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ONTOLOGY REPORT - ANNOTATIONS

Term:phosphoric diester hydrolase activity
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Accession:GO:0008081 term browser browse the term
Definition:Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
Synonyms:narrow_synonym: phosphodiesterase
 alt_id: GO:0004434;   GO:0016792
 xref: EC:3.1.4;   reactome:R-HSA-5693578 "TDP1 and TDP2 process unligatable DSB ends"


show annotations for term's descendants           Sort by:
phosphoric diester hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO
IEA
IBA 		(PMID:11478795), (PMID:18973764)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:11478795 PMID:18973764 GO_REF:0000033 GO_REF:0000107 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329 		JBrowse link
G Apex2 apurinic/apyrimidinic endodeoxyribonuclease 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:22,914,943...22,937,713
Ensembl chr  X:22,914,944...22,936,011 		JBrowse link
G Apex2l1 APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:71,378,722...71,380,608
Ensembl chr14:71,333,409...71,381,068 		JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 enables ISO (PMID:12533192), (PMID:27406238) RGD PMID:12533192 PMID:27406238 NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:22,518,069...22,583,044 		JBrowse link
G Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 enables ISO
IEA
ISS 		(PMID:15788404)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:15788404 GO_REF:0000024 GO_REF:0000107 NCBI chr16:51,898,557...52,026,789
Ensembl chr16:51,898,557...52,026,728 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 enables ISO
IBA
IDA 		(PMID:16255717)
GO_REF:0000033 		RGD
GO_Central		 PMID:16255717 PMID:16255717 GO_REF:0000033, RGD:25671389 NCBI chr10:104,740,763...104,745,760
Ensembl chr10:104,740,763...104,745,760 		JBrowse link
G ENSRNOG00000063954 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Gde1 glycerophosphodiester phosphodiesterase 1 enables IEA
ISO 		GO_REF:0000002
(PMID:25596343)
GO_REF:0000107 		InterPro
RGD
Ensembl		 PMID:25596343 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:182,451,182...182,466,569
Ensembl chr 1:182,451,184...182,466,772 		JBrowse link
G Gdpd1 glycerophosphodiester phosphodiesterase domain containing 1 enables ISO
IEA
IBA
ISS 		(PMID:27637550)
(PMID:25596343), (PMID:27637550)
GO_REF:0000002
GO_REF:0000107
GO_REF:0000033
GO_REF:0000117
GO_REF:0000024 		RGD
InterPro
Ensembl
GO_Central
UniProt		 PMID:25596343 PMID:27637550 GO_REF:0000002 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr10:72,318,716...72,381,143
Ensembl chr10:72,337,778...72,381,120 		JBrowse link
G Gdpd2 glycerophosphodiester phosphodiesterase domain containing 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:69,866,395...69,875,419
Ensembl chr  X:69,866,799...69,875,414 		JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 enables ISO
IEA
IBA 		(PMID:27637550)
GO_REF:0000117
GO_REF:0000002
GO_REF:0000033 		RGD
UniProt
InterPro
GO_Central		 PMID:27637550 GO_REF:0000002 GO_REF:0000033 GO_REF:0000117 NCBI chr 1:190,804,053...190,813,609
Ensembl chr 1:190,803,993...190,813,606 		JBrowse link
G Gdpd4 glycerophosphodiester phosphodiesterase domain containing 4 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:161,644,731...161,753,622
Ensembl chr 1:161,644,759...161,753,618 		JBrowse link
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:163,091,844...163,173,559
Ensembl chr 1:163,091,833...163,173,559 		JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:140,240,574...140,285,469
Ensembl chr 3:140,240,575...140,285,372 		JBrowse link
G Mppe1 metallophosphoesterase 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:63,033,329...63,051,461
Ensembl chr18:63,027,281...63,051,461 		JBrowse link
G Mpped2 metallophosphoesterase domain containing 2 enables IDA PMID:21824479 UniProt PMID:21824479 RGD:14397554 NCBI chr 3:113,635,614...113,810,307
Ensembl chr 3:113,635,407...113,811,783 		JBrowse link
G Pde10a phosphodiesterase 10A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051 		JBrowse link
G Pde11a phosphodiesterase 11A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:81,320,822...81,704,397
Ensembl chr 3:81,320,822...81,680,612 		JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002
G Pde1a phosphodiesterase 1A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:85,154,184...85,519,212 		JBrowse link
G Pde1b phosphodiesterase 1B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033 		JBrowse link
G Pde1c phosphodiesterase 1C enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:86,629,074...87,108,147
Ensembl chr 4:86,626,282...87,193,259 		JBrowse link
G Pde2a phosphodiesterase 2A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:165,235,623...165,327,466 		JBrowse link
G Pde3a phosphodiesterase 3A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:175,904,077...176,169,270 		JBrowse link
G Pde3b phosphodiesterase 3B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:178,041,207...178,204,503
Ensembl chr 1:178,041,207...178,204,503 		JBrowse link
G Pde4a phosphodiesterase 4A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:27,966,996...28,046,924 		JBrowse link
G Pde4b phosphodiesterase 4B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267 		JBrowse link
G Pde4c phosphodiesterase 4C enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:18,724,703...18,745,528
Ensembl chr16:18,725,674...18,744,037 		JBrowse link
G Pde4d phosphodiesterase 4D enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569 		JBrowse link
G Pde5a phosphodiesterase 5A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298 		JBrowse link
G Pde6a phosphodiesterase 6A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:56,947,249...57,019,015
Ensembl chr18:56,947,249...57,019,015 		JBrowse link
G Pde6b phosphodiesterase 6B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:1,468,302...1,511,435
Ensembl chr14:1,468,302...1,511,435 		JBrowse link
G Pde6c phosphodiesterase 6C enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:245,322,015...245,377,874
Ensembl chr 1:245,322,015...245,377,852 		JBrowse link
G Pde7a phosphodiesterase 7A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:103,631,655...103,723,057
Ensembl chr 2:103,634,594...103,722,890 		JBrowse link
G Pde7b phosphodiesterase 7B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:16,994,072...17,312,828
Ensembl chr 1:17,002,286...17,312,456 		JBrowse link
G Pde8a phosphodiesterase 8A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:144,575,203...144,698,216
Ensembl chr 1:144,575,428...144,698,215 		JBrowse link
G Pde8b phosphodiesterase 8B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:28,009,841...28,244,050
Ensembl chr 2:28,011,359...28,244,327 		JBrowse link
G Pde9a phosphodiesterase 9A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:9,471,136...9,564,286
Ensembl chr20:9,471,167...9,564,286 		JBrowse link
G Plcb1 phospholipase C beta 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646 		JBrowse link
G Plcb2 phospholipase C, beta 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:126,134,925...126,158,303
Ensembl chr 3:126,138,736...126,158,221 		JBrowse link
G Plcb3 phospholipase C beta 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:213,572,499...213,589,585
Ensembl chr 1:213,574,166...213,589,583 		JBrowse link
G Plcb4 phospholipase C, beta 4 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:143,405,950...143,775,113 		JBrowse link
