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ONTOLOGY REPORT - ANNOTATIONS

Term:integrin-mediated signaling pathway
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Accession:GO:0007229 term browser browse the term
Definition:The series of molecular signals initiated by an extracellular ligand binding to an integrin on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: integrin-mediated signalling pathway


show annotations for term's descendants           Sort by:
integrin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in ISO
IEA
IBA 		(PMID:24863063)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:24863063 GO_REF:0000033 GO_REF:0000107 NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065 		JBrowse link
G Adam15 ADAM metallopeptidase domain 15 involved_in ISO
IEA
IBA 		(PMID:22505472)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:22505472 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:174,754,629...174,765,136
Ensembl chr 2:174,754,633...174,765,113 		JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO
IEA 		(PMID:23726972)
GO_REF:0000107 		RGD
Ensembl		 PMID:23726972 GO_REF:0000107 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in ISO
ISS
IEA 		(PMID:8649368)
GO_REF:0000024
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:8649368 GO_REF:0000024 GO_REF:0000107 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Ccn1 cellular communication network factor 1 involved_in ISO
IEA 		(PMID:20675382)
GO_REF:0000107 		RGD
Ensembl		 PMID:20675382 GO_REF:0000107 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccn2 cellular communication network factor 2 acts_upstream_of_or_within ISO (PMID:10082563), (PMID:10446209) RGD PMID:10082563 PMID:10446209 NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cd40lg CD40 ligand involved_in IEA
ISO 		GO_REF:0000107
(PMID:31331973) 		Ensembl
RGD		 PMID:31331973 GO_REF:0000107 NCBI chr  X:140,164,341...140,176,057
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cd47 Cd47 molecule involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425 		JBrowse link
G Cdc42 cell division cycle 42 involved_in ISO (PMID:26051942) RGD PMID:26051942 NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:149,553,724...149,593,111 		JBrowse link
G Cdh17 cadherin 17 involved_in ISO
IEA 		(PMID:25336636)
GO_REF:0000107 		RGD
Ensembl		 PMID:25336636 GO_REF:0000107 NCBI chr 5:30,024,544...30,112,226
Ensembl chr 5:25,262,758...25,314,884 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex involved_in
acts_upstream_of_or_within 		ISO (PMID:36812915) RGD PMID:36812915 NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Col3a1 collagen type III alpha 1 chain involved_in ISO (PMID:14970208) RGD PMID:14970208 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Ctnna1 catenin alpha 1 acts_upstream_of ISO
IEA 		MGI:2677796 (PMID:22411810)
GO_REF:0000107 		RGD
Ensembl		 PMID:22411810 GO_REF:0000107 NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,728,485...26,860,910 		JBrowse link
G Cul3 cullin 3 involved_in ISS
ISO
IEA 		GO_REF:0000024
(PMID:22358839)
GO_REF:0000107 		UniProt
RGD
Ensembl		 PMID:22358839 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:81,592,641...81,670,462 		JBrowse link
G Dab2 DAB adaptor protein 2 NOT|involved_in ISO (PMID:19581412) RGD PMID:19581412 NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Diaph3 diaphanous-related formin 3 acts_upstream_of_or_within ISO
IEA 		(PMID:32576838)
GO_REF:0000107 		RGD
Ensembl		 PMID:32576838 GO_REF:0000107 NCBI chr15:68,951,992...69,421,623
Ensembl chr15:62,543,375...63,012,975 		JBrowse link
G Fbln1 fibulin 1 NOT|involved_in ISO (PMID:11792823) RGD PMID:11792823 NCBI chr 7:118,190,347...118,269,965
