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ONTOLOGY REPORT - ANNOTATIONS


Term:cell aging
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Accession:GO:0007569 term browser browse the term
Definition:An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).
Synonyms:exact_synonym: cell ageing


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cell aging term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator ISO (MGI:MGI:62849|PMID:8372353) MGI PMID:8372353 MGI:MGI:62849 NCBI chr18:56,481,212...56,679,012
Ensembl chr18:59,802,443...59,992,100
JBrowse link
G BGLAP bone gamma-carboxyglutamate protein ISO RGD PMID:19840645 RGD:2316145 NCBI chr 1:131,583,789...131,586,459
Ensembl chr 1:135,413,871...135,416,432
JBrowse link
G BRCA2 BRCA2 DNA repair associated ISO (MGI:MGI:1277623|PMID:9699678) MGI PMID:9699678 MGI:MGI:1277623 NCBI chr13:13,574,422...13,658,967
Ensembl chr13:32,010,066...32,091,332
JBrowse link
G CDK1 cyclin dependent kinase 1 ISO RGD PMID:15695611 RGD:2301352 NCBI chr10:57,314,692...57,331,261
Ensembl chr10:59,647,993...59,664,434
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO (MGI:MGI:2159048|PMID:11748239) MGI PMID:11748239 MGI:MGI:2159048 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 ISO RGD PMID:20569237 RGD:5147849 NCBI chr 6:137,134,142...137,136,550 JBrowse link
G DNAJA3 DnaJ heat shock protein family (Hsp40) member A3 ISO (MGI:MGI:3525039|PMID:15572682) MGI PMID:15572682 MGI:MGI:3525039 NCBI chr16:3,351,825...3,381,914
Ensembl chr16:4,519,965...4,550,786
JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO (MGI:MGI:2670239|PMID:12878730), (MGI:MGI:3525039|PMID:15572682) MGI PMID:12878730, PMID:15572682 MGI:MGI:2670239, MGI:MGI:3525039 NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078
JBrowse link
G HSD17B10 hydroxysteroid 17-beta dehydrogenase 10 ISO RGD PMID:12810569 RGD:2302236 NCBI chr  X:45,645,849...45,649,039
Ensembl chr  X:53,754,164...53,757,643
JBrowse link
G HTT huntingtin ISO (MGI:MGI:3619488|PMID:16403806) MGI PMID:16403806 MGI:MGI:3619488 NCBI chr 4:3,215,081...3,388,587
Ensembl chr 4:3,128,718...3,283,730
JBrowse link
G ICAM1 intercellular adhesion molecule 1 ISO vascular smooth muscle cells RGD PMID:20421514 RGD:4145420 NCBI chr19:9,821,402...9,837,021
Ensembl chr19:10,484,414...10,500,605
JBrowse link
G ILK integrin linked kinase ISO positive regulation of cellular senescence RGD PMID:17234816 RGD:2301768 NCBI chr11:6,735,735...6,742,922
Ensembl chr11:6,418,717...6,425,788
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase ISO cardiac progenitor cells RGD PMID:18202313 RGD:2317463 NCBI chr 7:108,646,278...108,772,238
Ensembl chr 7:121,365,438...121,468,159
JBrowse link
G MIF macrophage migration inhibitory factor ISO (MGI:MGI:2670239|PMID:12878730) MGI PMID:12878730 MGI:MGI:2670239 NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009
JBrowse link
G MNT MAX network transcriptional repressor ISO (MGI:MGI:2675510|PMID:12970171) MGI PMID:12970171 MGI:MGI:2675510 NCBI chr17:2,375,414...2,392,423 JBrowse link
G MORC3 MORC family CW-type zinc finger 3 ISO (PMID:17332504) MGI PMID:17332504 NCBI chr21:22,690,055...22,747,067
Ensembl chr21:36,048,825...36,104,051
JBrowse link
G MTOR mechanistic target of rapamycin kinase ISO RGD PMID:19698731 RGD:10003167 NCBI chr 1:9,871,700...10,028,704
