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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphoric diester hydrolase activity
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Accession:GO:0008081 term browser browse the term
Definition:Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
Synonyms:narrow_synonym: phosphodiesterase
 alt_id: GO:0004434;   GO:0016792
 xref: EC:3.1.4;   reactome:R-HSA-5693578 "TDP1 and TDP2 process unligatable DSB ends"


show annotations for term's descendants           Sort by:
phosphoric diester hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO
IBA		 (PMID:11478795), (PMID:18973764)
GO_REF:0000033		 RGD
GO_Central		 PMID:11478795 PMID:18973764 GO_REF:0000033 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
G Apex2 apurinic/apyrimidinic endodeoxyribonuclease 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:19,425,684...19,508,459
Ensembl chr  X:19,487,419...19,508,439 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 enables ISO (PMID:12533192), (PMID:27406238) RGD PMID:12533192 PMID:27406238 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 enables ISO
ISS		 (PMID:15788404)
GO_REF:0000024		 RGD
UniProt		 PMID:15788404 GO_REF:0000024 NCBI chr16:45,165,883...45,294,126
Ensembl chr16:45,169,178...45,294,077 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 enables ISO
IDA		 (PMID:16255717) RGD PMID:16255717 PMID:16255717 RGD:25671389 NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589 		JBrowse link
G Gde1 glycerophosphodiester phosphodiesterase 1 enables ISO
IEA		 (PMID:25596343)
GO_REF:0000002		 RGD
InterPro		 PMID:25596343 GO_REF:0000002 NCBI chr 1:173,016,984...173,032,396
Ensembl chr 1:172,954,394...173,032,429 		JBrowse link
G Gdpd1 glycerophosphodiester phosphodiesterase domain containing 1 enables ISO
IBA
IEA
ISS		 (PMID:27637550)
(PMID:25596343), (PMID:27637550)
GO_REF:0000033
GO_REF:0000117
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:25596343 PMID:27637550 GO_REF:0000024 GO_REF:0000033 GO_REF:0000117 NCBI chr10:71,840,497...71,883,936
Ensembl chr10:71,840,497...71,883,850 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 enables ISO
IBA		 (PMID:27637550)
GO_REF:0000033		 RGD
GO_Central		 PMID:27637550 GO_REF:0000033 NCBI chr 1:181,373,505...181,383,063
Ensembl chr 1:181,366,626...181,383,063 		JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:119,787,681...119,832,550
Ensembl chr 3:119,787,682...119,832,517 		JBrowse link
G Mppe1 metallophosphoesterase 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:60,763,418...60,781,553
Ensembl chr18:60,763,419...60,781,553 		JBrowse link
G Mpped2 metallophosphoesterase domain containing 2 enables IDA PMID:21824479 UniProt PMID:21824479 RGD:14397554 NCBI chr 3:93,180,895...93,355,605
Ensembl chr 3:93,181,167...93,355,618 		JBrowse link
G Plcxd1 phosphatidylinositol-specific phospholipase C, X domain containing 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:46,578,917...46,582,181
Ensembl chr12:46,579,225...46,582,392 		JBrowse link
G Plcxd2 phosphatidylinositol-specific phospholipase C, X domain containing 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:54,800,977...54,853,348
Ensembl chr11:54,789,477...54,853,344 		JBrowse link
G Plcxd3 phosphatidylinositol-specific phospholipase C, X domain containing 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:53,567,022...53,746,384
Ensembl chr 2:53,567,022...53,746,384 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 enables ISO (PMID:10608884), (PMID:14741383) RGD PMID:10608884 PMID:14741383 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 enables ISO (PMID:14741383) RGD PMID:14741383 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:26783088), (PMID:28104755), (PMID:37890481)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:26783088 PMID:28104755 PMID:37890481 GO_REF:0000024 GO_REF:0000033 NCBI chr20:37,132,592...37,155,567
Ensembl chr20:37,132,592...37,155,567 		JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B enables ISO
IBA		 (PMID:26095358)
(PMID:26095358), (PMID:27687724)
GO_REF:0000033		 RGD
GO_Central		 PMID:26095358 PMID:27687724 GO_REF:0000033 NCBI chr 5:144,944,618...144,966,703
Ensembl chr 5:144,944,636...144,966,720 		JBrowse link
G Tdp1 tyrosyl-DNA phosphodiesterase 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:119,163,192...119,231,029
Ensembl chr 6:119,163,166...119,231,021 		JBrowse link
2',3'-cyclic-nucleotide 2'-phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adprm ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:51,732,073...51,744,635
Ensembl chr10:51,731,993...51,744,635 		JBrowse link
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase enables TAS
ISO
IBA
IEA
IDA		 (PMID:12590258)
GO_REF:0000033
GO_REF:0000104		 RGD
GO_Central
UniProt		 PMID:12590258 PMID:11842207 PMID:19357238 GO_REF:0000033 GO_REF:0000104, RGD:1298767, RGD:6480491 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720 		JBrowse link
3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pde1b phosphodiesterase 1B enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580 		JBrowse link