Ensembl chr 7:116,310,582...116,390,075 		JBrowse link
G Fcer1g Fc epsilon receptor Ig involved_in ISO (PMID:17086186) RGD PMID:17086186 NCBI chr13:86,181,908...86,186,766
Ensembl chr13:83,649,449...83,671,443 		JBrowse link
G Fermt1 FERM domain containing kindlin 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:140,624,434...140,666,419
Ensembl chr 3:120,171,561...120,213,555 		JBrowse link
G Fermt2 FERM domain containing kindlin 2 involved_in ISO
IEA 		(PMID:21325030)
GO_REF:0000107
GO_REF:0000002 		RGD
Ensembl
InterPro		 PMID:21325030 GO_REF:0000002 GO_REF:0000107 NCBI chr15:21,162,603...21,257,995
Ensembl chr15:18,682,927...18,751,811 		JBrowse link
G Fermt3 FERM domain containing kindlin 3 involved_in ISO
IEA 		(PMID:19234460)
GO_REF:0000107
GO_REF:0000002 		RGD
Ensembl
InterPro		 PMID:19234460 GO_REF:0000002 GO_REF:0000107 NCBI chr 1:204,189,483...204,207,683
Ensembl chr 1:204,189,484...204,207,587 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISO
IBA
ISS 		(PMID:10739672), (PMID:7519620)
(PMID:11672534)
GO_REF:0000033
GO_REF:0000024 		RGD
GO_Central
UniProt		 PMID:7519620 PMID:10739672 PMID:11672534 GO_REF:0000024 GO_REF:0000033 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326 		JBrowse link
G Fn1 fibronectin 1 involved_in
acts_upstream_of_or_within 		ISO
IEA 		(PMID:19126672)
GO_REF:0000107
(PMID:36812915) 		RGD
Ensembl		 PMID:19126672 PMID:36812915 GO_REF:0000107 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fut8 fucosyltransferase 8 acts_upstream_of_or_within ISO
IEA 		MGI:3608699 (PMID:17043354)
GO_REF:0000107 		RGD
Ensembl		 PMID:17043354 GO_REF:0000107 NCBI chr 6:101,682,354...101,909,784
Ensembl chr 6:95,949,991...96,176,677 		JBrowse link
G Fyb1 FYN binding protein 1 involved_in IEA
IBA 		GO_REF:0000002
GO_REF:0000033 		InterPro
GO_Central		 GO_REF:0000002 GO_REF:0000033 NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629 		JBrowse link
G Fyb2 FYN binding protein 2 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000002 		GO_Central
InterPro		 GO_REF:0000002 GO_REF:0000033 NCBI chr 5:119,677,116...119,800,911
Ensembl chr 5:119,677,204...119,800,910 		JBrowse link
G Gab2 GRB2-associated binding protein 2 acts_upstream_of_or_within ISO (PMID:11895767) RGD PMID:11895767 NCBI chr 1:160,841,066...161,036,940
Ensembl chr 1:151,429,695...151,625,031 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta involved_in
acts_upstream_of_or_within 		ISO (PMID:36812915) RGD PMID:36812915 NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Ilk integrin-linked kinase involved_in
acts_upstream_of_or_within 		IMP
IEA
ISO
IBA 		GO_REF:0000107
(PMID:20675382)
GO_REF:0000033
(PMID:9366252) 		Ensembl
RGD
GO_Central		 PMID:9366252 PMID:20675382 PMID:12629168 GO_REF:0000033 GO_REF:0000107, RGD:2302091 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier involved_in ISO
IEA 		(PMID:29100055)
GO_REF:0000107 		RGD
Ensembl		 PMID:29100055 GO_REF:0000107 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435 		JBrowse link
G Itga1 integrin subunit alpha 1 involved_in IEA
IBA 		GO_REF:0000043
GO_REF:0000033 		UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000043 NCBI chr 2:48,379,181...48,545,336
Ensembl chr 2:46,653,193...46,812,238 		JBrowse link
G Itga10 integrin subunit alpha 10 involved_in ISO
IEA
IBA 		(PMID:24823363)
GO_REF:0000043
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:24823363 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 2:184,182,869...184,202,172
Ensembl chr 2:184,182,869...184,202,172 		JBrowse link
G Itga11 integrin subunit alpha 11 involved_in ISO
IEA
IBA 		(PMID:24823363)
