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ONTOLOGY REPORT - ANNOTATIONS


Term:JNK cascade
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Accession:GO:0007254 term browser browse the term
Definition:An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Synonyms:exact_synonym: c-Jun N-terminal kinase cascade
 narrow_synonym: JNK1 cascade;   JNK2 cascade;   JNK3 cascade;   MAPK10 cascade;   MAPK8 cascade;   MAPK9 cascade
 broad_synonym: SAPK cascade;   stress-activated protein kinase cascade



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JNK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 involved_in ISO MGI:3720850 (MGI:3818095|PMID:18802055), (MGI:5007596|PMID:21533046) RGD PMID:18802055 PMID:21533046 MGI:3818095 MGI:5007596 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Card9 caspase recruitment domain family, member 9 acts_upstream_of ISO MGI:3698412 (MGI:3697751|PMID:17187069) RGD PMID:17187069 MGI:3697751 NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237
JBrowse link
G Casr calcium-sensing receptor IMP RGD PMID:15084499 RGD:1358486 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Cdc42ep5 CDC42 effector protein 5 acts_upstream_of_or_within ISO (MGI:1929482|PMID:10490598) RGD PMID:10490598 MGI:1929482 NCBI chr 1:70,035,921...70,038,990 JBrowse link
G Daxx death-domain associated protein involved_in ISO (PMID:9215629) RGD PMID:9215629 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Dusp19 dual specificity phosphatase 19 acts_upstream_of_or_within ISO (MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:2182169 NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor acts_upstream_of_or_within ISO MGI:1932102 (MGI:3654809|PMID:16319174) RGD PMID:16319174 MGI:3654809 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
JBrowse link
G Fgf12 fibroblast growth factor 12 acts_upstream_of_or_within ISO UniProtKB:Q9ERE9 (PMID:12815063) RGD PMID:12815063 NCBI chr11:71,997,049...72,564,965
Ensembl chr11:71,997,099...72,562,607
JBrowse link
G Fgf14 fibroblast growth factor 14 acts_upstream_of_or_within ISO UniProtKB:Q9ERE9 (PMID:12815063) RGD PMID:12815063 NCBI chr15:101,045,038...101,679,888
Ensembl chr15:101,045,036...101,679,900
JBrowse link
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 acts_upstream_of_or_within ISO (MGI:1859506|PMID:10747961) RGD PMID:10747961 MGI:1859506 NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
JBrowse link
G Il1b interleukin 1 beta acts_upstream_of ISO MGI:1346877 (MGI:3607973|PMID:16260493) RGD PMID:16260493 MGI:3607973 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il3 interleukin 3 acts_upstream_of ISO (MGI:3032484|PMID:14967141) RGD PMID:14967141 MGI:3032484 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 IMP RGD PMID:15890643 RGD:1579817 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 IMP RGD PMID:15890643 RGD:1579817 NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:19302196) RGD PMID:19302196 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Maged1 MAGE family member D1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr  X:59,422,715...59,429,381
Ensembl chr  X:59,422,717...59,429,364
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IDA RGD PMID:17064355 RGD:2298577 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 involved_in IDA
ISO
(MGI:2182169|PMID:11959862) RGD PMID:11959862 PMID:10051439 PMID:17064355 PMID:15680699 PMID:11849756 MGI:2182169, RGD:2298561, RGD:2298577, RGD:2298567, RGD:2298565 NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 acts_upstream_of_or_within ISO (MGI:3032484|PMID:14967141) RGD PMID:14967141 MGI:3032484 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 involved_in IDA
ISO
(PMID:15258589) RGD PMID:15258589 PMID:15680699 PMID:17064355 RGD:2298567, RGD:2298577 NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652
JBrowse link
G Map3k12 mitogen activated protein kinase kinase kinase 12 involved_in ISO
IEA
(MGI:5810221|PMID:27511108)
GO_REF:0000002
GO_REF:0000107
RGD
InterPro
Ensembl
PMID:27511108 GO_REF:0000002 GO_REF:0000107 MGI:5810221 NCBI chr 7:133,630,267...133,648,464
Ensembl chr 7:133,630,835...133,640,789
JBrowse link
G Map3k13 mitogen-activated protein kinase kinase kinase 13 involved_in ISO
IBA
(PMID:11726277), (PMID:9353328)
PMID:21873635
(MGI:5810221|PMID:27511108)
RGD PMID:9353328 PMID:11726277 PMID:27511108 PMID:21873635 MGI:5810221, RGD:13792537 NCBI chr11:79,094,087...79,235,181
Ensembl chr11:79,097,247...79,235,181
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 involved_in ISO
ISS
(PMID:11836244)
(PMID:11836244), (PMID:12220515), (PMID:14521931), (PMID:15737997), (PMID:32610081)
GO_REF:0000024
RGD
UniProt
PMID:11836244 PMID:12220515 PMID:14521931 PMID:15737997 PMID:32610081 GO_REF:0000024 NCBI chr 3:57,128,561...57,289,943
Ensembl chr 3:57,130,551...57,289,626
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 involved_in ISO
IDA
(PMID:11959862), (PMID:21771788)
(PMID:11959862), (PMID:21771788), (PMID:22095282)
RGD PMID:11959862 PMID:21771788 PMID:22095282 PMID:12524169 RGD:2298708 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 involved_in
acts_upstream_of
ISO
IBA
ISS
(PMID:9079627)
MGI:104798|MGI:96536|MGI:96824 (MGI:3607973|PMID:16260493)
(MGI:6162308|PMID:29291351)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:9079627 PMID:16260493 PMID:29291351 PMID:21873635 GO_REF:0000024 MGI:3607973 MGI:6162308, RGD:13792537 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Map4k1 mitogen activated protein kinase kinase kinase kinase 1 involved_in ISO (PMID:8824585) RGD PMID:8824585 NCBI chr 1:84,270,951...84,292,496
