ONTOLOGY REPORT - ANNOTATIONS
Term: synaptic transmission, cholinergic
Accession: GO:0007271
browse the term
Definition: The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
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Adora2a
adenosine A2a receptor
IMP
RGD
PMID:15297571
RGD:1625662
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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Anxa9
annexin A9
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 2:182,873,185...182,884,501
Ensembl chr 2:182,872,929...182,883,374
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Chrm3
cholinergic receptor, muscarinic 3
acts_upstream_of_or_within
ISO
MGI:1888740 (MGI:1888655|PMID:10944224)
RGD
PMID:10944224
MGI:1888655
NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278
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Chrna1
cholinergic receptor nicotinic alpha 1 subunit
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840
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Chrna10
cholinergic receptor nicotinic alpha 10 subunit
acts_upstream_of_or_within
TAS ISO
MGI:3774038 (MGI:3771935|PMID:18077337)
RGD
PMID:18077337 PMID:12117536
MGI:3771935 , RGD:632442
NCBI chr 1:156,487,279...156,494,277
Ensembl chr 1:156,487,279...156,491,476
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Chrna2
cholinergic receptor nicotinic alpha 2 subunit
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr15:40,342,317...40,358,601
Ensembl chr15:40,342,317...40,358,601
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Chrna3
cholinergic receptor nicotinic alpha 3 subunit
involved_in acts_upstream_of_or_within
IEA IBA ISO
GO_REF:0000108 PMID:21873635 MGI:2155602 (MGI:3590443|PMID:16162937)
GOC RGD
PMID:16162937 PMID:21873635
GO_REF:0000108 MGI:3590443 , RGD:13792537
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
involved_in acts_upstream_of_or_within
IMP IBA ISO IEA
PMID:21873635 MGI:2158758 (MGI:1931636|PMID:11226318), (MGI:2176631|PMID:11906696) GO_REF:0000108
RGD GOC
PMID:11226318 PMID:11906696 PMID:15026122 PMID:21873635
GO_REF:0000108 MGI:1931636 MGI:2176631 , RGD:1358635 , RGD:13792537
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrna5
cholinergic receptor nicotinic alpha 5 subunit
involved_in
IEA IBA
GO_REF:0000108 PMID:21873635
GOC
PMID:21873635
GO_REF:0000108, RGD:13792537
NCBI chr 8:55,369,794...55,398,526
Ensembl chr 8:55,369,794...55,398,146
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Chrna6
cholinergic receptor nicotinic alpha 6 subunit
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
involved_in acts_upstream_of_or_within
IMP ISO IBA IEA
UniProtKB:P05067 (MGI:4437154|PMID:20164328) PMID:21873635 MGI:1888407 (MGI:1099674|PMID:9364063) GO_REF:0000107
RGD Ensembl
PMID:9364063 PMID:20164328 PMID:15044058 PMID:21873635
GO_REF:0000107 MGI:1099674 MGI:4437154 , RGD:1600975 , RGD:13792537
NCBI chr 1:116,711,559...116,837,269
Ensembl chr 1:116,714,711...116,837,240
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Chrnb1
cholinergic receptor nicotinic beta 1 subunit
involved_in
ISO IEA
(PMID:8872460) GO_REF:0000107
RGD Ensembl
PMID:8872460
GO_REF:0000107
NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
IMP
RGD
PMID:12754307
RGD:1358637
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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Chrnb3
cholinergic receptor nicotinic beta 3 subunit
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr16:64,713,438...64,751,360
Ensembl chr16:64,714,169...64,751,360
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Chrnb4
cholinergic receptor nicotinic beta 4 subunit
involved_in
IEA
GO_REF:0000108
GOC
GO_REF:0000108
NCBI chr 8:55,417,583...55,437,027
Ensembl chr 8:55,418,313...55,437,027
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Dmd
dystrophin
involved_in acts_upstream_of_positive_effect
IEA ISO
GO_REF:0000107 MGI:1856328 (MGI:1098355|PMID:9334395)
Ensembl RGD
PMID:9334395
GO_REF:0000107 MGI:1098355
NCBI chr X:47,272,324...49,504,219
Ensembl chr X:47,272,331...49,504,207
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Lynx1
Ly6/neurotoxin 1
acts_upstream_of_or_within
ISO
(MGI:3838433|PMID:19246390)
RGD
PMID:19246390
MGI:3838433
NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023
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Lypd1
Ly6/Plaur domain containing 1
acts_upstream_of_or_within
ISO
(MGI:3838433|PMID:19246390)
RGD
PMID:19246390
MGI:3838433
NCBI chr13:37,326,459...37,368,515
Ensembl chr13:37,326,464...37,368,493
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Rapsn
receptor-associated protein of the synapse
acts_upstream_of_or_within involved_in
ISO IBA
UniProtKB:Q9GZZ6 (PMID:18420419) PMID:21873635
RGD
PMID:18420419 PMID:21873635
RGD:13792537
NCBI chr 3:77,015,073...77,024,378
Ensembl chr 3:76,983,471...77,024,373
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Ric3
RIC3 acetylcholine receptor chaperone
acts_upstream_of_or_within involved_in
IGI IBA
PMID:18420419 PMID:21873635
MGI GO_Central
PMID:18420419 PMID:21873635
RGD:2317082 , RGD:13792537
NCBI chr 1:163,030,621...163,086,583
