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ONTOLOGY REPORT - ANNOTATIONS

Term:acrosome reaction
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Accession:GO:0007340 term browser browse the term
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
Comment:If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
Synonyms:xref: Wikipedia:Acrosome_reaction

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acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase involved_in ISO (MGI:5770160|PMID:26989199) UniProt PMID:26989199 MGI:5770160 NCBI chrNW_004955416:15,878,972...15,983,322
Ensembl chrNW_004955416:15,884,624...15,983,322 		JBrowse link
G Acr acrosin involved_in ISO (PMID:2550339), (PMID:37004249) UniProt PMID:2550339 PMID:37004249 NCBI chrNW_004955413:33,721,984...33,728,088 JBrowse link
G Adcy3 adenylate cyclase 3 involved_in ISO (MGI:3576427|PMID:15705663) UniProt PMID:15705663 MGI:3576427 NCBI chrNW_004955469:6,933,208...7,026,179
Ensembl chrNW_004955469:6,929,092...7,026,758 		JBrowse link
G Garin1b golgi associated RAB2 interactor 1B involved_in ISO (MGI:6814641|PMID:34714330) UniProt PMID:34714330 MGI:6814641 NCBI chrNW_004955479:9,511,366...9,536,986
Ensembl chrNW_004955479:9,518,525...9,537,159 		JBrowse link
G Glra1 glycine receptor alpha 1 acts_upstream_of_or_within ISO (PMID:11076688) MGI PMID:11076688 NCBI chrNW_004955408:6,236,092...6,333,166
Ensembl chrNW_004955408:6,236,092...6,333,166 		JBrowse link
G Glrb glycine receptor beta acts_upstream_of_or_within ISO (PMID:11076688) MGI PMID:11076688 NCBI chrNW_004955471:10,153,197...10,238,052
Ensembl chrNW_004955471:10,152,156...10,238,832 		JBrowse link
G Iftap intraflagellar transport associated protein acts_upstream_of_or_within ISO (PMID:30521625) MGI PMID:30521625 NCBI chrNW_004955422:9,804,012...9,867,580
Ensembl chrNW_004955422:9,804,075...9,851,434 		JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 acts_upstream_of_or_within ISO (PMID:16371590) MGI PMID:16371590 NCBI chrNW_004955495:6,424,426...6,460,252
Ensembl chrNW_004955495:6,453,991...6,459,744 		JBrowse link
G Plcd4 phospholipase C delta 4 acts_upstream_of_or_within ISO (PMID:11340203) MGI PMID:11340203 NCBI chrNW_004955453:14,775,119...14,812,872
Ensembl chrNW_004955453:14,787,677...14,806,485 		JBrowse link
G Prnd prion like protein doppel involved_in ISO (MGI:3045928|PMID:15161660) UniProt PMID:15161660 MGI:3045928 NCBI chrNW_004955415:15,469,500...15,474,817
Ensembl chrNW_004955415:15,469,500...15,474,817 		JBrowse link
G Spesp1 sperm equatorial segment protein 1 acts_upstream_of_or_within ISO (PMID:20375058) MGI PMID:20375058 NCBI chrNW_004955450:7,355,144...7,370,413
Ensembl chrNW_004955450:7,355,082...7,370,735 		JBrowse link
G Stx2 syntaxin 2 involved_in ISO (MGI:3584221|PMID:15774481) HGNC-UCL PMID:15774481 MGI:3584221 NCBI chrNW_004955482:1,249,972...1,273,250
Ensembl chrNW_004955482:1,252,600...1,270,913 		JBrowse link
G Syt6 synaptotagmin 6 involved_in ISO (MGI:3584221|PMID:15774481) HGNC-UCL PMID:15774481 MGI:3584221 NCBI chrNW_004955435:17,349,971...17,405,526
Ensembl chrNW_004955435:17,347,011...17,405,526 		JBrowse link
G Syt8 synaptotagmin 8 involved_in ISO (MGI:3584221|PMID:15774481) HGNC-UCL PMID:15774481 MGI:3584221 NCBI chrNW_004955422:13,642,933...13,648,351
Ensembl chrNW_004955422:13,642,780...13,648,262 		JBrowse link
G Tnp2 transition protein 2 acts_upstream_of_or_within ISO (PMID:11385107) MGI PMID:11385107 NCBI chrNW_004955442:7,311,826...7,314,046 JBrowse link
