072193)
(PMID:30879903), (PMID:31557978)
(PMID:15824269), (PMID:16478720), (PMID:16870178)		 UniProt
UniProtKB		 PMID:15824269 PMID:16478720 PMID:16870178 PMID:27799543 PMID:30879903 More... NCBI chrNW_004955457:8,838,216...8,879,059
Ensembl chrNW_004955457:8,838,216...8,883,481 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 enables
contributes_to		 ISO (PMID:28031252)
(PMID:26437605), (PMID:29887397), (PMID:31297047)
PMID:30922174
(PMID:22036843), (PMID:30922174)		 UniProt PMID:22036843 PMID:26437605 PMID:28031252 PMID:29887397 PMID:30922174 More... RGD:42722001 NCBI chrNW_004955468:12,961,873...12,971,278
Ensembl chrNW_004955468:12,961,915...12,971,095 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 contributes_to
enables		 ISO (PMID:30140060)
(PMID:14729820)
(PMID:31916679), (PMID:33148885)		 UniProt PMID:14729820 PMID:30140060 PMID:31916679 PMID:33148885 NCBI chrNW_004955422:713,370...717,926
Ensembl chrNW_004955422:709,784...717,926 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 enables
contributes_to		 ISO (PMID:10747996)
(PMID:15038602), (PMID:16870178)
(PMID:16478720)
(PMID:18396137), (PMID:29501746)
(PMID:26712463)		 MGI
UniProtKB
UniProt		 PMID:10747996 PMID:15038602 PMID:16478720 PMID:16870178 PMID:18396137 More... NCBI chrNW_004955446:13,764,907...13,864,824
Ensembl chrNW_004955446:13,764,907...13,864,824 		JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 enables ISO (PMID:17275378) UniProt PMID:17275378 NCBI chrNW_004955495:6,540,360...6,548,072
Ensembl chrNW_004955495:6,540,450...6,547,975 		JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 enables
contributes_to		 ISO (PMID:22499348)
(PMID:9837812)		 UniProt
UniProtKB		 PMID:9837812 PMID:22499348 NCBI chrNW_004955422:17,781,374...17,785,395
Ensembl chrNW_004955422:17,781,204...17,784,404 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 enables ISO (PMID:28844695)
(PMID:29915388)		 UniProt PMID:28844695 PMID:29915388 NCBI chrNW_004955422:17,876,496...17,881,773
Ensembl chrNW_004955422:17,873,872...17,881,773 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 contributes_to
enables		 ISO (PMID:12754703)
(PMID:29915388)
(PMID:28844695)		 UniProt PMID:12754703 PMID:28844695 PMID:29915388 NCBI chrNW_004955402:2,802,366...2,818,049
Ensembl chrNW_004955402:2,800,447...2,818,375 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14380
    electron transfer activity 27
      NADH dehydrogenase (ubiquinone) activity 10
Path 2
Term Annotations click to browse term
  molecular_function 14380
    transporter activity 887
      transmembrane transporter activity 801
        active transmembrane transporter activity 271
          primary active transmembrane transporter activity 81
            oxidoreduction-driven active transmembrane transporter activity 16
              NADH dehydrogenase (ubiquinone) activity 10
paths to the root