Ensembl chr 1:11,093,765...11,249,841
JBrowse link
G NOX4 NADPH oxidase 4 ISO (MGI:MGI:3694159|PMID:10869423) UniProtKB PMID:10869423 MGI:MGI:3694159 NCBI chr11:84,330,362...84,496,755 JBrowse link
G NPM1 nucleophosmin 1 ISO (PMID:12080348) UniProtKB PMID:12080348 NCBI chr 5:166,735,904...166,756,321
Ensembl chr 5:173,490,197...173,510,656
JBrowse link
G NUP62 nucleoporin 62 ISO (MGI:MGI:3525039|PMID:15572682) MGI PMID:15572682 MGI:MGI:3525039 NCBI chr19:46,919,731...46,942,318 JBrowse link
G PDCD4 programmed cell death 4 ISO (PMID:12054647) UniProtKB PMID:12054647 NCBI chr10:107,465,084...107,493,285
Ensembl chr10:110,914,222...110,942,394
JBrowse link
G PML PML nuclear body scaffold ISO (MGI:MGI:3717518|PMID:10910364) UniProtKB PMID:10910364 MGI:MGI:3717518 NCBI chr15:52,903,874...52,955,151
Ensembl chr15:71,658,884...71,710,883
JBrowse link
G PRELP proline and arginine rich end leucine rich repeat protein ISO (MGI:MGI:3525039|PMID:15572682) MGI PMID:15572682 MGI:MGI:3525039 NCBI chr 1:179,077,892...179,092,796
Ensembl chr 1:183,372,028...183,386,619
JBrowse link
G RWDD1 RWD domain containing 1 ISO (MGI:MGI:5882884|PMID:18761815) CAFA PMID:18761815 MGI:MGI:5882884 NCBI chr 6:114,379,178...114,401,570
Ensembl chr 6:118,524,052...118,546,373
JBrowse link
G SIRT1 sirtuin 1 ISO RGD PMID:15501022 RGD:10047125 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
JBrowse link
G SOD1 superoxide dismutase 1 ISO (PMID:12871978) UniProtKB PMID:12871978 NCBI chr21:18,029,831...18,037,526 JBrowse link
G TBX2 T-box transcription factor 2 ISO (PMID:11748239)
(MGI:MGI:2159048|PMID:11748239)
UniProtKB
MGI
PMID:11748239 MGI:MGI:2159048 NCBI chr17:55,501,932...55,511,537
Ensembl chr17:60,622,098...60,630,189
JBrowse link
G TBX3 T-box transcription factor 3 ISO (PMID:11689487), (PMID:11748239)
(MGI:MGI:2159048|PMID:11748239)
UniProtKB
MGI
PMID:11689487, PMID:11748239 MGI:MGI:2159048 NCBI chr12:112,240,050...112,254,299
Ensembl chr12:115,620,002...115,631,316
JBrowse link
G TOP2B DNA topoisomerase II beta ISO RGD PMID:20708677 RGD:13432149 NCBI chr 3:25,499,239...25,566,029
Ensembl chr 3:25,828,879...25,896,912
JBrowse link
G TP53 tumor protein p53 ISO (PMID:12080348)
(MGI:MGI:3692019|PMID:17053789)
UniProtKB
MGI
PMID:12080348, PMID:17053789 MGI:MGI:3692019 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
JBrowse link
G TP63 tumor protein p63 ISO (MGI:MGI:3588617|PMID:16107615) MGI PMID:16107615 MGI:MGI:3588617 NCBI chr 3:186,651,879...186,918,300
Ensembl chr 3:195,199,167...195,474,104
JBrowse link
G WRN WRN RecQ like helicase ISO (PMID:18212065) UniProtKB PMID:18212065 NCBI chr 8:30,353,643...30,492,978
Ensembl chr 8:27,541,145...27,679,855
JBrowse link
G ZMIZ1 zinc finger MIZ-type containing 1 ISO (MGI:MGI:3525039|PMID:15572682) MGI PMID:15572682 MGI:MGI:3525039 NCBI chr10:75,581,794...75,829,748
Ensembl chr10:78,294,867...78,492,475
JBrowse link
age-dependent response to oxidative stress involved in chronological cell aging term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDE insulin degrading enzyme ISO (MGI:MGI:5912601|PMID:26637123) MGI PMID:26637123 MGI:MGI:5912601 NCBI chr10:89,196,295...89,320,223
Ensembl chr10:92,716,540...92,833,353
JBrowse link
G PLA2G3 phospholipase A2 group III ISO (MGI:MGI:5912601|PMID:26637123) MGI PMID:26637123 MGI:MGI:5912601 NCBI chr22:12,158,589...12,164,441