G Pde2a phosphodiesterase 2A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pde3a phosphodiesterase 3A enables ISO (PMID:8155697) RGD PMID:8155697 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
G Pde3b phosphodiesterase 3B enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334 		JBrowse link
3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A enables ISO
IEA
IBA
ISS		 (PMID:19689430)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000024		 RGD
Ensembl
GO_Central
UniProt		 PMID:19689430 PMID:19689430 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:12790642 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pde11a phosphodiesterase 11A enables ISO
IBA
IEA
ISS		 (PMID:19689430)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:19689430 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:60,913,562...61,297,154
Ensembl chr 3:60,913,562...61,297,158 		JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 enables ISS
IBA		 GO_REF:0000024
GO_REF:0000033		 UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033
G Pde1b phosphodiesterase 1B enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580 		JBrowse link
G Pde2a phosphodiesterase 2A enables ISO
IBA
IEA		 (PMID:17329248), (PMID:19689430)
(PMID:15210692)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:15210692 PMID:17329248 PMID:19689430 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pde3a phosphodiesterase 3A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
G Pde3b phosphodiesterase 3B enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334 		JBrowse link
3',5'-cyclic-AMP phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Pde10a phosphodiesterase 10A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pde11a phosphodiesterase 11A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:60,913,562...61,297,154
Ensembl chr 3:60,913,562...61,297,158 		JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Pde1a phosphodiesterase 1A enables ISO (PMID:15901640) RGD PMID:15901640 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874 		JBrowse link
G Pde1b phosphodiesterase 1B enables IDA
ISO		 PMID:1326532
(PMID:14687666), (PMID:8855339)		 RGD PMID:8855339 PMID:14687666 PMID:1326532 RGD:633601 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580 		JBrowse link
G Pde1c phosphodiesterase 1C enables ISO
IEA		 (PMID:29860631)
(PMID:8810348)
GO_REF:0000116		 RGD
RHEA		 PMID:8810348 PMID:29860631 GO_REF:0000116 NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219 		JBrowse link
G Pde2a phosphodiesterase 2A enables ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:21724846)
GO_REF:0000033
(PMID:15938621), (PMID:9210593)
GO_REF:0000107
(PMID:14687666)		 UniProt
RGD
GO_Central
Ensembl		 PMID:9210593 PMID:14687666 PMID:15938621 PMID:21724846 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pde3a phosphodiesterase 3A enables ISO
IBA		 (PMID:8155697)
(PMID:11420239)
GO_REF:0000033		 RGD
GO_Central		 PMID:8155697 PMID:11420239 GO_REF:0000033 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
G Pde3b phosphodiesterase 3B enables IDA
ISO
IBA
IEA		 (PMID:10454575)
GO_REF:0000033
PMID:9631240
(PMID:14592490)
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:10454575 PMID:14592490 PMID:12169692 PMID:9631240 GO_REF:0000033 GO_REF:0000107, RGD:729537, RGD:152995557 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334 		JBrowse link
G Pde4a phosphodiesterase 4A enables IEA
ISO
IBA
IDA		 GO_REF:0000003
(PMID:21670503)
(PMID:11267656)
GO_REF:0000033
GO_REF:0000116
PMID:21323643
(PMID:11306681)
(PMID:9677330)
(PMID:18095939)
(PMID:7888306)
PMID:8557632
UniProtKB:P06776|UniProtKB:P22434 (PMID:17404263), (PMID:8413254)		 UniProt
RGD
GO_Central
RHEA		 PMID:7888306 PMID:8413254 PMID:9677330 PMID:11267656 PMID:11306681 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000116, RGD:151356649, RGD:633604 NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961 		JBrowse link
G Pde4b phosphodiesterase 4B enables IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
GO_REF:0000116
UniProtKB:P06776|UniProtKB:P22434 (PMID:17404263), (PMID:8413254)
GO_REF:0000003		 GO_Central
Ensembl
RHEA
RGD
UniProt		 PMID:8413254 PMID:17404263 PMID:12441002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116, RGD:633623 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pde4c phosphodiesterase 4C enables IEA
IBA
ISO
ISS		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000107
(PMID:7843419)
GO_REF:0000024		 UniProt
GO_Central
Ensembl
RGD		 PMID:7843419 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640 		JBrowse link
G Pde4d phosphodiesterase 4D enables IEA
ISO
IBA		 GO_REF:0000003
(PMID:21670503)
(PMID:12121997)
UniProtKB:P06776|UniProtKB:P22434 (PMID:17404263), (PMID:20819076), (PMID:8413254), (PMID:9371713)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000116		 UniProt
RGD
GO_Central
Ensembl
RHEA		 PMID:8413254 PMID:9371713 PMID:12121997 PMID:17404263 PMID:20819076 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pde5a phosphodiesterase 5A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde6a phosphodiesterase 6A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:54,676,863...54,748,640
