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ONTOLOGY REPORT - ANNOTATIONS


Term:acrosome reaction
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Accession:GO:0007340 term browser browse the term
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
Comment:If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
Synonyms:xref: Wikipedia:Acrosome_reaction



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acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase involved_in ISO (MGI:5770160|PMID:26989199) RGD PMID:26989199 MGI:5770160 NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061
JBrowse link
G Acr acrosin involved_in IBA
ISS
TAS
ISO
PMID:21873635
GO_REF:0000024
PMID:12398221
(PMID:2550339)
UniProt
RGD
PMID:2550339 PMID:21873635 PMID:12398221 GO_REF:0000024, RGD:13792537, RGD:8553887 NCBI chr 7:120,636,581...120,644,474
Ensembl chr 7:120,638,321...120,644,474
JBrowse link
G Adcy3 adenylate cyclase 3 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3576427|PMID:15705663)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:15705663 GO_REF:0000024 GO_REF:0000107 MGI:3576427 NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686
JBrowse link
G Glra1 glycine receptor, alpha 1 acts_upstream_of_or_within ISO MGI:1856362 (MGI:3621686|PMID:11076688) RGD PMID:11076688 MGI:3621686 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
JBrowse link
G Glrb glycine receptor, beta acts_upstream_of_or_within ISO MGI:1856363 (MGI:3621686|PMID:11076688) RGD PMID:11076688 MGI:3621686 NCBI chr 2:166,134,624...166,207,509
Ensembl chr 2:166,134,626...166,207,489
JBrowse link
G Iftap intraflagellar transport associated protein involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:4362302 (MGI:6268817|PMID:30521625)
RGD PMID:30521625 PMID:21873635 MGI:6268817, RGD:13792537 NCBI chr 3:87,812,068...87,906,517
Ensembl chr 3:87,817,408...87,906,547
JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 involved_in
acts_upstream_of_or_within
ISS
ISO
IEA
GO_REF:0000024
MGI:2665512 (MGI:3619873|PMID:16371590)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:16371590 GO_REF:0000024 GO_REF:0000107 MGI:3619873 NCBI chr 7:9,381,366...9,389,589
Ensembl chr 7:9,381,361...9,389,585
JBrowse link
G Plcd4 phospholipase C, delta 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
GO_REF:0000002
MGI:2155167 (MGI:1934056|PMID:11340203)
Ensembl
InterPro
RGD
PMID:11340203 GO_REF:0000002 GO_REF:0000107 MGI:1934056 NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453
JBrowse link
G Prnd prion like protein doppel involved_in ISO (MGI:3045928|PMID:15161660) RGD PMID:15161660 MGI:3045928 NCBI chr 3:119,213,402...119,218,742
Ensembl chr 3:119,213,429...119,218,745
JBrowse link
G Spesp1 sperm equatorial segment protein 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:4838302 (MGI:4452161|PMID:20375058)
RGD PMID:20375058 PMID:21873635 MGI:4452161, RGD:13792537 NCBI chr 8:62,751,313...62,766,657
Ensembl chr 8:62,751,297...62,766,718
JBrowse link
G Stx2 syntaxin 2 involved_in IEA
ISO
GO_REF:0000002
(MGI:3584221|PMID:15774481)
InterPro
RGD
PMID:15774481 GO_REF:0000002 MGI:3584221 NCBI chr12:27,678,744...27,714,751
Ensembl chr12:27,689,819...27,714,751
JBrowse link
G Syt6 synaptotagmin 6 involved_in IEA
ISO
GO_REF:0000002
(MGI:3584221|PMID:15774481)
InterPro
RGD
PMID:15774481 GO_REF:0000002 MGI:3584221 NCBI chr 2:191,093,009...191,152,283
Ensembl chr 2:191,093,007...191,149,956
JBrowse link
G Syt8 synaptotagmin 8 involved_in IEA
ISO
GO_REF:0000107
(MGI:3584221|PMID:15774481)
Ensembl
RGD
PMID:15774481 GO_REF:0000107 MGI:3584221 NCBI chr 1:197,588,126...197,593,598
Ensembl chr 1:197,590,149...197,593,504
JBrowse link
G Tnp2 transition protein 2 involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
MGI:2180779 (MGI:2180725|PMID:11385107)
PMID:21873635
Ensembl
RGD
PMID:11385107 PMID:21873635 GO_REF:0000107 MGI:2180725, RGD:13792537 NCBI chr10:4,879,812...4,880,540
Ensembl chr10:4,879,812...4,880,538
JBrowse link
