ONTOLOGY REPORT - ANNOTATIONS
Term: synaptic transmission, cholinergic
Accession: GO:0007271
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Definition: The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
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Adora2a
adenosine A2a receptor
IMP
RGD
PMID:15297571
RGD:1625662
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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Anxa9
annexin A9
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 2:182,873,185...182,884,501
Ensembl chr 2:182,872,929...182,883,374
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Chrm3
cholinergic receptor, muscarinic 3
acts_upstream_of_or_within
ISO
MGI:1888740 (PMID:10944224)
RGD
PMID:10944224
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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Chrna1
cholinergic receptor nicotinic alpha 1 subunit
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
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Chrna10
cholinergic receptor nicotinic alpha 10 subunit
acts_upstream_of_or_within
TAS IEA ISO
GO_REF:0000107 MGI:3774038 (PMID:18077337)
Ensembl RGD
PMID:18077337 PMID:12117536
GO_REF:0000107, RGD:632442
NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476
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Chrna2
cholinergic receptor nicotinic alpha 2 subunit
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
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Chrna3
cholinergic receptor nicotinic alpha 3 subunit
involved_in acts_upstream_of_or_within
IEA ISO IBA
GO_REF:0000108 MGI:2155602 (PMID:16162937) GO_REF:0000033
GOC RGD GO_Central
PMID:16162937
GO_REF:0000033 GO_REF:0000108
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
involved_in acts_upstream_of_or_within
IMP ISO IDA ISS IBA
(PMID:17132685), (PMID:27698419), (PMID:29720657), (PMID:38454578) PMID:9882698 PMID:22593584 GO_REF:0000024 MGI:2158758 (PMID:11226318), (PMID:11906696) GO_REF:0000033
RGD UniProt GO_Central
PMID:11226318 PMID:11906696 PMID:17132685 PMID:27698419 PMID:29720657 PMID:38454578 PMID:15026122 PMID:9882698 PMID:22593584 More...
GO_REF:0000024 GO_REF:0000033, RGD:1358635 , RGD:596936194 , RGD:596936208
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrna5
cholinergic receptor nicotinic alpha 5 subunit
involved_in
IEA IBA
GO_REF:0000108 GO_REF:0000033
GOC GO_Central
GO_REF:0000033 GO_REF:0000108
NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146
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Chrna6
cholinergic receptor nicotinic alpha 6 subunit
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
acts_upstream_of_or_within involved_in
IMP IEA IDA ISO
GO_REF:0000107 PMID:17510177 UniProtKB:P05067 (PMID:20164328) MGI:1888407 (PMID:9364063)
Ensembl RGD
PMID:9364063 PMID:20164328 PMID:15044058 PMID:17510177
GO_REF:0000107, RGD:1600975 , RGD:596936198
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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Chrnb1
cholinergic receptor nicotinic beta 1 subunit
involved_in
ISO IEA
(PMID:8872460) GO_REF:0000107
RGD Ensembl
PMID:8872460
GO_REF:0000107
NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
involved_in
IMP ISO ISS
(PMID:17132685), (PMID:27698419), (PMID:29720657), (PMID:38454578) GO_REF:0000024
RGD UniProt
PMID:17132685 PMID:27698419 PMID:29720657 PMID:38454578 PMID:12754307
GO_REF:0000024, RGD:1358637
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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Chrnb3
cholinergic receptor nicotinic beta 3 subunit
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
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Chrnb4
cholinergic receptor nicotinic beta 4 subunit
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
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Chrnd
cholinergic receptor nicotinic delta subunit
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 9:87,862,417...87,870,833
Ensembl chr 9:87,862,407...87,870,833
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Chrne
cholinergic receptor nicotinic epsilon subunit
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr10:55,331,211...55,339,923
Ensembl chr10:55,331,212...55,335,530
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Chrng
cholinergic receptor nicotinic gamma subunit
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 9:87,878,085...87,884,193
Ensembl chr 9:87,878,085...87,914,482
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Dmd
dystrophin
acts_upstream_of_positive_effect
ISO IEA
MGI:1856328 (PMID:9334395) GO_REF:0000107
RGD Ensembl
PMID:9334395
GO_REF:0000107
NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207
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Lynx1
Ly6/neurotoxin 1
acts_upstream_of_or_within
ISO
(PMID:19246390)
RGD
PMID:19246390
NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023
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Lypd1
Ly6/Plaur domain containing 1
acts_upstream_of_or_within
ISO
(PMID:19246390)
RGD
PMID:19246390
NCBI chr13:37,326,459...37,368,515
Ensembl chr13:37,326,464...37,368,493
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Rapsn
receptor-associated protein of the synapse
