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ONTOLOGY REPORT - ANNOTATIONS


Term:protein kinase C-activating G protein-coupled receptor signaling pathway
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Accession:GO:0007205 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
Synonyms:related_synonym: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway;   activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway


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protein kinase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IDA in PC12 cells, PKCs epsilon and zeta activated after short-term activation of Adora2a RGD PMID:12590138 RGD:1625697 NCBI chr20:13,315,848...13,333,386 JBrowse link
G Bdkrb1 bradykinin receptor B1 IDA RGD PMID:15319421 RGD:1625754 NCBI chr 6:124,510,827...124,514,475 JBrowse link
G Cck cholecystokinin IDA RGD PMID:12496267 RGD:1626097 NCBI chr 8:121,153,499...121,160,194 JBrowse link
G Cish cytokine inducible SH2-containing protein involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2652984|PMID:12618484)
Ensembl
RGD
PMID:12618484 GO_REF:0000107 MGI:2652984 NCBI chr 8:107,972,306...107,977,254 JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:19439178 RGD:5130951 NCBI chr 4:84,222,897...84,265,924 JBrowse link
G Dgka diacylglycerol kinase, alpha involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:1,148,734...1,175,324 JBrowse link
G Dgkb diacylglycerol kinase, beta involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:54,640,948...55,397,210 JBrowse link
G Dgkd diacylglycerol kinase, delta involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:88,516,686...88,607,349 JBrowse link
G Dgke diacylglycerol kinase epsilon involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:73,852,679...73,877,334 JBrowse link
G Dgkg diacylglycerol kinase, gamma TAS RGD PMID:7809169 RGD:1298876 NCBI chr11:78,384,212...78,579,158 JBrowse link
G Dgkh diacylglycerol kinase, eta involved_in ISO (PMID:12810723) RGD PMID:12810723 NCBI chr15:53,981,079...54,150,470 JBrowse link
G Dgki diacylglycerol kinase, iota involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:65,410,878...65,872,733 JBrowse link
G Dgkk diacylglycerol kinase kappa involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:15,581,991...15,713,814 JBrowse link
G Dgkq diacylglycerol kinase, theta involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:1,059,125...1,073,131 JBrowse link
G Dgkz diacylglycerol kinase zeta involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:77,904,149...77,946,114 JBrowse link
G Edn1 endothelin 1 acts_upstream_of_or_within ISO (MGI:70451|PMID:2542249) RGD PMID:2542249 MGI:70451 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Edn2 endothelin 2 IMP RGD PMID:1533364 RGD:1581817 NCBI chr 5:133,751,316...133,756,814 JBrowse link
G Ednra endothelin receptor type A IMP RGD PMID:12628492 RGD:728499 NCBI chr19:30,233,540...30,303,727 JBrowse link
G F2r coagulation factor II (thrombin) receptor IMP RGD PMID:12644441 RGD:1582293 NCBI chr 2:26,869,343...26,885,856 JBrowse link
G Grm5 glutamate metabotropic receptor 5 involved_in IDA
TAS
PMID:12514208
PMID:15758184
UniProt PMID:12514208, PMID:15758184 RGD:728711, RGD:8554618 NCBI chr 1:141,310,069...141,884,980 JBrowse link
G Hcrt hypocretin neuropeptide precursor IMP RGD PMID:16247802 RGD:1600968 NCBI chr10:85,689,992...85,691,206 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B involved_in ISO (MGI:4821070|PMID:17325130) RGD PMID:17325130 MGI:4821070 NCBI chr 8:82,513,572...82,534,892 JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:4821070|PMID:17325130)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17325130 GO_REF:0000024 GO_REF:0000107 MGI:4821070 NCBI chr 9:86,735,793...86,756,640 JBrowse link
G Il2 interleukin 2 IMP RGD PMID:7859920 RGD:1600108 NCBI chr 2:120,004,862...120,009,566 JBrowse link
G Lrp1 LDL receptor related protein 1 IMP RGD PMID:17314289 RGD:1625020 NCBI chr 7:63,380,325...63,461,029 JBrowse link
G Ms4a2 membrane spanning 4-domains A2 IDA RGD PMID:11388899 RGD:1599963 NCBI chr 1:208,440,179...208,448,716 JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:10623590)
UniProt
Ensembl
RGD
PMID:10623590 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:110,796,623...110,816,850 JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in TAS PMID:8302854 UniProt PMID:8302854 RGD:68785 NCBI chr10:33,169,415...33,174,896 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    signaling 7457
      signal transduction 6880
        G protein-coupled receptor signaling pathway 2333
          protein kinase C-activating G protein-coupled receptor signaling pathway 28
Path 2
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological process 12769
        regulation of cellular process 12271
          signal transduction 6880
            G protein-coupled receptor signaling pathway 2333
              protein kinase C-activating G protein-coupled receptor signaling pathway 28
paths to the root