Ensembl chr 1:84,271,069...84,292,493
JBrowse link
G Mapk10 mitogen activated protein kinase 10 involved_in IDA
IBA
ISO
ISS
PMID:21873635
(MGI:1098190|PMID:9349820)
GO_REF:0000024
RGD
UniProt
PMID:9349820 PMID:10051439 PMID:21873635 PMID:15680699 GO_REF:0000024 MGI:1098190, RGD:2298561, RGD:13792537, RGD:2298567 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 involved_in
acts_upstream_of_or_within
ISO
IBA
ISS
(PMID:8654373)
(MGI:3573812|PMID:15579909)
PMID:21873635
(MGI:1855744|PMID:10811224)
GO_REF:0000024
RGD
UniProt
PMID:8654373 PMID:10811224 PMID:15579909 PMID:21873635 GO_REF:0000024 MGI:1855744 MGI:3573812, RGD:13792537 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 acts_upstream_of_or_within ISO (MGI:1888439|PMID:10827199) RGD PMID:10827199 MGI:1888439 NCBI chr 7:120,526,732...120,536,982
Ensembl chr 7:120,526,732...120,536,982
JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 acts_upstream_of_or_within ISO (MGI:1352260|PMID:10629060) RGD PMID:10629060 MGI:1352260 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 involved_in IDA
IBA
ISO
PMID:21873635
(PMID:8654373)
RGD PMID:8654373 PMID:10051439 PMID:21873635 RGD:2298561, RGD:13792537 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor acts_upstream_of IMP
ISO
MGI:2385681 (MGI:2669022|PMID:12855817) RGD PMID:12855817 PMID:15890643 MGI:2669022, RGD:1579817 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 involved_in ISO (MGI:3818095|PMID:18802055) RGD PMID:18802055 MGI:3818095 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 acts_upstream_of ISO (MGI:3775161|PMID:18261938) RGD PMID:18261938 MGI:3775161 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of ISO (MGI:3775161|PMID:18261938) RGD PMID:18261938 MGI:3775161 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Nox1 NADPH oxidase 1 acts_upstream_of
involved_in
ISO
IEA
MGI:3616995 (MGI:4881403|PMID:19661248)
GO_REF:0000107
RGD
Ensembl
PMID:19661248 GO_REF:0000107 MGI:4881403 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2155187|PMID:11562357)
Ensembl
RGD
PMID:11562357 GO_REF:0000107 MGI:2155187 NCBI chr 1:85,720,812...85,749,079
Ensembl chr 1:85,720,812...85,749,078
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 acts_upstream_of ISO MGI:1100089 (MGI:5308511|PMID:22073305) RGD PMID:22073305 MGI:5308511 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808
JBrowse link
G Ptger4 prostaglandin E receptor 4 involved_in IDA PMID:19233324 UniProt PMID:19233324 RGD:8554254 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Ptk2 protein tyrosine kinase 2 IMP RGD PMID:12782622 RGD:2292618 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of ISO MGI:2446070|MGI:2660793 (MGI:2176422|PMID:11894098), (MGI:2176424|PMID:11894097), (MGI:3775161|PMID:18261938) RGD PMID:11894097 PMID:11894098 PMID:18261938 MGI:2176422 MGI:2176424 MGI:3775161 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Ror2 receptor tyrosine kinase-like orphan receptor 2 acts_upstream_of_or_within ISO (MGI:3042073|PMID:12839624) RGD PMID:12839624 MGI:3042073 NCBI chr17:11,972,830...12,148,152
Ensembl chr17:11,972,830...12,148,152
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 NAS RGD PMID:12167088 RGD:737651 NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
JBrowse link
G Smad3 SMAD family member 3 involved_in ISO (MGI:3818095|PMID:18802055) RGD PMID:18802055 MGI:3818095 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
JBrowse link
G Spag9 sperm associated antigen 9 acts_upstream_of_or_within ISO (MGI:4835955|PMID:12391307) RGD PMID:12391307 MGI:4835955 NCBI chr10:78,943,439...79,077,797
Ensembl chr10:78,943,479...79,077,797
JBrowse link
G Stk3 serine/threonine kinase 3 acts_upstream_of
involved_in
ISO
IEA
MGI:104798|MGI:1929004 (MGI:4420852|PMID:20080598)
GO_REF:0000107
RGD
Ensembl
PMID:20080598 GO_REF:0000107 MGI:4420852 NCBI chr 7:66,053,209...66,323,292
Ensembl chr 7:66,052,345...66,323,233
JBrowse link
G Stradb STE20 related adaptor beta acts_upstream_of_or_within ISO (MGI:2656105|PMID:12574163) RGD PMID:12574163 MGI:2656105 NCBI chr 9:60,414,182...60,433,084
Ensembl chr 9:60,414,182...60,433,084
JBrowse link
G Tlr3 toll-like receptor 3 involved_in
acts_upstream_of
ISO (MGI:3818095|PMID:18802055)
(MGI:3607973|PMID:16260493)
RGD PMID:16260493 PMID:18802055 MGI:3607973 MGI:3818095 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr4 toll-like receptor 4 acts_upstream_of
involved_in
ISO
IEA
MGI:1346877 (MGI:3607973|PMID:16260493), (MGI:3775161|PMID:18261938)
GO_REF:0000107
RGD
Ensembl
PMID:16260493 PMID:18261938 GO_REF:0000107 MGI:3607973 MGI:3775161 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr7 toll-like receptor 7 involved_in ISO (MGI:3818095|PMID:18802055) RGD PMID:18802055 MGI:3818095 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754
JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO MGI:1341850 (MGI:3689241|PMID:17015619)
MGI:1346877 (MGI:3607973|PMID:16260493), (MGI:4420852|PMID:20080598)
RGD PMID:16260493 PMID:17015619 PMID:20080598 MGI:3607973 MGI:3689241 MGI:4420852 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf11 TNF superfamily member 11 acts_upstream_of
involved_in
ISO
IEA
MGI:109520 (MGI:5308511|PMID:22073305)
GO_REF:0000107
RGD
Ensembl
PMID:22073305 GO_REF:0000107 MGI:5308511 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Traf6 TNF receptor associated factor 6 IMP RGD PMID:15890643 RGD:1579817 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trib1 tribbles pseudokinase 1 involved_in ISO (PMID:17452330) RGD PMID:17452330 NCBI chr 7:91,206,579...91,213,126