Ensembl chr18:54,676,863...54,748,816 		JBrowse link
G Pde6b phosphodiesterase 6B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:1,323,310...1,366,450
Ensembl chr14:1,323,310...1,366,450 		JBrowse link
G Pde6c phosphodiesterase 6C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:235,909,583...235,965,435
Ensembl chr 1:235,909,775...235,965,315 		JBrowse link
G Pde7a phosphodiesterase 7A enables IEA
ISO
IBA		 GO_REF:0000107
(PMID:11027622)
GO_REF:0000033
(PMID:8389765), (PMID:8943082), (PMID:9195912)		 Ensembl
RGD
GO_Central		 PMID:8389765 PMID:8943082 PMID:9195912 PMID:11027622 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681 		JBrowse link
G Pde7b phosphodiesterase 7B enables IDA
ISO
IBA		 (PMID:10872825)
GO_REF:0000033
(PMID:10814504), (PMID:10872825)		 RGD
GO_Central		 PMID:10814504 PMID:10872825 PMID:11772393 GO_REF:0000033, RGD:625534 NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900 		JBrowse link
G Pde7b_v3 phosphodiesterase 7B, variant 3 IDA RGD PMID:11772393 RGD:625534
G Pde8a phosphodiesterase 8A enables ISO
IBA		 (PMID:9618252)
(PMID:9671792)
GO_REF:0000033		 RGD
GO_Central		 PMID:9618252 PMID:9671792 GO_REF:0000033 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024 		JBrowse link
G Pde8b phosphodiesterase 8B enables ISO
IBA		 (PMID:9784418)
(PMID:21187369)
GO_REF:0000033		 RGD
GO_Central		 PMID:9784418 PMID:21187369 GO_REF:0000033 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
G Pde9a phosphodiesterase 9A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
3',5'-cyclic-GMP phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pde11a phosphodiesterase 11A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:60,913,562...61,297,154
Ensembl chr 3:60,913,562...61,297,158 		JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Pde1a phosphodiesterase 1A enables ISO (PMID:15901640) RGD PMID:15901640 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874 		JBrowse link
G Pde1b phosphodiesterase 1B enables ISO (PMID:14687666) RGD PMID:14687666 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580 		JBrowse link
G Pde1c phosphodiesterase 1C enables ISO
IEA		 (PMID:29860631)
(PMID:8810348)
GO_REF:0000116		 RGD
RHEA		 PMID:8810348 PMID:29860631 GO_REF:0000116 NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219 		JBrowse link
G Pde2a phosphodiesterase 2A enables IEA
ISO
IBA		 GO_REF:0000107
(PMID:21724846)
GO_REF:0000033
(PMID:15938621), (PMID:9210593)
(PMID:14687666)		 Ensembl
RGD
GO_Central		 PMID:9210593 PMID:14687666 PMID:15938621 PMID:21724846 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pde3a phosphodiesterase 3A enables ISO
IBA		 (PMID:8155697)
GO_REF:0000033		 RGD
GO_Central		 PMID:8155697 GO_REF:0000033 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
G Pde3b phosphodiesterase 3B enables IDA
IBA		 PMID:9631240
GO_REF:0000033		 GO_Central PMID:9631240 GO_REF:0000033, RGD:152995557 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334 		JBrowse link
G Pde4a phosphodiesterase 4A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961 		JBrowse link
G Pde4b phosphodiesterase 4B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pde4c phosphodiesterase 4C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640 		JBrowse link
G Pde4d phosphodiesterase 4D enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pde5a phosphodiesterase 5A enables TAS
IBA
ISO
IDA		 GO_REF:0000033
(PMID:14687666)		 GO_Central
RGD		 PMID:14687666 PMID:9370351 PMID:15100365 PMID:15623434 GO_REF:0000033, RGD:729513, RGD:1582531, RGD:1582533 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde6a phosphodiesterase 6A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:54,676,863...54,748,640
Ensembl chr18:54,676,863...54,748,816 		JBrowse link
G Pde6b phosphodiesterase 6B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:1,323,310...1,366,450
Ensembl chr14:1,323,310...1,366,450 		JBrowse link
G Pde6c phosphodiesterase 6C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:235,909,583...235,965,435
Ensembl chr 1:235,909,775...235,965,315 		JBrowse link
G Pde7a phosphodiesterase 7A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681 		JBrowse link
G Pde7b phosphodiesterase 7B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900 		JBrowse link
G Pde8a phosphodiesterase 8A enables ISO
IBA		 (PMID:9618252)
GO_REF:0000033		 RGD
GO_Central		 PMID:9618252 GO_REF:0000033 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024 		JBrowse link
G Pde8b phosphodiesterase 8B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
G Pde9a phosphodiesterase 9A enables ISO
IBA		 (PMID:25799991), (PMID:9624146)
(PMID:9624145)
GO_REF:0000033		 RGD
GO_Central		 PMID:9624145 PMID:9624146 PMID:25799991 GO_REF:0000033 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
3',5'-cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A enables IEA
ISO		 GO_REF:0000002
(PMID:10359840), (PMID:27058446)		 InterPro
RGD		 PMID:10359840 PMID:27058446 GO_REF:0000002 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pde1b phosphodiesterase 1B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580 		JBrowse link
