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ONTOLOGY REPORT - ANNOTATIONS


Term:integrin-mediated signaling pathway
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Accession:GO:0007229 term browser browse the term
Definition:A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: integrin-mediated signalling pathway


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integrin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049499.1 involved_in IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 Ensembl chr 5:124,442,293...124,542,156 JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase involved_in ISO (PMID:24863063) RGD PMID:24863063 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Adam11 ADAM metallopeptidase domain 11 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:90,731,260...90,749,221
Ensembl chr10:90,731,148...90,749,217
JBrowse link
G Adam15 ADAM metallopeptidase domain 15 involved_in ISO
IBA
(PMID:22505472)
PMID:21873635
RGD PMID:22505472, PMID:21873635 RGD:13792537 NCBI chr 2:188,661,831...188,672,337
Ensembl chr 2:188,661,699...188,672,247
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 6:43,400,525...43,448,280
Ensembl chr 6:43,400,528...43,448,280
JBrowse link
G Adam2 ADAM metallopeptidase domain 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:42,708,536...42,751,281
Ensembl chr15:42,708,387...42,751,330
JBrowse link
G Adam4 a disintegrin and metalloprotease domain 4 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 6:105,158,024...105,160,470
Ensembl chr 6:105,158,026...105,160,470
JBrowse link
G Adam6 ADAM metallopeptidase domain 6A involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 6:138,432,550...138,435,038
Ensembl chr 6:138,432,550...138,435,035
JBrowse link
G Adam7 ADAM metallopeptidase domain 7 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr15:49,418,946...49,467,174
Ensembl chr15:49,418,946...49,467,174
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Adamts15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:31,977,001...32,000,378
Ensembl chr 8:31,977,001...32,000,378
JBrowse link
G Adamts19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr18:53,915,807...54,099,856
Ensembl chr18:53,915,807...54,099,120
JBrowse link
G Adamts2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:36,098,051...36,304,416
Ensembl chr10:36,098,051...36,304,409
JBrowse link
G Adamts3 ADAM metallopeptidase with thrombospondin type 1, motif 3 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr14:19,866,278...20,072,896
Ensembl chr14:19,866,408...20,070,994
JBrowse link
G Adamts5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr11:25,411,174...25,456,639
Ensembl chr11:25,410,975...25,456,836
JBrowse link
G Adamts9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 4:124,660,254...124,860,997
Ensembl chr 4:124,660,262...124,858,250
JBrowse link
G Apoa1 apolipoprotein A1 involved_in ISO (PMID:23726972) RGD PMID:23726972 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member involved_in ISO
IEA
ISS
(PMID:8649368)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:8649368 GO_REF:0000024 GO_REF:0000107 NCBI chr19:43,932,543...43,967,452
Ensembl chr19:43,932,554...43,955,783
JBrowse link
G Ccn2 cellular communication network factor 2 acts_upstream_of_or_within ISO (MGI:1333654|PMID:10082563), (MGI:1342849|PMID:10446209) RGD PMID:10082563 PMID:10446209 MGI:1333654 MGI:1342849 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Cd40lg CD40 ligand involved_in IEA
ISO
GO_REF:0000107
(PMID:31331973)
Ensembl
RGD
PMID:31331973 GO_REF:0000107 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cd47 Cd47 molecule involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cdc42 cell division cycle 42 involved_in ISO (PMID:26051942) RGD PMID:26051942 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdh17 cadherin 17 involved_in ISO (PMID:25336636) RGD PMID:25336636 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