G Plcd1 phospholipase C, delta 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:127,672,955...127,695,939
Ensembl chr 8:127,672,980...127,695,939 		JBrowse link
G Plcd3 phospholipase C, delta 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:88,526,802...88,548,116
Ensembl chr10:88,526,802...88,548,069 		JBrowse link
G Plcd4 phospholipase C, delta 4 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:83,564,616...83,613,742
Ensembl chr 9:83,564,606...83,606,454 		JBrowse link
G Plce1 phospholipase C, epsilon 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:245,655,855...245,964,966
Ensembl chr 1:245,657,080...245,963,828 		JBrowse link
G Plcg1 phospholipase C, gamma 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Plcg2 phospholipase C, gamma 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr19:62,456,196...62,592,684
Ensembl chr19:62,453,259...62,592,684 		JBrowse link
G Plch1 phospholipase C, eta 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:150,298,547...150,514,120
Ensembl chr 2:150,299,075...150,464,019 		JBrowse link
G Plch2 phospholipase C, eta 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:170,826,543...170,885,012
Ensembl chr 5:170,826,543...170,885,152 		JBrowse link
G Plcl1 phospholipase C-like 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:64,395,976...64,733,171
Ensembl chr 9:64,361,520...64,733,171 		JBrowse link
G Plcl2 phospholipase C-like 2 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:3,529,117...3,713,712
Ensembl chr 9:3,529,841...3,713,712 		JBrowse link
G Plcxd1 phosphatidylinositol-specific phospholipase C, X domain containing 1 enables IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr12:52,238,450...52,241,884
Ensembl chr12:52,238,623...52,241,865 		JBrowse link
G Plcxd2 phosphatidylinositol-specific phospholipase C, X domain containing 2 enables IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr11:68,263,626...68,315,962
Ensembl chr11:68,263,566...68,316,327 		JBrowse link
G Plcxd3 phosphatidylinositol-specific phospholipase C, X domain containing 3 enables IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 2:55,294,597...55,473,968
Ensembl chr 2:55,294,613...55,474,220 		JBrowse link
G Plcz1 phospholipase C, zeta 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:174,604,281...174,660,368
Ensembl chr 4:174,604,281...174,660,290 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 enables ISO
IEA 		(PMID:10608884), (PMID:14741383)
GO_REF:0000107 		RGD
Ensembl		 PMID:10608884 PMID:14741383 GO_REF:0000107 NCBI chr20:46,568,627...46,571,741
Ensembl chr20:46,568,629...46,571,741 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 enables ISO
IEA 		(PMID:14741383)
GO_REF:0000107
GO_REF:0000002 		RGD
Ensembl
InterPro		 PMID:14741383 GO_REF:0000002 GO_REF:0000107 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:51,072,209...51,085,936 		JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:109,889,532...109,892,428
Ensembl chr 7:109,889,875...109,893,384 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A enables ISS
IEA
ISO
IBA 		GO_REF:0000024
GO_REF:0000107
(PMID:26783088), (PMID:28104755), (PMID:37890481)
GO_REF:0000033 		UniProt
Ensembl
RGD
GO_Central		 PMID:26783088 PMID:28104755 PMID:37890481 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:37,679,004...37,701,979
Ensembl chr20:37,678,964...37,704,260 		JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B enables ISO
IEA
IBA 		(PMID:26095358)
(PMID:26095358), (PMID:27687724)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:26095358 PMID:27687724 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 5:150,228,607...150,250,688
Ensembl chr 5:150,228,611...150,250,688 		JBrowse link
G Tdp1 tyrosyl-DNA phosphodiesterase 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:124,892,821...124,960,646
Ensembl chr 6:124,881,574...124,960,642 		JBrowse link
2',3'-cyclic-nucleotide 2'-phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adprm ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:52,231,085...52,243,637
Ensembl chr10:52,230,233...52,243,569 		JBrowse link
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase enables TAS
ISO
IEA
IBA
IDA 		(PMID:12590258)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000116
GO_REF:0000003
GO_REF:0000002
GO_REF:0000033
GO_REF:0000104 		RGD
UniProt
Ensembl
RHEA
InterPro
GO_Central		 PMID:12590258 PMID:11842207 PMID:19357238 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:1298767, RGD:6480491 NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063 		JBrowse link
3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde3a phosphodiesterase 3A enables ISO
IEA 		(PMID:8155697)
GO_REF:0000107 		RGD
Ensembl		 PMID:8155697 GO_REF:0000107 NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:175,904,077...176,169,270 		JBrowse link
3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A enables ISO
IBA
ISS 		(PMID:19689430)
GO_REF:0000033
GO_REF:0000024 		RGD
GO_Central
UniProt		 PMID:19689430 PMID:19689430 GO_REF:0000024 GO_REF:0000033, RGD:12790642 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051 		JBrowse link
G Pde11a phosphodiesterase 11A enables ISO
IBA
IEA
ISS 		(PMID:19689430)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024 		RGD
GO_Central
Ensembl
UniProt		 PMID:19689430 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:81,320,822...81,704,397
Ensembl chr 3:81,320,822...81,680,612 		JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 enables ISS
IBA 		GO_REF:0000024
GO_REF:0000033 		UniProt
GO_Central		 GO_REF:0000024 GO_REF:0000033
G Pde2a phosphodiesterase 2A enables ISO
IBA 		(PMID:17329248), (PMID:19689430)
(PMID:15210692)
GO_REF:0000033 		RGD
GO_Central		 PMID:15210692 PMID:17329248 PMID:19689430 GO_REF:0000033 NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:165,235,623...165,327,466 		JBrowse link
3',5'-cyclic-AMP phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:22,518,069...22,583,044 		JBrowse link
G Pde10a phosphodiesterase 10A enables IBA
IEA 		GO_REF:0000033
GO_REF:0000116 		GO_Central
RHEA		 GO_REF:0000033 GO_REF:0000116 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051 		JBrowse link
G Pde11a phosphodiesterase 11A enables IBA
IEA 		GO_REF:0000033
GO_REF:0000003
GO_REF:0000116 		GO_Central
UniProt
RHEA		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr 3:81,320,822...81,704,397
Ensembl chr 3:81,320,822...81,680,612 		JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 enables IBA
IEA 		GO_REF:0000033
GO_REF:0000003
GO_REF:0000116 		GO_Central
UniProt
RHEA		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116
G Pde1a phosphodiesterase 1A enables IEA
ISO 		GO_REF:0000116
(PMID:15901640)
GO_REF:0000107 		RHEA
RGD
Ensembl		 PMID:15901640 GO_REF:0000107 GO_REF:0000116 NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:85,154,184...85,519,212 		JBrowse link
G Pde1b phosphodiesterase 1B enables IDA
IEA
ISO 		PMID:1326532
GO_REF:0000107
GO_REF:0000116
(PMID:14687666), (PMID:8855339) 		Ensembl
RHEA
RGD		 PMID:8855339 PMID:14687666 PMID:1326532 GO_REF:0000107 GO_REF:0000116, RGD:633601 NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033 		JBrowse link
G Pde1c phosphodiesterase 1C enables ISO
IEA 		(PMID:29860631)
(PMID:8810348)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000116 		RGD
UniProt
Ensembl
RHEA		 PMID:8810348 PMID:29860631 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117 NCBI chr 4:86,629,074...87,108,147
Ensembl chr 4:86,626,282...87,193,259 		JBrowse link