Ensembl chr22:29,995,364...30,001,160
JBrowse link
G TTPA alpha tocopherol transfer protein ISO (MGI:MGI:5912601|PMID:26637123) MGI PMID:26637123 MGI:MGI:5912601 NCBI chr 8:59,591,592...59,619,658
Ensembl chr 8:61,266,954...61,293,699
JBrowse link
cellular senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALR calreticulin ISO (MGI:MGI:3813434|PMID:14726956)
(PMID:14726956)
BHF-UCL PMID:14726956 MGI:MGI:3813434 NCBI chr19:12,501,013...12,506,909
Ensembl chr19:13,242,900...13,249,416
JBrowse link
G CAV1 caveolin 1 ISO RGD PMID:23941874 RGD:9588563 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A ISO (PMID:15149599), (PMID:17553787) BHF-UCL PMID:15149599, PMID:17553787 NCBI chr 6:36,241,405...36,250,032
Ensembl chr 6:37,436,990...37,445,599
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO (PMID:14966292), (PMID:16243918)
(MGI:MGI:5299398|PMID:21911473)
(MGI:MGI:5449665|PMID:22729085)
BHF-UCL
MGI
PMID:14966292, PMID:16243918, PMID:21911473, PMID:22729085 MGI:MGI:5299398, MGI:MGI:5449665 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G CDKN2B cyclin dependent kinase inhibitor 2B ISO (PMID:17553787) BHF-UCL PMID:17553787 NCBI chr 9:21,838,902...21,845,355
Ensembl chr 9:22,455,662...22,462,156
JBrowse link
G ECRG4 ECRG4 augurin precursor ISO (MGI:MGI:4454240|PMID:20404145) MGI PMID:20404145 MGI:MGI:4454240 NCBI chr2A:95,762,149...95,774,834
Ensembl chr2A:107,140,895...107,152,967
JBrowse link
G HRAS HRas proto-oncogene, GTPase ISO (PMID:9054499) RGD
BHF-UCL
PMID:9054499, PMID:17706954 RGD:11060281 NCBI chr11:537,488...540,810
Ensembl chr11:568,305...571,078
JBrowse link
G ID2 inhibitor of DNA binding 2 ISO (MGI:MGI:4412240|PMID:18474814) UniProtKB PMID:18474814 MGI:MGI:4412240 NCBI chr2A:8,681,592...8,684,014
Ensembl chr2A:8,847,776...8,850,720
JBrowse link
G IGF1R insulin like growth factor 1 receptor ISO RGD PMID:19862643 RGD:10045872 NCBI chr15:77,332,926...77,648,474
Ensembl chr15:96,535,164...96,832,974
JBrowse link
G KAT6A lysine acetyltransferase 6A ISO (PMID:23431171) UniProtKB PMID:23431171 NCBI chr 8:41,173,833...41,296,547
Ensembl chr 8:38,625,156...38,741,538
JBrowse link
G LMNA lamin A/C ISO RGD PMID:20362703 RGD:12791030 NCBI chr 1:131,456,819...131,482,275
Ensembl chr 1:135,253,700...135,311,539
JBrowse link
G LOC100994157 histone H2AX ISO RGD PMID:19946210 RGD:8693719 NCBI chr11:113,932,078...113,933,679 JBrowse link
G MAGEA2B MAGE family member A2B ISO (PMID:22117195) UniProtKB PMID:22117195 NCBI chr  X:142,314,688...142,316,495 JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 ISO (PMID:9765203) BHF-UCL PMID:9765203 NCBI chr15:45,337,117...45,438,826
Ensembl chr15:63,613,961...63,714,161
JBrowse link
G NSMCE2 NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase ISO (PMID:17589526) UniProtKB PMID:17589526 NCBI chr 8:121,777,986...122,052,094
Ensembl chr 8:124,529,268...124,803,114
JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase ISO (PMID:17545159) UniProtKB PMID:17545159 NCBI chr 3:190,890,242...190,995,133
Ensembl chr 3:201,207,607...201,312,358
JBrowse link
G PML PML nuclear body scaffold ISO (PMID:22002537), (PMID:22117195), (PMID:23431171) UniProtKB PMID:22002537, PMID:22117195, PMID:23431171 NCBI chr15:52,903,874...52,955,151
Ensembl chr15:71,658,884...71,710,883
