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Term:cholesterol 7-alpha-monooxygenase activity
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Accession:GO:0008123 term browser browse the term
Definition:Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O.
Synonyms:exact_synonym: cholesterol 7-alpha-hydroxylase activity
 narrow_synonym: cytochrome P450 CYP7A1
 related_synonym: cholesterol 7alpha-hydroxylase activity;   cholesterol 7alpha-monooxygenase activity;   cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
 xref: EC:;   MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN;   RHEA:21812;   reactome:R-HSA-192051 "CYP7A1 7-hydroxylates CHOL"

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cholesterol 7-alpha-monooxygenase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 enables IDA
(MGI:1933035|PMID:11279518), (MGI:2386518|PMID:12114517), (MGI:3603484|PMID:15845870)
RGD PMID:11279518 PMID:12077124 PMID:12114517 PMID:15845870 PMID:2335522 More... MGI:1933035 MGI:2386518 MGI:3603484, RGD:70535, RGD:70534, RGD:13792537 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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  molecular_function 20464
    catalytic activity 6032
      oxidoreductase activity 862
        monooxygenase activity 159
          steroid hydroxylase activity 33
            cholesterol 7-alpha-monooxygenase activity 2
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