Ensembl chr 7:91,206,579...91,214,731
JBrowse link
G Wnt5a Wnt family member 5A acts_upstream_of_or_within ISO (MGI:3042073|PMID:12839624) RGD PMID:12839624 MGI:3042073 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
JUN phosphorylation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk10 mitogen activated protein kinase 10 IDA RGD PMID:10597270 RGD:7495842 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 acts_upstream_of_or_within
involved_in
ISO MGI:2384141 (MGI:3032484|PMID:14967141)
(PMID:14967141)
(PMID:21095239)
RGD PMID:14967141 PMID:21095239 MGI:3032484 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 acts_upstream_of_or_within ISO (MGI:1306759|PMID:9235893) RGD PMID:9235893 MGI:1306759 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:16942465 RGD:2304233 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
negative regulation of JNK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated involved_in ISO UniProtKB:O35625 (MGI:3799599|PMID:17681137) RGD PMID:17681137 MGI:3799599 NCBI chr13:94,940,311...94,967,920
Ensembl chr13:94,939,741...94,967,920
JBrowse link
G Akt1 AKT serine/threonine kinase 1 IDA RGD PMID:17064355 RGD:2298577 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:3693042|PMID:17081782) RGD PMID:17081782 MGI:3693042 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Cyld CYLD lysine 63 deubiquitinase involved_in ISO
ISS
(PMID:29291351)
(MGI:6162308|PMID:29291351)
GO_REF:0000024
RGD
UniProt
PMID:29291351 GO_REF:0000024 MGI:6162308 NCBI chr19:18,310,632...18,373,696
Ensembl chr19:18,314,019...18,373,658
JBrowse link
G Dact1 dishevelled-binding antagonist of beta-catenin 1 involved_in IBA
ISO
PMID:21873635
(MGI:5437437|PMID:17197390)
(PMID:17197390)
RGD PMID:17197390 PMID:21873635 MGI:5437437, RGD:13792537 NCBI chr 6:89,790,676...89,818,254
Ensembl chr 6:89,790,644...89,817,906
JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in
acts_upstream_of_or_within
ISO (PMID:10391943)
MGI:3052343 (MGI:3051749|PMID:15306813)
RGD PMID:10391943 PMID:15306813 MGI:3051749 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Dusp19 dual specificity phosphatase 19 involved_in ISO (MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:2182169 NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534
JBrowse link
G Dusp3 dual specificity phosphatase 3 involved_in IBA
ISO
PMID:21873635
(PMID:11085983), (PMID:19010898)
RGD PMID:11085983 PMID:19010898 PMID:21873635 RGD:13792537 NCBI chr10:86,920,014...86,933,739
Ensembl chr10:86,920,014...86,933,962
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:19781631) RGD PMID:19781631 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Fktn fukutin involved_in ISO (PMID:18808525) RGD PMID:18808525 NCBI chr 5:68,339,803...68,396,412
Ensembl chr 5:68,340,028...68,396,409
JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in ISO (PMID:11931768)
(MGI:6148454|PMID:22424771)
RGD PMID:11931768 PMID:22424771 MGI:6148454 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
JBrowse link
G Hdac3 histone deacetylase 3 involved_in ISO (PMID:11931768) RGD PMID:11931768 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Itch itchy E3 ubiquitin protein ligase involved_in ISO (MGI:3774677|PMID:18246070) RGD PMID:18246070 MGI:3774677 NCBI chr 3:143,642,348...143,733,745
Ensembl chr 3:143,645,637...143,733,543
JBrowse link
G Klhl31 kelch-like family member 31 involved_in ISO
IBA
(PMID:18719355)
PMID:21873635
RGD PMID:18719355 PMID:21873635 RGD:13792537 NCBI chr 8:78,515,514...78,538,873
Ensembl chr 8:78,515,514...78,538,873
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 IMP RGD PMID:12064607 RGD:1299562 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
JBrowse link
G Marveld3 MARVEL domain containing 3 acts_upstream_of_or_within ISO (PMID:24567356) RGD PMID:24567356 NCBI chr19:37,908,727...37,923,420
Ensembl chr19:37,905,638...37,923,420
JBrowse link
G Mecom MDS1 and EVI1 complex locus involved_in ISO (PMID:10856240) RGD PMID:10856240 NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590
JBrowse link
G Men1 menin 1 involved_in ISO (PMID:12226747) RGD PMID:12226747 NCBI chr 1:203,638,905...203,644,871
Ensembl chr 1:203,639,000...203,644,871
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 involved_in ISO (PMID:11931768) RGD PMID:11931768 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032
JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 acts_upstream_of_or_within ISO MGI:1100089 (MGI:5308511|PMID:22073305) RGD PMID:22073305 MGI:5308511 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808
JBrowse link
G Per1 period circadian regulator 1 involved_in IMP PMID:24447840 UniProt PMID:24447840 RGD:8655527 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISS GO_REF:0000024 ParkinsonsUK-UCL GO_REF:0000024 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Prmt1 protein arginine methyltransferase 1 involved_in ISO
ISS
(PMID:22095282)
GO_REF:0000024
RGD
UniProt
PMID:22095282 GO_REF:0000024 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
JBrowse link
G Sfrp4 secreted frizzled-related protein 4 IDA RGD PMID:18567805 RGD:4107045 NCBI chr17:45,278,867...45,330,806
Ensembl chr17:45,234,097...45,330,736
JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 involved_in IMP PMID:22128169 UniProt PMID:22128169 RGD:13673844 NCBI chr18:34,045,715...34,148,342
Ensembl chr18:34,046,879...34,146,856
JBrowse link
