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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, cholinergic
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Accession:GO:0007271 term browser browse the term
Definition:The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IMP RGD PMID:15297571 RGD:1625662 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Anxa9 annexin A9 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:196,470,318...196,481,568
Ensembl chr 2:196,470,858...196,479,770
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 acts_upstream_of_or_within ISO MGI:1888740 (MGI:1888655|PMID:10944224) RGD PMID:10944224 MGI:1888655 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:60,445,657...60,460,724
Ensembl chr 3:60,445,666...60,460,724
JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit acts_upstream_of_or_within TAS
ISO
MGI:3774038 (MGI:3771935|PMID:18077337) RGD PMID:18077337, PMID:12117536 MGI:3771935, RGD:632442 NCBI chr 1:167,206,722...167,212,199
Ensembl chr 1:167,206,722...167,210,919
JBrowse link
G Chrna2 cholinergic receptor nicotinic alpha 2 subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:42,808,897...42,825,179
Ensembl chr15:42,808,897...42,825,179
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000108
MGI:2155602 (MGI:3590443|PMID:16162937)
GOC
RGD
PMID:16162937 GO_REF:0000108 MGI:3590443 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
IEA
MGI:2158758 (MGI:1931636|PMID:11226318), (MGI:2176631|PMID:11906696)
PMID:21873635
GO_REF:0000108
RGD
GOC
PMID:11226318 PMID:11906696, PMID:15026122, PMID:21873635 GO_REF:0000108 MGI:1931636 MGI:2176631, RGD:1358635, RGD:13792537 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit involved_in IEA
IBA
GO_REF:0000108
PMID:21873635
GOC PMID:21873635 GO_REF:0000108, RGD:13792537 NCBI chr 8:59,561,817...59,590,172
Ensembl chr 8:59,561,721...59,590,172
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
IEA
MGI:1888407 (MGI:1099674|PMID:9364063)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:9364063, PMID:15044058, PMID:21873635 GO_REF:0000107 MGI:1099674, RGD:1600975, RGD:13792537 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit involved_in ISO (PMID:8872460) RGD PMID:8872460 NCBI chr10:56,390,671...56,403,255
Ensembl chr10:56,390,671...56,403,188
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit IMP RGD PMID:12754307 RGD:1358637 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:68,876,442...68,913,628
Ensembl chr16:68,875,709...68,913,628
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
G Lynx1 Ly6/neurotoxin 1 acts_upstream_of_or_within ISO (MGI:3838433|PMID:19246390) RGD PMID:19246390 MGI:3838433 NCBI chr 7:115,982,877...115,988,121
Ensembl chr 7:115,982,876...115,988,090
JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 acts_upstream_of_or_within ISO (MGI:3838433|PMID:19246390) RGD PMID:19246390 MGI:3838433 NCBI chr13:42,219,884...42,263,024
Ensembl chr13:42,219,887...42,263,024
JBrowse link
G Rapsn receptor-associated protein of the synapse acts_upstream_of_or_within ISO UniProtKB:Q9GZZ6 (PMID:18420419) RGD PMID:18420419 NCBI chr 3:79,859,815...79,869,486
Ensembl chr 3:79,860,179...79,869,524
JBrowse link
G Ric3 RIC3 acetylcholine receptor chaperone involved_in
acts_upstream_of_or_within
IBA
IGI
PMID:21873635
PMID:18420419
GO_Central
MGI
PMID:21873635, PMID:18420419 RGD:13792537, RGD:2317082 NCBI chr 1:173,629,218...173,682,226
Ensembl chr 1:173,630,761...173,682,226
JBrowse link
G Slc5a7 solute carrier family 5 member 7 involved_in
acts_upstream_of_or_within
IBA
ISO
IEA
PMID:21873635
MGI:3045463 (MGI:3044863|PMID:15173594), (MGI:3590443|PMID:16162937)
GO_REF:0000107
RGD
Ensembl
PMID:15173594 PMID:16162937, PMID:21873635 GO_REF:0000107 MGI:3044863 MGI:3590443, RGD:13792537 NCBI chr 9:5,294,377...5,330,822
Ensembl chr 9:5,294,381...5,330,815
JBrowse link
acetylcholine catabolic process in synaptic cleft term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase involved_in IC PMID:26820598 SynGO PMID:26820598 RGD:12050110 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
