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ONTOLOGY REPORT - ANNOTATIONS

Term:mesodermal cell fate specification
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Accession:GO:0007501 term browser browse the term
Definition:The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
Comment:Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'.
Synonyms:exact_synonym: mesoderm cell fate specification


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mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EYA1 EYA transcriptional coactivator and phosphatase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:71,197,433...71,548,094
Ensembl chr 8:71,197,433...71,592,025 		JBrowse link
G EYA2 EYA transcriptional coactivator and phosphatase 2 involved_in TAS (PMID:9020840) PINC PMID:9020840 NCBI chr20:46,894,843...47,188,844
Ensembl chr20:46,894,624...47,188,844 		JBrowse link
G HOXA11 homeobox A11 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:27,181,157...27,185,232
Ensembl chr 7:27,181,157...27,185,232 		JBrowse link
G PAX2 paired box 2 involved_in ISS UniProt GO_REF:0000024 NCBI chr10:100,735,396...100,829,944
Ensembl chr10:100,735,396...100,829,944 		JBrowse link
G SFRP2 secreted frizzled related protein 2 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:17462603) Ensembl
MGI		 PMID:17462603 GO_REF:0000107 NCBI chr 4:153,780,591...153,789,083
Ensembl chr 4:153,780,591...153,789,083 		JBrowse link
G SIX2 SIX homeobox 2 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:45,005,182...45,009,452
Ensembl chr 2:45,005,182...45,009,452 		JBrowse link
G TBX6 T-box transcription factor 6 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9490412) Ensembl
MGI		 PMID:9490412 GO_REF:0000107 NCBI chr16:30,085,793...30,091,924
Ensembl chr16:30,085,793...30,091,924 		JBrowse link
axial mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NODAL nodal growth differentiation factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14511481) Ensembl
MGI		 PMID:14511481 GO_REF:0000107 NCBI chr10:70,431,936...70,447,951
Ensembl chr10:70,431,936...70,447,951 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DKK1 dickkopf WNT signaling pathway inhibitor 1 involved_in IDA (PMID:20559569) BHF-UCL PMID:20559569 NCBI chr10:52,314,281...52,317,657
Ensembl chr10:52,314,281...52,318,042 		JBrowse link
G MESP1 mesoderm posterior bHLH transcription factor 1 involved_in IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr15:89,732,446...89,751,249
Ensembl chr15:89,749,875...89,751,249 		JBrowse link
G SFRP2 secreted frizzled related protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17462603) Ensembl
MGI		 PMID:17462603 GO_REF:0000107 NCBI chr 4:153,780,591...153,789,083
Ensembl chr 4:153,780,591...153,789,083 		JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G WNT3A Wnt family member 3A involved_in IDA (PMID:20559569) BHF-UCL PMID:20559569 NCBI chr 1:228,006,998...228,061,271
Ensembl chr 1:228,006,998...228,061,271 		JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMPR1A bone morphogenetic protein receptor type 1A involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16943278) Ensembl
MGI		 PMID:16943278 GO_REF:0000107 NCBI chr10:86,755,763...86,932,844
Ensembl chr10:86,756,596...86,932,825 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16943278) Ensembl
MGI		 PMID:16943278 GO_REF:0000107 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    developmental process 7610
      cellular developmental process 5182
        cell fate specification 120
          mesodermal cell fate specification 13
            axial mesodermal cell fate specification + 1
            intermediate mesodermal cell fate specification + 0
            lateral mesodermal cell fate specification + 2
            negative regulation of mesodermal cell fate specification + 3
            paraxial mesodermal cell fate specification + 0
            positive regulation of mesodermal cell fate specification + 1
            regulation of mesodermal cell fate specification + 6
Path 2
Term Annotations click to browse term
  biological_process 19669
    developmental process 7610
      anatomical structure development 7020
        multicellular organism development 5632
          embryo development 1396
            embryonic morphogenesis 724
              gastrulation 226
                formation of primary germ layer 145
                  mesoderm formation 86
                    mesodermal cell differentiation 38
                      mesodermal cell fate commitment 20
                        mesodermal cell fate specification 13
                          axial mesodermal cell fate specification + 1
                          intermediate mesodermal cell fate specification + 0
                          lateral mesodermal cell fate specification + 2
                          negative regulation of mesodermal cell fate specification + 3
                          paraxial mesodermal cell fate specification + 0
                          positive regulation of mesodermal cell fate specification + 1
                          regulation of mesodermal cell fate specification + 6
paths to the root