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ONTOLOGY REPORT - ANNOTATIONS

Term:lactation
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Accession:GO:0007595 term browser browse the term
Definition:The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.
Synonyms:exact_synonym: milk secretion
 xref: Wikipedia:Lactation
 only_in_taxon: NCBITaxon:40674 ! Mammalia


show annotations for term's descendants           Sort by:
lactation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 ISO RGD PMID:19702690 RGD:2315565 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 ISO RGD PMID:18255020 RGD:4144779 NCBI chr  X:46,703,477...46,731,767
Ensembl chr  X:46,703,477...46,723,529 		JBrowse link
G APRT adenine phosphoribosyltransferase ISO RGD PMID:2451510 RGD:1599204 NCBI chr 5:64,563,154...64,565,537
Ensembl chr 5:64,563,192...64,565,445 		JBrowse link
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO (PMID:15302868) MGI PMID:15302868 NCBI chr20:7,665,468...8,037,407
Ensembl chr20:7,749,807...8,034,474 		JBrowse link
G ATP7A ATPase copper transporting alpha ISO RGD PMID:16741141 RGD:1599391 NCBI chr  X:60,203,336...60,356,525
Ensembl chr  X:60,203,270...60,352,869 		JBrowse link
G ATP7B ATPase copper transporting beta acts_upstream_of_or_within ISO (PMID:1588441), (PMID:6863890) RGD
MGI		 PMID:1588441 PMID:6863890 PMID:16741141 PMID:28089327 MGI:71982 RGD:1599391 RGD:25671605 NCBI chr22:162,474...225,599
Ensembl chr22:191,888...225,266 		JBrowse link
G BCAT2 branched chain amino acid transaminase 2 ISO RGD PMID:11171603 PMID:11787736 RGD:1599445 RGD:62398 NCBI chr 1:107,539,125...107,549,286
Ensembl chr 1:107,538,465...107,549,234 		JBrowse link
G CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase ISO RGD PMID:1476792 RGD:5132591 NCBI chr17:21,198,839...21,221,897
Ensembl chr17:21,197,826...21,221,635 		JBrowse link
G CAV1 caveolin 1 acts_upstream_of_negative_effect ISO (PMID:12388746) MGI PMID:12388746 NCBI chr14:55,458,934...55,494,563
Ensembl chr14:55,461,048...55,492,935 		JBrowse link
G CCND1 cyclin D1 acts_upstream_of_or_within ISO (PMID:11747812)
(PMID:10419681)		 MGI PMID:10419681 PMID:11747812 NCBI chr18:48,501,905...48,509,684
Ensembl chr18:48,501,899...48,516,005 		JBrowse link
G CDO1 cysteine dioxygenase type 1 ISO RGD PMID:6509133 RGD:2301364 NCBI chr11:5,512,996...5,524,556
Ensembl chr11:5,371,378...5,524,562 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex acts_upstream_of_or_within ISO (PMID:11747812) MGI PMID:11747812 NCBI chr28:12,964,670...13,001,557
Ensembl chr28:12,965,479...13,001,512 		JBrowse link
G CP ceruloplasmin ISO RGD PMID:28089327 RGD:25671605 NCBI chr23:43,969,297...44,033,226
Ensembl chr23:43,969,435...44,030,369 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16141355) Ensembl
MGI		 PMID:16141355 GO_REF:0000107 NCBI chr37:15,921,214...15,978,492
Ensembl chr37:15,939,138...15,977,556 		JBrowse link
G CSN2 casein beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:59,436,726...59,444,398
Ensembl chr13:59,438,601...59,444,398 		JBrowse link
G CSN3 casein kappa involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16698927) Ensembl
MGI
TreeGrafter		 PMID:16698927 GO_REF:0000107 GO_REF:0000118 NCBI chr13:59,613,026...59,629,095
Ensembl chr13:59,621,106...59,626,552 		JBrowse link