G Pde2a phosphodiesterase 2A enables ISS
ISO
IEA
IBA 		GO_REF:0000024
(PMID:21724846)
GO_REF:0000116
GO_REF:0000033
(PMID:15938621), (PMID:9210593)
(PMID:14687666) 		UniProt
RGD
RHEA
GO_Central		 PMID:9210593 PMID:14687666 PMID:15938621 PMID:21724846 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:165,235,623...165,327,466 		JBrowse link
G Pde3a phosphodiesterase 3A enables ISO
IEA
IBA 		(PMID:8155697)
(PMID:11420239)
GO_REF:0000107
GO_REF:0000116
GO_REF:0000033 		RGD
Ensembl
RHEA
GO_Central		 PMID:8155697 PMID:11420239 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:175,904,077...176,169,270 		JBrowse link
G Pde3b phosphodiesterase 3B enables IDA
ISO
IEA
IBA 		(PMID:10454575)
GO_REF:0000116
GO_REF:0000033
PMID:9631240
(PMID:14592490) 		RGD
RHEA
GO_Central		 PMID:10454575 PMID:14592490 PMID:12169692 PMID:9631240 GO_REF:0000033 GO_REF:0000116, RGD:729537, RGD:152995557 NCBI chr 1:178,041,207...178,204,503
Ensembl chr 1:178,041,207...178,204,503 		JBrowse link
G Pde4a phosphodiesterase 4A enables IEA
ISO
IBA
IDA 		GO_REF:0000003
(PMID:21670503)
(PMID:11267656)
GO_REF:0000107
GO_REF:0000033
GO_REF:0000116
PMID:21323643
(PMID:11306681)
(PMID:9677330)
(PMID:18095939)
(PMID:7888306)
PMID:8557632
UniProtKB:P06776|UniProtKB:P22434 (PMID:17404263), (PMID:8413254) 		UniProt
RGD
Ensembl
GO_Central
RHEA		 PMID:7888306 PMID:8413254 PMID:9677330 PMID:11267656 PMID:11306681 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116, RGD:151356649, RGD:633604 NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:27,966,996...28,046,924 		JBrowse link
G Pde4b phosphodiesterase 4B enables IDA
ISO
IBA
IEA 		(PMID:21670503)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000116
UniProtKB:P06776|UniProtKB:P22434 (PMID:17404263), (PMID:8413254)
GO_REF:0000003 		RGD
GO_Central
Ensembl
RHEA
UniProt		 PMID:8413254 PMID:17404263 PMID:21670503 PMID:12441002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116, RGD:633623 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267 		JBrowse link
G Pde4c phosphodiesterase 4C enables IEA
IBA
ISO
ISS 		GO_REF:0000003
GO_REF:0000116
GO_REF:0000033
GO_REF:0000107
(PMID:7843419)
GO_REF:0000024 		UniProt
RHEA
GO_Central
Ensembl
RGD		 PMID:7843419 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr16:18,724,703...18,745,528
Ensembl chr16:18,725,674...18,744,037 		JBrowse link
G Pde4d phosphodiesterase 4D enables IEA
ISO
IBA 		GO_REF:0000003
(PMID:21670503)
GO_REF:0000033
(PMID:12121997)
UniProtKB:P06776|UniProtKB:P22434 (PMID:17404263), (PMID:20819076), (PMID:8413254), (PMID:9371713)
GO_REF:0000107
GO_REF:0000116 		UniProt
RGD
GO_Central
Ensembl
RHEA		 PMID:8413254 PMID:9371713 PMID:12121997 PMID:17404263 PMID:20819076 More... GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569 		JBrowse link
G Pde5a phosphodiesterase 5A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298 		JBrowse link
G Pde6a phosphodiesterase 6A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:56,947,249...57,019,015
Ensembl chr18:56,947,249...57,019,015 		JBrowse link
G Pde6b phosphodiesterase 6B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:1,468,302...1,511,435
Ensembl chr14:1,468,302...1,511,435 		JBrowse link
G Pde6c phosphodiesterase 6C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:245,322,015...245,377,874
Ensembl chr 1:245,322,015...245,377,852 		JBrowse link
G Pde7a phosphodiesterase 7A enables ISO
IEA
IBA 		(PMID:8389765), (PMID:8943082), (PMID:9195912)
(PMID:11027622)
GO_REF:0000003
GO_REF:0000116
GO_REF:0000033 		RGD
UniProt
RHEA
GO_Central		 PMID:8389765 PMID:8943082 PMID:9195912 PMID:11027622 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr 2:103,631,655...103,723,057
Ensembl chr 2:103,634,594...103,722,890 		JBrowse link
G Pde7b phosphodiesterase 7B enables ISO
IEA 		(PMID:10814504), (PMID:10872825)
(PMID:10872825)
GO_REF:0000003
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:10814504 PMID:10872825 GO_REF:0000003 GO_REF:0000107 NCBI chr 1:16,994,072...17,312,828
Ensembl chr 1:17,002,286...17,312,456 		JBrowse link
G Pde7b_v3 phosphodiesterase 7B, variant 3 IDA RGD PMID:11772393 RGD:625534
G Pde8a phosphodiesterase 8A enables ISO
IEA
IBA 		(PMID:9618252)
(PMID:9671792)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:9618252 PMID:9671792 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 1:144,575,203...144,698,216
Ensembl chr 1:144,575,428...144,698,215 		JBrowse link
G Pde8b phosphodiesterase 8B enables ISO
IEA
IBA 		(PMID:9784418)
(PMID:21187369)
GO_REF:0000003
GO_REF:0000117
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:9784418 PMID:21187369 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 2:28,009,841...28,244,050
Ensembl chr 2:28,011,359...28,244,327 		JBrowse link
G Pde9a phosphodiesterase 9A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr20:9,471,136...9,564,286
Ensembl chr20:9,471,167...9,564,286 		JBrowse link
3',5'-cyclic-GMP phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A enables IBA
IEA 		GO_REF:0000033
GO_REF:0000116 		GO_Central
RHEA		 GO_REF:0000033 GO_REF:0000116 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051 		JBrowse link
G Pde11a phosphodiesterase 11A enables IBA
IEA 		GO_REF:0000033
GO_REF:0000003
GO_REF:0000116 		GO_Central
UniProt
RHEA		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr 3:81,320,822...81,704,397
Ensembl chr 3:81,320,822...81,680,612 		JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 enables IBA
IEA 		GO_REF:0000033
GO_REF:0000003
GO_REF:0000116 		GO_Central
UniProt
RHEA		 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116
G Pde1a phosphodiesterase 1A enables IEA
ISO 		GO_REF:0000107
(PMID:15901640)
GO_REF:0000116 		Ensembl
RGD
RHEA		 PMID:15901640 GO_REF:0000107 GO_REF:0000116 NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:85,154,184...85,519,212 		JBrowse link
G Pde1b phosphodiesterase 1B enables ISO
IEA 		(PMID:14687666)
GO_REF:0000116
GO_REF:0000107 		RGD
RHEA
Ensembl		 PMID:14687666 GO_REF:0000107 GO_REF:0000116 NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033 		JBrowse link
G Pde1c phosphodiesterase 1C enables ISO
IEA 		(PMID:29860631)
(PMID:8810348)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000116 		RGD
UniProt
Ensembl
RHEA		 PMID:8810348 PMID:29860631 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117 NCBI chr 4:86,629,074...87,108,147
Ensembl chr 4:86,626,282...87,193,259 		JBrowse link
G Pde2a phosphodiesterase 2A enables ISO
IEA
IBA 		(PMID:14687666)
(PMID:21724846)
GO_REF:0000116
GO_REF:0000033
(PMID:15938621), (PMID:9210593) 		RGD
RHEA
GO_Central		 PMID:9210593 PMID:14687666 PMID:15938621 PMID:21724846 GO_REF:0000033 GO_REF:0000116 NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:165,235,623...165,327,466 		JBrowse link
G Pde3a phosphodiesterase 3A enables ISO
IEA
IBA 		(PMID:8155697)
GO_REF:0000116
GO_REF:0000107
GO_REF:0000033 		RGD
RHEA
Ensembl
GO_Central		 PMID:8155697 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:175,904,077...176,169,270 		JBrowse link
G Pde3b phosphodiesterase 3B enables IDA
IEA
IBA 		PMID:9631240
GO_REF:0000116
GO_REF:0000033 		RHEA
GO_Central		 PMID:9631240 GO_REF:0000033 GO_REF:0000116, RGD:152995557 NCBI chr 1:178,041,207...178,204,503
Ensembl chr 1:178,041,207...178,204,503 		JBrowse link
G Pde4a phosphodiesterase 4A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:27,966,996...28,046,924 		JBrowse link
G Pde4b phosphodiesterase 4B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267 		JBrowse link
