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ONTOLOGY REPORT - ANNOTATIONS

Term:lactation
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Accession:GO:0007595 term browser browse the term
Definition:The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
Synonyms:exact_synonym: milk secretion
 xref: Wikipedia:Lactation
 only_in_taxon: NCBITaxon:40674 ! Mammalia


show annotations for term's descendants           Sort by:
lactation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 ISO RGD PMID:19702690 RGD:2315565 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 ISO RGD PMID:18255020 RGD:4144779 NCBI chr  X:47,871,519...47,896,041
Ensembl chr  X:47,871,523...47,896,000 		JBrowse link
G APRT adenine phosphoribosyltransferase ISO RGD PMID:2451510 RGD:1599204 NCBI chr 6:890,272...893,278
Ensembl chr 6:890,831...893,276 		JBrowse link
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO (PMID:15302868) MGI PMID:15302868 NCBI chr13:66,526,508...66,897,125
Ensembl chr13:66,528,323...66,897,128 		JBrowse link
G ATP7A ATPase copper transporting alpha ISO RGD PMID:16741141 RGD:1599391 NCBI chr  X:61,972,544...62,110,058
Ensembl chr  X:61,972,991...62,110,048 		JBrowse link
G ATP7B ATPase copper transporting beta acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:1588441), (PMID:6863890) RGD
MGI
Ensembl		 PMID:1588441 PMID:6863890 PMID:16741141 PMID:28089327 GO_REF:0000107 MGI:71982 RGD:1599391 RGD:25671605 NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064 		JBrowse link
G BCAT2 branched chain amino acid transaminase 2 ISO RGD PMID:11171603 PMID:11787736 RGD:1599445 RGD:62398 NCBI chr 6:54,107,682...54,123,595
Ensembl chr 6:54,107,684...54,142,790 		JBrowse link
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase ISO RGD PMID:1476792 RGD:5132591 NCBI chr 3:111,887,017...111,914,511
Ensembl chr 3:111,887,020...111,914,492 		JBrowse link
G CAV1 caveolin 1 involved_in
acts_upstream_of_negative_effect		 IEA
ISO		 (PMID:12388746) Ensembl
MGI		 PMID:12388746 GO_REF:0000107 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465 		JBrowse link
G CCND1 cyclin D1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11747812)
(PMID:10419681)		 Ensembl
MGI		 PMID:10419681 PMID:11747812 GO_REF:0000107 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296 		JBrowse link
G CDO1 cysteine dioxygenase type 1 ISO RGD PMID:6509133 RGD:2301364 NCBI chr 2:119,927,768...119,940,690
Ensembl chr 2:119,927,772...119,940,665 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex acts_upstream_of_or_within ISO (PMID:11747812) MGI PMID:11747812 NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868 		JBrowse link
G CP ceruloplasmin ISO RGD PMID:28089327 RGD:25671605 NCBI chr13:89,396,713...89,463,540
Ensembl chr13:89,396,708...89,463,476 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16141355) Ensembl
MGI		 PMID:16141355 GO_REF:0000107 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728 		JBrowse link
G CSN2 casein beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:66,914,231...66,922,636
Ensembl chr 8:66,915,923...66,922,636 		JBrowse link
G CSN3 casein kappa involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 (PMID:16698927) Ensembl
GO_Central
TreeGrafter
MGI		 PMID:16698927 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 8:67,099,131...67,109,112
Ensembl chr 8:67,099,131...67,106,987 		JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 ISO RGD PMID:8333523 RGD:2307320 NCBI chr 5:23,053,129...23,058,865
Ensembl chr 5:23,053,892...23,058,470 		JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) ISO RGD PMID:1476792 RGD:5132591 NCBI chr 6:14,942,898...14,956,000
Ensembl chr 6:14,942,933...14,955,997 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (PMID:18852460) MGI PMID:18852460 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:113,966,573...115,096,984
Ensembl chr15:113,974,437...115,096,565 		JBrowse link
G FOXB1 forkhead box B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:111,997,638...112,000,550
Ensembl chr 1:111,997,642...112,000,550 		JBrowse link
G GC GC vitamin D binding protein ISO RGD PMID:217634 RGD:2315536 NCBI chr 8:68,326,293...68,360,262
Ensembl chr 8:68,326,299...68,360,262 		JBrowse link
G GHRHR growth hormone releasing hormone receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:1270792), (PMID:2980124) Ensembl