GO_REF:0000043
GO_REF:0000033 		RGD
UniProt
GO_Central		 PMID:24823363 GO_REF:0000033 GO_REF:0000043 NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407 		JBrowse link
G Itga2 integrin subunit alpha 2 involved_in ISO
IEA
IBA 		(PMID:24823363)
GO_REF:0000107
GO_REF:0000043
GO_REF:0000033 		RGD
Ensembl
UniProt
GO_Central		 PMID:24823363 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Itga2b integrin subunit alpha 2b involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr10:87,408,532...87,426,055
Ensembl chr10:87,408,536...87,426,168 		JBrowse link
G Itga3 integrin subunit alpha 3 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr10:80,486,998...80,522,548
Ensembl chr10:79,990,161...80,022,118 		JBrowse link
G Itga4 integrin subunit alpha 4 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr 3:84,569,487...84,646,276
Ensembl chr 3:64,163,085...64,233,715 		JBrowse link
G Itga5 integrin subunit alpha 5 involved_in
acts_upstream_of_or_within 		IDA
IBA
ISO
IEA 		GO_REF:0000033
(PMID:10022831), (PMID:31331973)
GO_REF:0000043
GO_REF:0000107
(PMID:36812915) 		GO_Central
RGD
UniProt
Ensembl		 PMID:10022831 PMID:31331973 PMID:36812915 PMID:12821041 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107, RGD:1300196 NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:134,478,968...134,502,837 		JBrowse link
G Itga6 integrin subunit alpha 6 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428 		JBrowse link
G Itga7 integrin subunit alpha 7 involved_in IDA
IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt
RGD		 PMID:1315319 GO_REF:0000033 GO_REF:0000043, RGD:70774 NCBI chr 7:1,360,125...1,388,886
Ensembl chr 7:1,359,940...1,388,450 		JBrowse link
G Itga8 integrin subunit alpha 8 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510 		JBrowse link
G Itga9 integrin subunit alpha 9 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr 8:118,307,424...118,615,527
Ensembl chr 8:118,307,381...118,613,754 		JBrowse link
G Itgad integrin subunit alpha D involved_in IEA
IBA 		GO_REF:0000043
GO_REF:0000033 		UniProt
GO_Central		 GO_REF:0000033 GO_REF:0000043 NCBI chr 1:182,759,762...182,788,422
Ensembl chr 1:182,759,740...182,788,161 		JBrowse link
G Itgae integrin subunit alpha E involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr10:57,704,813...57,764,093
Ensembl chr10:57,591,753...57,764,093
Ensembl chr10:57,591,753...57,764,093 		JBrowse link
G Itgal integrin subunit alpha L involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr 1:181,918,183...181,955,735
Ensembl chr 1:181,918,183...181,955,732 		JBrowse link
G Itgam integrin subunit alpha M involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Itgav integrin subunit alpha V involved_in ISO
IEA
IBA 		(PMID:11970960), (PMID:26934001)
GO_REF:0000107
GO_REF:0000043
(PMID:20675382)
GO_REF:0000033 		RGD
Ensembl
UniProt
GO_Central		 PMID:11970960 PMID:20675382 PMID:26934001 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:68,838,189...68,926,639 		JBrowse link
G Itgax integrin subunit alpha X involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698 		JBrowse link
G Itgb1 integrin subunit beta 1 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:24823363), (PMID:31331973)
GO_REF:0000043
GO_REF:0000033
(PMID:36812915) 		RGD
UniProt
GO_Central		 PMID:24823363 PMID:31331973 PMID:36812915 GO_REF:0000033 GO_REF:0000043 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 involved_in ISO (PMID:11919189), (PMID:15703214) RGD PMID:11919189 PMID:15703214 NCBI chr 6:46,549,994...46,564,735
Ensembl chr 6:40,821,339...40,836,037 		JBrowse link
G Itgb2 integrin subunit beta 2 involved_in
acts_upstream_of_or_within 		ISO