G Pde4c phosphodiesterase 4C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr16:18,724,703...18,745,528
Ensembl chr16:18,725,674...18,744,037 		JBrowse link
G Pde4d phosphodiesterase 4D enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569 		JBrowse link
G Pde5a phosphodiesterase 5A enables TAS
IEA
IBA
ISO
IDA 		GO_REF:0000116
GO_REF:0000003
GO_REF:0000033
(PMID:14687666) 		RHEA
UniProt
GO_Central
RGD		 PMID:14687666 PMID:9370351 PMID:15623434 PMID:15100365 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116, RGD:729513, RGD:1582533, RGD:1582531 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298 		JBrowse link
G Pde6a phosphodiesterase 6A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:56,947,249...57,019,015
Ensembl chr18:56,947,249...57,019,015 		JBrowse link
G Pde6b phosphodiesterase 6B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:1,468,302...1,511,435
Ensembl chr14:1,468,302...1,511,435 		JBrowse link
G Pde6c phosphodiesterase 6C enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:245,322,015...245,377,874
Ensembl chr 1:245,322,015...245,377,852 		JBrowse link
G Pde6g phosphodiesterase 6G enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:106,219,849...106,224,496
Ensembl chr10:106,219,849...106,224,496 		JBrowse link
G Pde6h phosphodiesterase 6H enables IEA GO_REF:0000003
GO_REF:0000116 		UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 4:171,588,896...171,604,142
Ensembl chr 4:171,588,974...171,604,249 		JBrowse link
G Pde7a phosphodiesterase 7A enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:103,631,655...103,723,057
Ensembl chr 2:103,634,594...103,722,890 		JBrowse link
G Pde8a phosphodiesterase 8A enables ISO
IEA
IBA 		(PMID:9618252)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:9618252 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:144,575,203...144,698,216
Ensembl chr 1:144,575,428...144,698,215 		JBrowse link
G Pde8b phosphodiesterase 8B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 2:28,009,841...28,244,050
Ensembl chr 2:28,011,359...28,244,327 		JBrowse link
G Pde9a phosphodiesterase 9A enables ISO
IEA
IBA 		(PMID:25799991), (PMID:9624146)
(PMID:9624145)
GO_REF:0000003
GO_REF:0000107
GO_REF:0000116
GO_REF:0000033 		RGD
UniProt
Ensembl
RHEA
GO_Central		 PMID:9624145 PMID:9624146 PMID:25799991 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr20:9,471,136...9,564,286
Ensembl chr20:9,471,167...9,564,286 		JBrowse link
3',5'-cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A enables IEA
ISO 		GO_REF:0000002
(PMID:10359840), (PMID:27058446)
GO_REF:0000003
GO_REF:0000116 		InterPro
RGD
UniProt
RHEA		 PMID:10359840 PMID:27058446 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051 		JBrowse link
G Pde11a phosphodiesterase 11A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:81,320,822...81,704,397
Ensembl chr 3:81,320,822...81,680,612 		JBrowse link
G Pde11a_v3 phosphodiesterase 11A, variant 3 enables IEA GO_REF:0000002 InterPro GO_REF:0000002
G Pde1a phosphodiesterase 1A enables IEA GO_REF:0000002
GO_REF:0000003
GO_REF:0000116 		InterPro
UniProt
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:85,154,184...85,519,212 		JBrowse link
G Pde1b phosphodiesterase 1B enables IEA GO_REF:0000002
GO_REF:0000116
GO_REF:0000003 		InterPro
RHEA
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033 		JBrowse link
G Pde1c phosphodiesterase 1C enables IEA GO_REF:0000002
GO_REF:0000003
GO_REF:0000116 		InterPro
UniProt
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 NCBI chr 4:86,629,074...87,108,147
Ensembl chr 4:86,626,282...87,193,259 		JBrowse link
G Pde2a phosphodiesterase 2A enables IEA GO_REF:0000002
GO_REF:0000116
GO_REF:0000003 		InterPro
RHEA
UniProt		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:165,235,623...165,327,466 		JBrowse link
G Pde3a phosphodiesterase 3A enables ISO
IEA 		(PMID:27975297)
GO_REF:0000002
GO_REF:0000116
GO_REF:0000003
GO_REF:0000107 		RGD
InterPro
RHEA
UniProt
Ensembl		 PMID:27975297 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:175,904,077...176,169,270 		JBrowse link
G Pde3b phosphodiesterase 3B enables ISO
IEA 		(PMID:8562305), (PMID:9102399)
GO_REF:0000003
GO_REF:0000116
GO_REF:0000002
(PMID:14592490) 		RGD
UniProt
RHEA
InterPro		 PMID:8562305 PMID:9102399 PMID:14592490 GO_REF:0000002 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:178,041,207...178,204,503
Ensembl chr 1:178,041,207...178,204,503 		JBrowse link
G Pde4a phosphodiesterase 4A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:27,966,996...28,046,924 		JBrowse link
G Pde4b phosphodiesterase 4B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267 		JBrowse link
G Pde4c phosphodiesterase 4C enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr16:18,724,703...18,745,528
Ensembl chr16:18,725,674...18,744,037 		JBrowse link
G Pde4d phosphodiesterase 4D enables IEA
ISO 		GO_REF:0000002
(PMID:10518565) 		InterPro
RGD		 PMID:10518565 GO_REF:0000002 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569 		JBrowse link
G Pde5a phosphodiesterase 5A enables IEA
ISO 		GO_REF:0000002
(PMID:19474061)
GO_REF:0000117 		InterPro
RGD
UniProt		 PMID:19474061 GO_REF:0000002 GO_REF:0000117 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298 		JBrowse link
G Pde6a phosphodiesterase 6A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:56,947,249...57,019,015
Ensembl chr18:56,947,249...57,019,015 		JBrowse link
G Pde6b phosphodiesterase 6B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:1,468,302...1,511,435
Ensembl chr14:1,468,302...1,511,435 		JBrowse link
G Pde6c phosphodiesterase 6C enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:245,322,015...245,377,874
Ensembl chr 1:245,322,015...245,377,852 		JBrowse link
G Pde6g phosphodiesterase 6G enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:106,219,849...106,224,496
Ensembl chr10:106,219,849...106,224,496 		JBrowse link
G Pde6h phosphodiesterase 6H enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:171,588,896...171,604,142
Ensembl chr 4:171,588,974...171,604,249 		JBrowse link
G Pde7a phosphodiesterase 7A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:103,631,655...103,723,057
Ensembl chr 2:103,634,594...103,722,890 		JBrowse link
G Pde7b phosphodiesterase 7B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:16,994,072...17,312,828
Ensembl chr 1:17,002,286...17,312,456 		JBrowse link
G Pde8a phosphodiesterase 8A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:144,575,203...144,698,216
Ensembl chr 1:144,575,428...144,698,215 		JBrowse link
G Pde8b phosphodiesterase 8B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:28,009,841...28,244,050
Ensembl chr 2:28,011,359...28,244,327 		JBrowse link
G Pde9a phosphodiesterase 9A enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:9,471,136...9,564,286
Ensembl chr20:9,471,167...9,564,286 		JBrowse link
3'-tyrosyl-DNA phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp1 tyrosyl-DNA phosphodiesterase 1 enables ISS
IBA
ISO 		GO_REF:0000024
GO_REF:0000033
(PMID:17118488), (PMID:17576665), (PMID:17948061), (PMID:22822062) 		UniProt
GO_Central
RGD		 PMID:17118488 PMID:17576665 PMID:17948061 PMID:22822062 GO_REF:0000024 GO_REF:0000033 NCBI chr 6:124,892,821...124,960,646
Ensembl chr 6:124,881,574...124,960,642 		JBrowse link
5'-tyrosyl-DNA phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp2 tyrosyl-DNA phosphodiesterase 2 enables ISO
IBA
IEA
ISS 		(PMID:19794497), (PMID:21030584), (PMID:22405347), (PMID:22822062)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024 		RGD