G Sirpa signal-regulatory protein alpha involved_in ISO (MGI:3760575|PMID:17954568) RGD PMID:17954568 MGI:3760575 NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098
JBrowse link
G Taok3 TAO kinase 3 involved_in ISO
IEA
(PMID:10559204)
GO_REF:0000107
RGD
Ensembl
PMID:10559204 GO_REF:0000107 NCBI chr12:39,314,027...39,394,243
Ensembl chr12:39,314,027...39,461,244
JBrowse link
G Zmynd11 zinc finger, MYND-type containing 11 involved_in ISO (PMID:20732415) RGD PMID:20732415 NCBI chr17:60,542,669...60,631,913
Ensembl chr17:60,543,077...60,631,902
JBrowse link
negative regulation of JUN kinase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aida axin interactor, dorsalization associated acts_upstream_of_or_within ISO (MGI:3799599|PMID:17681137)
(PMID:17681137)
RGD PMID:17681137 MGI:3799599 NCBI chr13:94,940,311...94,967,920
Ensembl chr13:94,939,741...94,967,920
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 involved_in ISO
ISS
(PMID:24512202)
GO_REF:0000024
RGD
UniProt
PMID:24512202 GO_REF:0000024 NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
JBrowse link
G Dusp10 dual specificity phosphatase 10 involved_in
acts_upstream_of_or_within
ISO
IBA
(PMID:10391943)
MGI:3052343 (MGI:3051749|PMID:15306813)
PMID:21873635
RGD PMID:10391943 PMID:15306813 PMID:21873635 MGI:3051749, RGD:13792537 NCBI chr13:95,613,716...95,651,716
Ensembl chr13:95,614,292...95,651,716
JBrowse link
G Dusp16 dual specificity phosphatase 16 involved_in ISO (PMID:11489891) RGD PMID:11489891 NCBI chr 4:167,546,780...167,629,949
Ensembl chr 4:167,548,155...167,629,980
JBrowse link
G Dusp19 dual specificity phosphatase 19 involved_in ISO (MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:2182169 NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534
JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:3721484|PMID:12646564), (MGI:5009198|PMID:10945608), (MGI:5009411|PMID:16023107)
(PMID:16636664)
BHF-UCL
RGD
PMID:10945608 PMID:12646564 PMID:16023107 PMID:16636664 GO_REF:0000024 MGI:3721484 MGI:5009198 MGI:5009411 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hipk3 homeodomain interacting protein kinase 3 involved_in ISO (MGI:1913166|PMID:11034606) RGD PMID:11034606 MGI:1913166 NCBI chr 3:90,796,980...90,866,701
Ensembl chr 3:90,800,296...90,867,759
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 involved_in IMP PMID:21076496 RGD
UniProt
PMID:12064607 PMID:21076496 RGD:1299562, RGD:13673827 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
JBrowse link
G Nppa natriuretic peptide A involved_in ISO (PMID:22399583) RGD PMID:22399583 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Pdcd4 programmed cell death 4 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Ptpn22 protein tyrosine phosphatase, non-receptor type 22 involved_in ISO (PMID:23991106) RGD PMID:23991106 NCBI chr 2:191,366,761...191,414,782
Ensembl chr 2:191,366,808...191,414,779
JBrowse link
G Serpinb3 serpin family B member 3 involved_in ISO (PMID:21383048) RGD PMID:21383048 NCBI chr13:23,274,120...23,280,082
Ensembl chr13:23,274,484...23,313,682
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:108078|MGI:1860298 (MGI:3839161|PMID:19300477)
Ensembl
RGD
PMID:19300477 GO_REF:0000107 MGI:3839161 NCBI chr16:68,575,763...68,613,905
Ensembl chr16:68,575,763...68,614,286
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 acts_upstream_of_or_within ISO MGI:1860298|MGI:892014 (MGI:3839161|PMID:19300477) RGD PMID:19300477 MGI:3839161 NCBI chr 2:169,089,517...169,097,064
Ensembl chr 2:169,089,517...169,097,063
JBrowse link
G Sfrp5 secreted frizzled-related protein 5 acts_upstream_of_or_within ISO MGI:108078|MGI:892014 (MGI:3839161|PMID:19300477) RGD PMID:19300477 MGI:3839161 NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224
JBrowse link
G Tp73 tumor protein p73 acts_upstream_of_or_within ISO (MGI:3574697|PMID:15483136) RGD PMID:15483136 MGI:3574697 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
JBrowse link
positive regulation of JNK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end product-specific receptor involved_in ISO ComplexPortal:CPX-1134|UniProtKB:P10749 (PMID:20739563) RGD PMID:20739563 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Ankrd6 ankyrin repeat domain 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:47,197,981...47,343,183
Ensembl chr 5:47,202,873...47,343,090
JBrowse link
G App amyloid beta precursor protein involved_in ISO ComplexPortal:CPX-1134 (PMID:23921129) RGD PMID:23921129 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Axin1 axin 1 involved_in
acts_upstream_of_or_within
ISS
ISO
GO_REF:0000024
MGI:1856035 (MGI:3797993|PMID:18316368)
(MGI:3799599|PMID:17681137)
UniProt
RGD
PMID:17681137 PMID:18316368 GO_REF:0000024 MGI:3797993 MGI:3799599 NCBI chr10:15,163,684...15,215,615
Ensembl chr10:15,163,684...15,215,615
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 involved_in ISO (PMID:11865055) RGD PMID:11865055 NCBI chr 3:168,047,824...168,052,606
Ensembl chr 3:168,047,824...168,052,606
JBrowse link
G Card9 caspase recruitment domain family, member 9 acts_upstream_of_or_within ISO MGI:3698412 (MGI:3697751|PMID:17187069)
(PMID:17187069)
RGD PMID:17187069 MGI:3697751 NCBI chr 3:9,171,814...9,180,310
Ensembl chr 3:9,171,815...9,180,237
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 involved_in ISO (PMID:15778365) RGD PMID:15778365 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl21 C-C motif chemokine ligand 21 involved_in ISO (PMID:15778365) RGD PMID:15778365 NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686
JBrowse link
