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ONTOLOGY REPORT - ANNOTATIONS

Term:acrosome reaction
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Accession:GO:0007340 term browser browse the term
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
Comment:If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
Synonyms:xref: Wikipedia:Acrosome_reaction


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acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase involved_in ISO (PMID:26989199) RGD PMID:26989199 NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061 		JBrowse link
G Acr acrosin involved_in TAS
ISO
IBA
ISS		 PMID:12398221
(PMID:2550339), (PMID:37004249)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:2550339 PMID:37004249 PMID:12398221 GO_REF:0000024 GO_REF:0000033, RGD:8553887 NCBI chr 7:120,636,581...120,644,474
Ensembl chr 7:120,638,321...120,644,474 		JBrowse link
G Adcy3 adenylate cyclase 3 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:15705663)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:15705663 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686 		JBrowse link
G Garin1b golgi associated RAB2 interactor 1B involved_in ISS
ISO		 GO_REF:0000024
(PMID:34714330)		 UniProt
RGD		 PMID:34714330 GO_REF:0000024 NCBI chr 4:57,915,184...57,938,593
Ensembl chr 4:57,920,790...57,938,591 		JBrowse link
G Glra1 glycine receptor, alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:1856362 (PMID:11076688)		 Ensembl
RGD		 PMID:11076688 GO_REF:0000107 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162 		JBrowse link
G Glrb glycine receptor, beta acts_upstream_of_or_within ISO MGI:1856363 (PMID:11076688) RGD PMID:11076688 NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489 		JBrowse link
G Iftap intraflagellar transport associated protein involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:4362302 (PMID:30521625)		 GO_Central
RGD		 PMID:30521625 GO_REF:0000033 NCBI chr 3:87,812,068...87,906,517
Ensembl chr 3:87,817,408...87,906,547 		JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 GO_REF:0000024
MGI:2665512 (PMID:16371590)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:16371590 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:9,381,366...9,389,589
Ensembl chr 7:9,381,361...9,389,585 		JBrowse link
G Plcd4 phospholipase C, delta 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2155167 (PMID:11340203)		 Ensembl
RGD		 PMID:11340203 GO_REF:0000107 NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453 		JBrowse link
G Prnd prion like protein doppel involved_in ISO (PMID:15161660) RGD PMID:15161660 NCBI chr 3:119,213,462...119,218,742
Ensembl chr 3:119,213,429...119,218,745 		JBrowse link
G Spesp1 sperm equatorial segment protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000002
MGI:4838302 (PMID:20375058)
GO_REF:0000033		 InterPro
RGD
GO_Central		 PMID:20375058 GO_REF:0000002 GO_REF:0000033 NCBI chr 8:62,751,313...62,766,657
Ensembl chr 8:62,751,297...62,766,718 		JBrowse link
G Stx2 syntaxin 2 involved_in ISO (PMID:15774481) RGD PMID:15774481 NCBI chr12:27,678,744...27,714,751
Ensembl chr12:27,689,819...27,714,751 		JBrowse link
G Syt6 synaptotagmin 6 involved_in ISO (PMID:15774481) RGD PMID:15774481 NCBI chr 2:191,093,009...191,152,283
Ensembl chr 2:191,093,007...191,149,956 		JBrowse link
G Syt8 synaptotagmin 8 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15774481)		 Ensembl
RGD		 PMID:15774481 GO_REF:0000107 NCBI chr 1:197,588,126...197,593,598
Ensembl chr 1:197,590,149...197,593,504 		JBrowse link
G Tnp2 transition protein 2 involved_in
acts_upstream_of_or_within		 IBA
IEA
ISO		 GO_REF:0000033
GO_REF:0000107
MGI:2180779 (PMID:11385107)		 GO_Central
Ensembl
RGD		 PMID:11385107 GO_REF:0000033 GO_REF:0000107 NCBI chr10:4,879,812...4,880,540
Ensembl chr10:4,879,812...4,880,538 		JBrowse link
G Trim36 tripartite motif-containing 36 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:12917430)		 GO_Central