G CYP27B1 cytochrome P450 family 27 subfamily B member 1 ISO RGD PMID:8333523 RGD:2307320 NCBI chr10:1,825,224...1,830,845
Ensembl chr10:1,826,046...1,829,911 		JBrowse link
G DHODH dihydroorotate dehydrogenase (quinone) ISO RGD PMID:1476792 RGD:5132591 NCBI chr 5:77,756,411...77,766,207
Ensembl chr 5:77,756,407...77,774,090 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 acts_upstream_of_or_within ISO (PMID:18852460) MGI PMID:18852460 NCBI chr17:37,886,397...37,950,671
Ensembl chr17:37,886,601...37,949,812 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr37:19,029,647...20,134,576
Ensembl chr37:19,037,217...20,134,426 		JBrowse link
G FOXB1 forkhead box B1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:24,822,137...24,825,833
Ensembl chr30:24,823,815...24,824,792 		JBrowse link
G GC GC vitamin D binding protein ISO RGD PMID:217634 RGD:2315536 NCBI chr13:60,795,305...60,828,038
Ensembl chr13:60,795,305...60,827,929 		JBrowse link
G GHRHR growth hormone releasing hormone receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:1270792), (PMID:2980124) Ensembl
MGI		 PMID:1270792 PMID:2980124 GO_REF:0000107 NCBI chr14:43,626,862...43,638,737
Ensembl chr14:43,626,845...43,638,753 		JBrowse link
G GOT2 glutamic-oxaloacetic transaminase 2 ISO RGD PMID:28798692 RGD:13504863 NCBI chr 2:57,968,833...57,994,219
Ensembl chr 2:57,968,833...57,994,218 		JBrowse link
G GPAT4 glycerol-3-phosphate acyltransferase 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16449762) Ensembl
MGI		 PMID:16449762 GO_REF:0000107 NCBI chr16:23,990,142...24,022,822
Ensembl chr16:23,911,972...24,010,152 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12620994) Ensembl
MGI		 PMID:12620994 GO_REF:0000107 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692 		JBrowse link
G HK2 hexokinase 2 ISO RGD PMID:10562464 RGD:1624366 NCBI chr17:48,287,367...48,329,470
Ensembl chr17:48,289,272...48,348,663 		JBrowse link
G KALRN kalirin RhoGEF kinase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23116210) Ensembl
MGI		 PMID:23116210 GO_REF:0000107 NCBI chr33:27,161,403...27,752,891
Ensembl chr33:27,161,504...27,746,497 		JBrowse link
G MED1 mediator complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15647257) Ensembl
MGI		 PMID:15647257 GO_REF:0000107 NCBI chr 9:22,989,257...23,019,350
Ensembl chr 9:22,989,301...23,019,349 		JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO RGD PMID:7628535 RGD:729001 NCBI chr14:55,599,047...55,711,626
Ensembl chr14:55,598,337...55,724,027 		JBrowse link
G MIR222 microRNA mir-222 ISO RGD PMID:30698333 RGD:152023732 NCBI chr  X:39,524,519...39,524,608
Ensembl chr  X:39,524,519...39,524,608 		JBrowse link
G MIR27A microRNA mir-27a ISO RGD PMID:30698333 RGD:152023732 NCBI chr20:48,620,556...48,620,615
Ensembl chr20:48,620,556...48,620,615 		JBrowse link
G MT-CO2 mitochondrially encoded cytochrome c oxidase II ISO RGD PMID:2557014 RGD:2302300 NCBI chr MT:7,034...7,717
Ensembl chr MT:7,034...7,717 		JBrowse link
G MTX1 metaxin 1 ISO RGD PMID:19702690 RGD:2315565 NCBI chr 7:42,322,755...42,327,918
Ensembl chr 7:42,322,762...42,328,701 		JBrowse link
G MUC4 mucin 4, cell surface associated ISO RGD PMID:15499570 RGD:1582108 NCBI chr33:29,061,372...29,084,938
Ensembl chr33:29,063,096...29,111,802 		JBrowse link
G NCOA1 nuclear receptor coactivator 1 ISO RGD PMID:15946693 RGD:5688303 NCBI chr17:18,880,676...19,124,300