GO_Central
Ensembl
UniProt		 PMID:19794497 PMID:21030584 PMID:22405347 PMID:22822062 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr17:40,656,969...40,668,362
Ensembl chr17:40,656,971...40,668,288 		JBrowse link
acid sphingomyelin phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd1 sphingomyelin phosphodiesterase 1 enables ISO
IEA
IBA 		(PMID:17303575), (PMID:18815062), (PMID:20807762), (PMID:8702487)
(PMID:16025116), (PMID:23046545), (PMID:8702487)
(PMID:35705808)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:8702487 PMID:16025116 PMID:17303575 PMID:18815062 PMID:20807762 More... GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:169,304,708...169,308,614 		JBrowse link
alkylglycerophosphoethanolamine phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 enables IDA
ISO
IBA
IEA 		(PMID:15096095)
GO_REF:0000033
GO_REF:0000117
GO_REF:0000003
GO_REF:0000116 		RGD
GO_Central
UniProt
RHEA		 PMID:15096095 PMID:24747415 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117, RGD:9685414 NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957 		JBrowse link
G ENSRNOG00000063937 enables IEA GO_REF:0000117 UniProt GO_REF:0000117
G Gna11 G protein subunit alpha 11 enables IDA
IEA 		PMID:21812758
GO_REF:0000117 		UniProt PMID:21812758 GO_REF:0000117, RGD:10448949 NCBI chr 7:8,814,285...8,828,628
Ensembl chr 7:8,814,327...8,830,558 		JBrowse link
G Gna14 G protein subunit alpha 14 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 1:223,141,802...223,324,210
Ensembl chr 1:223,141,802...223,324,210 		JBrowse link
G Gnaq G protein subunit alpha q enables IDA
IEA 		PMID:21812758
GO_REF:0000117 		UniProt PMID:21812758 GO_REF:0000117, RGD:10448949 NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:222,852,097...223,126,742 		JBrowse link
G Gnas GNAS complex locus enables IDA PMID:21812758 MGI PMID:21812758 RGD:10448949 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536 		JBrowse link
G Gnb1 G protein subunit beta 1 enables IDA PMID:21812758 MGI PMID:21812758 RGD:10448949 NCBI chr 5:171,357,778...171,424,489
Ensembl chr 5:171,357,797...171,424,488 		JBrowse link
calcium-dependent phospholipase C activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plcg1 phospholipase C, gamma 1 enables IDA PMID:7531435 UniProt PMID:7531435 RGD:39458025 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Plch1 phospholipase C, eta 1 enables ISO
IEA 		(PMID:15702972)
GO_REF:0000002 		RGD
InterPro		 PMID:15702972 GO_REF:0000002 NCBI chr 2:150,298,547...150,514,120
Ensembl chr 2:150,299,075...150,464,019 		JBrowse link
calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde1a phosphodiesterase 1A enables IMP
ISO
IEA
IBA 		(PMID:15901640)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:15901640 PMID:16514069 GO_REF:0000033 GO_REF:0000107, RGD:2312521 NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:85,154,184...85,519,212 		JBrowse link
G Pde1b phosphodiesterase 1B enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033 		JBrowse link
G Pde1c phosphodiesterase 1C enables IDA
IBA 		PMID:7568196
GO_REF:0000033 		GO_Central PMID:7568196 GO_REF:0000033, RGD:68318 NCBI chr 4:86,629,074...87,108,147
Ensembl chr 4:86,626,282...87,193,259 		JBrowse link
calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde1a phosphodiesterase 1A enables ISO
IEA
IBA 		(PMID:8557689)
(PMID:15901640)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:8557689 PMID:15901640 GO_REF:0000033 GO_REF:0000107 GO_REF:0000117 NCBI chr 3:85,152,053...85,432,289
Ensembl chr 3:85,154,184...85,519,212 		JBrowse link
G Pde1b phosphodiesterase 1B enables ISS
IEA
IBA
ISO 		GO_REF:0000024
GO_REF:0000107
GO_REF:0000033
(PMID:9419816) 		UniProt
Ensembl
GO_Central
RGD		 PMID:9419816 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033 		JBrowse link
G Pde1c phosphodiesterase 1C enables IDA
IBA
IEA
ISO 		GO_REF:0000033
GO_REF:0000107
(PMID:8557689)
PMID:7568196 		GO_Central
Ensembl
RGD		 PMID:8557689 PMID:7568196 PMID:7568196 GO_REF:0000033 GO_REF:0000107, RGD:68318, RGD:68318 NCBI chr 4:86,629,074...87,108,147
Ensembl chr 4:86,626,282...87,193,259 		JBrowse link
cardiolipin hydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pld6 phospholipase D family, member 6 enables ISO (PMID:17028579), (PMID:21397848) RGD PMID:17028579 PMID:21397848 NCBI chr10:45,078,081...45,080,732
Ensembl chr10:45,077,080...45,087,160 		JBrowse link
cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A enables IDA
IEA 		GO_REF:0000117 UniProt
RGD		 PMID:10583409 PMID:14604994 GO_REF:0000117, RGD:68285, RGD:2312517 NCBI chr 1:54,313,343...54,765,668
Ensembl chr 1:54,317,732...54,764,051 		JBrowse link
G Pde1b phosphodiesterase 1B IDA RGD PMID:1326532 RGD:633601 NCBI chr 7:136,505,834...136,533,034
Ensembl chr 7:136,505,689...136,533,033 		JBrowse link
G Pde3a phosphodiesterase 3A enables TAS
IEA 		GO_REF:0000117 UniProt
RGD		 PMID:11673261 GO_REF:0000117, RGD:731220 NCBI chr 4:175,904,276...176,170,531
Ensembl chr 4:175,904,077...176,169,270 		JBrowse link
G Pde3b phosphodiesterase 3B enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 1:178,041,207...178,204,503
Ensembl chr 1:178,041,207...178,204,503 		JBrowse link
G Pde4a phosphodiesterase 4A IDA RGD PMID:12810716 RGD:632260 NCBI chr 8:27,966,978...28,029,721
Ensembl chr 8:27,966,996...28,046,924 		JBrowse link
G Pde4a_v2 phosphodiesterase 4A, variant 2 IDA RGD PMID:12810716 RGD:632260
G Pde4d phosphodiesterase 4D IDA RGD PMID:12834813 RGD:633641 NCBI chr 2:41,748,337...43,262,567
Ensembl chr 2:42,110,838...43,262,569 		JBrowse link
G Pde5a phosphodiesterase 5A enables ISO (PMID:12554648) RGD PMID:12554648 NCBI chr 2:213,542,822...213,687,638
Ensembl chr 2:213,542,923...213,684,298 		JBrowse link
G Pde7a phosphodiesterase 7A enables IMP
IEA 		GO_REF:0000117 UniProt
RGD		 PMID:17010967 GO_REF:0000117, RGD:2312520 NCBI chr 2:103,631,655...103,723,057
Ensembl chr 2:103,634,594...103,722,890 		JBrowse link
G Pde7b phosphodiesterase 7B enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 1:16,994,072...17,312,828
Ensembl chr 1:17,002,286...17,312,456 		JBrowse link
glycerophosphocholine cholinephosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 enables ISS
ISO
IEA 		GO_REF:0000024
(PMID:26888014)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000116
GO_REF:0000003
(PMID:15788404) 		UniProt
RGD
Ensembl
RHEA		 PMID:15788404 PMID:26888014 GO_REF:0000003 GO_REF:0000024 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117 NCBI chr16:51,898,557...52,026,789
Ensembl chr16:51,898,557...52,026,728 		JBrowse link
glycerophosphocholine phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 enables ISO (PMID:18667693) RGD PMID:18667693 NCBI chr 1:163,091,844...163,173,559
Ensembl chr 1:163,091,833...163,173,559 		JBrowse link
G Gpcpd1 glycerophosphocholine phosphodiesterase 1 enables IBA
ISO
IEA 		GO_REF:0000033
(PMID:20576599)
GO_REF:0000116
GO_REF:0000003 		GO_Central
RGD
RHEA
UniProt		 PMID:20576599 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr 3:140,240,574...140,285,469
Ensembl chr 3:140,240,575...140,285,372 		JBrowse link
glycerophosphodiester phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 enables IBA
ISO
IEA 		GO_REF:0000033
(PMID:15788404)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:15788404 GO_REF:0000033 GO_REF:0000107 NCBI chr16:51,898,557...52,026,789
Ensembl chr16:51,898,557...52,026,728 		JBrowse link
G Gde1 glycerophosphodiester phosphodiesterase 1 enables ISS
ISO
IEA
IBA 		GO_REF:0000024
(PMID:21801852)