MGI		 PMID:1270792 PMID:2980124 GO_REF:0000107 NCBI chr18:42,030,505...42,046,178
Ensembl chr18:42,030,510...42,046,184 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 ISO RGD PMID:28798692 RGD:13504863 NCBI chr 6:20,407,203...20,431,849
Ensembl chr 6:20,407,200...20,432,067 		JBrowse link
G GPAT4 glycerol-3-phosphate acyltransferase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16449762) Ensembl
MGI		 PMID:16449762 GO_REF:0000107 NCBI chr17:10,705,998...10,724,486
Ensembl chr17:10,691,751...10,725,024 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12620994) Ensembl
MGI		 PMID:12620994 GO_REF:0000107 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845 		JBrowse link
G HK2 hexokinase 2 ISO RGD PMID:10562464 RGD:1624366 NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,153,835...68,231,615 		JBrowse link
G KALRN kalirin RhoGEF kinase acts_upstream_of_or_within ISO (PMID:23116210) MGI PMID:23116210 NCBI chr13:135,653,795...136,277,072 JBrowse link
G MED1 mediator complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15647257) Ensembl
MGI		 PMID:15647257 GO_REF:0000107 NCBI chr12:22,830,405...22,872,420
Ensembl chr12:22,841,205...22,872,409 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO RGD PMID:7628535 RGD:729001 NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512 		JBrowse link
G MIR222 microRNA mir-222 ISO RGD PMID:30698333 RGD:152023732 NCBI chr  X:40,571,808...40,571,887
Ensembl chr  X:40,571,808...40,571,887 		JBrowse link
G MIR27A microRNA mir-27a ISO RGD PMID:30698333 RGD:152023732 NCBI chr 2:65,308,294...65,308,375
Ensembl chr 2:65,308,294...65,308,375 		JBrowse link
G MT-CO2 mitochondrially encoded cytochrome c oxidase II ISO RGD PMID:2557014 RGD:2302300 NCBI chr MT:8,203...8,890
Ensembl chr MT:8,203...8,890 		JBrowse link
G MTX1 metaxin 1 ISO RGD PMID:19702690 RGD:2315565 NCBI chr 4:94,606,576...94,611,439
Ensembl chr 4:94,606,562...94,611,865 		JBrowse link
G MUC4 mucin 4, cell surface associated ISO RGD PMID:15499570 RGD:1582108 NCBI chr13:134,192,412...134,248,435 JBrowse link
G NCOA1 nuclear receptor coactivator 1 ISO RGD PMID:15946693 RGD:5688303 NCBI chr 3:113,997,214...114,251,080
Ensembl chr 3:113,999,253...114,250,298 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO RGD PMID:15946693 RGD:5688303 NCBI chr12:59,256,868...59,392,564
Ensembl chr12:59,273,100...59,392,562 		JBrowse link
G NCOR2 nuclear receptor corepressor 2 ISO RGD PMID:15946693 RGD:5688303 NCBI chr14:28,642,774...28,819,404
Ensembl chr14:28,624,702...28,819,404 		JBrowse link
G NEURL1 neuralized E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11585928) Ensembl
MGI		 PMID:11585928 GO_REF:0000107 NCBI chr14:114,436,887...114,515,713
Ensembl chr14:114,437,045...114,516,721 		JBrowse link
G NME1 NME/NM23 nucleoside diphosphate kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12848338) Ensembl
MGI		 PMID:12848338 GO_REF:0000107 NCBI chr12:27,416,308...27,435,044
Ensembl chr12:27,416,346...27,436,140 		JBrowse link
G PAM peptidylglycine alpha-amidating monooxygenase ISO RGD PMID:16448835 RGD:2302418 NCBI chr 2:108,255,923...108,536,192
Ensembl chr 2:108,255,930...108,536,880 		JBrowse link
G PMCH pro-melanin concentrating hormone ISO RGD PMID:14962080 RGD:1642485 NCBI chr 5:82,018,915...82,020,267
Ensembl chr 5:82,018,915...82,020,266 		JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase ISO RGD PMID:2451510 RGD:1599204 NCBI chr 8:55,652,194...55,701,077
Ensembl chr 8:55,654,377...55,701,077 		JBrowse link
G PRL prolactin involved_in IEA UniProt GO_REF:0000043 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710 		JBrowse link
G PRLR prolactin receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11445538)
(PMID:11706048), (PMID:16469767)		 Ensembl
MGI		 PMID:11445538 PMID:11706048 PMID:16469767 GO_REF:0000107 NCBI chr16:20,637,568...20,655,881
Ensembl chr16:20,618,875...20,810,140 		JBrowse link
G RPLP0 ribosomal protein lateral stalk subunit P0 ISO RGD PMID:20863866 RGD:11039458 NCBI chr14:40,219,196...40,223,943
Ensembl chr14:40,219,193...40,223,966 		JBrowse link
G SERPINC1 serpin family C member 1 ISO RGD PMID:22776112 RGD:11035275 NCBI chr 9:116,181,988...116,193,100
Ensembl chr 9:116,181,670...116,193,201 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 ISO RGD PMID:19702690 RGD:2315565 NCBI chr 7:39,217,974...39,234,683
Ensembl chr 7:39,218,051...39,234,685 		JBrowse link