JBrowse link
G PRKCD protein kinase C delta ISO (PMID:15282327) BHF-UCL PMID:15282327 NCBI chr 3:53,104,137...53,135,588
Ensembl chr 3:54,330,328...54,357,910
JBrowse link
G PRMT6 protein arginine methyltransferase 6 ISO (MGI:MGI:5504576|PMID:22904064) MGI PMID:22904064 MGI:MGI:5504576 NCBI chr 1:109,582,715...109,586,744
Ensembl chr 1:108,699,098...108,700,225
JBrowse link
G SMC5 structural maintenance of chromosomes 5 ISO (PMID:17589526) UniProtKB PMID:17589526 NCBI chr 9:54,446,863...54,543,249 JBrowse link
G SMC6 structural maintenance of chromosomes 6 ISO (PMID:17589526) UniProtKB PMID:17589526 NCBI chr2A:17,648,371...17,735,910
Ensembl chr2A:17,776,276...17,854,052
JBrowse link
G SRF serum response factor ISO (PMID:15282327) BHF-UCL PMID:15282327 NCBI chr 6:42,763,099...42,773,332
Ensembl chr 6:44,057,192...44,066,768
JBrowse link
G TBX2 T-box transcription factor 2 ISO (PMID:22002537) UniProtKB PMID:22002537 NCBI chr17:55,501,932...55,511,537
Ensembl chr17:60,622,098...60,630,189
JBrowse link
G TBX3 T-box transcription factor 3 ISO (PMID:22002537) UniProtKB PMID:22002537 NCBI chr12:112,240,050...112,254,299
Ensembl chr12:115,620,002...115,631,316
JBrowse link
chronological cell aging term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENG endoglin ISO (PMID:18974388) BHF-UCL PMID:18974388 NCBI chr 9:98,934,080...98,973,862
Ensembl chr 9:127,605,608...127,644,641
JBrowse link
G SERPINE1 serpin family E member 1 ISO (PMID:18974388) BHF-UCL PMID:18974388 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
JBrowse link
negative regulation of cell aging term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXM1 forkhead box M1 ISO (PMID:19696738) UniProtKB PMID:19696738 NCBI chr12:2,978,400...2,999,077
Ensembl chr12:2,910,028...2,930,503
JBrowse link
G FZR1 fizzy and cell division cycle 20 related 1 ISO (MGI:MGI:5009768|PMID:21241890) BHF-UCL PMID:21241890 MGI:MGI:5009768 NCBI chr19:2,533,172...2,564,301
Ensembl chr19:3,500,117...3,510,867
JBrowse link
G MARCHF5 membrane associated ring-CH-type finger 5 ISO (PMID:20103533) UniProtKB PMID:20103533 NCBI chr10:89,038,753...89,101,305
Ensembl chr10:92,556,500...92,618,319
JBrowse link
G MIF macrophage migration inhibitory factor ISO (PMID:10562313) BHF-UCL PMID:10562313 NCBI chr22:4,646,986...4,647,831
Ensembl chr22:22,730,807...22,732,009
JBrowse link
G PTEN phosphatase and tensin homolog ISO (MGI:MGI:5009768|PMID:21241890) BHF-UCL PMID:21241890 MGI:MGI:5009768 NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605
JBrowse link
G WNT1 Wnt family member 1 ISO (PMID:16501043) BHF-UCL PMID:16501043 NCBI chr12:39,767,839...39,772,460
Ensembl chr12:40,648,413...40,652,583
JBrowse link
negative regulation of cellular senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO (MGI:MGI:5449665|PMID:22729085) MGI PMID:22729085 MGI:MGI:5449665 NCBI chr 9:101,834,189...102,005,811
Ensembl chr 9:130,484,333...130,652,941
JBrowse link
G AKT3 AKT serine/threonine kinase 3 ISO (PMID:25323119) BHF-UCL PMID:25323119 NCBI chr 1:219,107,482...219,463,140
Ensembl chr 1:224,480,784...224,824,838
JBrowse link
G BCL2L12 BCL2 like 12 ISO (MGI:MGI:4834958|PMID:20837658) MGI PMID:20837658 MGI:MGI:4834958 NCBI chr19:46,679,749...46,688,539 JBrowse link
