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ONTOLOGY REPORT - ANNOTATIONS

Term:mesodermal cell fate specification
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Accession:GO:0007501 term browser browse the term
Definition:The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
Comment:Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'.
Synonyms:exact_synonym: mesoderm cell fate specification


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mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 involved_in ISO (PMID:17785448) RGD PMID:17785448 NCBI chr 5:4,863,501...5,101,483
Ensembl chr 5:4,955,543...5,101,483 		JBrowse link
G Hoxa11 homeobox A11 involved_in ISO (PMID:17785448) RGD PMID:17785448 NCBI chr 4:81,342,527...81,346,189
Ensembl chr 4:81,342,528...81,346,232 		JBrowse link
G Pax2 paired box 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17785448)		 UniProt
RGD		 PMID:17785448 GO_REF:0000024 NCBI chr 1:243,616,509...243,697,454
Ensembl chr 1:243,616,606...243,695,321 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of ISO MGI:98956 (PMID:17462603) RGD PMID:17462603 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
G Six2 SIX homeobox 2 involved_in ISO (PMID:17785448) RGD PMID:17785448 NCBI chr 6:8,974,859...8,981,345
Ensembl chr 6:8,967,157...8,981,193 		JBrowse link
G Tbx6 T-box transcription factor 6 acts_upstream_of_or_within ISO MGI:2447721 (PMID:9490412) RGD PMID:9490412 NCBI chr 1:181,387,851...181,392,762
Ensembl chr 1:181,388,684...181,392,593 		JBrowse link
axial mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nodal nodal growth differentiation factor acts_upstream_of_or_within ISO (PMID:14511481) RGD PMID:14511481 NCBI chr20:29,368,436...29,376,837
Ensembl chr20:29,368,436...29,376,837 		JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202 		JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 involved_in ISO (PMID:18593560) RGD PMID:18593560 NCBI chr 1:133,738,357...133,739,875
Ensembl chr 1:133,738,357...133,739,875 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within ISO MGI:98956 (PMID:17462603) RGD PMID:17462603 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063 		JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A involved_in ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:44,034,174...44,078,366
Ensembl chr10:44,034,194...44,078,324 		JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A acts_upstream_of_or_within ISO MGI:95522 (PMID:16943278) RGD PMID:16943278 NCBI chr16:9,736,390...9,829,825
Ensembl chr16:9,736,630...9,780,616 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO MGI:1338938 (PMID:16943278) RGD PMID:16943278 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20075
    developmental process 7069
      cellular developmental process 4781
        cell fate specification 102
          mesodermal cell fate specification 12
            axial mesodermal cell fate specification + 1
            intermediate mesodermal cell fate specification + 0
            lateral mesodermal cell fate specification + 2
            negative regulation of mesodermal cell fate specification + 3
            paraxial mesodermal cell fate specification + 0
            positive regulation of mesodermal cell fate specification + 1
            regulation of mesodermal cell fate specification + 6
Path 2
Term Annotations click to browse term
  biological_process 20075
    developmental process 7069
      anatomical structure development 6572
        multicellular organism development 5298
          embryo development 1366
            embryonic morphogenesis 707
              gastrulation 219
                formation of primary germ layer 139
                  mesoderm formation 81
                    mesodermal cell differentiation 35
                      mesodermal cell fate commitment 17
                        mesodermal cell fate specification 12
                          axial mesodermal cell fate specification + 1
                          intermediate mesodermal cell fate specification + 0
                          lateral mesodermal cell fate specification + 2
                          negative regulation of mesodermal cell fate specification + 3
                          paraxial mesodermal cell fate specification + 0
                          positive regulation of mesodermal cell fate specification + 1
                          regulation of mesodermal cell fate specification + 6
paths to the root