JBrowse link
G Col3a1 collagen type III alpha 1 chain involved_in ISO (PMID:14970208) RGD PMID:14970208 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cul3 cullin 3 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5312166|PMID:22358839)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:22358839 GO_REF:0000024 GO_REF:0000107 MGI:5312166 NCBI chr 9:86,044,485...86,129,066
Ensembl chr 9:86,044,485...86,129,329
JBrowse link
G Fbln1 fibulin 1 NOT|involved_in ISO (PMID:11792823) RGD PMID:11792823 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig involved_in ISO (MGI:3693026|PMID:17086186) RGD PMID:17086186 MGI:3693026 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Fermt1 FERM domain containing kindlin 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:125,566,744...125,607,864
Ensembl chr 3:125,566,643...125,607,735
JBrowse link
G Fermt2 FERM domain containing kindlin 2 involved_in ISO (PMID:21325030) RGD PMID:21325030 NCBI chr15:19,807,806...19,876,557
Ensembl chr15:19,807,808...19,876,408
JBrowse link
G Fermt3 FERM domain containing kindlin 3 involved_in ISO (PMID:19234460) RGD PMID:19234460 NCBI chr 1:222,254,183...222,272,775
Ensembl chr 1:222,254,184...222,272,285
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase involved_in ISO
IBA
ISS
(PMID:10739672), (PMID:7519620)
(MGI:3640451|PMID:11672534)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:7519620 PMID:10739672 PMID:11672534, PMID:21873635 GO_REF:0000024 MGI:3640451, RGD:13792537 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Fn1 fibronectin 1 involved_in ISO
IEA
(PMID:19126672)
GO_REF:0000107
RGD
Ensembl
PMID:19126672 GO_REF:0000107 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fut8 fucosyltransferase 8 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3608699 (MGI:3697036|PMID:17043354)
Ensembl
RGD
PMID:17043354 GO_REF:0000107 MGI:3697036 NCBI chr 6:100,305,957...100,537,208
Ensembl chr 6:100,337,226...100,537,224
JBrowse link
G Fyb1 FYN binding protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:55,834,904...55,983,805
Ensembl chr 2:55,835,151...55,983,804
JBrowse link
G Gab2 GRB2-associated binding protein 2 acts_upstream_of_or_within ISO (MGI:2177910|PMID:11895767) RGD PMID:11895767 MGI:2177910 NCBI chr 1:162,082,876...162,283,379
Ensembl chr 1:162,083,030...162,279,727
JBrowse link
G Ibsp integrin-binding sialoprotein involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
JBrowse link
G Ilk integrin-linked kinase acts_upstream_of_or_within
involved_in
IMP
ISO
IBA
(PMID:9366252)
PMID:21873635
RGD PMID:9366252, PMID:12629168, PMID:21873635 RGD:2302091, RGD:13792537 NCBI chr 1:170,578,941...170,585,192
Ensembl chr 1:170,578,889...170,585,189
JBrowse link
G Ilkap ILK associated serine/threonine phosphatase involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 9:98,514,599...98,536,586
Ensembl chr 9:98,514,584...98,536,581
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier involved_in ISO (PMID:29100055) RGD PMID:29100055 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Itga1 integrin subunit alpha 1 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:47,127,403...47,281,387
Ensembl chr 2:47,127,219...47,281,421
JBrowse link
G Itga10 integrin subunit alpha 10 involved_in ISO (PMID:24823363) RGD PMID:24823363 NCBI chr 2:198,772,937...198,792,253
Ensembl chr 2:198,772,937...198,792,253
JBrowse link
G Itga11 integrin subunit alpha 11 involved_in ISO (PMID:24823363) RGD PMID:24823363 NCBI chr 8:67,566,874...67,683,973
Ensembl chr 8:67,615,635...67,683,973
JBrowse link
G Itga2 integrin subunit alpha 2 involved_in ISO (PMID:24823363) RGD PMID:24823363 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itga2b integrin subunit alpha 2b involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:90,397,960...90,416,550
