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ONTOLOGY REPORT - ANNOTATIONS


Term:salivary gland development
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Accession:GO:0007431 term browser browse the term
Definition:The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity.



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salivary gland development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ascl3 achaete-scute family bHLH transcription factor 3 involved_in ISO (MGI:3807402|PMID:18572159), (MGI:5050445|PMID:21377457) RGD PMID:18572159 PMID:21377457 MGI:3807402 MGI:5050445 NCBI chr 1:163,755,306...163,755,951
Ensembl chr 1:163,754,956...163,759,682
JBrowse link
G Cst3 cystatin C IEP Submandibular gland RGD PMID:10075146 RGD:2306516 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Cyss cystatin S IEP RGD PMID:10075146 RGD:2306516 NCBI chr 3:137,432,049...137,436,654
Ensembl chr 3:137,432,049...137,436,610
JBrowse link
G Fgf10 fibroblast growth factor 10 involved_in ISO (PMID:17213838) RGD PMID:17213838 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Nkx3-1 NK3 homeobox 1 acts_upstream_of_or_within ISO MGI:1928654 (PMID:10906459) RGD PMID:10906459 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Tfcp2l1 transcription factor CP2-like 1 acts_upstream_of_or_within ISO MGI:3707684 (PMID:17079272) RGD PMID:17079272 NCBI chr13:29,733,813...29,793,870
Ensembl chr13:29,733,840...29,793,870
JBrowse link
branch elongation involved in salivary gland morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1859647 (PMID:15972105) RGD PMID:15972105 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO MGI:1099809|MGI:2153811 (PMID:15972105) RGD PMID:15972105 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
branching involved in salivary gland morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp7 bone morphogenetic protein 7 acts_upstream_of_or_within ISO MGI:1857654 (PMID:11731698) RGD PMID:11731698 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Dag1 dystroglycan 1 acts_upstream_of_or_within ISO (PMID:11798066) RGD PMID:11798066 NCBI chr 8:108,890,926...108,955,611
Ensembl chr 8:108,890,929...108,952,325
JBrowse link
G Esrp1 epithelial splicing regulatory protein 1 acts_upstream_of_or_within ISO MGI:1924661 (PMID:26371508) RGD PMID:26371508 NCBI chr 5:24,427,611...24,482,157
Ensembl chr 5:24,428,717...24,482,062
JBrowse link
G Esrp2 epithelial splicing regulatory protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1917326 (PMID:26371508)
Ensembl
RGD
PMID:26371508 GO_REF:0000107 NCBI chr19:34,034,559...34,041,726
Ensembl chr19:34,034,559...34,041,726
JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:95523 (PMID:15972105), (PMID:18559345) RGD PMID:15972105 PMID:18559345 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Fgf7 fibroblast growth factor 7 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:18559345)
Ensembl
RGD
PMID:18559345 GO_REF:0000107 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929
JBrowse link
G Fgf8 fibroblast growth factor 8 acts_upstream_of_or_within ISO MGI:2686826|MGI:98297 (PMID:15042696), (PMID:15063181) RGD PMID:15042696 PMID:15063181 NCBI chr 1:244,584,477...244,590,578
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO (PMID:12421715), (PMID:18559345) RGD PMID:12421715 PMID:18559345 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO MGI:2153814 (PMID:11731698) RGD PMID:11731698 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:11275690) RGD PMID:11275690 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Lama1 laminin subunit alpha 1 acts_upstream_of_or_within ISO (PMID:11798066) RGD PMID:11798066 NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
JBrowse link
G Lama5 laminin subunit alpha 5 acts_upstream_of_or_within ISO (PMID:14568553) RGD PMID:14568553 NCBI chr 3:167,270,296...167,318,370
Ensembl chr 3:167,270,296...167,318,451
JBrowse link
G Pdgfb platelet derived growth factor subunit B acts_upstream_of_or_within ISO (PMID:18559345) RGD PMID:18559345 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857796|MGI:99604 (PMID:15042696)
Ensembl
RGD
PMID:15042696 GO_REF:0000107 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Tgm2 transglutaminase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:15970210)
Ensembl
RGD
PMID:15970210 GO_REF:0000107 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
cell differentiation involved in salivary gland development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 acts_upstream_of_or_within ISO MGI:2183262 (PMID:11976342) RGD PMID:11976342 NCBI chr11:80,197,741...80,211,657
