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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, cholinergic
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Accession:GO:0007271 term browser browse the term
Definition:The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO RGD PMID:15297571 RGD:1625662 NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189
JBrowse link
G CHRM3 cholinergic receptor muscarinic 3 acts_upstream_of_or_within ISO (MGI:1888655|PMID:10944224) MGI PMID:10944224 MGI:1888655 NCBI chr 1:214,931,514...215,452,739 JBrowse link
G CHRNA10 cholinergic receptor nicotinic alpha 10 subunit acts_upstream_of_or_within ISO (MGI:3771935|PMID:18077337) MGI PMID:18077337 MGI:3771935 NCBI chr11:3,543,450...3,552,036
Ensembl chr11:3,651,580...3,656,780
JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit acts_upstream_of_or_within ISO (MGI:3590443|PMID:16162937) MGI PMID:16162937 MGI:3590443 NCBI chr15:57,523,553...57,550,228
Ensembl chr15:76,487,710...76,512,044
JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit acts_upstream_of_or_within ISO (MGI:1931636|PMID:11226318)
(MGI:2176631|PMID:11906696)
RGD
MGI
PMID:11226318 PMID:11906696 PMID:15026122 MGI:1931636 MGI:2176631 RGD:1358635 NCBI chr20:59,730,759...59,748,678
Ensembl chr20:61,270,631...61,283,005
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit acts_upstream_of_or_within ISO (MGI:1099674|PMID:9364063) RGD
MGI
PMID:9364063 PMID:15044058 MGI:1099674 RGD:1600975 NCBI chr15:10,525,535...10,667,227
Ensembl chr15:29,565,885...29,705,194
JBrowse link
G CHRNB1 cholinergic receptor nicotinic beta 1 subunit involved_in ISO (PMID:8872460) UniProt PMID:8872460 NCBI chr17:7,479,056...7,490,314
Ensembl chr17:7,465,229...7,476,099
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit ISO RGD PMID:12754307 RGD:1358637 NCBI chr 1:129,922,740...129,931,582
Ensembl chr 1:133,535,023...133,547,361
JBrowse link
G LYNX1 Ly6/neurotoxin 1 acts_upstream_of_or_within ISO (MGI:3838433|PMID:19246390) MGI PMID:19246390 MGI:3838433 NCBI chr 8:139,483,627...139,490,722
Ensembl chr 8:142,526,506...142,533,707
JBrowse link
G LYPD1 LY6/PLAUR domain containing 1 acts_upstream_of_or_within ISO (MGI:3838433|PMID:19246390) MGI PMID:19246390 MGI:3838433 NCBI chr2B:27,170,199...27,201,789
Ensembl chr2B:136,738,362...136,769,150
JBrowse link
G RAPSN receptor associated protein of the synapse acts_upstream_of_or_within ISO (PMID:18420419) MGI PMID:18420419 NCBI chr11:47,387,324...47,398,579
Ensembl chr11:47,940,530...47,951,667
JBrowse link
G RIC3 RIC3 acetylcholine receptor chaperone acts_upstream_of_or_within ISO PMID:18420419 MGI PMID:18420419 RGD:2317082 NCBI chr11:8,210,061...8,287,211
Ensembl chr11:7,969,236...8,032,884
JBrowse link
G SLC5A7 solute carrier family 5 member 7 acts_upstream_of_or_within ISO (MGI:3044863|PMID:15173594)
(MGI:3590443|PMID:16162937)
MGI PMID:15173594 PMID:16162937 MGI:3044863 MGI:3590443 NCBI chr2A:93,917,086...93,944,308
Ensembl chr2A:109,017,805...109,046,860
JBrowse link
negative regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR6 5-hydroxytryptamine receptor 6 ISO RGD PMID:16987217 RGD:2317005 NCBI chr 1:18,619,683...18,635,822
Ensembl chr 1:19,662,978...19,678,680
JBrowse link
positive regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO phrenic nerve terminals in the presence of adenosine transport inhibitor deoxycoformycin RGD PMID:12679375 RGD:1625693 NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189
JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C ISO RGD PMID:15266551 RGD:1625007 NCBI chr  X:103,673,172...103,999,133
