Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, cholinergic
go back to main search page
Accession:GO:0007271 term browser browse the term
Definition:The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.



show annotations for term's descendants           Sort by:
 
synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IMP RGD PMID:15297571 RGD:1625662 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Anxa9 annexin A9 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:182,873,185...182,884,501
Ensembl chr 2:182,872,929...182,883,374
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 acts_upstream_of_or_within ISO MGI:1888740 (MGI:1888655|PMID:10944224) RGD PMID:10944224 MGI:1888655 NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 acts_upstream_of_or_within ISO (MGI:61071|PMID:7916637) RGD PMID:7916637 MGI:61071 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit acts_upstream_of_or_within TAS
ISO
MGI:3774038 (MGI:3771935|PMID:18077337) RGD PMID:18077337 PMID:12117536 MGI:3771935, RGD:632442 NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000108
MGI:2155602 (MGI:3590443|PMID:16162937)
GOC
RGD
PMID:16162937 GO_REF:0000108 MGI:3590443 NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
IEA
MGI:2158758 (MGI:1931636|PMID:11226318), (MGI:2176631|PMID:11906696)
PMID:21873635
GO_REF:0000108
RGD
GOC
PMID:11226318 PMID:11906696 PMID:15026122 PMID:21873635 GO_REF:0000108 MGI:1931636 MGI:2176631, RGD:1358635, RGD:13792537 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit involved_in
acts_upstream_of_or_within
IMP
IBA
ISO
IEA
PMID:21873635
MGI:1888407 (MGI:1099674|PMID:9364063)
GO_REF:0000107
RGD
Ensembl
PMID:9364063 PMID:15044058 PMID:21873635 GO_REF:0000107 MGI:1099674, RGD:1600975, RGD:13792537 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit involved_in ISO (PMID:8872460) RGD PMID:8872460 NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit IMP RGD PMID:12754307 RGD:1358637 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:55,418,379...55,436,967
Ensembl chr 8:55,418,313...55,437,027
JBrowse link
G Lynx1 Ly6/neurotoxin 1 acts_upstream_of_or_within ISO (MGI:3838433|PMID:19246390) RGD PMID:19246390 MGI:3838433 NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023
JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 acts_upstream_of_or_within ISO (MGI:3838433|PMID:19246390) RGD PMID:19246390 MGI:3838433 NCBI chr13:37,326,459...37,368,515
Ensembl chr13:37,326,464...37,368,493
JBrowse link
G Rapsn receptor-associated protein of the synapse acts_upstream_of_or_within
involved_in
ISO
IBA
UniProtKB:Q9GZZ6 (PMID:18420419)
PMID:21873635
RGD PMID:18420419 PMID:21873635 RGD:13792537 NCBI chr 3:77,014,699...77,024,373
Ensembl chr 3:76,983,471...77,024,373
JBrowse link
G Ric3 RIC3 acetylcholine receptor chaperone acts_upstream_of_or_within
involved_in
IGI
IBA
PMID:18420419
PMID:21873635
MGI
GO_Central
PMID:18420419 PMID:21873635 RGD:2317082, RGD:13792537 NCBI chr 1:163,030,621...163,086,583
Ensembl chr 1:163,032,158...163,086,519
JBrowse link
G Slc5a7 solute carrier family 5 member 7 involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
MGI:3045463 (MGI:3044863|PMID:15173594), (MGI:3590443|PMID:16162937)
GO_REF:0000107
RGD
Ensembl
PMID:15173594 PMID:16162937 PMID:21873635 GO_REF:0000107 MGI:3044863 MGI:3590443, RGD:13792537 NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258
JBrowse link
acetylcholine catabolic process in synaptic cleft term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase involved_in IC PMID:26820598 SynGO PMID:26820598 RGD:12050110 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
negative regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr6 5-hydroxytryptamine receptor 6 IMP RGD PMID:16987217 RGD:2317005 NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
JBrowse link
positive regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IMP phrenic nerve terminals in the presence of adenosine transport inhibitor deoxycoformycin RGD PMID:12679375 RGD:1625693 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C IMP RGD PMID:15266551 RGD:1625007 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Slc18a3 solute carrier family 18 member A3 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr16:7,713,630...7,716,491 JBrowse link
G Tacr2 tachykinin receptor 2 IMP RGD PMID:12747940 RGD:5147477 NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446
JBrowse link
positive regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma IDA RGD PMID:1900518 RGD:2311499 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Lama2 laminin subunit alpha 2 acts_upstream_of_or_within ISO MGI:1856026 (MGI:77287|PMID:8568931) RGD PMID:8568931 MGI:77287 NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
JBrowse link
G Musk muscle associated receptor tyrosine kinase IMP RGD PMID:16870737 RGD:2317092 NCBI chr 5:73,058,427...73,169,696
Ensembl chr 5:73,058,121...73,171,932
JBrowse link
G Nalcn sodium leak channel, non-selective involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:100,398,615...100,712,283
Ensembl chr15:100,398,615...100,741,001
JBrowse link
G Ngfr nerve growth factor receptor IMP medial septum and diagonal band of Broca (MS-DBB) neurons stimulated by NGF RGD PMID:18256260 RGD:5508750 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Tac1 tachykinin, precursor 1 IDA RGD PMID:17949415 RGD:2304335 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:17949415 RGD:2304335 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:15944374 RGD:2306844 NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237
JBrowse link
regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209|MGI:2181384 (MGI:2654957|PMID:12624181), (MGI:3606714|PMID:10686170) RGD PMID:10686170 PMID:12624181 MGI:2654957 MGI:3606714 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit acts_upstream_of_or_within ISO MGI:2155602 (MGI:3590443|PMID:16162937) RGD PMID:16162937 MGI:3590443 NCBI chr 8:55,401,981...55,415,012
Ensembl chr 8:55,401,702...55,415,165
JBrowse link
regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) RGD PMID:19332541 MGI:4352609 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    signaling 7708
      cell-cell signaling 1825
        synaptic signaling 979
          trans-synaptic signaling 945
            anterograde trans-synaptic signaling 937
              chemical synaptic transmission 937
                synaptic transmission, cholinergic 35
                  acetylcholine catabolic process in synaptic cleft 1
                  acetylcholine secretion, neurotransmission + 7
                  negative regulation of synaptic transmission, cholinergic + 1
                  positive regulation of synaptic transmission, cholinergic + 12
                  regulation of synaptic transmission, cholinergic + 16
Path 2
Term Annotations click to browse term
  biological_process 20091
    cellular process 18675
      cell communication 7802
        cell-cell signaling 1825
          synaptic signaling 979
            trans-synaptic signaling 945
              anterograde trans-synaptic signaling 937
                chemical synaptic transmission 937
                  synaptic transmission, cholinergic 35
                    acetylcholine catabolic process in synaptic cleft 1
                    acetylcholine secretion, neurotransmission + 7
                    negative regulation of synaptic transmission, cholinergic + 1
                    positive regulation of synaptic transmission, cholinergic + 12
                    regulation of synaptic transmission, cholinergic + 16
paths to the root