Ensembl chr10:90,398,132...90,415,070
JBrowse link
G Itga3 integrin subunit alpha 3 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:82,855,841...82,887,755
Ensembl chr10:82,855,613...82,887,497
JBrowse link
G Itga4 integrin subunit alpha 4 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Itga5 integrin subunit alpha 5 involved_in IDA
ISO
(PMID:31331973) RGD PMID:31331973, PMID:12821041 RGD:1300196 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itga6 integrin subunit alpha 6 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:58,442,904...58,515,124
Ensembl chr 3:58,443,101...58,515,124
JBrowse link
G Itga7 integrin subunit alpha 7 involved_in IDA
IEA
GO_REF:0000043 UniProt PMID:1315319 GO_REF:0000043, RGD:70774 NCBI chr 7:3,355,079...3,383,886
Ensembl chr 7:3,355,116...3,384,675
JBrowse link
G Itga8 integrin subunit alpha 8 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr17:79,321,893...79,676,927
Ensembl chr17:79,321,900...79,676,499
JBrowse link
G Itga9 integrin subunit alpha 9 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 8:127,271,029...127,576,709
Ensembl chr 8:127,271,289...127,572,988
JBrowse link
G Itgad integrin subunit alpha D involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:199,595,968...199,623,931
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgae integrin subunit alpha E involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:59,652,324...59,711,885
Ensembl chr10:59,539,405...59,711,874
JBrowse link
G Itgal integrin subunit alpha L involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Itgam integrin subunit alpha M involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgav integrin subunit alpha V involved_in IEA
ISO
GO_REF:0000043
(PMID:26934001)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:26934001 GO_REF:0000043 GO_REF:0000107 NCBI chr 3:71,113,269...71,205,958
Ensembl chr 3:71,114,100...71,202,411
JBrowse link
G Itgax integrin subunit alpha X involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932
JBrowse link
G Itgb1 integrin subunit beta 1 involved_in IMP
IEA
IBA
ISO
PMID:22973009
GO_REF:0000107
PMID:21873635
(PMID:24823363), (PMID:31331973)
Ensembl
RGD
PMID:24823363 PMID:31331973, PMID:22973009, PMID:21873635 GO_REF:0000107, RGD:12050116, RGD:13792537 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 involved_in ISO (PMID:11919189), (PMID:15703214) RGD PMID:11919189 PMID:15703214 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G Itgb1bp2 integrin subunit beta 1 binding protein 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr  X:71,342,770...71,347,623
Ensembl chr  X:71,342,775...71,347,619
JBrowse link
G Itgb2 integrin subunit beta 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3050945|PMID:15249579)
(PMID:25453580)
(PMID:28807980)
RGD PMID:15249579 PMID:25453580 PMID:28807980, PMID:21873635 MGI:3050945, RGD:13792537 NCBI chr20:11,777,773...11,815,647
Ensembl chr20:11,777,783...11,815,647
JBrowse link
G Itgb3 integrin subunit beta 3 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Itgb4 integrin subunit beta 4 involved_in TAS
IBA
IEA
PMID:21873635
GO_REF:0000043
UniProt PMID:8026337, PMID:21873635 GO_REF:0000043, RGD:729025, RGD:13792537 NCBI chr10:104,524,000...104,560,180
Ensembl chr10:104,523,996...104,561,078
JBrowse link
G Itgb5 integrin subunit beta 5 involved_in ISO (PMID:24036928)
(MGI:5582864|PMID:24036928)
RGD PMID:24036928 MGI:5582864 NCBI chr11:70,056,500...70,172,164
Ensembl chr11:70,056,500...70,172,372
JBrowse link
G Itgb6 integrin subunit beta 6 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Itgb7 integrin subunit beta 7 involved_in ISO
IBA
(PMID:23986478)
PMID:21873635
RGD PMID:23986478, PMID:21873635 RGD:13792537 NCBI chr 7:143,820,236...143,837,802
Ensembl chr 7:143,820,900...143,837,780
JBrowse link
G Itgb8 integrin subunit beta 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813