G Trim36 tripartite motif containing 36 acts_upstream_of_or_within ISO (PMID:12917430) MGI PMID:12917430 NCBI chrNW_004955408:34,909,194...34,939,635
Ensembl chrNW_004955408:34,909,194...34,939,636 		JBrowse link
acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eqtn equatorin acts_upstream_of_or_within ISO (PMID:19285662) MGI PMID:19285662 NCBI chrNW_004955472:7,554,243...7,563,620 JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in ISO (PMID:22248876) UniProt PMID:22248876 NCBI chrNW_004955524:3,220,108...3,224,376
Ensembl chrNW_004955524:3,221,366...3,224,376 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:22248876) UniProt PMID:22248876 NCBI chrNW_004955488:6,999,128...7,196,583
Ensembl chrNW_004955488:6,936,952...7,197,022 		JBrowse link
G Syt6 synaptotagmin 6 involved_in ISO (PMID:11437455) BHF-UCL PMID:11437455 NCBI chrNW_004955435:17,349,971...17,405,526
Ensembl chrNW_004955435:17,347,011...17,405,526 		JBrowse link
G Zp4 zona pellucida glycoprotein 4 involved_in ISO (PMID:19004505) UniProt PMID:19004505 NCBI chrNW_004955492:2,599,579...2,606,837 JBrowse link
acrosome matrix dispersal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acr acrosin ISO RGD PMID:28859281 RGD:13464336 NCBI chrNW_004955413:33,721,984...33,728,088 JBrowse link
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal3 hyaluronidase 3 involved_in ISO (MGI:4834982|PMID:20586096) UniProt PMID:20586096 MGI:4834982 NCBI chrNW_004955532:2,107,019...2,112,356
Ensembl chrNW_004955532:2,106,565...2,108,892 		JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISO (PMID:19246320)
(PMID:19004505)		 UniProt PMID:19004505 PMID:19246320 NCBI chrNW_004955456:15,013,472...15,020,809 JBrowse link
positive regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO (PMID:20394732) UniProt PMID:20394732 NCBI chrNW_004955442:16,047,965...16,108,862
Ensembl chrNW_004955442:16,045,895...16,108,862 		JBrowse link
G Ccdc87 coiled-coil domain containing 87 involved_in ISO (MGI:6201938|PMID:29733332) UniProt PMID:29733332 MGI:6201938 NCBI chrNW_004955422:18,772,869...18,775,548 JBrowse link
G Fam170b family with sequence similarity 170 member B involved_in ISO (MGI:5705205|PMID:26179146) UniProt PMID:26179146 MGI:5705205 NCBI chrNW_004955556:1,072,826...1,075,332
Ensembl chrNW_004955556:1,072,692...1,077,761 		JBrowse link
G Glra1 glycine receptor alpha 1 involved_in ISO (PMID:11751269) UniProt PMID:11751269 NCBI chrNW_004955408:6,236,092...6,333,166
Ensembl chrNW_004955408:6,236,092...6,333,166 		JBrowse link
G LOC102021703 IQ domain-containing protein F1 involved_in ISO (MGI:5708001|PMID:25380116) UniProt PMID:25380116 MGI:5708001 NCBI chrNW_004955532:3,559,990...3,561,238 JBrowse link
G Pla2g10 phospholipase A2 group X involved_in ISO (MGI:4459353|PMID:20424324) UniProt PMID:20424324 MGI:4459353 NCBI chrNW_004955442:4,208,497...4,225,893
Ensembl chrNW_004955442:4,208,575...4,225,834 		JBrowse link
G Plb1 phospholipase B1 acts_upstream_of_or_within ISO (PMID:23943622) MGI PMID:23943622 NCBI chrNW_004955469:10,370,646...10,511,263
Ensembl chrNW_004955469:10,401,178...10,511,057 		JBrowse link
G Plcb1 phospholipase C beta 1 involved_in ISO (MGI:2136696|PMID:11464583) BHF-UCL PMID:11464583 MGI:2136696 NCBI chrNW_004955415:18,210,608...18,915,099
Ensembl chrNW_004955415:18,210,662...18,915,158 		JBrowse link
G Prss37 serine protease 37 involved_in ISO (PMID:27649891) UniProt PMID:27649891 NCBI chrNW_004955494:1,742,104...1,747,310