negative regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr6 5-hydroxytryptamine receptor 6 IMP RGD PMID:16987217 RGD:2317005 NCBI chr 5:157,501,202...157,518,870
Ensembl chr 5:157,503,040...157,518,631
JBrowse link
positive regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IMP phrenic nerve terminals in the presence of adenosine transport inhibitor deoxycoformycin RGD PMID:12679375 RGD:1625693 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C IMP RGD PMID:15266551 RGD:1625007 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Tacr2 tachykinin receptor 2 IMP RGD PMID:12747940 RGD:5147477 NCBI chr20:31,892,515...31,905,153
Ensembl chr20:31,892,515...31,905,153
JBrowse link
positive regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ifng interferon gamma IDA RGD PMID:1900518 RGD:2311499 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Lama2 laminin subunit alpha 2 acts_upstream_of_or_within ISO MGI:1856026 (MGI:77287|PMID:8568931) RGD PMID:8568931 MGI:77287 NCBI chr 1:18,491,264...19,143,486
Ensembl chr 1:18,491,384...19,143,269
JBrowse link
G Musk muscle associated receptor tyrosine kinase IMP RGD PMID:16870737 RGD:2317092 NCBI chr 5:75,392,790...75,498,694
Ensembl chr 5:75,392,790...75,498,694
JBrowse link
G Ngfr nerve growth factor receptor IMP medial septum and diagonal band of Broca (MS-DBB) neurons stimulated by NGF RGD PMID:18256260 RGD:5508750 NCBI chr10:83,389,828...83,408,061
Ensembl chr10:83,389,847...83,408,061
JBrowse link
G Tac1 tachykinin, precursor 1 IDA RGD PMID:17949415 RGD:2304335 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:17949415 RGD:2304335 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Uts2 urotensin 2 IDA RGD PMID:15944374 RGD:2306844 NCBI chr 5:168,078,748...168,084,133
Ensembl chr 5:168,078,748...168,084,145
JBrowse link
regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209|MGI:2181384 (MGI:2654957|PMID:12624181), (MGI:3606714|PMID:10686170) RGD PMID:10686170 PMID:12624181 MGI:2654957 MGI:3606714 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit acts_upstream_of_or_within ISO MGI:2155602 (MGI:3590443|PMID:16162937) RGD PMID:16162937 MGI:3590443 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
regulation of synaptic transmission, cholinergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II beta acts_upstream_of_or_within ISO (MGI:4352609|PMID:19332541) RGD PMID:19332541 MGI:4352609 NCBI chr14:86,208,876...86,297,727
Ensembl chr14:86,208,901...86,297,652
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    signaling 7458
      cell-cell signaling 1731
        synaptic signaling 916
          trans-synaptic signaling 889
            anterograde trans-synaptic signaling 880
              chemical synaptic transmission 880
                synaptic transmission, cholinergic 32
                  acetylcholine catabolic process in synaptic cleft 1
                  acetylcholine secretion, neurotransmission + 6
                  negative regulation of synaptic transmission, cholinergic + 1
                  positive regulation of synaptic transmission, cholinergic + 10
                  regulation of synaptic transmission, cholinergic + 14
Path 2
Term Annotations click to browse term
  biological_process 19491
    cellular process 18343
      cell communication 7539
        cell-cell signaling 1731
          synaptic signaling 916
            trans-synaptic signaling 889
              anterograde trans-synaptic signaling 880
                chemical synaptic transmission 880
                  synaptic transmission, cholinergic 32
                    acetylcholine catabolic process in synaptic cleft 1
                    acetylcholine secretion, neurotransmission + 6
                    negative regulation of synaptic transmission, cholinergic + 1
                    positive regulation of synaptic transmission, cholinergic + 10
                    regulation of synaptic transmission, cholinergic + 14
paths to the root