Ensembl chr11:80,198,153...80,211,657
JBrowse link
G Muc19 mucin 19, oligomeric acts_upstream_of_or_within ISO MGI:1857043|MGI:5515435 (PMID:12847143), (PMID:23580649) RGD PMID:12847143 PMID:23580649 NCBI chr 7:123,017,896...123,139,053
Ensembl chr 7:123,017,896...123,139,053
JBrowse link
G Nfib nuclear factor I/B acts_upstream_of_or_within ISO MGI:3530139 (PMID:25403566) RGD PMID:25403566 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479
JBrowse link
dichotomous subdivision of terminal units involved in salivary gland branching term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nrp1 neuropilin 1 acts_upstream_of_or_within ISO MGI:107558 (PMID:17626059) RGD PMID:17626059 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Plxna1 plexin A1 acts_upstream_of_or_within ISO (PMID:17626059) RGD PMID:17626059 NCBI chr 4:121,737,934...121,782,901
Ensembl chr 4:121,737,945...122,024,196
JBrowse link
G Plxnd1 plexin D1 acts_upstream_of_or_within ISO (PMID:17626059) RGD PMID:17626059 NCBI chr 4:149,002,786...149,043,097
Ensembl chr 4:149,002,784...149,043,244
JBrowse link
G Sema3a semaphorin 3A acts_upstream_of_or_within ISO MGI:106206 (PMID:17626059) RGD PMID:17626059 NCBI chr 4:21,282,398...21,754,834
Ensembl chr 4:21,287,982...21,494,432
JBrowse link
G Sema3c semaphorin 3C acts_upstream_of_or_within ISO (PMID:17626059) RGD PMID:17626059 NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534
JBrowse link
epithelial cell differentiation involved in salivary gland development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnnd1 catenin delta 1 acts_upstream_of_or_within ISO MGI:3617486 (PMID:16399075) RGD PMID:16399075 NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516
JBrowse link
epithelial cell maturation involved in salivary gland development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xbp1 X-box binding protein 1 acts_upstream_of_or_within ISO MGI:2386788 (PMID:16362047) RGD PMID:16362047 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
epithelial cell proliferation involved in salivary gland morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1859647|MGI:95523 (PMID:15972105) RGD PMID:15972105 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 acts_upstream_of_or_within ISO MGI:1099809|MGI:2153811 (PMID:15972105) RGD PMID:15972105 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (PMID:11275690) RGD PMID:11275690 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nkx3-1 NK3 homeobox 1 acts_upstream_of_or_within ISO MGI:1928654 (PMID:10906459) RGD PMID:10906459 NCBI chr15:44,473,851...44,476,443
Ensembl chr15:44,473,851...44,476,441
JBrowse link
G Pdgfb platelet derived growth factor subunit B acts_upstream_of_or_within ISO (PMID:18559345) RGD PMID:18559345 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:15042696)
Ensembl
RGD
PMID:15042696 GO_REF:0000107 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO (PMID:11241200) RGD PMID:11241200 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
regulation of branching involved in salivary gland morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btbd7 BTB domain containing 7 involved_in
acts_upstream_of_or_within
IBA
ISO
GO_REF:0000033
(PMID:20671187)
GO_Central
RGD
PMID:20671187 GO_REF:0000033 NCBI chr 6:121,920,365...122,010,114
Ensembl chr 6:121,923,023...121,972,405
JBrowse link
G Cdh1 cadherin 1 acts_upstream_of_or_within ISO (PMID:18816447) RGD PMID:18816447 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Snai2 snail family transcriptional repressor 2 acts_upstream_of_or_within ISO (PMID:20671187) RGD PMID:20671187 NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO (PMID:11241200) RGD PMID:11241200 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdgfa platelet derived growth factor subunit A involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
(PMID:18559345)
UniProt
RGD
PMID:18559345 GO_REF:0000024 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ntn4 netrin 4 acts_upstream_of_or_within ISO (PMID:17588941) RGD PMID:17588941 NCBI chr 7:28,186,611...28,300,390
Ensembl chr 7:28,186,611...28,300,390
JBrowse link
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO (PMID:18559345) RGD PMID:18559345 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Fgf7 fibroblast growth factor 7 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:18559345)
Ensembl
RGD
PMID:18559345 GO_REF:0000107 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO (PMID:18559345) RGD PMID:18559345 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Hgf hepatocyte growth factor acts_upstream_of_or_within