G BCL6 BCL6 transcription repressor ISO (MGI:MGI:5469797|PMID:23209284) MGI PMID:23209284 MGI:MGI:5469797 NCBI chr 3:184,748,135...184,772,375
Ensembl chr 3:193,308,296...193,332,124
JBrowse link
G CDK6 cyclin dependent kinase 6 ISO (PMID:17420273) UniProtKB PMID:17420273 NCBI chr 7:84,603,419...84,835,082 JBrowse link
G FBXO5 F-box protein 5 ISO (PMID:17875940) UniProt PMID:17875940 NCBI chr 6:150,793,020...150,806,008
Ensembl chr 6:155,481,753...155,494,231
JBrowse link
G HMGA2 high mobility group AT-hook 2 ISO (MGI:MGI:5582375|PMID:23072816) BHF-UCL PMID:23072816 MGI:MGI:5582375 NCBI chr12:22,954,946...23,096,623 JBrowse link
G MAP3K3 mitogen-activated protein kinase kinase kinase 3 ISO (PMID:28640956) BHF-UCL PMID:28640956 NCBI chr17:57,702,242...57,776,601
Ensembl chr17:62,858,635...62,922,874
JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase ISO RGD PMID:28125705 RGD:13781884 NCBI chr 7:98,227,071...98,262,254 JBrowse link
G PLK2 polo like kinase 2 ISO (MGI:MGI:6120300|PMID:27908889) BHF-UCL PMID:27908889 MGI:MGI:6120300 NCBI chr 5:55,543,828...55,550,116
Ensembl chr 5:57,177,836...57,184,793
JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit ISO RGD PMID:22981234 RGD:8696027 NCBI chr 8:44,201,391...44,386,803
Ensembl chr 8:41,593,029...41,778,299
JBrowse link
G RBL1 RB transcriptional corepressor like 1 ISO (PMID:28595801) BHF-UCL PMID:28595801 NCBI chr20:33,324,663...33,419,891
Ensembl chr20:34,443,203...34,534,109
JBrowse link
G SIRT1 sirtuin 1 ISO (PMID:20424141)
(PMID:20203304)
BHF-UCL
UniProtKB
AgBase
PMID:20203304, PMID:20424141 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
JBrowse link
G SLC30A10 solute carrier family 30 member 10 ISO (PMID:22427991) UniProtKB PMID:22427991 NCBI chr 1:195,480,707...195,528,243
Ensembl chr 1:200,522,554...200,566,228
JBrowse link
G TERF2 telomeric repeat binding factor 2 ISO (PMID:11927518) BHF-UCL PMID:11927518 NCBI chr16:49,729,906...49,763,002
Ensembl chr16:69,116,539...69,148,423
JBrowse link
G TERT telomerase reverse transcriptase ISO (PMID:11927518)
(PMID:11313459)
BHF-UCL PMID:11313459, PMID:11927518 NCBI chr 5:1,542,217...1,586,775
Ensembl chr 5:1,300,960...1,338,872
JBrowse link
G TP63 tumor protein p63 ISO (PMID:19451233) UniProtKB PMID:19451233 NCBI chr 3:186,651,879...186,918,300
Ensembl chr 3:195,199,167...195,474,104
JBrowse link
G TWIST1 twist family bHLH transcription factor 1 ISO (PMID:17690110) BHF-UCL PMID:17690110 NCBI chr 7:19,761,041...19,765,665 JBrowse link
G YBX1 Y-box binding protein 1 ISO (MGI:MGI:6158172|PMID:29712925) UniProt PMID:29712925 MGI:MGI:6158172 NCBI chr 1:41,982,365...42,002,430
Ensembl chr 1:43,360,052...43,380,313
JBrowse link
G ZKSCAN3 zinc finger with KRAB and SCAN domains 3 ISO (PMID:23434374) UniProtKB PMID:23434374 NCBI chr 6:28,157,736...28,174,906
Ensembl chr 6:28,828,298...28,847,596
JBrowse link
nucleolar fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZNF354A zinc finger protein 354A ISO RGD PMID:10075651 RGD:1303369 NCBI chr 5:173,869,993...173,931,852
Ensembl chr 5:181,126,400...181,141,632
JBrowse link
oncogene-induced cell senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMGA1 high mobility group AT-hook 1 ISO (PMID:16901784) UniProtKB PMID:16901784 NCBI chr 6:33,807,171...33,816,603 JBrowse link
G HMGA2 high mobility group AT-hook 2 ISO (PMID:16901784) UniProtKB PMID:16901784 NCBI chr12:22,954,946...23,096,623 JBrowse link
