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ONTOLOGY REPORT - ANNOTATIONS

Term:mesodermal cell fate specification
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Accession:GO:0007501 term browser browse the term
Definition:The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
Comment:Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'.
Synonyms:exact_synonym: mesoderm cell fate specification


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mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EYA1 EYA transcriptional coactivator and phosphatase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:63,970,939...64,328,107
Ensembl chr 4:63,970,807...64,328,105 		JBrowse link
G HOXA11 homeobox A11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:45,388,523...45,392,190
Ensembl chr18:45,388,375...45,391,953 		JBrowse link
G PAX2 paired box 2 involved_in ISO (MGI:3768605|PMID:17785448) UniProt PMID:17785448 MGI:3768605 NCBI chr14:111,822,334...111,914,950
Ensembl chr14:111,823,308...111,913,969 		JBrowse link
G SFRP2 secreted frizzled related protein 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:17462603) Ensembl
MGI		 PMID:17462603 GO_REF:0000107 NCBI chr 8:75,337,311...75,345,926
Ensembl chr 8:75,337,144...75,345,921 		JBrowse link
G SIX2 SIX homeobox 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:95,460,046...95,463,428
Ensembl chr 3:95,459,945...95,463,251 		JBrowse link
G TBX6 T-box transcription factor 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9490412) Ensembl
MGI		 PMID:9490412 GO_REF:0000107 NCBI chr 3:18,271,983...18,277,864
Ensembl chr 3:18,271,983...18,277,580 		JBrowse link
axial mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NODAL nodal growth differentiation factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14511481) Ensembl
MGI		 PMID:14511481 GO_REF:0000107 NCBI chr14:73,350,358...73,357,064
Ensembl chr14:73,353,258...73,360,654 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKK1 dickkopf WNT signaling pathway inhibitor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:97,487,854...97,490,118
Ensembl chr14:97,487,226...97,490,288 		JBrowse link
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:55,322,016...55,327,600
Ensembl chr 7:55,322,274...55,323,539 		JBrowse link
G SFRP2 secreted frizzled related protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17462603) Ensembl
MGI		 PMID:17462603 GO_REF:0000107 NCBI chr 8:75,337,311...75,345,926
Ensembl chr 8:75,337,144...75,345,921 		JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT3A Wnt family member 3A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:51,153,978...51,203,678
Ensembl chr 2:51,153,970...51,202,176 		JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1A bone morphogenetic protein receptor type 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16943278) Ensembl
MGI		 PMID:16943278 GO_REF:0000107 NCBI chr14:87,743,270...87,891,790
Ensembl chr14:87,742,459...87,891,790 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16943278) Ensembl
MGI		 PMID:16943278 GO_REF:0000107 NCBI chr15:48,053,895...48,106,634
Ensembl chr15:48,053,340...48,106,724 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17813
    developmental process 6722
      cellular developmental process 4526
        cell fate specification 104
          mesodermal cell fate specification 12
            axial mesodermal cell fate specification + 1
            intermediate mesodermal cell fate specification + 0
            lateral mesodermal cell fate specification + 2
            negative regulation of mesodermal cell fate specification + 3
            paraxial mesodermal cell fate specification + 0
            positive regulation of mesodermal cell fate specification + 1
            regulation of mesodermal cell fate specification + 6
Path 2
Term Annotations click to browse term
  biological_process 17813
    developmental process 6722
      anatomical structure development 6316
        multicellular organism development 5107
          embryo development 1329
            embryonic morphogenesis 689
              gastrulation 210
                formation of primary germ layer 139
                  mesoderm formation 81
                    mesodermal cell differentiation 35
                      mesodermal cell fate commitment 17
                        mesodermal cell fate specification 12
                          axial mesodermal cell fate specification + 1
                          intermediate mesodermal cell fate specification + 0
                          lateral mesodermal cell fate specification + 2
                          negative regulation of mesodermal cell fate specification + 3
                          paraxial mesodermal cell fate specification + 0
                          positive regulation of mesodermal cell fate specification + 1
                          regulation of mesodermal cell fate specification + 6
paths to the root