G Pde1c phosphodiesterase 1C enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219 		JBrowse link
G Pde2a phosphodiesterase 2A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pde3a phosphodiesterase 3A enables ISO (PMID:27975297) RGD PMID:27975297 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
G Pde3b phosphodiesterase 3B enables ISO (PMID:8562305), (PMID:9102399)
(PMID:14592490)		 RGD PMID:8562305 PMID:9102399 PMID:14592490 NCBI chr 1:168,606,762...168,770,078
Ensembl chr 1:168,607,022...168,769,334 		JBrowse link
G Pde4a phosphodiesterase 4A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961 		JBrowse link
G Pde4b phosphodiesterase 4B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pde4c phosphodiesterase 4C enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640 		JBrowse link
G Pde4d phosphodiesterase 4D enables ISO
IEA		 (PMID:10518565)
GO_REF:0000002		 RGD
InterPro		 PMID:10518565 GO_REF:0000002 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pde5a phosphodiesterase 5A enables ISO
IEA		 (PMID:19474061)
GO_REF:0000107
GO_REF:0000002		 RGD
Ensembl
InterPro		 PMID:19474061 GO_REF:0000002 GO_REF:0000107 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde6h phosphodiesterase 6H enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:169,857,793...169,872,969
Ensembl chr 4:169,857,812...169,872,969 		JBrowse link
G Pde7a phosphodiesterase 7A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681 		JBrowse link
G Pde9a phosphodiesterase 9A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
3'-tyrosyl-DNA phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp1 tyrosyl-DNA phosphodiesterase 1 enables ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000107
(PMID:17118488), (PMID:17576665), (PMID:17948061), (PMID:22822062)		 UniProt
GO_Central
Ensembl
RGD		 PMID:17118488 PMID:17576665 PMID:17948061 PMID:22822062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:119,163,192...119,231,029
Ensembl chr 6:119,163,166...119,231,021 		JBrowse link
5'-tyrosyl-DNA phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp2 tyrosyl-DNA phosphodiesterase 2 enables ISO
IBA
IEA
ISS		 (PMID:19794497), (PMID:21030584), (PMID:22405347), (PMID:22822062)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024		 RGD
GO_Central
Ensembl
UniProt		 PMID:19794497 PMID:21030584 PMID:22405347 PMID:22822062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr17:40,228,943...40,240,337
Ensembl chr17:40,228,947...40,240,313 		JBrowse link
acid sphingomyelin phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd1 sphingomyelin phosphodiesterase 1 enables ISO
IBA		 (PMID:17303575), (PMID:18815062), (PMID:20807762), (PMID:8702487)
(PMID:16025116), (PMID:23046545), (PMID:35705808), (PMID:8702487)
GO_REF:0000033		 RGD
GO_Central		 PMID:8702487 PMID:16025116 PMID:17303575 PMID:18815062 PMID:20807762 More... GO_REF:0000033 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
alkylglycerophosphoethanolamine phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 enables IDA
ISO
IBA
IEA		 (PMID:15096095)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:15096095 PMID:24747415 GO_REF:0000033 GO_REF:0000107, RGD:9685414 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Gna11 G protein subunit alpha 11 enables IDA PMID:21812758 MGI PMID:21812758 RGD:10448949 NCBI chr 7:8,163,520...8,177,863
Ensembl chr 7:8,162,750...8,179,812 		JBrowse link
G Gnaq G protein subunit alpha q enables IDA PMID:21812758 MGI PMID:21812758 RGD:10448949 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Gnas GNAS complex locus enables IDA PMID:21812758 MGI PMID:21812758 RGD:10448949 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gnb1 G protein subunit beta 1 enables IDA PMID:21812758 MGI PMID:21812758 RGD:10448949 NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124 		JBrowse link
calcium-dependent phospholipase C activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plcg1 phospholipase C, gamma 1 enables IDA PMID:7531435 UniProt PMID:7531435 RGD:39458025 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Plch1 phospholipase C, eta 1 enables ISO (PMID:15702972) RGD PMID:15702972 NCBI chr 2:148,148,908...148,363,616
Ensembl chr 2:148,148,921...148,364,097 		JBrowse link
calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde11a phosphodiesterase 11A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:60,913,562...61,297,154
Ensembl chr 3:60,913,562...61,297,158 		JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003
G Pde1a phosphodiesterase 1A enables IMP
ISO
IBA		 (PMID:15901640)
GO_REF:0000033		 RGD
GO_Central		 PMID:15901640 PMID:16514069 GO_REF:0000033, RGD:2312521 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874 		JBrowse link
G Pde1b phosphodiesterase 1B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580 		JBrowse link
G Pde1c phosphodiesterase 1C enables IDA
IBA		 PMID:7568196
GO_REF:0000033		 GO_Central PMID:7568196 GO_REF:0000033, RGD:68318 NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219 		JBrowse link