JBrowse link
G Itgbl1 integrin subunit beta like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:110,114,148...110,378,970
Ensembl chr15:110,114,148...110,378,969
JBrowse link
G Lama5 laminin subunit alpha 5 involved_in ISO
IBA
(PMID:11821406)
PMID:21873635
RGD PMID:11821406, PMID:21873635 RGD:13792537 NCBI chr 3:175,553,042...175,601,112
Ensembl chr 3:175,553,045...175,601,127
JBrowse link
G Lat linker for activation of T cells involved_in ISO (PMID:15100278) RGD PMID:15100278 NCBI chr 1:197,765,644...197,770,669
Ensembl chr 1:197,765,644...197,770,669
JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 involved_in ISO
IBA
(PMID:23986478)
PMID:21873635
RGD PMID:23986478, PMID:21873635 RGD:13792537 NCBI chr 7:12,918,352...12,922,509
Ensembl chr 7:12,918,710...12,922,112
JBrowse link
G Mpig6b megakaryocyte and platelet inhibitory receptor G6b involved_in
acts_upstream_of_or_within
ISS
ISO
IBA
IEA
GO_REF:0000024
MGI:2675830 (MGI:5512895|PMID:23112346)
PMID:21873635
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:23112346, PMID:21873635 GO_REF:0000024 GO_REF:0000107 MGI:5512895, RGD:13792537 NCBI chr20:5,054,419...5,056,655
Ensembl chr20:5,054,583...5,056,488
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 involved_in ISO
ISS
(PMID:11919189)
GO_REF:0000024
RGD
UniProt
PMID:11919189 GO_REF:0000024 NCBI chr10:81,648,216...81,653,717
Ensembl chr10:81,648,216...81,653,717
JBrowse link
G Nrp1 neuropilin 1 involved_in ISO (PMID:24863063), (PMID:26051942)
(MGI:5588737|PMID:24863063)
RGD PMID:24863063 PMID:26051942 MGI:5588737 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Plek pleckstrin involved_in ISO (PMID:10995449) RGD PMID:10995449 NCBI chr14:100,151,518...100,184,192
Ensembl chr14:100,151,210...100,217,913
JBrowse link
G Plpp3 phospholipid phosphatase 3 acts_upstream_of ISO
ISS
(PMID:12660161)
GO_REF:0000024
RGD
UniProt
PMID:12660161 GO_REF:0000024 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
JBrowse link
G Pram1 PML-RARA regulated adaptor molecule 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3579812 (MGI:3525750|PMID:15572693)
RGD PMID:15572693, PMID:21873635 MGI:3525750, RGD:13792537 NCBI chr 7:18,507,878...18,516,321
Ensembl chr 7:18,510,354...18,515,503
JBrowse link
G Ptk2 protein tyrosine kinase 2 involved_in IDA
IEA
ISS
ISO
PMID:22973009
GO_REF:0000107
GO_REF:0000024
(PMID:11331870), (PMID:24036928)
Ensembl
UniProt
RGD
PMID:11331870 PMID:24036928, PMID:22973009 GO_REF:0000024 GO_REF:0000107, RGD:12050116 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta involved_in ISS
ISO
GO_REF:0000024
(PMID:15050747)
UniProt
RGD
PMID:15050747 GO_REF:0000024 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Ptn pleiotrophin involved_in ISO
ISS
(PMID:19141530)
GO_REF:0000024
RGD
UniProt
PMID:19141530 GO_REF:0000024 NCBI chr 4:64,239,156...64,330,996
Ensembl chr 4:64,239,158...64,330,996
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 acts_upstream_of_or_within ISO MGI:3690333 (MGI:5494903|PMID:23509158) RGD PMID:23509158 MGI:5494903 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:5442237|PMID:22801373)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:22801373 GO_REF:0000024 GO_REF:0000107 MGI:5442237 NCBI chr 3:122,976,066...123,084,585
Ensembl chr 3:122,976,104...123,084,863
JBrowse link
G Pxn paxillin acts_upstream_of_or_within ISO MGI:2158458 (MGI:2157255|PMID:11784865) RGD PMID:11784865 MGI:2157255 NCBI chr12:46,797,953...46,845,107
Ensembl chr12:46,797,954...46,845,080
JBrowse link
G Rcc2 regulator of chromosome condensation 2 involved_in ISO (PMID:19738201) RGD PMID:19738201 NCBI chr 5:159,220,531...159,236,313
Ensembl chr 5:159,220,979...159,234,320
JBrowse link
G Sema7a semaphorin 7A (John Milton Hagen blood group) involved_in ISO
IBA
(PMID:12879062)
(MGI:3710037|PMID:17377534)
PMID:21873635