GO_REF:0000107
GO_REF:0000033 		UniProt
RGD
Ensembl
GO_Central		 PMID:21801852 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:182,451,182...182,466,569
Ensembl chr 1:182,451,184...182,466,772 		JBrowse link
G Gdpd2 glycerophosphodiester phosphodiesterase domain containing 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:69,866,395...69,875,419
Ensembl chr  X:69,866,799...69,875,414 		JBrowse link
G Gdpd4 glycerophosphodiester phosphodiesterase domain containing 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:161,644,731...161,753,622
Ensembl chr 1:161,644,759...161,753,618 		JBrowse link
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:163,091,844...163,173,559
Ensembl chr 1:163,091,833...163,173,559 		JBrowse link
glycerophosphoinositol glycerophosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gde1 glycerophosphodiester phosphodiesterase 1 enables ISS
ISO
IEA 		GO_REF:0000024
(PMID:18227059), (PMID:25596343)
GO_REF:0000116
GO_REF:0000003
GO_REF:0000107 		UniProt
RGD
RHEA
Ensembl		 PMID:18227059 PMID:25596343 GO_REF:0000003 GO_REF:0000024 GO_REF:0000107 GO_REF:0000116 NCBI chr 1:182,451,182...182,466,569
Ensembl chr 1:182,451,184...182,466,772 		JBrowse link
glycosylphosphatidylinositol phospholipase D activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 enables TAS
ISO
IEA
IBA
IDA 		(PMID:15946906), (PMID:17720976), (PMID:9716655)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000116
GO_REF:0000033
GO_REF:0000002
(PMID:15907827), (PMID:17720976), (PMID:1833386), (PMID:19135435), (PMID:2760042)
GO_REF:0000003
PMID:1849823 		RGD
UniProt
Ensembl
RHEA
GO_Central
InterPro		 PMID:1833386 PMID:2760042 PMID:9716655 PMID:15907827 PMID:15946906 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:632912, RGD:8553426 NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,512,660...40,554,975 		JBrowse link
GPI-mannose ethanolamine phosphate phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mppe1 metallophosphoesterase 1 enables ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr18:63,033,329...63,051,461
Ensembl chr18:63,027,281...63,051,461 		JBrowse link
N-acylphosphatidylethanolamine-specific phospholipase D activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Napepld N-acyl phosphatidylethanolamine phospholipase D enables ISS
ISO
IEA
IBA 		GO_REF:0000024
MGI:3695401 (PMID:14634025), (PMID:15760304), (PMID:16605240), (PMID:16818490)
GO_REF:0000116
GO_REF:0000003
GO_REF:0000033
GO_REF:0000002
(PMID:25684574), (PMID:27571266) 		UniProt
RGD
RHEA
GO_Central
InterPro		 PMID:14634025 PMID:15760304 PMID:16605240 PMID:16818490 PMID:25684574 More... GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000116 NCBI chr 4:14,251,591...14,291,010
Ensembl chr 4:14,252,692...14,291,014 		JBrowse link
neutral sphingomyelin phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd3 sphingomyelin phosphodiesterase 3 enables IEA
ISO 		GO_REF:0000107
(PMID:16025116), (PMID:23046545), (PMID:23973266), (PMID:25287744) 		Ensembl
RGD		 PMID:16025116 PMID:23046545 PMID:23973266 PMID:25287744 GO_REF:0000107 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:51,072,209...51,085,936 		JBrowse link
phosphatidylcholine phospholipase C activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd1 sphingomyelin phosphodiesterase 1 enables IEA
ISO 		GO_REF:0000003
(PMID:25339683)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:25339683 GO_REF:0000003 GO_REF:0000107 NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:169,304,708...169,308,614 		JBrowse link
phosphatidylinositol phospholipase C activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plcb1 phospholipase C beta 1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646 		JBrowse link
G Plcb2 phospholipase C, beta 2 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 3:126,134,925...126,158,303
Ensembl chr 3:126,138,736...126,158,221 		JBrowse link
G Plcb3 phospholipase C beta 3 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 1:213,572,499...213,589,585
Ensembl chr 1:213,574,166...213,589,583 		JBrowse link
G Plcb4 phospholipase C, beta 4 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:143,405,950...143,775,113 		JBrowse link
G Plcd1 phospholipase C, delta 1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 8:127,672,955...127,695,939
Ensembl chr 8:127,672,980...127,695,939 		JBrowse link
G Plcd4 phospholipase C, delta 4 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 9:83,564,616...83,613,742
Ensembl chr 9:83,564,606...83,606,454 		JBrowse link
G Plcg1 phospholipase C, gamma 1 enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
phosphatidylinositol-4,5-bisphosphate phospholipase C activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 enables ISO (PMID:10734056) RGD PMID:10734056 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Ccr1 C-C motif chemokine receptor 1 enables ISO (PMID:10734056) RGD PMID:10734056 NCBI chr 8:132,433,711...132,439,266
Ensembl chr 8:132,431,592...132,439,374 		JBrowse link
G Plcb1 phospholipase C beta 1 enables IDA
ISO
IEA
IBA 		(PMID:9762362)
GO_REF:0000117
GO_REF:0000107
GO_REF:0000033
GO_REF:0000002
GO_REF:0000104
(PMID:9188725)
GO_REF:0000003
GO_REF:0000116 		RGD
UniProt
Ensembl
GO_Central
InterPro
RHEA		 PMID:9188725 PMID:9762362 PMID:15159145 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:1582559 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646 		JBrowse link
G Plcb2 phospholipase C, beta 2 enables IMP
IEA
IBA
ISO
ISS 		PMID:9860142
GO_REF:0000107
GO_REF:0000002
GO_REF:0000033
GO_REF:0000104
(PMID:8519600)
(PMID:9188725)
GO_REF:0000116
GO_REF:0000003
GO_REF:0000024 		Ensembl
InterPro
GO_Central
UniProt
RGD
RHEA		 PMID:8519600 PMID:9188725 PMID:9860142 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116, RGD:729588 NCBI chr 3:126,134,925...126,158,303
Ensembl chr 3:126,138,736...126,158,221 		JBrowse link
G Plcb3 phospholipase C beta 3 enables IDA
ISO
IEA
IBA 		PMID:8454637
(PMID:9188725)
GO_REF:0000117
GO_REF:0000002
GO_REF:0000116
GO_REF:0000107
GO_REF:0000033
(PMID:20966218), (PMID:37991948), (PMID:9188725)
GO_REF:0000104
GO_REF:0000003 		RGD
UniProt
InterPro
RHEA
Ensembl
GO_Central		 PMID:9188725 PMID:20966218 PMID:37991948 PMID:8454637 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:61699 NCBI chr 1:213,572,499...213,589,585
Ensembl chr 1:213,574,166...213,589,583 		JBrowse link
G Plcb4 phospholipase C, beta 4 enables IEA
IBA 		GO_REF:0000003
GO_REF:0000002
GO_REF:0000033
GO_REF:0000104
GO_REF:0000116 		UniProt
InterPro
GO_Central
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116 NCBI chr 3:143,405,721...143,775,129
Ensembl chr 3:143,405,950...143,775,113 		JBrowse link
G Plcd1 phospholipase C, delta 1 enables IDA
IEA
IBA
ISO 		GO_REF:0000117
GO_REF:0000116
GO_REF:0000033
GO_REF:0000107
GO_REF:0000002
GO_REF:0000003
(PMID:9188725) 		UniProt
RHEA
GO_Central
Ensembl
InterPro
RGD		 PMID:9188725 PMID:9287165 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:2301017 NCBI chr 8:127,672,955...127,695,939
Ensembl chr 8:127,672,980...127,695,939 		JBrowse link
G Plcd3 phospholipase C, delta 3 enables IBA
IEA 		GO_REF:0000033
GO_REF:0000117
GO_REF:0000116
GO_REF:0000003
GO_REF:0000002 		GO_Central
UniProt
RHEA
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117 NCBI chr10:88,526,802...88,548,116
Ensembl chr10:88,526,802...88,548,069 		JBrowse link
G Plcd4 phospholipase C, delta 4 enables IDA
IEA
IBA 		GO_REF:0000117
GO_REF:0000003
GO_REF:0000116
GO_REF:0000033
GO_REF:0000002 		UniProt
RHEA
