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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, cholinergic
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Accession:GO:0007271 term browser browse the term
Definition:The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO RGD PMID:15297571 RGD:1625662 NCBI chr14:49,467,186...49,485,845
Ensembl chr14:49,468,862...49,485,841
JBrowse link
G ANXA9 annexin A9 involved_in IEA GOC GO_REF:0000108 NCBI chr 4:98,224,436...98,243,957
Ensembl chr 4:98,221,851...98,242,718
JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 acts_upstream_of_or_within ISO (MGI:1888655|PMID:10944224) MGI PMID:10944224 MGI:1888655 NCBI chr14:51,818,625...52,363,662
Ensembl chr14:51,828,052...51,830,077
JBrowse link
G CHRNA1 cholinergic receptor nicotinic alpha 1 subunit involved_in IEA GOC GO_REF:0000108 NCBI chr15:80,673,072...80,692,256
Ensembl chr15:80,673,033...80,692,208
JBrowse link
G CHRNA10 cholinergic receptor nicotinic alpha 10 subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3771935|PMID:18077337) Ensembl
MGI
PMID:18077337 GO_REF:0000107 MGI:3771935 NCBI chr 9:6,427,832...6,431,881
Ensembl chr 9:6,427,191...6,431,871
JBrowse link
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,191,842...11,207,381
JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3590443|PMID:16162937) GOC
MGI
PMID:16162937 GO_REF:0000108 MGI:3590443 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,778...47,384,303
JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(MGI:1931636|PMID:11226318)
(MGI:2176631|PMID:11906696)
(PMID:21873635)
GOC
MGI
RGD
GO_Central
PMID:11226318 PMID:11906696 PMID:15026122 PMID:21873635 GO_REF:0000108 MGI:1931636 MGI:2176631 RGD:1358635 NCBI chr17:62,424,672...62,436,646
Ensembl chr17:62,420,546...62,436,165
JBrowse link
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:47,382,860...47,425,871
Ensembl chr 7:47,382,764...47,425,950
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
(MGI:1099674|PMID:9364063)
(PMID:21873635)
Ensembl
MGI
RGD
GO_Central
PMID:9364063 PMID:15044058 PMID:21873635 GO_REF:0000107 MGI:1099674 RGD:1600975 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,698...142,937,788
JBrowse link
G CHRNB1 cholinergic receptor nicotinic beta 1 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,749,422...52,774,642
Ensembl chr12:52,742,098...52,759,676
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit involved_in ISO
IEA
RGD
GOC
PMID:12754307 GO_REF:0000108 RGD:1358637 NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037
JBrowse link
G CHRNB3 cholinergic receptor nicotinic beta 3 subunit involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:11,687,646...11,714,357
Ensembl chr17:11,687,557...11,722,183
JBrowse link
G FGF11 fibroblast growth factor 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:52,742,090...52,749,331
Ensembl chr12:52,742,098...52,759,676
JBrowse link
G LYNX1 Ly6/neurotoxin 1 acts_upstream_of_or_within ISO (MGI:3838433|PMID:19246390) MGI PMID:19246390 MGI:3838433 NCBI chr 4:1,450,112...1,455,000
Ensembl chr 4:1,450,147...1,455,889
JBrowse link
G LYPD1 LY6/PLAUR domain containing 1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3838433|PMID:19246390) Ensembl
MGI
PMID:19246390 GO_REF:0000107 MGI:3838433 NCBI chr15:19,522,045...19,559,819
Ensembl chr15:19,522,828...19,567,890
JBrowse link
G RIC3 RIC3 acetylcholine receptor chaperone involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
PMID:18420419
GO_Central
MGI
PMID:18420419 PMID:21873635 RGD:2317082 NCBI chr 9:1,134,915...1,183,873
Ensembl chr 9:1,134,906...1,194,979
JBrowse link
G SLC5A7 solute carrier family 5 member 7 involved_in
acts_upstream_of_or_within
IBA
ISO
(PMID:21873635)
(MGI:3044863|PMID:15173594)
(MGI:3590443|PMID:16162937)
GO_Central
MGI
PMID:15173594 PMID:16162937 PMID:21873635 MGI:3044863 MGI:3590443 NCBI chr 3:47,994,116...48,020,744
Ensembl chr 3:47,996,307...48,022,503
JBrowse link