G SLC29A2 solute carrier family 29 member 2 ISO RGD PMID:19702690 RGD:2315565 NCBI chr 2:6,027,287...6,036,280
Ensembl chr 2:6,027,287...6,036,280 		JBrowse link
G SLC30A4 solute carrier family 30 member 4 ISO RGD PMID:14608047 RGD:2299951 NCBI chr 1:126,236,971...126,268,102
Ensembl chr 1:126,237,032...126,268,094 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9247269) Ensembl
MGI		 PMID:9247269 GO_REF:0000107 NCBI chr16:79,186,114...79,220,302
Ensembl chr16:79,186,108...79,220,297 		JBrowse link
G SOCS2 suppressor of cytokine signaling 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11445538) Ensembl
MGI		 PMID:11445538 GO_REF:0000107 NCBI chr 5:89,581,081...89,587,424
Ensembl chr 5:89,581,090...89,584,581 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A involved_in
acts_upstream_of_or_within		 IEA
ISS
ISO		 (PMID:9630227)
(PMID:11706048)		 UniProt
AgBase
RGD
MGI		 PMID:7519723 PMID:8584036 PMID:9630227 PMID:11706048 GO_REF:0000024 GO_REF:0000043 RGD:151665740 RGD:730121 NCBI chr12:20,474,221...20,498,785
Ensembl chr12:20,474,227...20,499,138 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 (PMID:11706048), (PMID:9630227) AgBase
MGI
Ensembl		 PMID:9630227 PMID:11706048 GO_REF:0000024 GO_REF:0000107 NCBI chr12:20,498,103...20,574,365
Ensembl chr12:20,508,404...20,574,266 		JBrowse link
G UMPS uridine monophosphate synthetase ISO RGD PMID:1476792 RGD:5132591 NCBI chr13:135,611,857...135,650,656
Ensembl chr13:135,610,058...135,650,603 		JBrowse link
G UPRT uracil phosphoribosyltransferase homolog ISO RGD PMID:1476792 RGD:5132591 NCBI chr  X:60,426,955...60,448,174
Ensembl chr  X:60,426,975...60,451,480 		JBrowse link
G USF2 upstream transcription factor 2, c-fos interacting involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12907752) Ensembl
MGI		 PMID:12907752 GO_REF:0000107 NCBI chr 6:44,774,417...44,783,594
Ensembl chr 6:44,774,008...44,783,592 		JBrowse link
G VDR vitamin D receptor acts_upstream_of_or_within ISO (PMID:15178742) MGI PMID:15178742 NCBI chr 5:78,205,807...78,266,505
Ensembl chr 5:78,205,810...78,266,475 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17625068) Ensembl
MGI		 PMID:17625068 GO_REF:0000107 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
G XDH xanthine dehydrogenase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12502743) Ensembl
MGI		 PMID:12502743 GO_REF:0000107 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:94,780,404...94,796,722
Ensembl chr 4:94,780,408...94,796,657 		JBrowse link
milk ejection reflex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20089884) Ensembl
MGI		 PMID:20089884 GO_REF:0000107 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
positive regulation of lactation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase ISO RGD PMID:648869 RGD:11557979 (All species) (All species) NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998 		JBrowse link
G PRL prolactin involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr 7:17,451,367...17,463,771
Ensembl chr 7:17,451,367...17,463,710 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (MGI:5496939|PMID:23623498) UniProt PMID:23623498 MGI:5496939 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526 		JBrowse link
regulation of lactation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OAS2 2'-5'-oligoadenylate synthetase 2 involved_in ISO (MGI:6094812|PMID:29117179) UniProt PMID:29117179 MGI:6094812 NCBI chr14:38,827,667...38,847,697
Ensembl chr14:38,827,660...38,860,820 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17799
    biological regulation 12896
      regulation of biological quality 3225
        regulation of body fluid levels 366
          body fluid secretion 128
            lactation 65
              milk ejection reflex 1
              negative regulation of lactation 0
              positive regulation of lactation + 3
              regulation of lactation + 4
Path 2
Term Annotations click to browse term
  biological_process 17799
    localization 5399
      establishment of localization 4701
        transport 4392
          secretion 1144
            body fluid secretion 128
              lactation 65
                milk ejection reflex 1
                negative regulation of lactation 0
                positive regulation of lactation + 3
                regulation of lactation + 4
paths to the root