GO_Central
InterPro
RGD		 PMID:8550568 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 GO_REF:0000117, RGD:633664 NCBI chr 9:83,564,616...83,613,742
Ensembl chr 9:83,564,606...83,606,454 		JBrowse link
G Plce1 phospholipase C, epsilon 1 enables IDA
IEA
IBA
ISO
ISS 		GO_REF:0000117
GO_REF:0000116
GO_REF:0000002
GO_REF:0000033
GO_REF:0000107
GO_REF:0000003
(PMID:11022047), (PMID:11022048)
GO_REF:0000024 		UniProt
RHEA
InterPro
GO_Central
Ensembl
RGD		 PMID:11022047 PMID:11022048 PMID:11179219 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:68714 NCBI chr 1:245,655,855...245,964,966
Ensembl chr 1:245,657,080...245,963,828 		JBrowse link
G Plcg1 phospholipase C, gamma 1 enables IEA
ISO
IBA
TAS
IDA 		GO_REF:0000003
(PMID:8615781)
GO_REF:0000116
GO_REF:0000107
GO_REF:0000104
GO_REF:0000002
GO_REF:0000033
GO_REF:0000117
Reactome:R-RNO-622387
Reactome:R-RNO-182061
PMID:7531435
(PMID:2550068) 		UniProt
RGD
RHEA
Ensembl
InterPro
GO_Central
Reactome		 PMID:2550068 PMID:8615781 PMID:7531435 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117 Reactome:R-RNO-182061 Reactome:R-RNO-622387, RGD:39458025 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Plcg2 phospholipase C, gamma 2 enables IDA
ISO
IEA
IBA 		(PMID:8615781)
GO_REF:0000104
GO_REF:0000002
GO_REF:0000033
GO_REF:0000116
GO_REF:0000117
(PMID:11606584), (PMID:12181444), (PMID:32514138)
GO_REF:0000003 		RGD
UniProt
InterPro
GO_Central
RHEA		 PMID:8615781 PMID:11606584 PMID:12181444 PMID:32514138 PMID:2557343 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000116 GO_REF:0000117, RGD:69934 NCBI chr19:62,456,196...62,592,684
Ensembl chr19:62,453,259...62,592,684 		JBrowse link
G Plch1 phospholipase C, eta 1 enables IBA
IEA 		GO_REF:0000033
GO_REF:0000116
GO_REF:0000003
GO_REF:0000002 		GO_Central
RHEA
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr 2:150,298,547...150,514,120
Ensembl chr 2:150,299,075...150,464,019 		JBrowse link
G Plch2 phospholipase C, eta 2 enables ISO
IEA 		(PMID:18361507)
GO_REF:0000003
GO_REF:0000116
GO_REF:0000107
GO_REF:0000002 		RGD
UniProt
RHEA
Ensembl
InterPro		 PMID:18361507 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 GO_REF:0000116 NCBI chr 5:170,826,543...170,885,012
Ensembl chr 5:170,826,543...170,885,152 		JBrowse link
G Plcl1 phospholipase C-like 1 enables IEA
IBA 		GO_REF:0000003
GO_REF:0000002
GO_REF:0000033
GO_REF:0000116 		UniProt
InterPro
GO_Central
RHEA		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000116 NCBI chr 9:64,395,976...64,733,171
Ensembl chr 9:64,361,520...64,733,171 		JBrowse link
G Plcl2 phospholipase C-like 2 enables IBA
IEA 		GO_REF:0000033
GO_REF:0000003
GO_REF:0000002 		GO_Central
UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 NCBI chr 9:3,529,117...3,713,712
Ensembl chr 9:3,529,841...3,713,712 		JBrowse link
G Plcz1 phospholipase C, zeta 1 enables ISO
IEA
IBA 		(PMID:28270562)
(PMID:14701816)
GO_REF:0000107
GO_REF:0000002
GO_REF:0000116
GO_REF:0000003
GO_REF:0000033 		RGD
Ensembl
InterPro
RHEA
UniProt
GO_Central		 PMID:14701816 PMID:28270562 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr 4:174,604,281...174,660,368
Ensembl chr 4:174,604,281...174,660,290 		JBrowse link
phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 enables ISO
IEA 		(PMID:1627644)
GO_REF:0000107 		RGD
Ensembl		 PMID:1627644 GO_REF:0000107 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329 		JBrowse link
phosphodiesterase I activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 enables IDA
ISO
IEA
IBA
ISS 		MGI:6402836 (PMID:15096095), (PMID:1647027), (PMID:24770645)
GO_REF:0000117
GO_REF:0000003
GO_REF:0000033
GO_REF:0000024
(PMID:27467858) 		RGD
UniProt
GO_Central		 PMID:1647027 PMID:15096095 PMID:24770645 PMID:27467858 PMID:17187902 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000117, RGD:13204714 NCBI chr 1:22,518,051...22,583,044
Ensembl chr 1:22,518,069...22,583,044 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 enables IMP
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:17307740 GO_REF:0000033, RGD:9685416 NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957 		JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 enables TAS
IEA
ISO
ISS 		GO_REF:0000003
(PMID:11342463)
GO_REF:0000024 		UniProt
RGD		 PMID:11342463 PMID:9096610 GO_REF:0000003 GO_REF:0000024, RGD:1299489 NCBI chr 1:22,382,717...22,454,324
Ensembl chr 1:22,382,964...22,454,314 		JBrowse link
G Fan1 FANCD2 and FANCI associated nuclease 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:127,327,098...127,356,807
Ensembl chr 1:127,330,016...127,356,400 		JBrowse link
phospholipase C activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plcb2 phospholipase C, beta 2 enables IMP
IEA 		GO_REF:0000002 InterPro
RGD		 PMID:9860142 GO_REF:0000002, RGD:729588 NCBI chr 3:126,134,925...126,158,303
Ensembl chr 3:126,138,736...126,158,221 		JBrowse link
G Plcb3 phospholipase C beta 3 TAS RGD PMID:8454637 RGD:61699 NCBI chr 1:213,572,499...213,589,585
Ensembl chr 1:213,574,166...213,589,583 		JBrowse link
G Plcd1 phospholipase C, delta 1 enables IEA
ISO 		GO_REF:0000107
(PMID:23892088) 		Ensembl
RGD		 PMID:23892088 GO_REF:0000107 NCBI chr 8:127,672,955...127,695,939
Ensembl chr 8:127,672,980...127,695,939 		JBrowse link
G Plce1 phospholipase C, epsilon 1 enables ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000107
(PMID:11022047) 		UniProt
Ensembl
RGD		 PMID:11022047 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:245,655,855...245,964,966
Ensembl chr 1:245,657,080...245,963,828 		JBrowse link
G Plcg1 phospholipase C, gamma 1 enables ISO
IEA 		(PMID:20510673), (PMID:37422272)
(PMID:28004780)
GO_REF:0000107 		RGD
Ensembl		 PMID:20510673 PMID:28004780 PMID:37422272 GO_REF:0000107 NCBI chr 3:169,805,299...169,836,040
Ensembl chr 3:169,804,846...169,836,050 		JBrowse link
G Plch2 phospholipase C, eta 2 enables IEA
ISO 		GO_REF:0000002
(PMID:15899900)
GO_REF:0000117
GO_REF:0000107 		InterPro
RGD
UniProt
Ensembl		 PMID:15899900 GO_REF:0000002 GO_REF:0000107 GO_REF:0000117 NCBI chr 5:170,826,543...170,885,012
Ensembl chr 5:170,826,543...170,885,152 		JBrowse link
G Plcz1 phospholipase C, zeta 1 enables IEA
ISO 		GO_REF:0000107
(PMID:12117804) 		Ensembl
RGD		 PMID:12117804 GO_REF:0000107 NCBI chr 4:174,604,281...174,660,368
Ensembl chr 4:174,604,281...174,660,290 		JBrowse link
phospholipase D activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 enables IEA GO_REF:0000116
GO_REF:0000003 		RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:88,092,140...88,214,957 		JBrowse link
G Fam83b family with sequence similarity 83, member B NOT|enables ISO (PMID:22886302) RGD PMID:22886302 NCBI chr 8:86,167,778...86,244,222
Ensembl chr 8:86,167,778...86,244,222 		JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 enables ISO
IEA 		(PMID:2760042)
GO_REF:0000107 		RGD
Ensembl		 PMID:2760042 GO_REF:0000107 NCBI chr17:40,512,659...40,560,483
Ensembl chr17:40,512,660...40,554,975 		JBrowse link
G Hmox1 heme oxygenase 1 IDA RGD PMID:12511545 RGD:628519 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818 		JBrowse link
G Pld1 phospholipase D1 enables IDA
IEA
IBA
ISO 		GO_REF:0000107
GO_REF:0000002
GO_REF:0000104
GO_REF:0000117
GO_REF:0000033
(PMID:25936805)
GO_REF:0000003
GO_REF:0000116 		Ensembl
InterPro
UniProt
GO_Central
RGD
RHEA		 PMID:25936805 PMID:12431982 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:729596 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:112,777,951...112,976,245 		JBrowse link
G Pld2 phospholipase D2 enables IDA
