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ONTOLOGY REPORT - ANNOTATIONS

Term:NADH dehydrogenase (ubiquinone) activity
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Accession:GO:0008137 term browser browse the term
Definition:Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out).
Synonyms:exact_synonym: ubiquinone reductase activity
 narrow_synonym: mitochondrial electron transport complex 1 activity
 related_synonym: DPNH-coenzyme Q reductase activity;   DPNH-ubiquinone reductase activity;   NADH coenzyme Q1 reductase activity;   NADH-CoQ oxidoreductase activity;   NADH-CoQ reductase activity;   NADH-Q6 oxidoreductase activity;   NADH-coenzyme Q oxidoreductase activity;   NADH-coenzyme Q reductase activity;   NADH-ubiquinone oxidoreductase activity;   NADH-ubiquinone reductase activity;   NADH-ubiquinone-1 reductase activity;   NADH:ubiquinone oxidoreductase complex activity;   coenzyme Q reductase activity;   complex 1 dehydrogenase activity;   complex I (NADH:Q1 oxidoreductase) activity;   complex I (electron transport chain) activity;   complex I (mitochondrial electron transport) activity;   dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity;   electron transfer complex I activity;   reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity;   type 1 dehydrogenase activity
 xref: EC:7.1.1.2;   MetaCyc:NADH-DEHYDROG-A-RXN;   RHEA:29091;   reactome:R-HSA-163217 "Complex I oxidises NADH to NAD+, reduces CoQ to QH2"


show annotations for term's descendants           Sort by:
NADH dehydrogenase (ubiquinone) activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 enables ISO
ISS		 (PMID:1959619)
GO_REF:0000024		 RGD
UniProt		 PMID:1959619 GO_REF:0000024 NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694 		JBrowse link
G Mt-nd2 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2 enables ISO
ISS
IBA		 (PMID:16996290)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:16996290 GO_REF:0000024 GO_REF:0000033 NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
NCBI chr MT:3,904...4,942
Ensembl chr MT:3,904...4,942 		JBrowse link
G Mt-nd3 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3 enables ISO
ISS
IBA		 (PMID:25118196)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:25118196 GO_REF:0000024 GO_REF:0000033 NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798 		JBrowse link
G Mt-nd4 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 enables ISO
ISS		 (PMID:15250827), (PMID:8344246), (PMID:8644732)
GO_REF:0000024		 RGD
UniProt		 PMID:8344246 PMID:8644732 PMID:15250827 GO_REF:0000024 NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
NCBI chr MT:10,160...11,537
Ensembl chr MT:10,160...11,537 		JBrowse link
G Mt-nd4l mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L enables ISS
ISO		 GO_REF:0000024
(PMID:28844695), (PMID:29915388)		 UniProt
RGD		 PMID:28844695 PMID:29915388 GO_REF:0000024 NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
NCBI chr MT:9,870...10,166
Ensembl chr MT:9,870...10,166 		JBrowse link
G Mt-nd5 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 enables
contributes_to		 ISO
ISS		 (PMID:15250827)
GO_REF:0000024
(PMID:18729827)		 RGD
UniProt		 PMID:15250827 PMID:18729827 GO_REF:0000024 NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
NCBI chr MT:11,736...13,565
Ensembl chr MT:11,736...13,565 		JBrowse link
G Mt-nd6 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 enables ISS
ISO		 GO_REF:0000024
(PMID:14595656), (PMID:8644732)
(MGI:6508662|PMID:9707444)		 UniProt
RGD		 PMID:8644732 PMID:9707444 PMID:14595656 GO_REF:0000024 MGI:6508662 NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
NCBI chr MT:13,543...14,061
Ensembl chr MT:13,543...14,061 		JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 enables ISO (PMID:24652937) RGD PMID:24652937 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560 		JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 enables ISO (PMID:33502047) RGD PMID:33502047 NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 contributes_to
enables		 ISS
ISO
IEA
IBA		 GO_REF:0000024
(PMID:15824269), (PMID:16478720), (PMID:16870178)
(PMID:30879903), (PMID:31557978)
(MGI:6432573|PMID:32072193), (MGI:6478059|PMID:27799543)
GO_REF:0000002
GO_REF:0000033		 UniProt
RGD
InterPro
GO_Central		 PMID:15824269 PMID:16478720 PMID:16870178 PMID:27799543 PMID:30879903 More... GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 MGI:6432573 MGI:6478059 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 contributes_to
enables		 ISO
IMP
ISS		 (PMID:22036843), (PMID:30922174)
(MGI:6208149|PMID:29887397), (MGI:6220487|PMID:26437605), (MGI:6380745|PMID:31297047)
(PMID:28031252)
GO_REF:0000024		 RGD
UniProt		 PMID:22036843 PMID:26437605 PMID:28031252 PMID:29887397 PMID:30922174 More... GO_REF:0000024 MGI:6208149 MGI:6220487 MGI:6380745, RGD:42722001 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 enables
contributes_to		 ISO (MGI:6391555|PMID:31916679), (MGI:6505357|PMID:33148885)
(PMID:30140060)
(PMID:14729820)		 RGD PMID:14729820 PMID:30140060 PMID:31916679 PMID:33148885 MGI:6391555 MGI:6505357 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 contributes_to
enables		 ISO
IEA		 (PMID:15038602), (PMID:16870178)
(PMID:16478720)
GO_REF:0000107
MGI:3527173|MGI:3793713 (PMID:10747996), (PMID:18396137), (PMID:26712463), (PMID:29501746)		 RGD
Ensembl		 PMID:10747996 PMID:15038602 PMID:16478720 PMID:16870178 PMID:18396137 More... GO_REF:0000107 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846 		JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 enables ISO
IBA		 (PMID:17275378)
GO_REF:0000033		 RGD
GO_Central		 PMID:17275378 GO_REF:0000033 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195 		JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 contributes_to
enables		 ISO (PMID:9837812)
(PMID:22499348)		 RGD PMID:9837812 PMID:22499348 NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 enables ISO (PMID:28844695)
(MGI:6730397|PMID:29915388)		 RGD PMID:28844695 PMID:29915388 MGI:6730397 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 contributes_to
enables		 ISO
ISS
IEA		 (PMID:12754703)
GO_REF:0000024
GO_REF:0000107
(PMID:28844695)
(MGI:6730397|PMID:29915388)		 RGD
UniProt
Ensembl		 PMID:12754703 PMID:28844695 PMID:29915388 GO_REF:0000024 GO_REF:0000107 MGI:6730397 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 21010
    electron transfer activity 59
      NADH dehydrogenase (ubiquinone) activity 17
Path 2
Term Annotations click to browse term
  molecular_function 21010
    transporter activity 1259
      transmembrane transporter activity 1163
        active transmembrane transporter activity 448
          primary active transmembrane transporter activity 153
            oxidoreduction-driven active transmembrane transporter activity 35
              NADH dehydrogenase (ubiquinone) activity 17
paths to the root