IEA
IBA 		(PMID:28807980)
GO_REF:0000107
GO_REF:0000043
GO_REF:0000033
(PMID:15249579)
(PMID:25453580) 		RGD
Ensembl
UniProt
GO_Central		 PMID:15249579 PMID:25453580 PMID:28807980 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,061,430...11,097,600 		JBrowse link
G Itgb3 integrin subunit beta 3 involved_in IEA
ISO
IBA 		GO_REF:0000043
(PMID:10022831), (PMID:8837777)
GO_REF:0000107
(PMID:20675382)
GO_REF:0000033 		UniProt
RGD
Ensembl
GO_Central		 PMID:8837777 PMID:10022831 PMID:20675382 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679 		JBrowse link
G Itgb4 integrin subunit beta 4 involved_in TAS
IEA
IBA 		GO_REF:0000043
GO_REF:0000033
GO_REF:0000002 		UniProt
GO_Central
InterPro
RGD		 PMID:8026337 GO_REF:0000002 GO_REF:0000033 GO_REF:0000043, RGD:729025 NCBI chr10:101,206,657...101,243,012
Ensembl chr10:101,206,665...101,243,012 		JBrowse link
G Itgb5 integrin subunit beta 5 involved_in ISO
IEA
IBA 		(PMID:24036928)
GO_REF:0000043
GO_REF:0000107
GO_REF:0000033 		RGD
UniProt
Ensembl
GO_Central		 PMID:24036928 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr11:80,333,588...80,449,373
Ensembl chr11:66,829,285...66,944,472 		JBrowse link
G Itgb6 integrin subunit beta 6 involved_in IBA
IEA 		GO_REF:0000033
GO_REF:0000043 		GO_Central
UniProt		 GO_REF:0000033 GO_REF:0000043 NCBI chr 3:65,454,964...65,579,179
Ensembl chr 3:45,048,044...45,121,671 		JBrowse link
G Itgb7 integrin subunit beta 7 involved_in ISO
IBA
IEA 		(PMID:23986478)
GO_REF:0000033
GO_REF:0000043
GO_REF:0000107 		RGD
GO_Central
UniProt
Ensembl		 PMID:23986478 GO_REF:0000033 GO_REF:0000043 GO_REF:0000107 NCBI chr 7:133,347,927...133,364,955
Ensembl chr 7:133,347,960...133,364,876 		JBrowse link
G Itgb8 integrin subunit beta 8 involved_in ISO
IEA
IBA 		(PMID:11970960)
GO_REF:0000043
GO_REF:0000033 		RGD
UniProt
GO_Central		 PMID:11970960 GO_REF:0000033 GO_REF:0000043 NCBI chr 6:146,267,982...146,351,245
Ensembl chr 6:140,127,203...140,208,476 		JBrowse link
G Itgbl1 integrin subunit beta like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:100,780,184...101,041,734
Ensembl chr15:100,780,184...101,041,733 		JBrowse link
G Lama5 laminin subunit alpha 5 involved_in ISO
IEA 		(PMID:11821406)
GO_REF:0000107 		RGD
Ensembl		 PMID:11821406 GO_REF:0000107 NCBI chr 3:167,270,296...167,318,370
Ensembl chr 3:167,270,296...167,318,451 		JBrowse link
G Lat linker for activation of T cells involved_in ISO (PMID:15100278) RGD PMID:15100278 NCBI chr 1:190,367,111...190,372,515
Ensembl chr 1:180,936,534...180,941,578 		JBrowse link
G Lims1 LIM zinc finger domain containing 1 acts_upstream_of ISO MGI:2385067 (PMID:19652092) RGD PMID:19652092 NCBI chr20:26,851,364...26,961,607
Ensembl chr20:26,309,895...26,418,500 		JBrowse link
G Lims2 LIM zinc finger domain containing 2 acts_upstream_of ISO
IEA 		MGI:1195263 (PMID:19652092)
GO_REF:0000107 		RGD
Ensembl		 PMID:19652092 GO_REF:0000107 NCBI chr18:23,828,164...23,866,363
Ensembl chr18:23,553,937...23,592,137 		JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 involved_in ISO
IEA
IBA 		(PMID:23986478)
GO_REF:0000002
GO_REF:0000033 		RGD
InterPro
GO_Central		 PMID:23986478 GO_REF:0000002 GO_REF:0000033 NCBI chr 7:10,036,301...10,039,703
Ensembl chr 7:10,036,301...10,039,703 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 involved_in ISO (PMID:36812915) RGD PMID:36812915 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mpig6b megakaryocyte and platelet inhibitory receptor G6b involved_in
acts_upstream_of_or_within 		ISS
IEA
ISO
IBA 		GO_REF:0000024
GO_REF:0000107
MGI:2675830 (PMID:23112346)
GO_REF:0000033 		UniProt
Ensembl
RGD