RGD PMID:12879062 PMID:17377534, PMID:21873635 MGI:3710037, RGD:13792537 NCBI chr 8:62,723,788...62,746,530
Ensembl chr 8:62,723,788...62,745,868
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:24036928) RGD PMID:24036928 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Syk spleen associated tyrosine kinase involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3693026|PMID:17086186), (MGI:5306324|PMID:11940607)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:11940607 PMID:17086186 GO_REF:0000024 GO_REF:0000107 MGI:3693026 MGI:5306324 NCBI chr17:12,614,311...12,669,568
Ensembl chr17:12,614,311...12,669,573
JBrowse link
G Tec tec protein tyrosine kinase involved_in IBA
ISO
PMID:21873635
(PMID:9652744)
RGD PMID:9652744, PMID:21873635 RGD:13792537 NCBI chr14:37,918,884...38,027,953
Ensembl chr14:37,918,652...38,027,925
JBrowse link
G Thy1 Thy-1 cell surface antigen involved_in ISO
ISS
(PMID:18346467)
(MGI:3796911|PMID:18346467)
RGD PMID:18346467, PMID:18346467 MGI:3796911, RGD:12793016 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tln1 talin 1 involved_in ISO (MGI:4439219|PMID:20150896) RGD PMID:20150896 MGI:4439219 NCBI chr 5:59,033,635...59,063,592
Ensembl chr 5:59,033,636...59,063,592
JBrowse link
G Tspan32 tetraspanin 32 acts_upstream_of_or_within ISO MGI:2183564 (MGI:3804129|PMID:16720835) RGD PMID:16720835 MGI:3804129 NCBI chr 1:216,189,535...216,206,202
Ensembl chr 1:216,191,886...216,206,200
JBrowse link
G Tubgcp2 tubulin, gamma complex associated protein 2 involved_in IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 1:212,333,740...212,359,352
Ensembl chr 1:212,333,741...212,354,273
JBrowse link
G Txk TXK tyrosine kinase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:38,029,809...38,085,822
Ensembl chr14:38,030,189...38,085,919
JBrowse link
G Tyrobp transmembrane immune signaling adaptor Tyrobp involved_in ISO (MGI:3693026|PMID:17086186) RGD PMID:17086186 MGI:3693026 NCBI chr 1:88,875,370...88,879,305
Ensembl chr 1:88,875,375...88,879,303
JBrowse link
G Vav1 vav guanine nucleotide exchange factor 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1888518 (MGI:3050945|PMID:15249579)
Ensembl
RGD
PMID:15249579 GO_REF:0000107 MGI:3050945 NCBI chr 9:9,617,551...9,675,167
Ensembl chr 9:9,617,786...9,675,110
JBrowse link
G Vav3 vav guanine nucleotide exchange factor 3 acts_upstream_of_or_within ISO MGI:98923 (MGI:3050945|PMID:15249579) RGD PMID:15249579 MGI:3050945 NCBI chr 2:212,247,061...212,585,818
Ensembl chr 2:212,247,451...212,585,818
JBrowse link
G Zyx zyxin involved_in ISO
IBA
(PMID:24036928)
(MGI:5582864|PMID:24036928)
PMID:21873635
RGD PMID:24036928, PMID:21873635 MGI:5582864, RGD:13792537 NCBI chr 4:71,740,188...71,749,386
Ensembl chr 4:71,740,532...71,749,386
JBrowse link
negative regulation of integrin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctnna1 catenin alpha 1 acts_upstream_of_or_within ISO MGI:2677796 (MGI:5315030|PMID:22411810) RGD PMID:22411810 MGI:5315030 NCBI chr18:27,923,229...28,055,972
Ensembl chr18:27,923,572...28,055,960
JBrowse link
G Phactr4 phosphatase and actin regulator 4 involved_in ISO (MGI:5302129|PMID:22215812) RGD PMID:22215812 MGI:5302129 NCBI chr 5:150,533,895...150,609,423
Ensembl chr 5:150,546,430...150,609,352
JBrowse link
G Slc2a10 solute carrier family 2 member 10 acts_upstream_of ISO (PMID:26376865) RGD PMID:26376865 NCBI chr 3:162,182,156...162,194,610
Ensembl chr 3:162,181,974...162,194,804
JBrowse link
positive regulation of integrin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd63 Cd63 molecule involved_in ISO
ISS
(PMID:16917503), (PMID:23632027)
GO_REF:0000024
RGD
UniProt
PMID:16917503 PMID:23632027 GO_REF:0000024 NCBI chr 7:3,320,250...3,335,583
Ensembl chr 7:3,320,103...3,335,582
JBrowse link
G Dab2 DAB adaptor protein 2 involved_in ISO (MGI:5442513|PMID:15734730) RGD PMID:15734730 MGI:5442513 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270