G Ccn2 cellular communication network factor 2 involved_in ISO (PMID:20008146) RGD PMID:20008146 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Cd27 CD27 molecule involved_in ISO (MGI:3687722|PMID:9692890) RGD PMID:9692890 MGI:3687722 NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592
JBrowse link
G Cdc42 cell division cycle 42 IDA RGD PMID:17161586 RGD:2298583 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 acts_upstream_of_or_within ISO (MGI:2667426|PMID:12832451) RGD PMID:12832451 MGI:2667426 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Cracr2a calcium release activated channel regulator 2A involved_in ISO
IBA
(PMID:27016526)
(MGI:6141997|PMID:27016526)
PMID:21873635
RGD PMID:27016526 PMID:21873635 MGI:6141997, RGD:13792537 NCBI chr 4:160,428,987...160,517,427
Ensembl chr 4:160,408,077...160,518,107
JBrowse link
G Crk CRK proto-oncogene, adaptor protein IMP RGD PMID:12198159 RGD:1298803 NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406
JBrowse link
G Dab2 DAB adaptor protein 2 involved_in ISO (MGI:5442512|PMID:15894542) RGD PMID:15894542 MGI:5442512 NCBI chr 2:55,514,692...55,567,476
Ensembl chr 2:55,514,700...55,567,476
JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISS
ISO
GO_REF:0000024
(PMID:17389591), (PMID:19903888)
UniProt
RGD
PMID:17389591 PMID:19903888 GO_REF:0000024 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280
JBrowse link
G Dixdc1 DIX domain containing 1 IMP RGD PMID:19339625 RGD:2308917 NCBI chr 8:51,007,835...51,081,191
Ensembl chr 8:51,007,838...51,081,090
JBrowse link
G Dusp19 dual specificity phosphatase 19 involved_in ISO (MGI:2182169|PMID:11959862) RGD PMID:11959862 MGI:2182169 NCBI chr 3:65,538,424...65,554,465
Ensembl chr 3:65,538,420...65,553,534
JBrowse link
G Dusp22 dual specificity phosphatase 22 acts_upstream_of_or_within ISO (MGI:2387732|PMID:12138158) RGD PMID:12138158 MGI:2387732 NCBI chr17:33,780,980...33,831,540
Ensembl chr17:33,780,981...33,831,321
JBrowse link
G Eda2r ectodysplasin A2 receptor involved_in IBA
ISO
PMID:21873635
(PMID:12270937)
RGD PMID:12270937 PMID:21873635 RGD:13792537 NCBI chr  X:62,224,763...62,269,344
Ensembl chr  X:62,228,229...62,269,268
JBrowse link
G Edar ectodysplasin-A receptor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:26,587,836...26,666,543
Ensembl chr20:26,587,839...26,666,494
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO (PMID:11413129) RGD PMID:11413129 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Fcgr2b Fc gamma receptor 2B involved_in ISO (MGI:5514474|PMID:23921129) RGD PMID:23921129 MGI:5514474 NCBI chr13:83,191,253...83,207,776
Ensembl chr13:83,193,163...83,207,778
JBrowse link
G Fgd4 FYVE, RhoGEF and PH domain containing 4 IMP RGD PMID:9668039 RGD:1299389 NCBI chr11:84,399,885...84,551,013
Ensembl chr11:84,399,816...84,546,972
JBrowse link
G Fgf19 fibroblast growth factor 19 involved_in ISO (PMID:12815072) RGD PMID:12815072 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 involved_in ISO
IEA
(PMID:16076871)
GO_REF:0000107
RGD
Ensembl
PMID:16076871 GO_REF:0000107 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha involved_in ISO
IEA
(PMID:9827804)
GO_REF:0000107
RGD
Ensembl
PMID:9827804 GO_REF:0000107 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta involved_in ISO (PMID:9827804) RGD PMID:9827804 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gadd45g growth arrest and DNA-damage-inducible, gamma involved_in ISO (PMID:9827804) RGD PMID:9827804 NCBI chr17:13,376,842...13,378,587
Ensembl chr17:13,376,839...13,378,610
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 involved_in ISO (PMID:14678985) RGD PMID:14678985 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223
JBrowse link
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:12765338) RGD PMID:12765338 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Hras HRas proto-oncogene, GTPase involved_in ISO (PMID:22065586) RGD PMID:22065586 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Il1a interleukin 1 alpha IDA RGD PMID:15671867 RGD:1358666 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta involved_in
acts_upstream_of_or_within
IDA
ISO
ComplexPortal:CPX-1134|UniProtKB:Q15109 (MGI:5902681|PMID:20739563)
MGI:1346877 (MGI:3607973|PMID:16260493)
RGD PMID:16260493 PMID:20739563 PMID:15671867 MGI:3607973 MGI:5902681, RGD:1358666 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il3 interleukin 3 acts_upstream_of_or_within ISO (MGI:3032484|PMID:14967141) RGD PMID:14967141 MGI:3032484 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Ltbr lymphotoxin beta receptor involved_in ISO (PMID:20732415) RGD PMID:20732415 NCBI chr 4:158,108,884...158,115,339
Ensembl chr 4:158,108,886...158,121,539
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IDA RGD PMID:17064355 RGD:2298577 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 involved_in IDA
ISO
(MGI:1101248|PMID:9405446) RGD PMID:9405446 PMID:10051439 PMID:11849756 PMID:17064355 MGI:1101248, RGD:2298561, RGD:2298565, RGD:2298577 NCBI chr12:2,591,312...2,604,211
Ensembl chr12:2,591,219...2,604,222
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 IDA RGD PMID:9110999 RGD:2293488 NCBI chr 2:43,348,572...43,414,706
Ensembl chr 2:43,350,098...43,414,463
JBrowse link
G Map3k10 mitogen activated protein kinase kinase kinase 10 involved_in ISO (PMID:17584736) RGD PMID:17584736 NCBI chr 1:82,955,783...82,974,084
Ensembl chr 1:82,955,207...82,974,084
JBrowse link
G Map3k11 mitogen-activated protein kinase kinase kinase 11 involved_in IDA
ISO
(PMID:17584736) RGD PMID:17584736 PMID:17064355 RGD:2298577 NCBI chr 1:202,975,353...202,988,655