Ensembl chrNW_004955494:1,744,044...1,747,213 		JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISO (PMID:11751269), (PMID:18667750), (PMID:20394732)
(MGI:4942264|PMID:10793136)		 UniProt PMID:10793136 PMID:11751269 PMID:18667750 PMID:20394732 MGI:4942264 NCBI chrNW_004955456:15,013,472...15,020,809 JBrowse link
G Zp4 zona pellucida glycoprotein 4 involved_in ISO (PMID:18667750), (PMID:20394732) UniProt PMID:18667750 PMID:20394732 NCBI chrNW_004955492:2,599,579...2,606,837 JBrowse link
protein localization involved in acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glipr1l1 GLIPR1 like 1 involved_in ISO (PMID:31672133) UniProt PMID:31672133 NCBI chrNW_004955405:14,710,789...14,755,709
Ensembl chrNW_004955405:14,710,431...14,755,826 		JBrowse link
regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stxbp1 syntaxin binding protein 1 involved_in ISO (PMID:23091057) UniProt PMID:23091057 NCBI chrNW_004955419:963,829...1,000,759
Ensembl chrNW_004955419:963,829...1,000,759 		JBrowse link
regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B4galt1 beta-1,4-galactosyltransferase 1 acts_upstream_of_or_within ISO (PMID:9374408) MGI PMID:9374408 NCBI chrNW_004955472:2,490,649...2,536,053
Ensembl chrNW_004955472:2,490,661...2,536,317 		JBrowse link
G Hvcn1 hydrogen voltage gated channel 1 involved_in ISO (PMID:30478045) UniProt PMID:30478045 NCBI chrNW_004955482:7,529,009...7,563,273
Ensembl chrNW_004955482:7,529,277...7,538,363 		JBrowse link
G Pkdrej polycystin family receptor for egg jelly acts_upstream_of_or_within ISO (PMID:18562295) MGI PMID:18562295 NCBI chrNW_004955413:30,377,627...30,384,749
Ensembl chrNW_004955413:30,378,603...30,384,681 		JBrowse link
G Serpina10 serpin family A member 10 NOT|involved_in ISO (PMID:11751269) UniProt PMID:11751269 NCBI chrNW_004955438:16,335,201...16,345,093
Ensembl chrNW_004955438:16,335,544...16,345,094 		JBrowse link
G Spink1 serine peptidase inhibitor Kazal type 1 acts_upstream_of_or_within ISO (PMID:22228629) MGI PMID:22228629 NCBI chrNW_004955415:6,328,672...6,378,611
Ensembl chrNW_004955415:6,371,059...6,378,529 		JBrowse link
G Zp2 zona pellucida glycoprotein 2 NOT|involved_in ISO (PMID:11751269), (PMID:20394732) UniProt PMID:11751269 PMID:20394732 NCBI chrNW_004955493:400,868...412,660
Ensembl chrNW_004955493:400,868...412,596 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    reproductive process 1482
      acrosome reaction 38
        acrosomal vesicle exocytosis + 8
        acrosome matrix dispersal 1
        membrane fusion involved in acrosome reaction 0
        negative regulation of acrosome reaction 0
        positive regulation of acrosome reaction 11
        protein localization involved in acrosome reaction 1
        regulation of acrosome reaction + 17
Path 2
Term Annotations click to browse term
  biological_process 12346
    reproductive process 1482
      sexual reproduction 917
        fertilization 170
          single fertilization 126
            acrosome reaction 38
              acrosomal vesicle exocytosis + 8
              acrosome matrix dispersal 1
              membrane fusion involved in acrosome reaction 0
              negative regulation of acrosome reaction 0
              positive regulation of acrosome reaction 11
              protein localization involved in acrosome reaction 1
              regulation of acrosome reaction + 17
paths to the root