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ONTOLOGY REPORT - ANNOTATIONS

Term:thiopurine S-methyltransferase activity
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Accession:GO:0008119 term browser browse the term
Definition:Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.
Synonyms:related_synonym: 6-thiopurine transmethylase activity;   S-adenosyl-L-methionine:thiopurine S-methyltransferase activity;   TPMT;   mercaptopurine methyltransferase activity;   thiopurine methyltransferase activity
 xref: EC:2.1.1.67;   MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN;   Reactome:R-HSA-5603379 "TPMT does not transfer CH3 from AdoMet to 6MP";   Reactome:R-HSA-9748979 "TPMT transfers methyl group to 6TIMP, forming 6MeTIMP";   Reactome:R-HSA-9748983 "TPMT transfers methyl group to 6MP, forming 6MeMP";   reactome:R-HSA-158609 "TPMT transfers CH3 from AdoMet to 6MP"


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thiopurine S-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tpmt thiopurine S-methyltransferase enables ISO
IEA
IBA		 (PMID:18484748), (PMID:657528)
GO_REF:0000003
GO_REF:0000107
GO_REF:0000033
(PMID:9539138)		 RGD
UniProt
Ensembl
GO_Central		 PMID:657528 PMID:9539138 PMID:18484748 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 21087
    catalytic activity 6127
      transferase activity 2447
        transferase activity, transferring one-carbon groups 214
          methyltransferase activity 203
            S-adenosylmethionine-dependent methyltransferase activity 169
              thiopurine S-methyltransferase activity 1
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