G Pde5a phosphodiesterase 5A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde6g phosphodiesterase 6G enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:105,721,502...105,726,150
Ensembl chr10:105,721,682...105,726,719 		JBrowse link
G Pde6h phosphodiesterase 6H enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:169,857,793...169,872,969
Ensembl chr 4:169,857,812...169,872,969 		JBrowse link
G Pde9a phosphodiesterase 9A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde11a phosphodiesterase 11A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 3:60,913,562...61,297,154
Ensembl chr 3:60,913,562...61,297,158 		JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 enables IEA GO_REF:0000003 UniProt GO_REF:0000003
G Pde1a phosphodiesterase 1A enables ISO
IBA		 (PMID:8557689)
(PMID:15901640)
GO_REF:0000033		 RGD
GO_Central		 PMID:8557689 PMID:15901640 GO_REF:0000033 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874 		JBrowse link
G Pde1b phosphodiesterase 1B enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:9419816)		 UniProt
GO_Central
RGD		 PMID:9419816 GO_REF:0000024 GO_REF:0000033 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580 		JBrowse link
G Pde1c phosphodiesterase 1C enables IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
(PMID:8557689)
PMID:7568196		 GO_Central
Ensembl
RGD		 PMID:8557689 PMID:7568196 PMID:7568196 GO_REF:0000033 GO_REF:0000107, RGD:68318, RGD:68318 NCBI chr 4:85,300,858...85,777,948
Ensembl chr 4:85,300,858...85,863,219 		JBrowse link
G Pde5a phosphodiesterase 5A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde6g phosphodiesterase 6G enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:105,721,502...105,726,150
Ensembl chr10:105,721,682...105,726,719 		JBrowse link
G Pde6h phosphodiesterase 6H enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:169,857,793...169,872,969
Ensembl chr 4:169,857,812...169,872,969 		JBrowse link
G Pde9a phosphodiesterase 9A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
cardiolipin hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pld6 phospholipase D family, member 6 enables ISO (PMID:17028579), (PMID:21397848) RGD PMID:17028579 PMID:21397848 NCBI chr10:44,578,536...44,581,187
Ensembl chr10:44,577,675...44,581,077 		JBrowse link
cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A IDA RGD PMID:10583409 PMID:14604994 RGD:68285, RGD:2312517 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pde1b phosphodiesterase 1B IDA RGD PMID:1326532 RGD:633601 NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580 		JBrowse link
G Pde3a phosphodiesterase 3A TAS RGD PMID:11673261 RGD:731220 NCBI chr 4:174,172,804...174,443,944
Ensembl chr 4:174,172,868...174,438,274 		JBrowse link
G Pde4d phosphodiesterase 4D IDA RGD PMID:12834813 RGD:633641 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pde5a phosphodiesterase 5A enables ISO (PMID:12554648) RGD PMID:12554648 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde7a phosphodiesterase 7A IMP RGD PMID:17010967 RGD:2312520 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681 		JBrowse link
glycerophosphocholine cholinephosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 enables ISS
ISO
IEA		 GO_REF:0000024
(PMID:26888014)
GO_REF:0000003
(PMID:15788404)		 UniProt
RGD		 PMID:15788404 PMID:26888014 GO_REF:0000003 GO_REF:0000024 NCBI chr16:45,165,883...45,294,126
Ensembl chr16:45,169,178...45,294,077 		JBrowse link
glycerophosphocholine phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 enables ISO (PMID:18667693) RGD PMID:18667693 NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446 		JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 enables IEA
ISO
IBA		 GO_REF:0000107
(PMID:20576599)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:20576599 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:119,787,681...119,832,550
Ensembl chr 3:119,787,682...119,832,517 		JBrowse link
glycerophosphodiester phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 enables IBA
ISO		 GO_REF:0000033
(PMID:15788404)		 GO_Central
RGD		 PMID:15788404 GO_REF:0000033 NCBI chr16:45,165,883...45,294,126
Ensembl chr16:45,169,178...45,294,077 		JBrowse link
G Gde1 glycerophosphodiester phosphodiesterase 1 enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:21801852)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:21801852 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:173,016,984...173,032,396
Ensembl chr 1:172,954,394...173,032,429 		JBrowse link
G Gdpd2 glycerophosphodiester phosphodiesterase domain containing 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:65,826,273...65,835,361
Ensembl chr  X:65,826,574...65,835,361 		JBrowse link
G Gdpd4 glycerophosphodiester phosphodiesterase domain containing 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:152,233,516...152,342,329
Ensembl chr 1:152,233,499...152,342,158 		JBrowse link
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446 		JBrowse link
glycerophosphoinositol glycerophosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gde1 glycerophosphodiester phosphodiesterase 1 enables ISS
ISO		 GO_REF:0000024
(PMID:18227059), (PMID:25596343)		 UniProt