oxidative stress-induced premature senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARNTL aryl hydrocarbon receptor nuclear translocator like ISO (MGI:MGI:5554364|PMID:22101268) UniProtKB PMID:22101268 MGI:MGI:5554364 NCBI chr11:13,436,580...13,547,135
Ensembl chr11:13,163,028...13,240,376
JBrowse link
G PLA2R1 phospholipase A2 receptor 1 ISO (PMID:19197340) UniProtKB PMID:19197340 NCBI chr2B:47,226,791...47,355,831
Ensembl chr2B:164,605,440...164,726,017
JBrowse link
G TP53 tumor protein p53 ISO (PMID:19951988) BHF-UCL PMID:19951988 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
JBrowse link
G WNT16 Wnt family member 16 ISO (PMID:19951988) BHF-UCL PMID:19951988 NCBI chr 7:113,338,322...113,354,002
Ensembl chr 7:126,025,337...126,041,057
JBrowse link
positive regulation of cell aging term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LMNA lamin A/C ISO (PMID:20458013) UniProtKB PMID:20458013 NCBI chr 1:131,456,819...131,482,275
Ensembl chr 1:135,253,700...135,311,539
JBrowse link
G TP53 tumor protein p53 ISO (MGI:MGI:5142390|PMID:10562313) BHF-UCL PMID:10562313 MGI:MGI:5142390 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
JBrowse link
positive regulation of cellular senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARG2 arginase 2 ISO (PMID:22928666) UniProtKB PMID:22928666 NCBI chr14:48,197,831...48,231,829
Ensembl chr14:67,075,941...67,109,962
JBrowse link
G B2M beta-2-microglobulin ISO (PMID:28213472) ARUK-UCL PMID:28213472 NCBI chr15:23,668,108...23,674,791
Ensembl chr15:41,836,345...41,842,991
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO (PMID:16901784) UniProtKB PMID:16901784 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G CGAS cyclic GMP-AMP synthase ISO (MGI:MGI:5909142|PMID:28759028) UniProtKB PMID:28759028 MGI:MGI:5909142 NCBI chr 6:71,252,050...71,279,121
Ensembl chr 6:74,544,251...74,566,965
JBrowse link
G EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 ISO (PMID:25465621) BHF-UCL PMID:25465621 NCBI chr 6:7,911,807...7,940,918
Ensembl chr 6:8,192,997...8,222,056
JBrowse link
G HMGA1 high mobility group AT-hook 1 ISO (PMID:16901784) UniProtKB PMID:16901784 NCBI chr 6:33,807,171...33,816,603 JBrowse link
G HMGA2 high mobility group AT-hook 2 ISO (PMID:16901784) UniProtKB PMID:16901784 NCBI chr12:22,954,946...23,096,623 JBrowse link
G KRAS KRAS proto-oncogene, GTPase ISO RGD PMID:17706954 RGD:11060281 NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335
JBrowse link
G PAWR pro-apoptotic WT1 regulator ISO (MGI:MGI:5648604|PMID:25472717) BHF-UCL PMID:25472717 MGI:MGI:5648604 NCBI chr12:77,114,282...77,224,116
Ensembl chr12:79,969,517...80,070,796
JBrowse link
G SIRT1 sirtuin 1 ISO (PMID:18687677) UniProtKB PMID:18687677 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
JBrowse link
G STK11 serine/threonine kinase 11 ISO (PMID:20203304) AgBase PMID:20203304 Ensembl chr19:1,188,537...1,210,677 JBrowse link
G YPEL3 yippee like 3 ISO (PMID:20388804) HGNC PMID:20388804 Ensembl chr16:30,467,490...30,471,256 JBrowse link
regulation of cellular senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase ISO (MGI:MGI:5449665|PMID:22729085) MGI PMID:22729085 MGI:MGI:5449665 NCBI chr 9:101,834,189...102,005,811
Ensembl chr 9:130,484,333...130,652,941
