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ONTOLOGY REPORT - ANNOTATIONS

Term:Toll signaling pathway
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Accession:GO:0008063 term browser browse the term
Definition:The series of molecular signals initiated by an extracellular ligand binding to the receptor Toll on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: Tl signaling pathway;   Tl signalling pathway;   Toll signalling pathway


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Toll signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irak1 interleukin-1 receptor-associated kinase 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor involved_in IDA
IBA 		GO_REF:0000033 GO_Central
RGD		 PMID:14962484 GO_REF:0000033, RGD:1302746 NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Palm3 paralemmin 3 involved_in ISO
IBA 		(PMID:21187075)
GO_REF:0000033 		RGD
GO_Central		 PMID:21187075 GO_REF:0000033 NCBI chr19:24,121,984...24,126,079
Ensembl chr19:24,122,239...24,130,448 		JBrowse link
G Traf3 Tnf receptor-associated factor 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:136,025,097...136,128,363
Ensembl chr 6:130,206,484...130,305,481 		JBrowse link
negative regulation of Toll signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ano9 anoctamin 9 involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 1:196,208,863...196,230,381
Ensembl chr 1:196,197,341...196,229,900 		JBrowse link
G Nlrp12 NLR family, pyrin domain containing 12 involved_in ISO (PMID:16203735) RGD PMID:16203735 NCBI chr 1:65,932,610...65,969,873
Ensembl chr 1:65,932,595...65,960,934 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 acts_upstream_of_or_within ISO MGI:2156367 (PMID:23042151) RGD PMID:23042151 NCBI chr 1:211,659,416...211,672,280
Ensembl chr 1:202,232,228...202,242,857 		JBrowse link
G Sigirr single Ig and TIR domain containing involved_in ISO
ISS 		(PMID:12925853)
GO_REF:0000024 		RGD
HGNC-UCL		 PMID:12925853 GO_REF:0000024 NCBI chr 1:196,195,363...196,208,692
Ensembl chr 1:196,199,462...196,202,269 		JBrowse link
positive regulation of Toll signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein involved_in ISO UniProtKB:O00206|UniProtKB:P16671|UniProtKB:Q9Y2C9 (PMID:20037584) RGD PMID:20037584 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
regulation of Toll signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Peli1 pellino E3 ubiquitin protein ligase 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:99,455,970...99,510,474
Ensembl chr14:95,254,589...95,308,285
Ensembl chr 1:95,254,589...95,308,285 		JBrowse link
G Peli2 pellino E3 ubiquitin protein ligase family member 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:23,872,984...24,017,448
Ensembl chr15:21,393,262...21,535,106 		JBrowse link
G Peli3 pellino E3 ubiquitin protein ligase family member 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:211,659,416...211,672,280
Ensembl chr 1:202,232,228...202,242,857 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      signal transduction 7313
        cell surface receptor signaling pathway 2915
          Toll signaling pathway 14
            negative regulation of Toll signaling pathway 4
            positive regulation of Toll signaling pathway 1
            regulation of Toll signaling pathway + 7
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        signaling 7874
          signal transduction 7313
            cell surface receptor signaling pathway 2915
              Toll signaling pathway 14
                negative regulation of Toll signaling pathway 4
                positive regulation of Toll signaling pathway 1
                regulation of Toll signaling pathway + 7
paths to the root