Ensembl chr 1:163,032,158...163,086,519
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Slc5a7
solute carrier family 5 member 7
involved_in acts_upstream_of_or_within
IBA ISO IEA
PMID:21873635 MGI:3045463 (MGI:3044863|PMID:15173594), (MGI:3590443|PMID:16162937) GO_REF:0000107
RGD Ensembl
PMID:15173594 PMID:16162937 PMID:21873635
GO_REF:0000107 MGI:3044863 MGI:3590443 , RGD:13792537
NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258
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Ache
acetylcholinesterase
involved_in
IC
PMID:26820598
SynGO
PMID:26820598
RGD:12050110
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Htr6
5-hydroxytryptamine receptor 6
IMP
RGD
PMID:16987217
RGD:2317005
NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912
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Adora2a
adenosine A2a receptor
IMP
phrenic nerve terminals in the presence of adenosine transport inhibitor deoxycoformycin
RGD
PMID:12679375
RGD:1625693
NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
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Htr2c
5-hydroxytryptamine receptor 2C
IMP
RGD
PMID:15266551
RGD:1625007
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Slc18a3
solute carrier family 18 member A3
involved_in
ISS ISO
GO_REF:0000024 (MGI:4366600|PMID:19635813)
UniProt RGD
PMID:19635813
GO_REF:0000024 MGI:4366600
NCBI chr16:7,713,630...7,716,491
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Tacr2
tachykinin receptor 2
IMP
RGD
PMID:12747940
RGD:5147477
NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446
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Ifng
interferon gamma
IDA
RGD
PMID:1900518
RGD:2311499
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Lama2
laminin subunit alpha 2
acts_upstream_of_or_within
ISO
MGI:1856026 (MGI:77287|PMID:8568931)
RGD
PMID:8568931
MGI:77287
NCBI chr 1:17,672,675...18,320,641
Ensembl chr 1:17,672,536...18,320,530
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Musk
muscle associated receptor tyrosine kinase
IMP
RGD
PMID:16870737
RGD:2317092
NCBI chr 5:73,058,427...73,169,696
Ensembl chr 5:73,058,121...73,171,932
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Nalcn
sodium leak channel, non-selective
involved_in
IBA
PMID:21873635
GO_Central
PMID:21873635
RGD:13792537
NCBI chr15:100,398,583...100,741,243
Ensembl chr15:100,398,615...100,741,001
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Ngfr
nerve growth factor receptor
IMP
medial septum and diagonal band of Broca (MS-DBB) neurons stimulated by NGF
RGD
PMID:18256260
RGD:5508750
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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Tac1
tachykinin, precursor 1
IDA
RGD
PMID:17949415
RGD:2304335
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tacr1
tachykinin receptor 1
IMP
RGD
PMID:17949415
RGD:2304335
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
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Uts2
urotensin 2
IDA
RGD
PMID:15944374
RGD:2306844
NCBI chr 5:161,450,846...161,456,235
Ensembl chr 5:161,450,846...161,456,237
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Cacna1a
calcium voltage-gated channel subunit alpha1 A
acts_upstream_of_or_within
ISO
MGI:1856209|MGI:2181384 (MGI:2654957|PMID:12624181), (MGI:3606714|PMID:10686170)
RGD
PMID:10686170 PMID:12624181
MGI:2654957 MGI:3606714
NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
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Chrna3
cholinergic receptor nicotinic alpha 3 subunit
acts_upstream_of_or_within
ISO
MGI:2155602 (MGI:3590443|PMID:16162937)
RGD
PMID:16162937
MGI:3590443
NCBI chr 8:55,401,668...55,415,165
Ensembl chr 8:55,401,702...55,415,165
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Camk2b
calcium/calmodulin-dependent protein kinase II beta
acts_upstream_of_or_within
ISO
(MGI:4352609|PMID:19332541)
RGD
PMID:19332541
MGI:4352609
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all
Path 1
biological_process
19553
cellular process
18233
cell communication
7683
cell-cell signaling
1799
synaptic signaling
954
trans-synaptic signaling
920
anterograde trans-synaptic signaling
913
chemical synaptic transmission
913
synaptic transmission, cholinergic
36
acetylcholine catabolic process in synaptic cleft
1
acetylcholine secretion, neurotransmission +
7
negative regulation of synaptic transmission, cholinergic +
1
positive regulation of synaptic transmission, cholinergic +
12
regulation of synaptic transmission, cholinergic +
16
Path 2
biological_process
19553
biological regulation
13187
regulation of biological process
12813
signaling
7552
cell-cell signaling
1799
synaptic signaling
954
trans-synaptic signaling
920
anterograde trans-synaptic signaling
913
chemical synaptic transmission
913
synaptic transmission, cholinergic
36
acetylcholine catabolic process in synaptic cleft
1
acetylcholine secretion, neurotransmission +
7
negative regulation of synaptic transmission, cholinergic +
1
positive regulation of synaptic transmission, cholinergic +
12
regulation of synaptic transmission, cholinergic +
16