acts_upstream_of_or_within involved_in
ISO IEA IBA
UniProtKB:Q9GZZ6 (PMID:18420419) GO_REF:0000107 GO_REF:0000033
RGD Ensembl GO_Central
PMID:18420419
GO_REF:0000033 GO_REF:0000107
NCBI chr 3:77,015,073...77,024,378
Ensembl chr 3:76,983,471...77,024,373
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Ric3
RIC3 acetylcholine receptor chaperone
acts_upstream_of_or_within involved_in
IGI IBA
PMID:18420419 GO_REF:0000033
GO_Central
PMID:18420419
GO_REF:0000033, RGD:2317082
NCBI chr 1:163,030,621...163,086,583
Ensembl chr 1:163,032,158...163,086,519
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Slc5a7
solute carrier family 5 member 7
involved_in acts_upstream_of_or_within
IBA IEA ISO
GO_REF:0000033 GO_REF:0000107 MGI:3045463 (PMID:15173594), (PMID:16162937)
GO_Central Ensembl RGD
PMID:15173594 PMID:16162937
GO_REF:0000033 GO_REF:0000107
NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258
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Htr6
5-hydroxytryptamine receptor 6
IMP
RGD
PMID:16987217
RGD:2317005
NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
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Adora2a
adenosine A2a receptor
IMP
phrenic nerve terminals in the presence of adenosine transport inhibitor deoxycoformycin
RGD
PMID:12679375
RGD:1625693
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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Htr2c
5-hydroxytryptamine receptor 2C
IMP
RGD
PMID:15266551
RGD:1625007
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Slc18a3
solute carrier family 18 member A3
involved_in
ISS ISO
GO_REF:0000024 (PMID:19635813)
UniProt RGD
PMID:19635813
GO_REF:0000024
NCBI chr16:7,713,630...7,716,491
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Tacr2
tachykinin receptor 2
IMP
RGD
PMID:12747940
RGD:5147477
NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446
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Ifng
interferon gamma
IDA
RGD
PMID:1900518
RGD:2311499
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Lama2
laminin subunit alpha 2
acts_upstream_of_or_within
ISO IEA
MGI:1856026 (PMID:8568931) GO_REF:0000107
RGD Ensembl
PMID:8568931
GO_REF:0000107
NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
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Musk
muscle associated receptor tyrosine kinase
IMP
RGD
PMID:16870737
RGD:2317092
NCBI chr 5:73,058,427...73,169,696
Ensembl chr 5:73,058,121...73,171,932
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Nalcn
sodium leak channel, non-selective
involved_in
IBA
GO_REF:0000033
GO_Central
GO_REF:0000033
NCBI chr15:100,398,583...100,741,243
Ensembl chr15:100,398,615...100,741,001
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Ngfr
nerve growth factor receptor
IMP
medial septum and diagonal band of Broca (MS-DBB) neurons stimulated by NGF
RGD
PMID:18256260
RGD:5508750
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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Tac1
tachykinin, precursor 1
IDA
RGD
PMID:17949415
RGD:2304335
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tacr1
tachykinin receptor 1
IMP
RGD
PMID:17949415
RGD:2304335
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
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Uts2
urotensin 2
IDA
RGD
PMID:15944374
RGD:2306844
NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237
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Cacna1a
calcium voltage-gated channel subunit alpha1 A
acts_upstream_of_or_within
ISO
MGI:1856209|MGI:2181384 (PMID:10686170), (PMID:12624181)
RGD
PMID:10686170 PMID:12624181
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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Chrna3
cholinergic receptor nicotinic alpha 3 subunit
acts_upstream_of_or_within
ISO
MGI:2155602 (PMID:16162937)
RGD
PMID:16162937
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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Camk2b
calcium/calmodulin-dependent protein kinase II beta
acts_upstream_of_or_within
ISO
(PMID:19332541)
RGD
PMID:19332541
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
biological_process
20543
cellular process
19534
cell communication
7907
cell-cell signaling
1491
synaptic signaling
1011
trans-synaptic signaling
967
anterograde trans-synaptic signaling
959
chemical synaptic transmission
959
synaptic transmission, cholinergic
38
acetylcholine catabolic process in synaptic cleft
0
acetylcholine secretion, neurotransmission +
7
negative regulation of synaptic transmission, cholinergic +
1
positive regulation of synaptic transmission, cholinergic +
12
regulation of synaptic transmission, cholinergic +
16
Path 2
biological_process
20543
biological regulation
13835
regulation of biological process
13398
signaling
7874
cell-cell signaling
1491
synaptic signaling
1011
trans-synaptic signaling
967
anterograde trans-synaptic signaling
959
chemical synaptic transmission
959
synaptic transmission, cholinergic
38
acetylcholine catabolic process in synaptic cleft
0
acetylcholine secretion, neurotransmission +
7
negative regulation of synaptic transmission, cholinergic +
1
positive regulation of synaptic transmission, cholinergic +
12
regulation of synaptic transmission, cholinergic +
16