negative regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR6 5-hydroxytryptamine receptor 6 ISO RGD PMID:16987217 RGD:2317005 NCBI chr 6:78,077,358...78,092,211 JBrowse link
positive regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO phrenic nerve terminals in the presence of adenosine transport inhibitor deoxycoformycin RGD PMID:12679375 RGD:1625693 NCBI chr14:49,467,186...49,485,845
Ensembl chr14:49,468,862...49,485,841
JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO RGD PMID:15266551 RGD:1625007 NCBI chr  X:94,053,415...94,313,352
Ensembl chr  X:94,053,456...94,313,356
JBrowse link
G TACR2 tachykinin receptor 2 ISO RGD PMID:12747940 RGD:5147477 NCBI chr14:72,463,405...72,476,034
Ensembl chr14:72,462,046...72,475,554
JBrowse link
positive regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma ISO RGD PMID:1900518 RGD:2311499 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G LAMA2 laminin subunit alpha 2 acts_upstream_of_or_within ISO (MGI:77287|PMID:8568931) MGI PMID:8568931 MGI:77287 NCBI chr 1:33,765,412...34,359,741
Ensembl chr 1:33,867,639...34,359,698
JBrowse link
G MUSK muscle associated receptor tyrosine kinase ISO RGD PMID:16870737 RGD:2317092 NCBI chr 1:251,650,151...251,758,538
Ensembl chr 1:251,650,710...251,756,608
JBrowse link
G NGFR nerve growth factor receptor ISO medial septum and diagonal band of Broca (MS-DBB) neurons stimulated by NGF RGD PMID:18256260 RGD:5508750 NCBI chr12:25,699,410...25,720,355
Ensembl chr12:25,699,427...25,720,357
JBrowse link
G TAC1 tachykinin precursor 1 ISO RGD PMID:17949415 RGD:2304335 NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,535...77,206,526
JBrowse link
G TACR1 tachykinin receptor 1 ISO RGD PMID:17949415 RGD:2304335 NCBI chr 3:67,839,367...68,021,733
Ensembl chr 3:67,839,411...68,021,728
JBrowse link
G UTS2 urotensin 2 ISO RGD PMID:15944374 RGD:2306844 NCBI chr 6:68,552,889...68,560,827
Ensembl chr 6:68,552,887...68,559,687
JBrowse link
regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (MGI:3606714|PMID:10686170)
(MGI:2654957|PMID:12624181)
MGI PMID:10686170 PMID:12624181 MGI:2654957 MGI:3606714 NCBI chr 2:65,491,784...65,871,068 JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit acts_upstream_of_or_within ISO (MGI:3590443|PMID:16162937) MGI PMID:16162937 MGI:3590443 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,778...47,384,303
JBrowse link
regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chr18:50,862,225...50,956,263
Ensembl chr18:50,861,466...50,957,945
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16579
    signaling 6568
      cell-cell signaling 1630
        synaptic signaling 859
          trans-synaptic signaling 831
            anterograde trans-synaptic signaling 823
              chemical synaptic transmission 823
                synaptic transmission, cholinergic 30
                  acetylcholine catabolic process in synaptic cleft 0
                  acetylcholine secretion, neurotransmission + 6
                  negative regulation of synaptic transmission, cholinergic + 1
                  positive regulation of synaptic transmission, cholinergic + 10
                  regulation of synaptic transmission, cholinergic + 14
Path 2
Term Annotations click to browse term
  biological_process 16579
    cellular process 15862
      cell communication 6641
        cell-cell signaling 1630
          synaptic signaling 859
            trans-synaptic signaling 831
              anterograde trans-synaptic signaling 823
                chemical synaptic transmission 823
                  synaptic transmission, cholinergic 30
                    acetylcholine catabolic process in synaptic cleft 0
                    acetylcholine secretion, neurotransmission + 6
                    negative regulation of synaptic transmission, cholinergic + 1
                    positive regulation of synaptic transmission, cholinergic + 10
                    regulation of synaptic transmission, cholinergic + 14
paths to the root