JBrowse link
G Dmtn dematin actin binding protein involved_in ISO (MGI:5465511|PMID:23060452) RGD PMID:23060452 MGI:5465511 NCBI chr15:52,292,762...52,320,385
Ensembl chr15:52,292,765...52,320,385
JBrowse link
G Emp2 epithelial membrane protein 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(PMID:16216233)
(MGI:3610242|PMID:16216233)
RGD PMID:16216233, PMID:21873635 MGI:3610242, RGD:13792537 NCBI chr10:5,433,248...5,467,840
Ensembl chr10:5,433,248...5,467,839
JBrowse link
G Flna filamin A involved_in ISO (PMID:18177638) RGD PMID:18177638 NCBI chr  X:156,460,785...156,487,245
Ensembl chr  X:156,463,953...156,487,245
JBrowse link
G Lims1 LIM zinc finger domain containing 1 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2385067 (MGI:4867167|PMID:19652092)
RGD PMID:19652092, PMID:21873635 MGI:4867167, RGD:13792537 NCBI chr20:27,895,981...28,004,767
Ensembl chr20:27,954,433...28,002,082
JBrowse link
G Lims2 LIM zinc finger domain containing 2 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:1195263 (MGI:4867167|PMID:19652092)
RGD PMID:19652092, PMID:21873635 MGI:4867167, RGD:13792537 NCBI chr18:24,707,951...24,746,159
Ensembl chr18:24,708,115...24,746,159
JBrowse link
G Loxl3 lysyl oxidase-like 3 involved_in ISO (MGI:5825413|PMID:26954549) RGD PMID:26954549 MGI:5825413 NCBI chr 4:113,866,782...113,883,713
Ensembl chr 4:113,866,804...113,883,477
JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 IMP RGD PMID:14970114 RGD:11556214 NCBI chr 1:236,031,988...236,313,858
Ensembl chr 1:236,031,988...236,313,858
JBrowse link
regulation of integrin-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd177 CD177 molecule involved_in ISO
IBA
(PMID:28807980)
PMID:21873635
RGD PMID:28807980, PMID:21873635 RGD:13792537 NCBI chr 1:82,964,683...82,987,306
Ensembl chr 1:82,964,683...82,987,253
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 involved_in ISO (MGI:5486544|PMID:18227284), (MGI:5486551|PMID:17654484) RGD PMID:17654484 PMID:18227284 MGI:5486544 MGI:5486551 NCBI chr 6:43,348,927...43,363,633
Ensembl chr 6:43,348,958...43,363,335
JBrowse link
G LOC681077 similar to testis expressed gene 101 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:82,922,429...82,937,637
Ensembl chr 1:81,548,892...81,550,598
JBrowse link
G RGD1564380 similar to BC049730 protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:82,830,153...82,902,864
Ensembl chr 1:82,831,952...82,918,444
Ensembl chr 1:82,831,952...82,918,444
Ensembl chr 1:82,831,952...82,918,444
JBrowse link
G RGD1565655 similar to BC049730 protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:81,592,004...81,597,637
Ensembl chr 1:81,593,800...81,596,819
Ensembl chr 1:81,593,800...81,596,819
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 involved_in ISO
ISS
(PMID:16917503)
GO_REF:0000024
RGD
UniProt
PMID:16917503 GO_REF:0000024 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19610
    signaling 7520
      signal transduction 6949
        cell surface receptor signaling pathway 2764
          integrin-mediated signaling pathway 114
            negative regulation of integrin-mediated signaling pathway 3
            positive regulation of integrin-mediated signaling pathway 9
            regulation of integrin-mediated signaling pathway + 18
Path 2
Term Annotations click to browse term
  biological_process 19610
    biological regulation 13577
      regulation of biological process 12853
        regulation of cellular process 12352
          signal transduction 6949
            cell surface receptor signaling pathway 2764
              integrin-mediated signaling pathway 114
                negative regulation of integrin-mediated signaling pathway 3
                positive regulation of integrin-mediated signaling pathway 9
                regulation of integrin-mediated signaling pathway + 18
paths to the root