GO_Central		 PMID:23112346 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr20:3,757,396...3,761,024
Ensembl chr20:3,757,536...3,760,735 		JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 involved_in ISO
ISS 		(PMID:11919189)
GO_REF:0000024 		RGD
UniProt		 PMID:11919189 GO_REF:0000024 NCBI chr10:79,394,999...79,400,418
Ensembl chr10:78,897,770...78,903,538
Ensembl chr20:78,897,770...78,903,538 		JBrowse link
G Nrp1 neuropilin 1 involved_in ISO
IEA 		(PMID:24863063), (PMID:26051942)
GO_REF:0000107 		RGD
Ensembl		 PMID:24863063 PMID:26051942 GO_REF:0000107 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Plek pleckstrin involved_in ISO
IEA 		(PMID:10995449)
GO_REF:0000107 		RGD
Ensembl		 PMID:10995449 GO_REF:0000107 NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131 		JBrowse link
G Plpp3 phospholipid phosphatase 3 acts_upstream_of ISO
ISS 		(PMID:12660161)
GO_REF:0000024 		RGD
UniProt		 PMID:12660161 GO_REF:0000024 NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:119,927,085...120,002,205 		JBrowse link
G Pram1 PML-RARA regulated adaptor molecule 1 acts_upstream_of_or_within
involved_in 		ISO
IEA 		MGI:3579812 (PMID:15572693)
GO_REF:0000002 		RGD
InterPro		 PMID:15572693 GO_REF:0000002 NCBI chr 7:14,428,548...14,438,081
Ensembl chr 7:14,420,165...14,438,166 		JBrowse link
G Ptk2 protein tyrosine kinase 2 involved_in ISO
ISS 		(PMID:11331870), (PMID:24036928)
GO_REF:0000024 		RGD
UniProt		 PMID:11331870 PMID:24036928 GO_REF:0000024 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISS
ISO 		GO_REF:0000024
(PMID:15050747) 		UniProt
RGD		 PMID:15050747 GO_REF:0000024 NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Ptn pleiotrophin involved_in ISO
ISS 		(PMID:19141530)
GO_REF:0000024 		RGD
UniProt		 PMID:19141530 GO_REF:0000024 NCBI chr 4:66,260,764...66,342,614
Ensembl chr 4:65,293,734...65,375,456 		JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within ISO
IEA 		MGI:3690333 (PMID:23509158)
GO_REF:0000107 		RGD
Ensembl		 PMID:23509158 GO_REF:0000107 NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925 		JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A involved_in ISS
ISO 		GO_REF:0000024
(PMID:22801373) 		UniProt
RGD		 PMID:22801373 GO_REF:0000024 NCBI chr 3:138,103,261...138,212,835
Ensembl chr 3:117,650,183...117,759,728 		JBrowse link
G Pxn paxillin acts_upstream_of_or_within ISO MGI:2158458 (PMID:11784865) RGD PMID:11784865 NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931 		JBrowse link
G Rcc2 regulator of chromosome condensation 2 involved_in ISO
IEA 		(PMID:19738201)
GO_REF:0000107 		RGD
Ensembl		 PMID:19738201 GO_REF:0000107 NCBI chr 5:158,277,476...158,300,294
Ensembl chr 5:152,993,665...153,017,205 		JBrowse link
G Sema7a semaphorin 7A (John Milton Hagen blood group) involved_in ISO
IEA
IBA 		(PMID:12879062)
GO_REF:0000107
(PMID:17377534)
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:12879062 PMID:17377534 GO_REF:0000033 GO_REF:0000107 NCBI chr 8:58,348,448...58,370,536
Ensembl chr 8:58,348,448...58,370,536 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:24036928) RGD PMID:24036928 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Syk spleen associated tyrosine kinase involved_in IEA
ISO
ISS 		GO_REF:0000107
(PMID:11940607), (PMID:17086186)
GO_REF:0000024 		Ensembl
RGD
UniProt		 PMID:11940607 PMID:17086186 GO_REF:0000024 GO_REF:0000107 NCBI chr17:12,756,493...12,830,927
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tec tec protein tyrosine kinase involved_in ISO
IEA 		(PMID:9652744)
GO_REF:0000107 		RGD
Ensembl		 PMID:9652744 GO_REF:0000107 NCBI chr14:35,706,557...35,815,563
Ensembl chr14:35,352,829...35,461,557 		JBrowse link