JBrowse link
G ARNTL aryl hydrocarbon receptor nuclear translocator like ISO (MGI:MGI:5554364|PMID:22101268) UniProtKB PMID:22101268 MGI:MGI:5554364 NCBI chr11:13,436,580...13,547,135
Ensembl chr11:13,163,028...13,240,376
JBrowse link
G BMPR1A bone morphogenetic protein receptor type 1A ISO (MGI:MGI:5449665|PMID:22729085) MGI PMID:22729085 MGI:MGI:5449665 NCBI chr10:83,185,040...83,353,239
Ensembl chr10:86,837,469...86,912,912
JBrowse link
G ICMT isoprenylcysteine carboxyl methyltransferase ISO (MGI:MGI:5500993|PMID:23686339) MGI PMID:23686339 MGI:MGI:5500993 NCBI chr 1:4,987,384...5,002,213
Ensembl chr 1:6,246,570...6,258,746
JBrowse link
G NEK4 NIMA related kinase 4 ISO (PMID:22851694) UniProtKB PMID:22851694 NCBI chr 3:52,649,280...52,712,645
Ensembl chr 3:53,878,760...53,938,520
JBrowse link
G NUAK1 NUAK family kinase 1 ISO (PMID:19927127) UniProtKB PMID:19927127 NCBI chr12:103,642,744...103,720,352
Ensembl chr12:107,037,627...107,113,163
JBrowse link
G PNPT1 polyribonucleotide nucleotidyltransferase 1 ISO (PMID:16055741) UniProtKB PMID:16055741 NCBI chr2A:55,792,412...55,848,242
Ensembl chr2A:56,931,365...56,986,326
JBrowse link
G RSL1D1 ribosomal L1 domain containing 1 ISO (PMID:18678645) UniProtKB PMID:18678645 NCBI chr16:10,776,243...10,790,280
Ensembl chr16:12,001,214...12,015,100
JBrowse link
G SUV39H1 suppressor of variegation 3-9 homolog 1 ISO (MGI:MGI:5913114|PMID:23695662) MGI PMID:23695662 MGI:MGI:5913114 NCBI chr  X:40,993,911...41,007,362
Ensembl chr  X:48,855,494...48,868,131
JBrowse link
G TP53 tumor protein p53 ISO (MGI:MGI:5504576|PMID:22904064) MGI PMID:22904064 MGI:MGI:5504576 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
JBrowse link
G VASH1 vasohibin 1 ISO (PMID:23056314) MGI PMID:23056314 NCBI chr14:57,315,866...57,337,465
Ensembl chr14:76,522,881...76,544,251
JBrowse link
G ZMPSTE24 zinc metallopeptidase STE24 ISO (MGI:MGI:5500993|PMID:23686339)
(MGI:MGI:3789238|PMID:16079796), (MGI:MGI:5139938|PMID:21746928)
MGI PMID:16079796, PMID:21746928, PMID:23686339 MGI:MGI:3789238, MGI:MGI:5139938, MGI:MGI:5500993 NCBI chr 1:39,545,264...39,589,721
Ensembl chr 1:40,869,076...40,912,747
JBrowse link
G ZNF277 zinc finger protein 277 ISO (MGI:MGI:5496352|PMID:20808772) MGI PMID:20808772 MGI:MGI:5496352 NCBI chr 7:104,169,603...104,307,262
Ensembl chr 7:116,872,205...117,008,463
JBrowse link
regulation of replicative cell aging term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NEK4 NIMA related kinase 4 ISO (PMID:22851694) UniProtKB PMID:22851694 NCBI chr 3:52,649,280...52,712,645
Ensembl chr 3:53,878,760...53,938,520
JBrowse link
replicative cell aging term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHEK2 checkpoint kinase 2 ISO (PMID:22851694) CACAO PMID:22851694 NCBI chr22:9,757,038...9,811,171 JBrowse link
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit ISO (MGI:MGI:893240|PMID:9197240)
(MGI:MGI:3699021|PMID:17173483)
MGI PMID:9197240, PMID:17173483 MGI:MGI:3699021, MGI:MGI:893240 NCBI chr19:42,356,039...42,427,754
Ensembl chr19:50,951,674...50,968,430
JBrowse link
G ROMO1 reactive oxygen species modulator 1 ISO (PMID:18836179) UniProtKB PMID:18836179 NCBI chr20:32,026,660...32,028,314
Ensembl chr20:33,148,002...33,149,345
JBrowse link
G TMEM115 transmembrane protein 115 ISO RGD PMID:19108381 RGD:2303064 NCBI chr 3:50,280,876...50,285,900