Ensembl chr17:18,880,383...19,122,258 		JBrowse link
G NCOR1 nuclear receptor corepressor 1 ISO RGD PMID:15946693 RGD:5688303 NCBI chr 5:39,687,530...39,837,003
Ensembl chr 5:39,687,543...39,836,464 		JBrowse link
G NCOR2 nuclear receptor corepressor 2 ISO RGD PMID:15946693 RGD:5688303 NCBI chr26:5,352,670...5,493,741
Ensembl chr26:5,331,459...5,493,830 		JBrowse link
G NEURL1 neuralized E3 ubiquitin protein ligase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11585928) Ensembl
MGI		 PMID:11585928 GO_REF:0000107 NCBI chr28:15,856,494...15,935,897
Ensembl chr28:15,856,616...15,933,763 		JBrowse link
G NME1 non-metastatic cells 1, protein (NM23A) expressed in acts_upstream_of_or_within ISO (PMID:12848338) MGI PMID:12848338 NCBI chr 9:26,990,336...26,998,895
Ensembl chr 9:26,990,469...26,998,955 		JBrowse link
G PAM peptidylglycine alpha-amidating monooxygenase ISO RGD PMID:16448835 RGD:2302418 NCBI chr 3:8,141,508...8,312,081
Ensembl chr 3:8,142,061...8,290,477 		JBrowse link
G PMCH pro-melanin concentrating hormone ISO RGD PMID:14962080 RGD:1642485 NCBI chr15:41,036,428...41,037,571
Ensembl chr15:41,036,428...41,037,553 		JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase ISO RGD PMID:2451510 RGD:1599204 NCBI chr13:48,618,460...48,656,164
Ensembl chr13:48,620,714...48,655,780 		JBrowse link
G PRLR prolactin receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11445538)
(PMID:11706048), (PMID:16469767)		 Ensembl
MGI		 PMID:11445538 PMID:11706048 PMID:16469767 GO_REF:0000107 NCBI chr 4:73,147,919...73,280,970
Ensembl chr 4:73,110,858...73,273,916 		JBrowse link
G RPLP0 ribosomal protein lateral stalk subunit P0 ISO RGD PMID:20863866 RGD:11039458 NCBI chr26:16,148,463...16,154,048
Ensembl chr26:16,148,460...16,153,614 		JBrowse link
G SERPINC1 serpin family C member 1 ISO RGD PMID:22776112 RGD:11035275 NCBI chr 7:25,322,668...25,333,022
Ensembl chr 7:25,316,129...25,332,987 		JBrowse link
G SLC29A1 solute carrier family 29 member 1 ISO RGD PMID:19702690 RGD:2315565 NCBI chr12:12,632,233...12,644,669
Ensembl chr12:12,634,194...12,644,667 		JBrowse link
G SLC29A2 solute carrier family 29 member 2 ISO RGD PMID:19702690 RGD:2315565 NCBI chr18:50,946,647...50,955,085
Ensembl chr18:50,946,724...50,954,413 		JBrowse link
G SLC30A4 solute carrier family 30 member 4 ISO RGD PMID:14608047 RGD:2299951 NCBI chr30:11,827,719...11,859,413
Ensembl chr30:11,834,678...11,859,311 		JBrowse link
G SLC6A3 solute carrier family 6 member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9247269) Ensembl
MGI		 PMID:9247269 GO_REF:0000107 NCBI chr34:11,209,118...11,245,456
Ensembl chr34:11,210,939...11,246,742 		JBrowse link
G SOCS2 suppressor of cytokine signaling 2 acts_upstream_of_or_within ISO (PMID:11445538) MGI PMID:11445538 NCBI chr15:33,761,434...33,788,973
Ensembl chr15:33,785,545...33,877,869 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:11706048)
(PMID:9630227)		 RGD
MGI
UniProt		 PMID:7519723 PMID:8584036 PMID:9630227 PMID:11706048 GO_REF:0000043 RGD:151665740 RGD:730121 NCBI chr 9:20,616,041...20,638,523
Ensembl chr 9:20,617,151...20,638,103 		JBrowse link
G STAT5B signal transducer and activator of transcription 5B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11706048), (PMID:9630227) Ensembl