RGD		 PMID:18227059 PMID:25596343 GO_REF:0000024 NCBI chr 1:173,016,984...173,032,396
Ensembl chr 1:172,954,394...173,032,429 		JBrowse link
glycosylphosphatidylinositol phospholipase D activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 enables TAS
ISO
IBA
IEA
IDA		 (PMID:15946906), (PMID:17720976), (PMID:1833386), (PMID:9716655)
GO_REF:0000033
GO_REF:0000002
(PMID:15907827), (PMID:17720976), (PMID:1833386), (PMID:19135435), (PMID:2760042)
GO_REF:0000003
PMID:1849823		 RGD
GO_Central
InterPro
UniProt		 PMID:1833386 PMID:2760042 PMID:9716655 PMID:15907827 PMID:15946906 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033, RGD:632912, RGD:8553426 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939 		JBrowse link
GPI-mannose ethanolamine phosphate phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mppe1 metallophosphoesterase 1 enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr18:60,763,418...60,781,553
Ensembl chr18:60,763,419...60,781,553 		JBrowse link
N-acylphosphatidylethanolamine-specific phospholipase D activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Napepld N-acyl phosphatidylethanolamine phospholipase D enables ISS
ISO
IEA
IBA		 GO_REF:0000024
MGI:3695401 (PMID:14634025), (PMID:15760304), (PMID:16605240), (PMID:16818490)
GO_REF:0000003
GO_REF:0000033
GO_REF:0000107
(PMID:25684574), (PMID:27571266)
GO_REF:0000002		 UniProt
RGD
GO_Central
Ensembl
InterPro		 PMID:14634025 PMID:15760304 PMID:16605240 PMID:16818490 PMID:25684574 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748 		JBrowse link
neutral sphingomyelin phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 enables IEA
ISO		 GO_REF:0000107
(PMID:16025116), (PMID:23046545), (PMID:23973266), (PMID:25287744)		 Ensembl
RGD		 PMID:16025116 PMID:23046545 PMID:23973266 PMID:25287744 GO_REF:0000107 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
phosphatidylinositol phospholipase C activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 enables ISO (PMID:10734056) RGD PMID:10734056 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 enables ISO (PMID:10734056) RGD PMID:10734056 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr1l1 chemokine (C-C motif) receptor 1-like 1 enables IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 8:123,589,997...123,613,767
Ensembl chr 8:123,589,621...123,612,687 		JBrowse link
G Plcb1 phospholipase C beta 1 enables IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:9762362)
GO_REF:0000002
GO_REF:0000104
(PMID:9188725)
GO_REF:0000003
GO_REF:0000116		 GO_Central
RGD
InterPro
UniProt
RHEA		 PMID:9188725 PMID:9762362 PMID:15159145 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116, RGD:1582559 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcb2 phospholipase C, beta 2 enables IMP
IBA
IEA
ISO
ISS		 PMID:9860142
GO_REF:0000033
GO_REF:0000104
(PMID:8519600)
(PMID:9188725)
GO_REF:0000116
GO_REF:0000003
GO_REF:0000024		 GO_Central
UniProt
RGD
RHEA		 PMID:8519600 PMID:9188725 PMID:9860142 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116, RGD:729588 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Plcb3 phospholipase C beta 3 enables IDA
IBA
ISO
IEA		 PMID:8454637
GO_REF:0000033
(PMID:9188725)
(PMID:20966218), (PMID:37991948), (PMID:9188725)
GO_REF:0000104
GO_REF:0000003		 GO_Central
RGD
UniProt		 PMID:9188725 PMID:20966218 PMID:37991948 PMID:8454637 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104, RGD:61699 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Plcb4 phospholipase C, beta 4 enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000104
GO_REF:0000116		 UniProt
GO_Central
RHEA		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Plcd1 phospholipase C, delta 1 enables IDA
IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
GO_REF:0000003
(PMID:9188725)		 GO_Central
Ensembl
InterPro
UniProt
RGD		 PMID:9188725 PMID:9287165 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107, RGD:2301017 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186 		JBrowse link
G Plcd3 phospholipase C, delta 3 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:88,026,707...88,048,080
Ensembl chr10:88,026,740...88,048,296 		JBrowse link
G Plcd4 phospholipase C, delta 4 enables IDA
IBA
IEA		 GO_REF:0000033
GO_REF:0000002		 GO_Central
InterPro
RGD		 PMID:8550568 GO_REF:0000002 GO_REF:0000033, RGD:633664 NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453 		JBrowse link
G Plce1 phospholipase C, epsilon 1 enables IDA
IBA
IEA
ISO
ISS		 GO_REF:0000033
GO_REF:0000107
GO_REF:0000003
(PMID:11022047), (PMID:11022048)
GO_REF:0000024		 GO_Central
Ensembl
UniProt
RGD		 PMID:11022047 PMID:11022048 PMID:11179219 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107, RGD:68714 NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438 		JBrowse link
G Plcg1 phospholipase C, gamma 1 enables IEA
IBA
ISO
TAS
IDA		 GO_REF:0000003
GO_REF:0000033
(PMID:8615781)
GO_REF:0000117
Reactome:R-RNO-622387
Reactome:R-RNO-182061
PMID:7531435
(PMID:2550068)		 UniProt
GO_Central
RGD
Reactome		 PMID:2550068 PMID:8615781 PMID:7531435 GO_REF:0000003 GO_REF:0000033 GO_REF:0000117 Reactome:R-RNO-182061 Reactome:R-RNO-622387, RGD:39458025 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Plcg2 phospholipase C, gamma 2 enables IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:8615781)