Ensembl chr 1:202,975,353...202,988,652
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 involved_in ISO (MGI:5616327|PMID:12050113) RGD PMID:12050113 MGI:5616327 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 acts_upstream_of_or_within ISO MGI:104798|MGI:96536|MGI:96824 (MGI:3607973|PMID:16260493) RGD PMID:16260493 MGI:3607973 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 involved_in ISO (PMID:17584736) RGD PMID:17584736 NCBI chr 1:203,645,098...203,660,515
Ensembl chr 1:203,645,153...203,660,331
JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 involved_in ISO (MGI:86683|PMID:9135144) RGD PMID:9135144 MGI:86683 NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5546548|PMID:23963642)
UniProt
RGD
PMID:23963642 GO_REF:0000024 MGI:5546548 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 involved_in IMP PMID:21076496 UniProt PMID:21076496 RGD:13673827 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273
JBrowse link
G Mapkbp1 mitogen activated protein kinase binding protein 1 acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:1344829|PMID:10471813)
PMID:21873635
RGD PMID:10471813 PMID:21873635 MGI:1344829, RGD:13792537 NCBI chr 3:106,947,342...106,998,368
Ensembl chr 3:106,947,827...106,996,199
JBrowse link
G Mbip MAP3K12 binding inhibitory protein 1 involved_in ISO (PMID:10801814), (PMID:32963352) RGD PMID:10801814 PMID:32963352 NCBI chr 6:73,808,133...73,825,394
Ensembl chr 6:73,808,133...73,825,374
JBrowse link
G Mfhas1 multifunctional ROCO family signaling regulator 1 involved_in ISO (PMID:28471450) RGD PMID:28471450 NCBI chr16:56,545,462...56,633,649
Ensembl chr16:56,546,207...56,633,743
JBrowse link
G Mink1 misshapen-like kinase 1 involved_in ISO
IEA
(PMID:15469942)
GO_REF:0000107
(MGI:1354211|PMID:10708748)
RGD
Ensembl
PMID:10708748 PMID:15469942 GO_REF:0000107 MGI:1354211 NCBI chr10:55,278,293...55,330,782
Ensembl chr10:55,278,391...55,330,782
JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IEA
ISO
GO_REF:0000107
(MGI:6201889|PMID:25049354)
Ensembl
RGD
PMID:25049354 GO_REF:0000107 MGI:6201889 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Mturn maturin, neural progenitor differentiation regulator homolog involved_in ISO (PMID:24681962) RGD PMID:24681962 NCBI chr 4:83,807,528...83,828,494
Ensembl chr 4:83,807,579...83,824,950
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor acts_upstream_of_or_within ISO MGI:2385681 (MGI:2669022|PMID:12855817) RGD PMID:12855817 MGI:2669022 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 involved_in ISO (PMID:11865055) RGD PMID:11865055 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 acts_upstream_of_or_within ISO (MGI:3775161|PMID:18261938) RGD PMID:18261938 MGI:3775161 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 acts_upstream_of_or_within ISO (MGI:3775161|PMID:18261938)
(PMID:17187069)
RGD PMID:17187069 PMID:18261938 MGI:3775161 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Nox1 NADPH oxidase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3616995 (MGI:4881403|PMID:19661248)
Ensembl
RGD
PMID:19661248 GO_REF:0000107 MGI:4881403 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236
JBrowse link
G Nrk Nik related kinase acts_upstream_of_or_within ISO (MGI:1860727|PMID:10801798) RGD PMID:10801798 MGI:1860727 NCBI chr  X:102,365,747...102,462,957
Ensembl chr  X:102,365,765...102,459,657
JBrowse link
G Pja2 praja ring finger ubiquitin ligase 2 involved_in ISO
ISS
(PMID:28471450)
GO_REF:0000024
RGD
UniProt
PMID:28471450 GO_REF:0000024 NCBI chr 9:103,956,678...104,006,763
Ensembl chr 9:103,956,678...104,006,783
JBrowse link
G Plcb1 phospholipase C beta 1 involved_in ISO
IEA
(PMID:9500449)
GO_REF:0000107
RGD
Ensembl
PMID:9500449 GO_REF:0000107 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISS
ISO
GO_REF:0000024
(PMID:8670418)
UniProt
RGD
PMID:8670418 GO_REF:0000024 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282
JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:21487011) RGD PMID:21487011 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 involved_in ISO (PMID:19933860) RGD PMID:19933860 NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
JBrowse link
G Rassf2 Ras association domain family member 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:19962960)
RGD PMID:19962960 PMID:21873635 RGD:13792537 NCBI chr 3:119,244,288...119,280,462
Ensembl chr 3:119,245,821...119,280,431
JBrowse link
G Rb1cc1 RB1-inducible coiled-coil 1 acts_upstream_of_or_within ISO MGI:104798 (MGI:3689241|PMID:17015619) RGD PMID:17015619 MGI:3689241 NCBI chr 5:13,161,648...13,225,560
Ensembl chr 5:13,161,648...13,225,560
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 involved_in ISO (PMID:17389591)
(MGI:5306563|PMID:20125124)
RGD PMID:17389591 PMID:20125124 MGI:5306563 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 acts_upstream_of_or_within ISO MGI:2446070|MGI:2660793 (MGI:2176422|PMID:11894098), (MGI:2176424|PMID:11894097), (MGI:3775161|PMID:18261938) RGD PMID:11894097 PMID:11894098 PMID:18261938 MGI:2176422 MGI:2176424 MGI:3775161 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Serpinf2 serpin family F member 2 involved_in ISO (PMID:20008146) RGD PMID:20008146 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243
JBrowse link
G Sh3rf1 SH3 domain containing ring finger 1 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:5546548|PMID:23963642), (MGI:6158776|PMID:27084103)
PMID:21873635
UniProt
RGD
PMID:23963642 PMID:27084103 PMID:21873635 GO_REF:0000024 MGI:5546548 MGI:6158776, RGD:13792537 NCBI chr16:28,735,522...28,901,690