G Thy1 Thy-1 cell surface antigen involved_in ISO
IBA
IEA
ISS 		(PMID:18346467)
GO_REF:0000033
GO_REF:0000107 		RGD
GO_Central
Ensembl		 PMID:18346467 PMID:18346467 GO_REF:0000033 GO_REF:0000107, RGD:12793016 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659 		JBrowse link
G Tln1 talin 1 involved_in ISO
IEA 		(PMID:20150896)
GO_REF:0000107 		RGD
Ensembl		 PMID:20150896 GO_REF:0000107 NCBI chr 5:62,583,730...62,613,687
Ensembl chr 5:57,787,943...57,817,900 		JBrowse link
G Tspan32 tetraspanin 32 acts_upstream_of_or_within ISO MGI:2183564 (PMID:16720835) RGD PMID:16720835 NCBI chr 1:198,190,128...198,204,447
Ensembl chr 1:198,190,164...198,204,445 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISO (PMID:17086186) RGD PMID:17086186 NCBI chr 1:85,672,931...85,676,856
Ensembl chr 1:85,672,994...85,676,848 		JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO
IEA 		MGI:1888518 (PMID:15249579)
GO_REF:0000107 		RGD
Ensembl		 PMID:15249579 GO_REF:0000107 NCBI chr 9:2,248,856...2,295,905
Ensembl chr 9:2,157,900...2,208,937 		JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 acts_upstream_of_or_within ISO
IEA 		MGI:98923 (PMID:15249579)
GO_REF:0000107 		RGD
Ensembl		 PMID:15249579 GO_REF:0000107 NCBI chr 2:199,699,861...200,042,344
Ensembl chr 2:197,011,831...197,354,321 		JBrowse link
G Vtn vitronectin involved_in IEA
ISO 		GO_REF:0000107
(PMID:10022831) 		Ensembl
RGD		 PMID:10022831 GO_REF:0000107 NCBI chr10:63,892,782...63,895,862
Ensembl chr10:63,394,719...63,397,810 		JBrowse link
G Zyx zyxin involved_in ISO
IEA
IBA 		(PMID:24036928)
GO_REF:0000107
GO_REF:0000033 		RGD
Ensembl
GO_Central		 PMID:24036928 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:71,236,767...71,246,553
Ensembl chr 4:71,237,451...71,246,553 		JBrowse link
negative regulation of integrin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnna1 catenin alpha 1 acts_upstream_of_or_within ISO
IEA 		MGI:2677796 (PMID:22411810)
GO_REF:0000107 		RGD
Ensembl		 PMID:22411810 GO_REF:0000107 NCBI chr18:27,002,330...27,135,009
Ensembl chr18:26,728,485...26,860,910 		JBrowse link
G Mir92b microRNA 92b acts_upstream_of ISO (PMID:26934001) RGD PMID:26934001 NCBI chr 2:174,633,890...174,633,972
Ensembl chr 2:174,633,890...174,633,972 		JBrowse link
G Phactr4 phosphatase and actin regulator 4 involved_in ISO
IEA 		(PMID:22215812)
GO_REF:0000104
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:22215812 GO_REF:0000104 GO_REF:0000107 NCBI chr 5:144,549,350...144,621,259
Ensembl chr 5:144,549,363...144,620,865 		JBrowse link
G Serpine1 serpin family E member 1 involved_in ISO (PMID:8837777) RGD PMID:8837777 NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Slc2a10 solute carrier family 2 member 10 acts_upstream_of ISO
IEA 		(PMID:26376865)
GO_REF:0000107 		RGD
Ensembl		 PMID:26376865 GO_REF:0000107 NCBI chr 3:154,240,395...154,252,690
Ensembl chr 3:154,240,391...154,252,690 		JBrowse link
positive regulation of integrin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd63 Cd63 molecule involved_in ISO
ISS
IEA 		(PMID:16917503), (PMID:23632027)
GO_REF:0000024
GO_REF:0000107 		RGD
UniProt
Ensembl		 PMID:16917503 PMID:23632027 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178 		JBrowse link
G Dab2 DAB adaptor protein 2 involved_in ISO (PMID:15734730) RGD PMID:15734730 NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476 		JBrowse link
G Emp2 epithelial membrane protein 2 acts_upstream_of_or_within
involved_in 		ISO
IBA 		(PMID:16216233)
GO_REF:0000033 		RGD
GO_Central		 PMID:16216233 GO_REF:0000033 NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733 		JBrowse link
G Flna filamin A involved_in ISO
IEA 		(PMID:18177638)