GO_REF:0000116
GO_REF:0000117
(PMID:11606584), (PMID:12181444), (PMID:32514138)
GO_REF:0000003		 GO_Central
RGD
RHEA
UniProt		 PMID:8615781 PMID:11606584 PMID:12181444 PMID:32514138 PMID:2557343 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117, RGD:69934 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930 		JBrowse link
G Plch1 phospholipase C, eta 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:148,148,908...148,363,616
Ensembl chr 2:148,148,921...148,364,097 		JBrowse link
G Plch2 phospholipase C, eta 2 enables ISO
IBA		 (PMID:18361507)
GO_REF:0000033		 RGD
GO_Central		 PMID:18361507 GO_REF:0000033 NCBI chr 5:165,544,209...165,613,769
Ensembl chr 5:165,544,200...165,602,356 		JBrowse link
G Plcl1 phospholipase C-like 1 enables IEA
IBA		 GO_REF:0000003
GO_REF:0000033
GO_REF:0000116		 UniProt
GO_Central
RHEA		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782 		JBrowse link
G Plcl2 phospholipase C-like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:3,292,564...3,477,009
Ensembl chr 9:3,292,695...3,477,009 		JBrowse link
G Plcz1 phospholipase C, zeta 1 enables ISO
IBA		 (PMID:28270562)
GO_REF:0000033
(PMID:14701816)		 RGD
GO_Central		 PMID:14701816 PMID:28270562 GO_REF:0000033 NCBI chr 4:172,873,110...172,929,191
Ensembl chr 4:172,873,112...172,928,358 		JBrowse link
phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO
IEA		 (PMID:1627644)
GO_REF:0000107		 RGD
Ensembl		 PMID:1627644 GO_REF:0000107 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785 		JBrowse link
phosphodiesterase I activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 enables IDA
ISO
IBA
ISS		 MGI:6402836 (PMID:15096095), (PMID:1647027), (PMID:24770645)
GO_REF:0000033
GO_REF:0000024
(PMID:27467858)		 RGD
GO_Central
UniProt		 PMID:1647027 PMID:15096095 PMID:24770645 PMID:27467858 PMID:17187902 GO_REF:0000024 GO_REF:0000033, RGD:13204714 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 enables IMP
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:17307740 GO_REF:0000033, RGD:9685416 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 enables TAS
ISO
ISS		 (PMID:11342463)
GO_REF:0000024		 RGD
UniProt		 PMID:11342463 PMID:9096610 GO_REF:0000024, RGD:1299489 NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041 		JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:117,915,323...117,945,044
Ensembl chr 1:117,917,099...117,944,977 		JBrowse link
phospholipase C activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plcb2 phospholipase C, beta 2 IMP RGD PMID:9860142 RGD:729588 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Plcb3 phospholipase C beta 3 TAS RGD PMID:8454637 RGD:61699 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228 		JBrowse link
G Plce1 phospholipase C, epsilon 1 enables ISS
ISO		 GO_REF:0000024
(PMID:11022047)		 UniProt
RGD		 PMID:11022047 GO_REF:0000024 NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438 		JBrowse link
G Plcg1 phospholipase C, gamma 1 enables ISO (PMID:20510673), (PMID:37422272)
(PMID:28004780)		 RGD PMID:20510673 PMID:28004780 PMID:37422272 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330 		JBrowse link
G Plch2 phospholipase C, eta 2 enables ISO (PMID:15899900) RGD PMID:15899900 NCBI chr 5:165,544,209...165,613,769
Ensembl chr 5:165,544,200...165,602,356 		JBrowse link
G Plcz1 phospholipase C, zeta 1 enables ISO (PMID:12117804) RGD PMID:12117804 NCBI chr 4:172,873,110...172,929,191
Ensembl chr 4:172,873,112...172,928,358 		JBrowse link
phospholipase D activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Fam83b family with sequence similarity 83, member B NOT|enables ISO (PMID:22886302) RGD PMID:22886302 NCBI chr 8:77,287,351...77,363,795
Ensembl chr 8:77,287,351...77,363,795 		JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 enables ISO (PMID:2760042) RGD PMID:2760042 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:12511545 RGD:628519 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Pld1 phospholipase D1 enables IDA
IBA
ISO
IEA		 GO_REF:0000033
(PMID:25936805)
GO_REF:0000003
GO_REF:0000116		 GO_Central
RGD
UniProt
RHEA		 PMID:25936805 PMID:12431982 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116, RGD:729596 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pld2 phospholipase D2 enables IDA
ISO
IBA
IEA		 (PMID:21085684)
GO_REF:0000033
GO_REF:0000104
GO_REF:0000116
GO_REF:0000003		 RGD
GO_Central
UniProt
RHEA		 PMID:21085684 PMID:9111050 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116, RGD:729617 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Pld3 phospholipase D family, member 3 NOT|enables ISO (PMID:9813063) RGD PMID:9813063 NCBI chr 1:82,821,863...82,844,280
Ensembl chr 1:82,821,875...82,844,072 		JBrowse link
G Pld4 phospholipase D family, member 4 NOT|enables ISO (PMID:21085684) RGD PMID:21085684 NCBI chr 6:131,818,860...131,827,457
Ensembl chr 6:131,818,860...131,826,376 		JBrowse link