RGD		 PMID:12917430 GO_REF:0000033 NCBI chr18:38,859,604...38,912,859
Ensembl chr18:38,861,018...38,912,859 		JBrowse link
G Trpc2 transient receptor potential cation channel subfamily C member 2 acts_upstream_of_or_within ISO (PMID:11331878) RGD PMID:11331878 NCBI chr 1:156,460,009...156,473,039
Ensembl chr 1:156,440,305...156,473,073 		JBrowse link
acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eqtn equatorin involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000002
(PMID:19285662)
GO_REF:0000033		 InterPro
RGD
GO_Central		 PMID:19285662 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:109,734,495...109,762,048
Ensembl chr 5:109,728,999...109,761,840 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family involved_in ISO
IBA
IEA		 (PMID:22248876)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:22248876 GO_REF:0000033 GO_REF:0000107 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336 		JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 involved_in ISO (PMID:22248876) RGD PMID:22248876 NCBI chr 9:24,696,959...25,196,404
Ensembl chr 9:24,698,854...25,196,631 		JBrowse link
G Syt6 synaptotagmin 6 involved_in ISO
IEA		 (PMID:11437455)
GO_REF:0000107		 RGD
Ensembl		 PMID:11437455 GO_REF:0000107 NCBI chr 2:191,093,009...191,152,283
Ensembl chr 2:191,093,007...191,149,956 		JBrowse link
G Unc13b unc-13 homolog B involved_in ISO (PMID:22248876) RGD PMID:22248876 NCBI chr 5:57,288,999...57,504,110
Ensembl chr 5:57,289,227...57,502,926 		JBrowse link
G Zp4 zona pellucida glycoprotein 4 involved_in ISO (PMID:19004505) RGD PMID:19004505 NCBI chr17:59,005,649...59,012,202
Ensembl chr17:59,005,649...59,012,202 		JBrowse link
acrosome matrix dispersal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acr acrosin IMP RGD PMID:28859281 RGD:13464336 NCBI chr 7:120,636,581...120,644,474
Ensembl chr 7:120,638,321...120,644,474 		JBrowse link
negative regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spink13 serine peptidase inhibitor Kazal type 13 involved_in IMP PMID:23430248 UniProt PMID:23430248 RGD:8553255 NCBI chr18:56,064,839...56,206,257
Ensembl chr18:56,064,839...56,206,257 		JBrowse link
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal3 hyaluronidase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20586096)		 UniProt
RGD		 PMID:20586096 GO_REF:0000024 NCBI chr 8:108,254,385...108,260,020
Ensembl chr 8:108,250,667...108,260,647 		JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISO
ISS		 (PMID:19004505), (PMID:19246320)
GO_REF:0000024		 RGD
UniProt		 PMID:19004505 PMID:19246320 GO_REF:0000024 NCBI chr12:20,690,547...20,697,513
Ensembl chr12:20,690,547...20,697,513 		JBrowse link
positive regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in ISO
IEA		 (PMID:20394732)
GO_REF:0000107		 RGD
Ensembl		 PMID:20394732 GO_REF:0000107 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376 		JBrowse link
G Ccdc87 coiled-coil domain containing 87 involved_in ISO (PMID:29733332) RGD PMID:29733332 NCBI chr 1:202,135,021...202,137,717
Ensembl chr 1:202,134,963...202,138,337 		JBrowse link
G Fam170b family with sequence similarity 170, member B involved_in ISO (PMID:26179146) RGD PMID:26179146 NCBI chr16:8,101,914...8,104,724
Ensembl chr16:8,101,914...8,104,705 		JBrowse link
G Glra1 glycine receptor, alpha 1 involved_in ISO
IEA		 (PMID:11751269)
GO_REF:0000107		 RGD
Ensembl		 PMID:11751269 GO_REF:0000107 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162 		JBrowse link
G Iqcf1 IQ motif containing F1 involved_in IBA
ISO		 GO_REF:0000033
(PMID:25380116)		 GO_Central
RGD		 PMID:25380116 GO_REF:0000033 NCBI chr 8:107,129,462...107,133,242
Ensembl chr 8:107,130,704...107,133,249 		JBrowse link
G Pla2g10 phospholipase A2, group X involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:20424324)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:20424324 GO_REF:0000024 GO_REF:0000107 NCBI chr10:1,597,761...1,610,822
Ensembl chr10:1,597,761...1,609,000 		JBrowse link