MGI		 PMID:9630227 PMID:11706048 GO_REF:0000107 NCBI chr 9:20,647,712...20,718,453
Ensembl chr 9:20,691,483...20,716,485 		JBrowse link
G UMPS uridine monophosphate synthetase ISO RGD PMID:1476792 RGD:5132591 NCBI chr33:27,754,592...27,782,517
Ensembl chr33:27,754,643...27,782,514 		JBrowse link
G UPRT uracil phosphoribosyltransferase homolog ISO RGD PMID:1476792 RGD:5132591 NCBI chr  X:58,570,623...58,576,980
Ensembl chr  X:58,543,425...58,575,926 		JBrowse link
G USF2 upstream transcription factor 2, c-fos interacting involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12907752) Ensembl
MGI		 PMID:12907752 GO_REF:0000107 NCBI chr 1:117,308,882...117,319,397
Ensembl chr 1:117,309,222...117,367,616 		JBrowse link
G VDR vitamin D receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15178742) Ensembl
MGI		 PMID:15178742 GO_REF:0000107 NCBI chr27:6,852,915...6,909,466
Ensembl chr27:6,852,723...6,909,470 		JBrowse link
G VEGFA vascular endothelial growth factor A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17625068) Ensembl
MGI		 PMID:17625068 GO_REF:0000107 NCBI chr12:12,209,032...12,224,978
Ensembl chr12:12,208,231...12,224,965 		JBrowse link
G XDH xanthine dehydrogenase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12502743) Ensembl
MGI		 PMID:12502743 GO_REF:0000107 NCBI chr17:24,900,708...24,960,748
Ensembl chr17:24,901,447...24,971,935 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,468,376...42,482,219
Ensembl chr 7:42,468,247...42,483,436 		JBrowse link
milk ejection reflex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20089884) Ensembl
MGI		 PMID:20089884 GO_REF:0000107 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
positive regulation of lactation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase ISO RGD PMID:648869 RGD:11557979 (All species) (All species) NCBI chr26:29,359,930...29,381,854
Ensembl chr26:29,360,356...29,366,008 		JBrowse link
G PRL prolactin involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr35:20,673,830...20,683,824
Ensembl chr35:20,673,839...20,683,824 		JBrowse link
G XBP1 X-box binding protein 1 involved_in ISO (MGI:5496939|PMID:23623498) UniProt PMID:23623498 MGI:5496939 NCBI chr26:22,162,675...22,168,149
Ensembl chr26:22,163,222...22,168,105 		JBrowse link
regulation of lactation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OAS2 2'-5'-oligoadenylate synthetase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:10,431,881...10,450,085
Ensembl chr26:10,432,042...10,449,009 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17878
    biological regulation 12365
      regulation of biological quality 3298
        regulation of body fluid levels 372
          body fluid secretion 130
            lactation 65
              milk ejection reflex 1
              negative regulation of lactation 0
              positive regulation of lactation + 3
              regulation of lactation + 4
Path 2
Term Annotations click to browse term
  biological_process 17878
    localization 5577
      establishment of localization 4868
        transport 4542
          secretion 1161
            body fluid secretion 130
              lactation 65
                milk ejection reflex 1
                negative regulation of lactation 0
                positive regulation of lactation + 3
                regulation of lactation + 4
paths to the root