protein adenylylhydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ficd FIC domain protein adenylyltransferase enables ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:36136088)		 UniProt
Ensembl
RGD		 PMID:36136088 GO_REF:0000024 GO_REF:0000107 NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070 		JBrowse link
sphingomyelin phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 enables ISO
IDA
ISS		 (PMID:12671034), (PMID:12885774), (PMID:16255717), (PMID:28292932)
(PMID:21177474)
GO_REF:0000024		 RGD
UniProt		 PMID:12671034 PMID:12885774 PMID:16255717 PMID:21177474 PMID:28292932 More... GO_REF:0000024, RGD:25671389 NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 enables ISO (PMID:21098024), (PMID:22573858), (PMID:33163980), (PMID:9660788) RGD PMID:9660788 PMID:21098024 PMID:22573858 PMID:33163980 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 enables IDA
ISO
IBA
IEA		 MGI:2183203 (PMID:15764706), (PMID:9520418)
GO_REF:0000033
GO_REF:0000107
(PMID:10608884), (PMID:14741383)		 RGD
GO_Central
Ensembl		 PMID:9520418 PMID:10608884 PMID:14741383 PMID:15764706 PMID:10832103 GO_REF:0000033 GO_REF:0000107, RGD:634108 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 enables ISS
ISO
IBA
IEA		 GO_REF:0000024
MGI:3575405 (PMID:10823942), (PMID:15764706), (PMID:21550973)
GO_REF:0000033
GO_REF:0000002
(PMID:14741383)		 UniProt
RGD
GO_Central
InterPro		 PMID:10823942 PMID:14741383 PMID:15764706 PMID:21550973 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Smpd4 sphingomyelin phosphodiesterase 4 enables ISO (PMID:25180167) RGD PMID:25180167 NCBI chr11:83,362,534...83,386,257
Ensembl chr11:83,362,534...83,386,250 		JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 enables IBA
ISO		 GO_REF:0000033
(PMID:20378533), (PMID:21183079)		 GO_Central
RGD		 PMID:20378533 PMID:21183079 GO_REF:0000033 NCBI chr 7:108,009,182...108,011,767
Ensembl chr 7:108,009,173...108,011,763 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A NOT|enables ISO
ISS		 (PMID:26783088)
GO_REF:0000024		 RGD
UniProt		 PMID:26783088 GO_REF:0000024 NCBI chr20:37,132,592...37,155,567
Ensembl chr20:37,132,592...37,155,567 		JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:144,944,618...144,966,703
Ensembl chr 5:144,944,636...144,966,720 		JBrowse link
sphingomyelin phosphodiesterase D activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd4 sphingomyelin phosphodiesterase 4 enables ISO
IBA		 (PMID:16517606), (PMID:25180167)
GO_REF:0000033		 RGD
GO_Central		 PMID:16517606 PMID:25180167 GO_REF:0000033 NCBI chr11:83,362,534...83,386,257
Ensembl chr11:83,362,534...83,386,250 		JBrowse link
tyrosyl-RNA phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp2 tyrosyl-DNA phosphodiesterase 2 enables ISO
IEA		 (PMID:22908287)
GO_REF:0000107		 RGD
Ensembl		 PMID:22908287 GO_REF:0000107 NCBI chr17:40,228,943...40,240,337
Ensembl chr17:40,228,947...40,240,313 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20634
    catalytic activity 6032
      hydrolase activity 2585
        hydrolase activity, acting on ester bonds 814
          phosphoric ester hydrolase activity 371
            phosphoric diester hydrolase activity 88
              7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity 0
              CMP-N-acylneuraminate phosphodiesterase activity 0
              GPI-mannose ethanolamine phosphate phosphodiesterase activity 1
              N-acylphosphatidylethanolamine-specific phospholipase D activity 1
              RNA 2',3'-cyclic 3'-phosphodiesterase activity 0
              [acyl-carrier-protein] phosphodiesterase activity 0
              alkylglycerophosphoethanolamine phosphodiesterase activity 5
              cardiolipin hydrolase activity 1
              cyclic-guanylate-specific phosphodiesterase activity 0
              cyclic-nucleotide phosphodiesterase activity + 28
              dolichylphosphate-glucose phosphodiesterase activity 0
              dolichylphosphate-mannose phosphodiesterase activity 0
              glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity 0
              glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity 0
              glycerophosphocholine cholinephosphodiesterase activity 1
              glycerophosphocholine phosphodiesterase activity 2
              glycerophosphodiester phosphodiesterase activity 5
              glycerophosphoinositol glycerophosphodiesterase activity 1
              glycerophosphoinositol inositolphosphodiesterase activity 0
              phosphodiesterase I activity 4
              phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands 1
              phospholipase C activity + 18
              phospholipase D activity + 8
              phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase activity 0
              phosphoribosyl 1,2-cyclic phosphate phosphodiesterase activity 0
              protein adenylylhydrolase activity 1
              serine-ethanolaminephosphate phosphodiesterase activity 0
              sphingomyelin phosphodiesterase D activity 1
              sphingomyelin phosphodiesterase activity + 8
              tyrosyl-DNA phosphodiesterase activity + 2
              tyrosyl-RNA phosphodiesterase activity 1
paths to the root