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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, cholinergic
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Accession:GO:0007271 term browser browse the term
Definition:The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO RGD PMID:15297571 RGD:1625662 NCBI chrNW_004936619:597,970...618,564 JBrowse link
G Chrm3 cholinergic receptor muscarinic 3 acts_upstream_of_or_within ISO (MGI:1888655|PMID:10944224) MGI PMID:10944224 MGI:1888655 NCBI chrNW_004936484:13,953,141...14,373,174 JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit acts_upstream_of_or_within ISO (MGI:3771935|PMID:18077337) MGI PMID:18077337 MGI:3771935 NCBI chrNW_004936498:1,224,123...1,230,640 JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit acts_upstream_of_or_within ISO (MGI:3590443|PMID:16162937) MGI PMID:16162937 MGI:3590443 NCBI chrNW_004936471:36,427,598...36,447,903 JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit acts_upstream_of_or_within ISO (MGI:1931636|PMID:11226318)
(MGI:2176631|PMID:11906696)
RGD
MGI
PMID:11226318 PMID:11906696 PMID:15026122 MGI:1931636 MGI:2176631 RGD:1358635 NCBI chrNW_004936514:10,680,893...10,695,859 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit acts_upstream_of_or_within ISO (MGI:1099674|PMID:9364063) RGD
MGI
PMID:9364063 PMID:15044058 MGI:1099674 RGD:1600975 NCBI chrNW_004937351:32,324...46,871 JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit involved_in ISO (PMID:8872460) UniProt PMID:8872460 NCBI chrNW_004936595:727,907...735,783 JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit ISO RGD PMID:12754307 RGD:1358637 NCBI chrNW_004936580:4,165,255...4,179,285 JBrowse link
G Lynx1 Ly6/neurotoxin 1 acts_upstream_of_or_within ISO (MGI:3838433|PMID:19246390) MGI PMID:19246390 MGI:3838433 NCBI chrNW_004936470:9,109,888...9,115,271 JBrowse link
G Lypd1 LY6/PLAUR domain containing 1 acts_upstream_of_or_within ISO (MGI:3838433|PMID:19246390) MGI PMID:19246390 MGI:3838433 NCBI chrNW_004936469:56,163,531...56,199,067 JBrowse link
G Rapsn receptor associated protein of the synapse acts_upstream_of_or_within ISO (PMID:18420419) MGI PMID:18420419 NCBI chrNW_004936562:1,796,087...1,804,153 JBrowse link
G Ric3 RIC3 acetylcholine receptor chaperone acts_upstream_of_or_within ISO PMID:18420419 MGI PMID:18420419 RGD:2317082 NCBI chrNW_004936528:9,790,594...9,829,120 JBrowse link
G Slc5a7 solute carrier family 5 member 7 acts_upstream_of_or_within ISO (MGI:3044863|PMID:15173594)
(MGI:3590443|PMID:16162937)
MGI PMID:15173594 PMID:16162937 MGI:3044863 MGI:3590443 NCBI chrNW_004936729:1,511,648...1,534,042 JBrowse link
negative regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr6 5-hydroxytryptamine receptor 6 ISO RGD PMID:16987217 RGD:2317005 NCBI chrNW_004936474:5,848,719...5,858,520 JBrowse link
positive regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO phrenic nerve terminals in the presence of adenosine transport inhibitor deoxycoformycin RGD PMID:12679375 RGD:1625693 NCBI chrNW_004936619:597,970...618,564 JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C ISO RGD PMID:15266551 RGD:1625007 NCBI chrNW_004936499:1,002,083...1,109,446 JBrowse link
G Tacr2 tachykinin receptor 2 ISO RGD PMID:12747940 RGD:5147477 NCBI chrNW_004936521:9,053,179...9,065,790 JBrowse link
positive regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma ISO RGD PMID:1900518 RGD:2311499 NCBI chrNW_004936545:6,139,130...6,144,543 JBrowse link
G Lama2 laminin subunit alpha 2 acts_upstream_of_or_within ISO (MGI:77287|PMID:8568931) MGI PMID:8568931 MGI:77287 NCBI chrNW_004936639:259,662...825,170 JBrowse link
G Musk muscle associated receptor tyrosine kinase ISO RGD PMID:16870737 RGD:2317092 NCBI chrNW_004936559:2,387,019...2,486,685 JBrowse link
G Ngfr nerve growth factor receptor ISO medial septum and diagonal band of Broca (MS-DBB) neurons stimulated by NGF RGD PMID:18256260 RGD:5508750 NCBI chrNW_004936490:12,038,500...12,057,257 JBrowse link
G Tac1 tachykinin precursor 1 ISO RGD PMID:17949415 RGD:2304335 NCBI chrNW_004936585:2,932,783...2,941,141 JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:17949415 RGD:2304335 NCBI chrNW_004936556:1,266,621...1,421,271 JBrowse link
G Uts2 urotensin 2 ISO RGD PMID:15944374 RGD:2306844 NCBI chrNW_004936623:2,339,259...2,345,717 JBrowse link
regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit acts_upstream_of_or_within ISO (MGI:3590443|PMID:16162937) MGI PMID:16162937 MGI:3590443 NCBI chrNW_004936471:36,427,598...36,447,903 JBrowse link
G LOC101960999 voltage-dependent P/Q-type calcium channel subunit alpha-1A acts_upstream_of_or_within ISO (MGI:2654957|PMID:12624181)
(MGI:3606714|PMID:10686170)
MGI PMID:10686170 PMID:12624181 MGI:2654957 MGI:3606714 NCBI chrNW_004936659:2,201,606...2,269,625 JBrowse link
regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chrNW_004936478:19,183,493...19,278,457 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12170
    signaling 4322
      cell-cell signaling 1371
        synaptic signaling 665
          trans-synaptic signaling 644
            anterograde trans-synaptic signaling 636
              chemical synaptic transmission 636
                synaptic transmission, cholinergic 25
                  acetylcholine catabolic process in synaptic cleft 0
                  acetylcholine secretion, neurotransmission + 6
                  negative regulation of synaptic transmission, cholinergic + 1
                  positive regulation of synaptic transmission, cholinergic + 10
                  regulation of synaptic transmission, cholinergic + 14
Path 2
Term Annotations click to browse term
  biological_process 12170
    cellular process 11365
      cell communication 4392
        cell-cell signaling 1371
          synaptic signaling 665
            trans-synaptic signaling 644
              anterograde trans-synaptic signaling 636
                chemical synaptic transmission 636
                  synaptic transmission, cholinergic 25
                    acetylcholine catabolic process in synaptic cleft 0
                    acetylcholine secretion, neurotransmission + 6
                    negative regulation of synaptic transmission, cholinergic + 1
                    positive regulation of synaptic transmission, cholinergic + 10
                    regulation of synaptic transmission, cholinergic + 14
paths to the root