Ensembl chr  X:114,199,485...114,503,201
JBrowse link
G TACR2 tachykinin receptor 2 ISO RGD PMID:12747940 RGD:5147477 NCBI chr10:65,872,795...65,885,154
Ensembl chr10:68,403,979...68,415,224
JBrowse link
positive regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma ISO RGD PMID:1900518 RGD:2311499 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829
JBrowse link
G LAMA2 laminin subunit alpha 2 acts_upstream_of_or_within ISO (MGI:77287|PMID:8568931) MGI PMID:8568931 MGI:77287 NCBI chr 6:126,672,013...127,307,870
Ensembl chr 6:130,781,781...131,415,337
JBrowse link
G MUSK muscle associated receptor tyrosine kinase ISO RGD PMID:16870737 RGD:2317092 NCBI chr 9:81,814,766...81,947,341
Ensembl chr 9:109,980,748...110,107,480
JBrowse link
G NGFR nerve growth factor receptor ISO medial septum and diagonal band of Broca (MS-DBB) neurons stimulated by NGF RGD PMID:18256260 RGD:5508750 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966
JBrowse link
G TAC1 tachykinin precursor 1 ISO RGD PMID:17949415 RGD:2304335 NCBI chr 7:89,675,834...89,684,391
Ensembl chr 7:103,257,501...103,266,389
JBrowse link
G TACR1 tachykinin receptor 1 ISO RGD PMID:17949415 RGD:2304335 NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018
JBrowse link
G UTS2 urotensin 2 ISO RGD PMID:15944374 RGD:2306844 NCBI chr 1:6,609,104...6,616,966
Ensembl chr 1:7,854,687...7,864,688
JBrowse link
regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (MGI:2654957|PMID:12624181)
(MGI:3606714|PMID:10686170)
MGI PMID:10686170 PMID:12624181 MGI:2654957 MGI:3606714 NCBI chr19:12,769,586...13,189,022
Ensembl chr19:13,507,102...13,804,729
JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit acts_upstream_of_or_within ISO (MGI:3590443|PMID:16162937) MGI PMID:16162937 MGI:3590443 NCBI chr15:57,523,553...57,550,228
Ensembl chr15:76,487,710...76,512,044
JBrowse link
regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAMK2B calcium/calmodulin dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) MGI PMID:19332541 MGI:4352609 NCBI chr 7:44,930,859...45,040,078
Ensembl chr 7:45,001,267...45,110,342
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12657
    signaling 4416
      cell-cell signaling 1389
        synaptic signaling 671
          trans-synaptic signaling 650
            anterograde trans-synaptic signaling 642
              chemical synaptic transmission 642
                synaptic transmission, cholinergic 25
                  acetylcholine catabolic process in synaptic cleft 0
                  acetylcholine secretion, neurotransmission + 6
                  negative regulation of synaptic transmission, cholinergic + 1
                  positive regulation of synaptic transmission, cholinergic + 10
                  regulation of synaptic transmission, cholinergic + 14
Path 2
Term Annotations click to browse term
  biological_process 12657
    cellular process 11790
      cell communication 4491
        cell-cell signaling 1389
          synaptic signaling 671
            trans-synaptic signaling 650
              anterograde trans-synaptic signaling 642
                chemical synaptic transmission 642
                  synaptic transmission, cholinergic 25
                    acetylcholine catabolic process in synaptic cleft 0
                    acetylcholine secretion, neurotransmission + 6
                    negative regulation of synaptic transmission, cholinergic + 1
                    positive regulation of synaptic transmission, cholinergic + 10
                    regulation of synaptic transmission, cholinergic + 14
paths to the root