G Trim36 tripartite motif-containing 36 acts_upstream_of_or_within ISO (MGI:2680779|PMID:12917430) RGD PMID:12917430 MGI:2680779 NCBI chr18:38,859,604...38,912,859
Ensembl chr18:38,861,018...38,912,859
JBrowse link
G Trpc2 transient receptor potential cation channel subfamily C member 2 acts_upstream_of_or_within ISO (MGI:3045541|PMID:11331878) RGD PMID:11331878 MGI:3045541 NCBI chr 1:156,460,009...156,473,039
Ensembl chr 1:156,440,305...156,473,073
JBrowse link
acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eqtn equatorin involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5293452|PMID:19285662)
RGD PMID:19285662 PMID:21873635 MGI:5293452, RGD:13792537 NCBI chr 5:109,734,495...109,762,048
Ensembl chr 5:109,728,999...109,761,840
JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in ISO (PMID:22248876) RGD PMID:22248876 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO
IEA
(PMID:22248876)
GO_REF:0000107
RGD
Ensembl
PMID:22248876 GO_REF:0000107 NCBI chr 9:24,696,959...25,196,368
Ensembl chr 9:24,698,854...25,196,631
JBrowse link
G Syt6 synaptotagmin 6 involved_in ISO (PMID:11437455) RGD PMID:11437455 NCBI chr 2:191,093,009...191,152,283
Ensembl chr 2:191,093,007...191,149,956
JBrowse link
G Unc13b unc-13 homolog B involved_in ISO (PMID:22248876) RGD PMID:22248876 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926
JBrowse link
G Zp4 zona pellucida glycoprotein 4 involved_in ISO
IEA
(PMID:19004505)
GO_REF:0000107
RGD
Ensembl
PMID:19004505 GO_REF:0000107 NCBI chr17:59,005,649...59,012,202
Ensembl chr17:59,005,649...59,012,202
JBrowse link
acrosome matrix dispersal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acr acrosin IMP RGD PMID:28859281 RGD:13464336 NCBI chr 7:120,636,581...120,644,474
Ensembl chr 7:120,638,321...120,644,474
JBrowse link
negative regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spink13 serine peptidase inhibitor Kazal type 13 involved_in IMP PMID:23430248 UniProt PMID:23430248 RGD:8553255 NCBI chr18:56,064,839...56,206,257
Ensembl chr18:56,064,839...56,206,257
JBrowse link
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal3 hyaluronidase 3 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:4834982|PMID:20586096)
UniProt
Ensembl
RGD
PMID:20586096 GO_REF:0000024 GO_REF:0000107 MGI:4834982 NCBI chr 8:108,254,385...108,260,020
Ensembl chr 8:108,250,667...108,260,647
JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISO
ISS
(PMID:19004505), (PMID:19246320)
GO_REF:0000024
RGD
UniProt
PMID:19004505 PMID:19246320 GO_REF:0000024 NCBI chr12:20,690,547...20,697,513
Ensembl chr12:20,690,547...20,697,513
JBrowse link
positive regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO
IEA
(PMID:20394732)
GO_REF:0000107
RGD
Ensembl
PMID:20394732 GO_REF:0000107 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Ccdc87 coiled-coil domain containing 87 involved_in ISO (MGI:6201938|PMID:29733332) RGD PMID:29733332 MGI:6201938 NCBI chr 1:202,135,021...202,137,717
Ensembl chr 1:202,134,963...202,138,337
JBrowse link
G Fam170b family with sequence similarity 170, member B involved_in ISO (MGI:5705205|PMID:26179146) RGD PMID:26179146 MGI:5705205 NCBI chr16:8,101,899...8,104,724
Ensembl chr16:8,101,914...8,104,705
JBrowse link
G Glra1 glycine receptor, alpha 1 involved_in ISO (PMID:11751269) RGD PMID:11751269 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
JBrowse link
G Iqcf1 IQ motif containing F1 involved_in IBA
ISO
PMID:21873635
(MGI:5708001|PMID:25380116)
RGD PMID:25380116 PMID:21873635 MGI:5708001, RGD:13792537 NCBI chr 8:107,129,462...107,133,242
Ensembl chr 8:107,130,704...107,133,249
JBrowse link
G Pla2g10 phospholipase A2, group X involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:4459353|PMID:20424324)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:20424324 GO_REF:0000024 GO_REF:0000107 MGI:4459353 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000
JBrowse link
G Plb1 phospholipase B1 acts_upstream_of_or_within ISO (MGI:5528927|PMID:23943622) RGD PMID:23943622 MGI:5528927 NCBI chr 6:24,087,051...24,227,167
Ensembl chr 6:24,089,214...24,210,117
JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:2136696|PMID:11464583)
Ensembl
RGD
PMID:11464583 GO_REF:0000107 MGI:2136696 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Prss37 serine protease 37 involved_in IBA
ISO
PMID:21873635
(PMID:27649891)
RGD PMID:27649891 PMID:21873635 RGD:13792537 NCBI chr 4:69,322,977...69,334,555
Ensembl chr 4:69,322,977...69,334,555
JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISS
ISO
IEA
IBA
GO_REF:0000024
(MGI:4942264|PMID:10793136)
GO_REF:0000104
PMID:21873635
(PMID:11751269), (PMID:18667750), (PMID:20394732)
UniProt
RGD
PMID:10793136 PMID:11751269 PMID:18667750 PMID:20394732 PMID:21873635 GO_REF:0000024 GO_REF:0000104 MGI:4942264, RGD:13792537 NCBI chr12:20,690,547...20,697,513
Ensembl chr12:20,690,547...20,697,513
JBrowse link
G Zp4 zona pellucida glycoprotein 4 involved_in ISO
IEA
(PMID:18667750), (PMID:20394732)
GO_REF:0000107
RGD
Ensembl
PMID:18667750 PMID:20394732 GO_REF:0000107 NCBI chr17:59,005,649...59,012,202
Ensembl chr17:59,005,649...59,012,202
JBrowse link
regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stxbp1 syntaxin binding protein 1 involved_in ISO (PMID:23091057) RGD PMID:23091057 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369
JBrowse link
regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B4galt1 beta-1,4-galactosyltransferase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2178779 (MGI:1098917|PMID:9374408)
Ensembl
RGD
PMID:9374408 GO_REF:0000107 MGI:1098917 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
JBrowse link
G Crisp1 cysteine-rich secretory protein 1 acts_upstream_of_or_within ISO MGI:4950060 (MGI:4949775|PMID:21482758) RGD PMID:21482758 MGI:4949775 NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796
JBrowse link
G Pkdrej polycystin family receptor for egg jelly acts_upstream_of_or_within ISO MGI:3799312 (MGI:3798326|PMID:18562295) RGD PMID:18562295 MGI:3798326 NCBI chr 7:116,909,094...116,915,468
Ensembl chr 7:116,909,094...116,915,468
JBrowse link
G Serpina10 serpin family A member 10 NOT|involved_in ISO (PMID:11751269) RGD PMID:11751269 NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 acts_upstream_of_or_within ISO (MGI:5428115|PMID:22228629) RGD PMID:22228629 MGI:5428115 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
JBrowse link
G Zp2 zona pellucida glycoprotein 2 NOT|involved_in ISO (PMID:11751269), (PMID:20394732) RGD PMID:11751269 PMID:20394732 NCBI chr 1:174,513,507...174,525,288
Ensembl chr 1:174,513,511...174,525,288
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    reproductive process 1827
      acrosome reaction 39
        acrosomal vesicle exocytosis + 9
        acrosome matrix dispersal 1
        membrane fusion involved in acrosome reaction 0
        negative regulation of acrosome reaction 1
        positive regulation of acrosome reaction 11
        positive regulation of actin filament depolymerization involved in acrosome reaction 0
        positive regulation of actin filament polymerization involved in acrosome reaction 0
        protein localization involved in acrosome reaction 0
        regulation of acrosome reaction + 18
Path 2
Term Annotations click to browse term
  biological_process 19497
    reproduction 1830
      reproductive process 1827
        multi-organism reproductive process 1272
          sexual reproduction 1020
            fertilization 205
              single fertilization 155
                acrosome reaction 39
                  acrosomal vesicle exocytosis + 9
                  acrosome matrix dispersal 1
                  membrane fusion involved in acrosome reaction 0
                  negative regulation of acrosome reaction 1
                  positive regulation of acrosome reaction 11
                  positive regulation of actin filament depolymerization involved in acrosome reaction 0
                  positive regulation of actin filament polymerization involved in acrosome reaction 0
                  protein localization involved in acrosome reaction 0
                  regulation of acrosome reaction + 18
paths to the root