GO_REF:0000107 		RGD
Ensembl		 PMID:18177638 GO_REF:0000107 NCBI chr  X:157,159,051...157,185,559
Ensembl chr  X:152,007,758...152,031,052 		JBrowse link
G Lims1 LIM zinc finger domain containing 1 involved_in
acts_upstream_of_or_within 		IBA
ISO 		GO_REF:0000033
MGI:2385067 (PMID:19652092) 		GO_Central
RGD		 PMID:19652092 GO_REF:0000033 NCBI chr20:26,851,364...26,961,607
Ensembl chr20:26,309,895...26,418,500 		JBrowse link
G Lims2 LIM zinc finger domain containing 2 involved_in
acts_upstream_of_or_within 		IBA
ISO
IEA 		GO_REF:0000033
MGI:1195263 (PMID:19652092)
GO_REF:0000107 		GO_Central
RGD
Ensembl		 PMID:19652092 GO_REF:0000033 GO_REF:0000107 NCBI chr18:23,828,164...23,866,363
Ensembl chr18:23,553,937...23,592,137 		JBrowse link
G Loxl3 lysyl oxidase-like 3 involved_in ISO (PMID:26954549) RGD PMID:26954549 NCBI chr 4:117,098,358...117,114,673
Ensembl chr 4:115,540,685...115,557,466 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 IMP RGD PMID:14970114 RGD:11556214 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600 		JBrowse link
G Vtn vitronectin involved_in ISO (PMID:8837777) RGD PMID:8837777 NCBI chr10:63,892,782...63,895,862
Ensembl chr10:63,394,719...63,397,810 		JBrowse link
regulation of integrin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd177 CD177 molecule involved_in ISO
IBA 		(PMID:28807980)
GO_REF:0000033 		RGD
GO_Central		 PMID:28807980 GO_REF:0000033 NCBI chr 1:89,467,926...89,488,490
Ensembl chr 1:80,340,034...80,360,621 		JBrowse link
G Cd177l1 CD177 molecule like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:89,416,086...89,421,699
Ensembl chr 1:80,288,194...80,293,484 		JBrowse link
G Cd177l2 CD177 molecule like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:89,451,755...89,456,377
Ensembl chr 1:80,323,863...80,328,311 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 involved_in ISO
IEA 		(PMID:17654484), (PMID:18227284)
GO_REF:0000107 		RGD
Ensembl		 PMID:17654484 PMID:18227284 GO_REF:0000107 NCBI chr 6:46,549,994...46,564,735
Ensembl chr 6:40,821,339...40,836,037 		JBrowse link
G Lypd10 Ly6/PLAUR domain containing 10 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:89,400,914...89,406,146
Ensembl chr 1:80,273,019...80,278,219 		JBrowse link
G Lypd10l1 Ly6/PLAUR domain containing 10 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:89,436,460...89,440,884
Ensembl chr 1:80,308,643...80,312,222 		JBrowse link
G Plau plasminogen activator, urokinase involved_in ISO (PMID:8837777) RGD PMID:8837777 NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 involved_in ISO
IEA
ISS 		(PMID:16917503)
GO_REF:0000107
GO_REF:0000024 		RGD
Ensembl
UniProt		 PMID:16917503 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20543
    cellular process 19534
      signal transduction 7313
        cell surface receptor signaling pathway 2915
          integrin-mediated signaling pathway 105
            negative regulation of integrin-mediated signaling pathway 5
            positive regulation of integrin-mediated signaling pathway 9
            regulation of integrin-mediated signaling pathway + 22
Path 2
Term Annotations click to browse term
  biological_process 20543
    biological regulation 13835
      regulation of biological process 13398
        signaling 7874
          signal transduction 7313
            cell surface receptor signaling pathway 2915
              integrin-mediated signaling pathway 105
                negative regulation of integrin-mediated signaling pathway 5
                positive regulation of integrin-mediated signaling pathway 9
                regulation of integrin-mediated signaling pathway + 22
paths to the root