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ONTOLOGY REPORT - ANNOTATIONS


Term:signal transduction downstream of smoothened
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Accession:GO:0007227 term browser browse the term
Definition:The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.



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signal transduction downstream of smoothened term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ift122 intraflagellar transport 122 involved_in ISO (MGI:4888042|PMID:21209331) RGD PMID:21209331 MGI:4888042 NCBI chr 4:148,905,031...148,975,458
Ensembl chr 4:148,905,046...148,975,458
JBrowse link
positive regulation of hh target transcription factor activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shh sonic hedgehog signaling molecule involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:95728 (MGI:1336531|PMID:10340755), (MGI:3624046|PMID:16611981), (MGI:3653954|PMID:16880529)
(MGI:5142377|PMID:11517919)
Ensembl
RGD
PMID:10340755 PMID:11517919 PMID:16611981 PMID:16880529 GO_REF:0000107 MGI:1336531 MGI:3624046 MGI:3653954 MGI:5142377 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Smo smoothened, frizzled class receptor involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:5142377|PMID:11517919)
UniProt
Ensembl
RGD
PMID:11517919 GO_REF:0000024 GO_REF:0000107 MGI:5142377 NCBI chr 4:58,344,101...58,372,828
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Stk36 serine/threonine kinase 36 involved_in IBA
ISO
PMID:21873635
(MGI:4943382|PMID:18600476)
RGD PMID:18600476 PMID:21873635 MGI:4943382, RGD:13792537 NCBI chr 9:76,176,922...76,204,423
Ensembl chr 9:76,176,920...76,204,422
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18877
    cellular process 17586
      signal transduction 6838
        intracellular signal transduction 2675
          signal transduction downstream of smoothened 4
            positive regulation of hh target transcription factor activity 3
Path 2
Term Annotations click to browse term
  biological_process 18877
    biological regulation 13380
      regulation of biological process 12644
        regulation of cellular process 11961
          signal transduction 6838
            cell surface receptor signaling pathway 2778
              smoothened signaling pathway 165
                signal transduction downstream of smoothened 4
                  positive regulation of hh target transcription factor activity 3
paths to the root