Ensembl chr16:28,735,440...28,901,644
JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 involved_in ISO
ISS
IBA
(PMID:24130170)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:24130170 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr18:34,045,715...34,148,342
Ensembl chr18:34,046,879...34,146,856
JBrowse link
G Sh3rf3 SH3 domain containing ring finger 3 involved_in ISO
IBA
(PMID:20696164)
PMID:21873635
RGD PMID:20696164 PMID:21873635 RGD:13792537 NCBI chr20:26,765,278...27,099,261
Ensembl chr20:26,765,015...27,099,257
JBrowse link
G Slamf1 signaling lymphocytic activation molecule family member 1 involved_in ISO (PMID:20231852) RGD PMID:20231852 NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497
JBrowse link
G Stk3 serine/threonine kinase 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:104798|MGI:1929004 (MGI:4420852|PMID:20080598)
Ensembl
RGD
PMID:20080598 GO_REF:0000107 MGI:4420852 NCBI chr 7:66,053,209...66,323,292
Ensembl chr 7:66,052,345...66,323,233
JBrowse link
G Taok1 TAO kinase 1 involved_in ISO
ISS
IEA
(PMID:16407310)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:16407310 GO_REF:0000024 GO_REF:0000107 NCBI chr10:62,373,076...62,465,295
Ensembl chr10:62,381,404...62,465,766
JBrowse link
G Taok2 TAO kinase 2 involved_in IEA
ISO
GO_REF:0000107
(PMID:10660600)
(MGI:5462161|PMID:22683681)
Ensembl
RGD
PMID:10660600 PMID:22683681 GO_REF:0000107 MGI:5462161 NCBI chr 1:181,475,708...181,494,738
Ensembl chr 1:181,475,711...181,494,613
JBrowse link
G Taok3 TAO kinase 3 involved_in ISO
IEA
(PMID:10924369)
GO_REF:0000107
RGD
Ensembl
PMID:10924369 GO_REF:0000107 NCBI chr12:39,314,027...39,394,243
Ensembl chr12:39,314,027...39,461,244
JBrowse link
G Tirap TIR domain containing adaptor protein involved_in ISO (PMID:11544529) RGD PMID:11544529 NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432
JBrowse link
G Tlr3 toll-like receptor 3 acts_upstream_of_or_within ISO (MGI:3607973|PMID:16260493) RGD PMID:16260493 MGI:3607973 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr4 toll-like receptor 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1346877 (MGI:3607973|PMID:16260493), (MGI:3775161|PMID:18261938)
Ensembl
RGD
PMID:16260493 PMID:18261938 GO_REF:0000107 MGI:3607973 MGI:3775161 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor acts_upstream_of_or_within ISO MGI:1346877 (MGI:3607973|PMID:16260493), (MGI:4420852|PMID:20080598) RGD PMID:16260493 PMID:20080598 MGI:3607973 MGI:4420852 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf19 TNF receptor superfamily member 19 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:35,092,206...35,158,472
Ensembl chr15:35,092,206...35,180,795
JBrowse link
G Tnfsf11 TNF superfamily member 11 acts_upstream_of_or_within
involved_in
ISO
IEA
MGI:109520 (MGI:5308511|PMID:22073305)
GO_REF:0000107
RGD
Ensembl
PMID:22073305 GO_REF:0000107 MGI:5308511 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tnik TRAF2 and NCK interacting kinase involved_in ISO (PMID:10521462), (PMID:15342639) RGD PMID:10521462 PMID:15342639 NCBI chr 2:111,184,352...111,587,993
Ensembl chr 2:111,184,387...111,580,750
JBrowse link
G Tpd52l1 TPD52 like 1 involved_in ISO (PMID:14761963) RGD PMID:14761963 NCBI chr 1:26,172,038...26,290,704
Ensembl chr 1:26,172,170...26,291,109
JBrowse link
G Traf1 TNF receptor-associated factor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:18,222,024...18,242,163
Ensembl chr 3:18,222,054...18,241,807
JBrowse link
G Traf2 Tnf receptor-associated factor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Traf3 Tnf receptor-associated factor 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
JBrowse link
G Traf4 Tnf receptor associated factor 4 involved_in IBA
ISO
PMID:21873635
(PMID:16157600)
RGD PMID:16157600 PMID:21873635 RGD:13792537 NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284
JBrowse link
G Traf5 TNF receptor-associated factor 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:103,569,944...103,618,756
Ensembl chr13:103,572,314...103,618,709
JBrowse link
G Traf6 TNF receptor associated factor 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
JBrowse link
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 involved_in ISO (MGI:5440106|PMID:23021218) RGD PMID:23021218 MGI:5440106 NCBI chr12:41,938,533...41,977,517
Ensembl chr12:41,938,560...41,977,517
JBrowse link
G Unc5cl unc-5 family C-terminal like involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:22158417)
RGD PMID:22158417 PMID:21873635 RGD:13792537 NCBI chr 9:12,528,109...12,543,382
Ensembl chr 9:12,528,246...12,542,233
JBrowse link
G Wnt16 Wnt family member 16 involved_in ISO (PMID:17200136) RGD PMID:17200136 NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380
JBrowse link
G Wnt5a Wnt family member 5A acts_upstream_of ISO (MGI:4820702|PMID:20032469) RGD PMID:20032469 MGI:4820702 NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234
JBrowse link
G Wnt7a Wnt family member 7A involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:18567805 PMID:21873635 RGD:4107045, RGD:13792537 NCBI chr 4:123,863,108...123,908,981
Ensembl chr 4:123,863,108...123,908,981
JBrowse link
G Wnt7b Wnt family member 7B involved_in IDA
IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:18177422 PMID:18177422 PMID:21873635 RGD:2292645, RGD:2292645, RGD:13792537 NCBI chr 7:116,634,817...116,679,089
Ensembl chr 7:116,634,814...116,679,581
JBrowse link