Ensembl chr 3:51,516,157...51,520,976
JBrowse link
G TP63 tumor protein p63 ISO RGD PMID:11850815 RGD:1600401 NCBI chr 3:186,651,879...186,918,300
Ensembl chr 3:195,199,167...195,474,104
JBrowse link
G WRN WRN RecQ like helicase ISO (MGI:MGI:1355173|PMID:10757812) MGI PMID:10757812 MGI:MGI:1355173 NCBI chr 8:30,353,643...30,492,978
Ensembl chr 8:27,541,145...27,679,855
JBrowse link
replicative senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATM ATM serine/threonine kinase ISO (PMID:15149599) BHF-UCL PMID:15149599 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041
JBrowse link
G ATR ATR serine/threonine kinase ISO (PMID:15149599) BHF-UCL PMID:15149599 NCBI chr 3:139,482,606...139,612,274
Ensembl chr 3:147,075,185...147,196,261
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A ISO (PMID:14720514) BHF-UCL PMID:14720514 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G CTC1 CST telomere replication complex component 1 ISO (MGI:MGI:5426340|PMID:22531781) MGI PMID:22531781 MGI:MGI:5426340 NCBI chr17:43,410,385...43,433,784
Ensembl chr17:48,142,864...48,165,537
JBrowse link
G MME membrane metalloendopeptidase ISO (PMID:20876573) UniProtKB PMID:20876573 NCBI chr 3:152,085,694...152,240,148
Ensembl chr 3:160,197,566...160,292,119
JBrowse link
G PLA2R1 phospholipase A2 receptor 1 ISO (PMID:19197340) UniProtKB PMID:19197340 NCBI chr2B:47,226,791...47,355,831
Ensembl chr2B:164,605,440...164,726,017
JBrowse link
G SERPINE1 serpin family E member 1 ISO (PMID:16862142) UniProtKB PMID:16862142 NCBI chr 7:93,267,517...93,279,728
Ensembl chr 7:106,510,130...106,518,450
JBrowse link
G TERT telomerase reverse transcriptase ISO (PMID:9454332) BHF-UCL PMID:9454332 NCBI chr 5:1,542,217...1,586,775
Ensembl chr 5:1,300,960...1,338,872
JBrowse link
G TP53 tumor protein p53 ISO (PMID:19951988) BHF-UCL PMID:19951988 NCBI chr17:7,699,449...7,717,812
Ensembl chr17:7,684,922...7,706,120
JBrowse link
G WNT16 Wnt family member 16 ISO (PMID:19951988) BHF-UCL PMID:19951988 NCBI chr 7:113,338,322...113,354,002
Ensembl chr 7:126,025,337...126,041,057
JBrowse link
stress-induced premature senescence term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK14 mitogen-activated protein kinase 14 ISO (PMID:20160708) BHF-UCL PMID:20160708 NCBI chr 6:35,586,847...35,683,041
Ensembl chr 6:36,788,233...36,871,114
JBrowse link
G MAPKAPK5 MAPK activated protein kinase 5 ISO (MGI:MGI:3697960|PMID:17254968)
(PMID:17254968)
UniProt
UniProtKB
PMID:17254968 MGI:MGI:3697960 NCBI chr12:109,416,610...109,471,729
Ensembl chr12:112,812,769...112,863,595
JBrowse link
G SIRT1 sirtuin 1 ISO (PMID:17916362) CACAO PMID:17916362 NCBI chr10:64,368,878...64,401,684
Ensembl chr10:66,681,598...66,715,069
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12529
    developmental process 5818
      aging 472
        cell aging 113
          cellular senescence + 69
          chronological cell aging + 5
          negative regulation of cell aging + 26
          nucleolar fragmentation + 1
          positive regulation of cell aging + 14
          progressive alteration of chromatin involved in cell aging + 0
          regulation of cell aging + 49
          replicative cell aging + 7
          replicative senescence + 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.