involved_in
ISO
IEA
(PMID:14517989)
GO_REF:0000107
RGD
Ensembl
PMID:14517989 GO_REF:0000107 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase acts_upstream_of_or_within ISO (PMID:14517989) RGD PMID:14517989 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
salivary gland cavitation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdh1 cadherin 1 acts_upstream_of_or_within ISO (PMID:18816447) RGD PMID:18816447 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Eda ectodysplasin-A acts_upstream_of_or_within ISO (PMID:12629675) RGD PMID:12629675 NCBI chr  X:65,078,454...65,480,172
Ensembl chr  X:65,078,673...65,480,172
JBrowse link
G Edar ectodysplasin-A receptor acts_upstream_of_or_within ISO (PMID:12629675) RGD PMID:12629675 NCBI chr20:26,587,836...26,666,543
Ensembl chr20:26,587,839...26,666,494
JBrowse link
G Nfib nuclear factor I/B acts_upstream_of_or_within ISO MGI:3530139 (PMID:25403566) RGD PMID:25403566 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479
JBrowse link
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:16332353)
Ensembl
RGD
PMID:16332353 GO_REF:0000107 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Tgm2 transglutaminase 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(PMID:15970210)
Ensembl
RGD
PMID:15970210 GO_REF:0000107 NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
JBrowse link
salivary gland morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp7 bone morphogenetic protein 7 acts_upstream_of_or_within ISO MGI:1857654 (PMID:11731698) RGD PMID:11731698 NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
JBrowse link
G Ctnnd1 catenin delta 1 acts_upstream_of_or_within ISO MGI:3617486 (PMID:16399075) RGD PMID:16399075 NCBI chr 3:69,683,328...69,734,550
Ensembl chr 3:69,683,313...69,734,516
JBrowse link
G Egfr epidermal growth factor receptor acts_upstream_of_or_within ISO MGI:1935113 (PMID:10521784) RGD PMID:10521784 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1859647 (PMID:15654336) RGD PMID:15654336 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 acts_upstream_of_or_within ISO (PMID:12421715) RGD PMID:12421715 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Pax6 paired box 6 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1856158 (PMID:11731698)
Ensembl
RGD
PMID:11731698 GO_REF:0000107 NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014
JBrowse link
G Polb DNA polymerase beta acts_upstream_of_or_within ISO MGI:5427084 (PMID:24388753) RGD PMID:24388753 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
JBrowse link
G Tgfb1 transforming growth factor, beta 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:18080134)
AgBase
RGD
PMID:18080134 GO_REF:0000024 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:18080134)
AgBase
RGD
PMID:18080134 GO_REF:0000024 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 involved_in ISS
ISO
GO_REF:0000024
(PMID:18080134)
AgBase
RGD
PMID:18080134 GO_REF:0000024 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 acts_upstream_of_or_within ISO MGI:3830633 (PMID:16289463) RGD PMID:16289463 NCBI chr 9:105,533,116...105,567,460
Ensembl chr 9:105,533,136...105,567,479
JBrowse link
submandibular salivary gland formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc42 cell division cycle 42 IEP RGD PMID:18784978 RGD:5688282 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Fgf10 fibroblast growth factor 10 acts_upstream_of_or_within ISO MGI:1859647 (PMID:11062007) RGD PMID:11062007 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    multicellular organismal process 8887
      multicellular organism development 5276
        system development 4559
          exocrine system development 62
            salivary gland development 48
              cell differentiation involved in salivary gland development + 5
              salivary gland boundary specification + 0
              salivary gland morphogenesis + 41
Path 2
Term Annotations click to browse term
  biological_process 20292
    developmental process 7042
      anatomical structure development 6550
        multicellular organism development 5276
          system development 4559
            exocrine system development 62
              salivary gland development 48
                cell differentiation involved in salivary gland development + 5
                salivary gland boundary specification + 0
                salivary gland morphogenesis + 41
paths to the root