G Plb1 phospholipase B1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:23943622)		 Ensembl
RGD		 PMID:23943622 GO_REF:0000107 NCBI chr 6:24,087,051...24,227,167
Ensembl chr 6:24,089,214...24,210,117 		JBrowse link
G Plcb1 phospholipase C beta 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:11464583)		 Ensembl
RGD		 PMID:11464583 GO_REF:0000107 NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Prss37 serine protease 37 involved_in ISO
IBA		 (PMID:27649891)
GO_REF:0000033		 RGD
GO_Central		 PMID:27649891 GO_REF:0000033 NCBI chr 4:69,322,977...69,334,555
Ensembl chr 4:69,322,977...69,334,555 		JBrowse link
G Zp3 zona pellucida glycoprotein 3 involved_in ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:10793136)
GO_REF:0000033
GO_REF:0000104
(PMID:11751269), (PMID:18667750), (PMID:20394732)		 UniProt
RGD
GO_Central		 PMID:10793136 PMID:11751269 PMID:18667750 PMID:20394732 GO_REF:0000024 GO_REF:0000033 GO_REF:0000104 NCBI chr12:20,690,547...20,697,513
Ensembl chr12:20,690,547...20,697,513 		JBrowse link
G Zp4 zona pellucida glycoprotein 4 involved_in ISO (PMID:18667750), (PMID:20394732) RGD PMID:18667750 PMID:20394732 NCBI chr17:59,005,649...59,012,202
Ensembl chr17:59,005,649...59,012,202 		JBrowse link
protein localization involved in acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glipr1l1 GLIPR1 like 1 involved_in ISO (PMID:31672133) RGD PMID:31672133 NCBI chr 7:47,550,637...47,577,611
Ensembl chr 7:47,550,631...47,577,617 		JBrowse link
regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stxbp1 syntaxin binding protein 1 involved_in ISO (PMID:23091057) RGD PMID:23091057 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B4galt1 beta-1,4-galactosyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2178779 (PMID:9374408)		 Ensembl
RGD		 PMID:9374408 GO_REF:0000107 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461 		JBrowse link
G Crisp1 cysteine-rich secretory protein 1 acts_upstream_of_or_within ISO MGI:4950060 (PMID:21482758) RGD PMID:21482758 NCBI chr 9:20,741,775...20,768,796
Ensembl chr 9:20,741,777...20,768,796 		JBrowse link
G Hvcn1 hydrogen voltage-gated channel 1 involved_in ISO (PMID:30478045) RGD PMID:30478045 NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141 		JBrowse link
G Pkdrej polycystin family receptor for egg jelly acts_upstream_of_or_within ISO MGI:3799312 (PMID:18562295) RGD PMID:18562295 NCBI chr 7:116,909,094...116,915,468
Ensembl chr 7:116,909,094...116,915,468 		JBrowse link
G Serpina10 serpin family A member 10 NOT|involved_in ISO (PMID:11751269) RGD PMID:11751269 NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 acts_upstream_of_or_within ISO (PMID:22228629) RGD PMID:22228629 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
G Zp2 zona pellucida glycoprotein 2 NOT|involved_in ISO (PMID:11751269), (PMID:20394732) RGD PMID:11751269 PMID:20394732 NCBI chr 1:174,513,507...174,525,288
Ensembl chr 1:174,513,511...174,525,288 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20076
    reproductive process 1922
      acrosome reaction 42
        acrosomal vesicle exocytosis + 9
        acrosome matrix dispersal 1
        membrane fusion involved in acrosome reaction 0
        negative regulation of acrosome reaction 1
        positive regulation of acrosome reaction 11
        protein localization involved in acrosome reaction 1
        regulation of acrosome reaction + 19
Path 2
Term Annotations click to browse term
  biological_process 20076
    reproductive process 1922
      sexual reproduction 1211
        fertilization 238
          single fertilization 188
            acrosome reaction 42
              acrosomal vesicle exocytosis + 9
              acrosome matrix dispersal 1
              membrane fusion involved in acrosome reaction 0
              negative regulation of acrosome reaction 1
              positive regulation of acrosome reaction 11
              protein localization involved in acrosome reaction 1
              regulation of acrosome reaction + 19
paths to the root