ISO
IEA
IBA 		(PMID:21085684)
GO_REF:0000104
GO_REF:0000107
GO_REF:0000002
GO_REF:0000117
GO_REF:0000033
GO_REF:0000116
GO_REF:0000003 		RGD
UniProt
Ensembl
InterPro
GO_Central
RHEA		 PMID:21085684 PMID:9111050 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000104 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:729617 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435 		JBrowse link
G Pld3 phospholipase D family, member 3 NOT|enables ISO (PMID:9813063) RGD PMID:9813063 NCBI chr 1:91,949,465...91,971,834
Ensembl chr 1:91,949,467...91,961,207 		JBrowse link
G Pld4 phospholipase D family, member 4 NOT|enables ISO (PMID:21085684) RGD PMID:21085684 NCBI chr 6:137,639,948...137,647,462
Ensembl chr 6:137,639,945...137,649,024 		JBrowse link
G Pld6 phospholipase D family, member 6 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr10:45,078,081...45,080,732
Ensembl chr10:45,077,080...45,087,160 		JBrowse link
protein adenylylhydrolase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ficd FIC domain protein adenylyltransferase enables ISS
IEA
ISO 		GO_REF:0000024
GO_REF:0000117
(PMID:36136088) 		UniProt
RGD		 PMID:36136088 GO_REF:0000024 GO_REF:0000117 NCBI chr12:48,549,737...48,554,626
Ensembl chr12:48,549,737...48,554,626 		JBrowse link
sphingomyelin phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 enables ISO
IEA
IDA
ISS 		(PMID:12671034), (PMID:12885774), (PMID:16255717), (PMID:28292932)
(PMID:21177474)
GO_REF:0000117
GO_REF:0000003
GO_REF:0000116
GO_REF:0000024 		RGD
UniProt
RHEA		 PMID:12671034 PMID:12885774 PMID:16255717 PMID:21177474 PMID:28292932 More... GO_REF:0000003 GO_REF:0000024 GO_REF:0000116 GO_REF:0000117, RGD:25671389 NCBI chr10:104,740,763...104,745,760
Ensembl chr10:104,740,763...104,745,760 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 enables ISO
IEA 		(PMID:21098024), (PMID:22573858), (PMID:33163980), (PMID:9660788)
GO_REF:0000003
GO_REF:0000002
GO_REF:0000107
GO_REF:0000104 		RGD
UniProt
InterPro
Ensembl		 PMID:9660788 PMID:21098024 PMID:22573858 PMID:33163980 GO_REF:0000002 GO_REF:0000003 GO_REF:0000104 GO_REF:0000107 NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:169,304,708...169,308,614 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 enables IDA
ISO
IEA
IBA 		(PMID:9520418)
MGI:2183203 (PMID:15764706)
GO_REF:0000117
GO_REF:0000003
GO_REF:0000002
GO_REF:0000116
GO_REF:0000033
GO_REF:0000107
(PMID:10608884), (PMID:14741383) 		RGD
UniProt
InterPro
RHEA
GO_Central
Ensembl		 PMID:9520418 PMID:10608884 PMID:14741383 PMID:15764706 PMID:10832103 GO_REF:0000002 GO_REF:0000003 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 GO_REF:0000117, RGD:634108 NCBI chr20:46,568,627...46,571,741
Ensembl chr20:46,568,629...46,571,741 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 enables ISS
ISO
IEA
IBA 		GO_REF:0000024
MGI:3575405 (PMID:10823942), (PMID:15764706), (PMID:21550973)
GO_REF:0000107
GO_REF:0000116
GO_REF:0000003
GO_REF:0000033
GO_REF:0000002
(PMID:14741383) 		UniProt
RGD
Ensembl
RHEA
GO_Central
InterPro		 PMID:10823942 PMID:14741383 PMID:15764706 PMID:21550973 GO_REF:0000002 GO_REF:0000003 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000116 NCBI chr19:51,072,209...51,155,639
Ensembl chr19:51,072,209...51,085,936 		JBrowse link
G Smpd4 sphingomyelin phosphodiesterase 4 enables IEA
ISO 		GO_REF:0000107
(PMID:25180167) 		Ensembl
RGD		 PMID:25180167 GO_REF:0000107 NCBI chr11:96,866,805...96,890,520
Ensembl chr11:96,866,805...96,890,520 		JBrowse link
G Smpd5 sphingomyelin phosphodiesterase 5 enables IEA
ISO 		GO_REF:0000002
(PMID:20378533), (PMID:21183079)
GO_REF:0000003
GO_REF:0000107 		InterPro
RGD
UniProt
Ensembl		 PMID:20378533 PMID:21183079 GO_REF:0000002 GO_REF:0000003 GO_REF:0000107 NCBI chr 7:109,889,532...109,892,428
Ensembl chr 7:109,889,875...109,893,384 		JBrowse link
G Smpdl3a sphingomyelin phosphodiesterase, acid-like 3A NOT|enables ISO
ISS 		(PMID:26783088)
GO_REF:0000024 		RGD
UniProt		 PMID:26783088 GO_REF:0000024 NCBI chr20:37,679,004...37,701,979
Ensembl chr20:37,678,964...37,704,260 		JBrowse link
G Smpdl3b sphingomyelin phosphodiesterase, acid-like 3B enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:150,228,607...150,250,688
Ensembl chr 5:150,228,611...150,250,688 		JBrowse link
sphingomyelin phosphodiesterase D activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smpd4 sphingomyelin phosphodiesterase 4 enables ISO
IEA
IBA 		(PMID:16517606), (PMID:25180167)
GO_REF:0000002
GO_REF:0000033 		RGD
InterPro
GO_Central		 PMID:16517606 PMID:25180167 GO_REF:0000002 GO_REF:0000033 NCBI chr11:96,866,805...96,890,520
Ensembl chr11:96,866,805...96,890,520 		JBrowse link
tyrosyl-DNA phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp2 tyrosyl-DNA phosphodiesterase 2 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr17:40,656,969...40,668,362
Ensembl chr17:40,656,971...40,668,288 		JBrowse link
tyrosyl-RNA phosphodiesterase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tdp2 tyrosyl-DNA phosphodiesterase 2 enables ISO
IEA 		(PMID:22908287)
GO_REF:0000107 		RGD
Ensembl		 PMID:22908287 GO_REF:0000107 NCBI chr17:40,656,969...40,668,362
Ensembl chr17:40,656,971...40,668,288 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19971
    catalytic activity 5918
      hydrolase activity 2489
        hydrolase activity, acting on ester bonds 735
          phosphoric ester hydrolase activity 369
            phosphoric diester hydrolase activity 92
              7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity 0
              CMP-N-acylneuraminate phosphodiesterase activity 0
              GPI-mannose ethanolamine phosphate phosphodiesterase activity 1
              N-acylphosphatidylethanolamine-specific phospholipase D activity 1
              RNA 2',3'-cyclic 3'-phosphodiesterase activity 0
              [acyl-carrier-protein] phosphodiesterase activity 0
              alkylglycerophosphoethanolamine phosphodiesterase activity 7
              cardiolipin hydrolase activity 1
              cyclic-guanylate-specific phosphodiesterase activity 0
              cyclic-nucleotide phosphodiesterase activity + 29
              dolichylphosphate-glucose phosphodiesterase activity 0
              dolichylphosphate-mannose phosphodiesterase activity 0
              glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase activity 0
              glycerol-1,2-cyclic-phosphate 2-phosphodiesterase activity 0
              glycerophosphocholine cholinephosphodiesterase activity 1
              glycerophosphocholine phosphodiesterase activity 2
              glycerophosphodiester phosphodiesterase activity 5
              glycerophosphoinositol glycerophosphodiesterase activity 1
              glycerophosphoinositol inositolphosphodiesterase activity 0
              phosphodiesterase I activity 4
              phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands 1
              phospholipase C activity + 18
              phospholipase D activity + 9
              phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase activity 0
              phosphoribosyl 1,2-cyclic phosphate phosphodiesterase activity 0
              protein adenylylhydrolase activity 1
              serine-ethanolaminephosphate phosphodiesterase activity 0
              sphingomyelin phosphodiesterase D activity 1
              sphingomyelin phosphodiesterase activity + 8
              tyrosyl-DNA phosphodiesterase activity + 2
              tyrosyl-RNA phosphodiesterase activity 1
paths to the root