G Xiap X-linked inhibitor of apoptosis involved_in ISO (PMID:11865055) RGD PMID:11865055 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
G Zfp622 zinc finger protein 622 involved_in ISO (PMID:21771788) RGD PMID:21771788 NCBI chr 2:76,479,605...76,494,405
Ensembl chr 2:76,335,609...76,493,898
JBrowse link
regulation of JNK cascade term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO (PMID:16410250) RGD PMID:16410250 NCBI chr 5:9,192,233...9,210,498
Ensembl chr 5:9,192,100...9,210,731
JBrowse link
G Egfr epidermal growth factor receptor involved_in ISO (PMID:26514923) RGD PMID:26514923 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Ephb1 Eph receptor B1 involved_in ISS
ISO
GO_REF:0000024
(PMID:9430661)
UniProt
RGD
PMID:9430661 GO_REF:0000024 NCBI chr 8:102,507,549...102,944,839
Ensembl chr 8:102,507,549...102,944,839
JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO
ISS
(PMID:16410250)
GO_REF:0000024
RGD
UniProt
PMID:16410250 GO_REF:0000024 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226
JBrowse link
G Grik2 glutamate ionotropic receptor kainate type subunit 2 involved_in IMP PMID:11152698 UniProt PMID:11152698 RGD:8554109 NCBI chr20:52,135,325...52,833,061
Ensembl chr20:52,133,851...52,838,375
JBrowse link
G Igf1r insulin-like growth factor 1 receptor involved_in ISO
ISS
IEA
IBA
(PMID:12556535)
GO_REF:0000024
GO_REF:0000107
PMID:21873635
RGD
UniProt
Ensembl
PMID:12556535 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Magi3 membrane associated guanylate kinase, WW and PDZ domain containing 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:191,514,726...191,717,048
Ensembl chr 2:191,518,506...191,716,735
JBrowse link
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 involved_in ISO (PMID:14966141) RGD PMID:14966141 NCBI chr 9:42,200,708...42,326,708
Ensembl chr 9:42,200,278...42,326,698
JBrowse link
G Mapk8ip1 mitogen-activated protein kinase 8 interacting protein 1 involved_in ISS
ISO
IBA
GO_REF:0000024
(MGI:2182167|PMID:11562351)
PMID:21873635
UniProt
RGD
PMID:11562351 PMID:21873635 GO_REF:0000024 MGI:2182167, RGD:13792537 NCBI chr 3:78,355,051...78,372,946
Ensembl chr 3:78,355,048...78,372,884
JBrowse link
G Mapk8ip2 mitogen-activated protein kinase 8 interacting protein 2 involved_in IBA
ISO
PMID:21873635
(PMID:10490659)
RGD PMID:10490659 PMID:21873635 RGD:13792537 NCBI chr 7:120,526,732...120,536,982
Ensembl chr 7:120,526,732...120,536,982
JBrowse link
G Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 involved_in ISO (MGI:1352260|PMID:10629060) RGD PMID:10629060 MGI:1352260 NCBI chr10:13,918,417...13,958,335
Ensembl chr10:13,918,400...13,958,273
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:17348686 RGD:2298766 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mdfi MyoD family inhibitor involved_in ISO (MGI:4441137|PMID:12192039) RGD PMID:12192039 MGI:4441137 NCBI chr 9:13,156,806...13,175,218
Ensembl chr 9:13,156,866...13,175,217
JBrowse link
G Mdfic MyoD family inhibitor domain containing involved_in ISO (PMID:12192039) RGD PMID:12192039 NCBI chr 4:43,972,310...44,052,162
Ensembl chr 4:43,972,507...44,052,161
JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 involved_in IEA
ISO
GO_REF:0000107
(PMID:17386267)
Ensembl
RGD
PMID:17386267 GO_REF:0000107 NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977
JBrowse link
G Rap2a RAP2A, member of RAS oncogene family involved_in ISO (PMID:14966141) RGD PMID:14966141 NCBI chr15:97,596,848...97,597,338
Ensembl chr15:97,596,020...97,624,138
JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 IMP RGD PMID:10811109 RGD:11534984 NCBI chr 3:12,898,349...13,016,234
Ensembl chr 3:12,898,266...13,013,984
JBrowse link
G Sh3rf2 SH3 domain containing ring finger 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:34,045,715...34,148,342
Ensembl chr18:34,046,879...34,146,856
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 NOT|involved_in ISO (MGI:2663364|PMID:12773577) RGD PMID:12773577 MGI:2663364 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
JBrowse link
G Traf2 Tnf receptor-associated factor 2 acts_upstream_of_or_within ISO (MGI:2680840|PMID:12958312) RGD PMID:12958312 MGI:2680840 NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
JBrowse link
G Ulk4 unc-51 like kinase 4 acts_upstream_of_or_within ISO (PMID:24284070) RGD PMID:24284070 NCBI chr 8:120,670,879...120,966,026
Ensembl chr 8:120,670,866...120,966,924
JBrowse link
G Zfp110 zinc finger protein 110 involved_in ISO (MGI:3579762|PMID:15668238) RGD PMID:15668238 MGI:3579762 NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    cellular process 18675
      signal transduction 7133
        intracellular signal transduction 2748
          MAPK cascade 859
            stress-activated MAPK cascade 257
              JNK cascade 179
                JUN phosphorylation 4
                negative regulation of JNK cascade + 40
                positive regulation of JNK cascade 100
                regulation of JNK cascade + 150
Path 2
Term Annotations click to browse term
  biological_process 20091
    biological regulation 13996
      regulation of biological process 13218
        regulation of cellular process 12482
          signal transduction 7133
            intracellular signal transduction 2748
              MAPK cascade 859
                stress-activated MAPK cascade 257
                  JNK cascade 179
                    JUN phosphorylation 4
                    negative regulation of JNK cascade + 40
                    positive regulation of JNK cascade 100
                    regulation of JNK cascade + 150
paths to the root